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1Academic Journal
المؤلفون: Carlin, Aaron, Beadle, James, Ardanuy, Jeremy, Clark, Alex, Rhodes, Victoria, Garretson, Aaron, Murphy, Joyce, Valiaeva, Nadejda, Schooley, Robert, Frieman, Matthew, Hostetler, Karl
المصدر: Antimicrobial Agents and Chemotherapy. 68(10)
مصطلحات موضوعية: COVID-19, SARS-CoV-2, antiviral agent, broad spectrum antiviral, in vivo efficacy, lipid prodrug, mouse model, pharmacokinetics, remdesivir, remdesivir nucleoside, Animals, Prodrugs, Mice, Antiviral Agents, SARS-CoV-2, Administration, Oral, Adenosine Monophosphate, Alanine, COVID-19 Drug Treatment, Female, Humans, Phospholipids, Chlorocebus aethiops, Vero Cells, COVID-19, Disease Models, Animal, Lung, Structure-Activity Relationship, Adenosine
وصف الملف: application/pdf
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2Academic Journal
المؤلفون: McMillan, Rachel, Lo, Michael, Zhang, Xing-Quan, Beadle, James, Valiaeva, Nadejda, Garretson, Aaron, Clark, Alex, Freshman, Jon, Murphy, Joyce, Montgomery, Joel, Spiropoulou, Christina, Schooley, Robert, Hostetler, Karl, Carlin, Aaron
مصطلحات موضوعية: Antiviral agents, Broad spectrum antiviral, Ebola virus, Filovirus, Flavivirus, GS-441524, GS-5734, Hemorrhagic fever viruses, Hendra virus, Henipavirus, Human coronavirus 229E, Lipid prodrugs, Nipah virus, Paramyxovirus, Pneumovirus, RNA virus, Remdesivir, Remdesivir nucleoside, Respiratory syncytial virus, Respiratory viruses, V2043, Zika virus, dengue virus, Antiviral Agents, Prodrugs, Nucleosides, Glycerol, Lipids
وصف الملف: application/pdf
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3Academic Journal
المؤلفون: Schooley, Robert T, Carlin, Aaron F, Beadle, James R, Valiaeva, Nadejda, Zhang, Xing-Quan, Clark, Alex E, McMillan, Rachel E, Leibel, Sandra L, McVicar, Rachael N, Xie, Jialei, Garretson, Aaron F, Smith, Victoria I, Murphy, Joyce, Hostetler, Karl Y
مصطلحات موضوعية: Prevention, Biodefense, Rare Diseases, Stem Cell Research, Infectious Diseases, Vaccine Related, Lung, Emerging Infectious Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, SARS-CoV-2, remdesivir, remdesivir nucleoside, antiviral agents, lipid prodrugs, Vero E6 cells, Calu-3 cells, Caco-2 cells, Huh7.5 cells, PSC-derived human lung cells, Huh7.5 cells and PSC-derived human lung cells, Remdesivir, Remdesivir nucleoside, Microbiology, Medical Microbiology, Pharmacology and Pharmaceutical Sciences
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/26s204w3
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4
المؤلفون: Aaron F. Carlin, Karl Y. Hostetler, Rachael N. McVicar, Xing-Quan Zhang, James R. Beadle, Joyce Murphy, Victoria I Smith, Robert T. Schooley, Rachel E McMillan, Alex E. Clark, Jialei Xie, Sandra L Leibel, Aaron F. Garretson, Nadejda Valiaeva
المصدر: Antimicrobial Agents and Chemotherapy
bioRxiv
article-version (status) pre
article-version (number) 1مصطلحات موضوعية: Adenosine, remdesivir, Pharmacology, Huh7.5 cells, 01 natural sciences, chemistry.chemical_compound, Cricetinae, Prodrugs, Pharmacology (medical), Induced pluripotent stem cell, Caco-2 cells, Lung, Huh7.5 cells and PSC-derived human lung cells, media_common, 0303 health sciences, Alanine, Pharmacology and Pharmaceutical Sciences, Prodrug, Lipids, Infectious Diseases, 5.1 Pharmaceuticals, Medical Microbiology, Vero E6 cells, Development of treatments and therapeutic interventions, Infection, Adenosine monophosphate, Drug, medicine.drug_class, media_common.quotation_subject, Remdesivir, Remdesivir nucleoside, Calu-3 cells, Microbiology, Antiviral Agents, Article, lipid prodrugs, Vaccine Related, 03 medical and health sciences, Rare Diseases, Pharmacokinetics, Biodefense, remdesivir nucleoside, antiviral agents, medicine, Animals, Humans, 030304 developmental biology, 010405 organic chemistry, business.industry, SARS-CoV-2, Prevention, PSC-derived human lung cells, Stem Cell Research, Adenosine Monophosphate, COVID-19 Drug Treatment, 0104 chemical sciences, Bioavailability, Emerging Infectious Diseases, Good Health and Well Being, chemistry, Vero cell, Antiviral drug, business, Nucleoside
وصف الملف: application/pdf
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5
المؤلفون: Michael K, Lo, Punya, Shrivastava-Ranjan, Payel, Chatterjee, Mike, Flint, James R, Beadle, Nadejda, Valiaeva, Joyce, Murphy, Robert T, Schooley, Karl Y, Hostetler, Joel M, Montgomery, Christina F, Spiropoulou
المصدر: bioRxiv
article-version (status) pre
article-version (number) 2مصطلحات موضوعية: filovirus, henipavirus, Adenosine, Remdesivir, Glyceryl Ethers, Nipah virus, Remdesivir nucleoside, Antiviral Agents, Article, lipid prodrugs, NCI-H358 cells, Ebola virus, paramyxovirus, respiratory viruses, ODBG, Animals, Humans, Prodrugs, human small airway epithelial cells (HSAEC1-KT), Alanine, SARS-CoV-2, hemorrhagic fever virus, GS-441524, Nucleosides, Lipids, Adenosine Monophosphate, Huh7 cells, COVID-19 Drug Treatment, human telomerase reverse-transcriptase (hTERT) immortalized microvascular endothelial cells (TIME), Vero E6 cells, GS-5734
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6
المؤلفون: Nadejda Valiaeva, Payel Chatterjee, Mike Flint, Punya Shrivastava-Ranjan, Robert T. Schooley, James R. Beadle, Karl Y. Hostetler, Joyce Murphy, Christina F. Spiropoulou, Joel M. Montgomery, Michael K. Lo
المصدر: Microbiology Spectrum, Vol 9, Iss 3 (2021)
Microbiology Spectrumمصطلحات موضوعية: ODBG-P-RVn, Physiology, Hospitalized patients, viruses, Observation, remdesivir, Disease, Nipah virus, Pharmacology, medicine.disease_cause, Ebola virus, Broad spectrum, Medicine, Ecology, biology, hemorrhagic fever virus, Prodrug, Huh7 cells, QR1-502, Infectious Diseases, human small airway epithelial cells, Drug delivery, Vero E6 cells, GS-5734, Henipavirus, Microbiology (medical), henipavirus, filovirus, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Microbiology, lipid prodrugs, NCI-H358 cells, paramyxovirus, In vivo, remdesivir nucleoside, ODBG, respiratory viruses, antiviral agents, Genetics, General Immunology and Microbiology, SARS-CoV-2, business.industry, GS-441524, Cell Biology, biology.organism_classification, human telomerase reverse-transcriptase (hTERT)-immortalized microvascular endothelial cells (TIME), In vitro, business, Nucleoside, HSAEC1-KT
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7
المؤلفون: Wenjuan Hu, Bo Tan, Lu Chang, Yuanchao Xie, Jia Liu, Chang-Qiang Ke, Jingshan Shen
المصدر: Journal of Pharmaceutical and Biomedical Analysis
مصطلحات موضوعية: Male, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, PPT, protein precipitation, Analytical Chemistry, chemistry.chemical_compound, Mice, FDA, United States Federal Drug Administration, Tandem Mass Spectrometry, Recovery, Drug Discovery, Nucleotide, Prodrugs, ATNs, active triphosphate nucleotide metabolites, IS, internal standard, RDV, remdesivir, Spectroscopy, FA, formic acid, chemistry.chemical_classification, Aqueous solution, Alanine, ESI, electrospray ionization, Prodrug, LLE, liquid-liquid extraction, Liver, COVID 19, coronavirus disease 2019, RSDs, relative standard deviations, RMP, remdesivir monophosphate, Stability, NH4Ac, ammonium acetate, LLOQ, lower limit of quantitation, Bioanalysis, ATP, adenosine triphosphate, Formic acid, UPLC-MS/MS, ultra-performance liquid chromatography coupled triple-quadrupole mass spectrometry, Electrospray ionization, KD, equilibrium dissociation constant, Remdesivir, Mass spectrometry, Antiviral Agents, Nucleotide triphosphate, Article, LC–MS/MS, FT-ICR MS, fourier transform ion cyclotron resonance mass spectrometry, RTP, remdesivir nucleotide triphosphate, Animals, Humans, AgNO3, silver nitrate, RdRp, RNA-dependent RNA polymerases, TCEP, tris (2 carboxyethyl) phosphine hydrochloride, Active metabolite, ComputingMethodologies_COMPUTERGRAPHICS, Chromatography, 010405 organic chemistry, Nucleotide monophosphate, 010401 analytical chemistry, SPE, solid-phase extraction, COVID-19, DTNB, 55′ dithiobis (2-nitrobenzoic acid), ACN, acetonitrile, Adenosine Monophosphate, 0104 chemical sciences, COVID-19 Drug Treatment, BNPP, bis (p-nitrophenyl) phosphate, QC, quality control, RN, remdesivir nucleoside, chemistry, SARS CoV 2, severe acute respiratory coronavirus 2, MeOH, methanol, UTP, uridine triphosphate, HSA, human serum albumin, Chromatography, Liquid