المؤلفون: Lingtian Zhang (8776091), Marialuisa Moccia (750013), David C. Briggs (8776097), Jaideep B. Bharate (1724008), Naga Rajiv Lakkaniga (8776094), Phillip Knowles (12007131), Wei Yan (4327), Phuc Tran (12007134), Anupreet Kharbanda (12007137), Xiuqi Wang (6247901), Yuet-Kin Leung (565316), Brendan Frett (1321818), Massimo Santoro (141869), Neil Q. McDonald (8776103), Francesca Carlomagno (103407), Hong-yu Li (1321812)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, trisubstituted pyrimidine derivatives, attractive therapeutic target, showing potent inhibition, ret phosphorylation indicated, 20 , wt <, ret inhibition, potent inhibitors, unique pose, several fda, ret revealed, resistant mutant, ray structure, gatekeeper mutant, frequently reported, driven lc, driven cancers, biological activity, bifurcates beneath

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_N_Trisubstituted_Pyrimidine_Derivatives_as_Type_I_RET_and_RET_Gatekeeper_Mutant_Inhibitors_with_a_Novel_Kinase_Binding_Pose/19076526

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01280.s001

المؤلفون: Lingtian Zhang (8776091), Marialuisa Moccia (750013), David C. Briggs (8776097), Jaideep B. Bharate (1724008), Naga Rajiv Lakkaniga (8776094), Phillip Knowles (12007131), Wei Yan (4327), Phuc Tran (12007134), Anupreet Kharbanda (12007137), Xiuqi Wang (6247901), Yuet-Kin Leung (565316), Brendan Frett (1321818), Massimo Santoro (141869), Neil Q. McDonald (8776103), Francesca Carlomagno (103407), Hong-yu Li (1321812)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, trisubstituted pyrimidine derivatives, attractive therapeutic target, showing potent inhibition, ret phosphorylation indicated, 20 , wt <, ret inhibition, potent inhibitors, unique pose, several fda, ret revealed, resistant mutant, ray structure, gatekeeper mutant, frequently reported, driven lc, driven cancers, biological activity, bifurcates beneath

Relation: https://figshare.com/articles/dataset/Discovery_of_N_Trisubstituted_Pyrimidine_Derivatives_as_Type_I_RET_and_RET_Gatekeeper_Mutant_Inhibitors_with_a_Novel_Kinase_Binding_Pose/19076529

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01280.s002