المؤلفون: Suttipat Srisutham (3934988), Wanassanan Madmanee (14271661), Jindarat Kouhathong (14271664), Kreepol Sutawong (14271667), Rupam Tripura (731049), Thomas J. Peto (3157794), Rob W. van der Pluijm (6390596), James J. Callery (8716128), Lek Dysoley (2577217), Mayfong Mayxay (132900), Paul N. Newton (132889), Tiengkham Pongvongsa (244713), Bouasy Hongvanthong (3436124), Nicholas P. J. Day (7305209), Nicholas J. White (35779), Arjen M. Dondorp (7305212), Mallika Imwong (151642)

مصطلحات موضوعية: Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Evolutionary Biology, Infectious Diseases, Virology, Physical Sciences not elsewhere classified, three asian countries, investigated using real, southeast asia due, single nucleotide polymorphisms, several study sites, 59 distinct haplotypes, sulfonamide resistance markers, relatively rapid evolution, laos decades ago, antimalarial drug sulfadoxine, plasmodium falciparum <, clinical drug resistance, irn , g , age , northeast thailand close, falciparum <, study assessed, required due, numerous haplotypes, including single

Relation: https://figshare.com/articles/journal_contribution/S1_Fig_-/21742501

الاتاحة: https://doi.org/10.1371/journal.pone.0278928.s001

المؤلفون: Suttipat Srisutham (3934988), Wanassanan Madmanee (14271661), Jindarat Kouhathong (14271664), Kreepol Sutawong (14271667), Rupam Tripura (731049), Thomas J. Peto (3157794), Rob W. van der Pluijm (6390596), James J. Callery (8716128), Lek Dysoley (2577217), Mayfong Mayxay (132900), Paul N. Newton (132889), Tiengkham Pongvongsa (244713), Bouasy Hongvanthong (3436124), Nicholas P. J. Day (7305209), Nicholas J. White (35779), Arjen M. Dondorp (7305212), Mallika Imwong (151642)

مصطلحات موضوعية: Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Evolutionary Biology, Infectious Diseases, Virology, Physical Sciences not elsewhere classified, three asian countries, investigated using real, southeast asia due, single nucleotide polymorphisms, several study sites, 59 distinct haplotypes, sulfonamide resistance markers, relatively rapid evolution, laos decades ago, antimalarial drug sulfadoxine, plasmodium falciparum <, clinical drug resistance, irn , g , age , northeast thailand close, falciparum <, study assessed, required due, numerous haplotypes, including single

Relation: https://figshare.com/articles/journal_contribution/Haplotypes_of_i_pfdhfr_i_and_i_pfdhps_i_in_i_Plasmodium_falciparum_i_isolated_from_Cambodia_Lao_PDR_and_Thailand_/21742510

الاتاحة: https://doi.org/10.1371/journal.pone.0278928.s004

المؤلفون: Suttipat Srisutham (3934988), Wanassanan Madmanee (14271661), Jindarat Kouhathong (14271664), Kreepol Sutawong (14271667), Rupam Tripura (731049), Thomas J. Peto (3157794), Rob W. van der Pluijm (6390596), James J. Callery (8716128), Lek Dysoley (2577217), Mayfong Mayxay (132900), Paul N. Newton (132889), Tiengkham Pongvongsa (244713), Bouasy Hongvanthong (3436124), Nicholas P. J. Day (7305209), Nicholas J. White (35779), Arjen M. Dondorp (7305212), Mallika Imwong (151642)

مصطلحات موضوعية: Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Evolutionary Biology, Infectious Diseases, Virology, Physical Sciences not elsewhere classified, three asian countries, investigated using real, southeast asia due, single nucleotide polymorphisms, several study sites, 59 distinct haplotypes, sulfonamide resistance markers, relatively rapid evolution, laos decades ago, antimalarial drug sulfadoxine, plasmodium falciparum <, clinical drug resistance, irn , g , age , northeast thailand close, falciparum <, study assessed, required due, numerous haplotypes, including single

Relation: https://figshare.com/articles/journal_contribution/Prevalence_of_i_pfdhfr_i_51I-59R-108N_and_i_pfdhps_i_437G-540E-581G_/21742504

الاتاحة: https://doi.org/10.1371/journal.pone.0278928.s002

المؤلفون: Suttipat Srisutham (3934988), Wanassanan Madmanee (14271661), Jindarat Kouhathong (14271664), Kreepol Sutawong (14271667), Rupam Tripura (731049), Thomas J. Peto (3157794), Rob W. van der Pluijm (6390596), James J. Callery (8716128), Lek Dysoley (2577217), Mayfong Mayxay (132900), Paul N. Newton (132889), Tiengkham Pongvongsa (244713), Bouasy Hongvanthong (3436124), Nicholas P. J. Day (7305209), Nicholas J. White (35779), Arjen M. Dondorp (7305212), Mallika Imwong (151642)

مصطلحات موضوعية: Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Evolutionary Biology, Infectious Diseases, Virology, Physical Sciences not elsewhere classified, three asian countries, investigated using real, southeast asia due, single nucleotide polymorphisms, several study sites, 59 distinct haplotypes, sulfonamide resistance markers, relatively rapid evolution, laos decades ago, antimalarial drug sulfadoxine, plasmodium falciparum <, clinical drug resistance, irn , g , age , northeast thailand close, falciparum <, study assessed, required due, numerous haplotypes, including single

Relation: https://figshare.com/articles/journal_contribution/Prevalence_of_i_pfdhfr_i_and_i_pfdhps_i_point_mutation_/21742507

الاتاحة: https://doi.org/10.1371/journal.pone.0278928.s003

المؤلفون: Shuang Li (146392), Bo Wang (86769), Shun Jiang (4838877), Yi Pan (68170), Yuhua Shi (379491), Wei Kong (294135), Yaming Shan (2545687)

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Computational Biology, specific neutralizing antibodies, soluble bg505 sosip, severe side effects, relatively rapid fabrication, promising alternative approach, promising vaccine candidates, naked dna vaccination, infection remains one, based isoleucine zipper, excellent safety profile, traditional vaccines composed, based vaccine platforms, efficiently delivering dna, naked dna vaccines, dna vaccines present, 664 trimer fused, 1 infection due, delivering dna, dna vaccines, licensed vaccine, 1 infection

Relation: https://figshare.com/articles/journal_contribution/Surface-Functionalized_Silica-Coated_Calcium_Phosphate_Nanoparticles_Efficiently_Deliver_DNA-Based_HIV_1_Trimeric_Envelope_Vaccines_against_HIV_1/16934060

الاتاحة: https://doi.org/10.1021/acsami.1c16989.s001

المؤلفون: Li-Juan Yu (807941), Duncan A. Cullen (11466469), Mahbod Morshedi (6209303), Michelle L. Coote (1421377), Nicholas G. White (818120)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Ecology, Inorganic Chemistry, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >–, substantial protective effect, principles kinetic modeling, found widespread use, corresponding primary amide, quantum chemistry combined, ph 13 ), higher ph ’, 2 , room temperature hydrolysis, room temperature, supramolecular chemistry, ph 9, ph 11, >< sub, unsubstituted benzamidinium, relatively rapid, g ., dominant pathway, aqueous base, amidinium motif

Relation: https://figshare.com/articles/journal_contribution/Room_Temperature_Hydrolysis_of_Benzamidines_and_Benzamidiniums_in_Weakly_Basic_Water/16660204

الاتاحة: https://doi.org/10.1021/acs.joc.1c01955.s001

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/dataset/ANOSIM_and_PERMANOVA_analysis_of_river_biofilm_and_isolate_biofilm_communities_at_4_8_and_24_hours_after_removal_of_founding_populations_/24554329

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.s003
https://figshare.com/articles/dataset/ANOSIM_and_PERMANOVA_analysis_of_river_biofilm_and_isolate_biofilm_communities_at_4_8_and_24_hours_after_removal_of_founding_populations_/24554329

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/dataset/The_top_25_populations_of_river_water_and_river_biofilm_/24554323

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.s001
https://figshare.com/articles/dataset/The_top_25_populations_of_river_water_and_river_biofilm_/24554323

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/NMDS_ANOSIM_and_PERMANOVA_analyses_of_river_biofilm_and_isolate_biofilm_communities_from_river_and_pre-established_biofilms_of_i_Hydrogenophaga_i_F14_i_Brevundimonas_i_F16_and_i_Acidovorax_i_F19_at_8_hours_incubation_/24554335

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.s005
https://figshare.com/articles/figure/NMDS_ANOSIM_and_PERMANOVA_analyses_of_river_biofilm_and_isolate_biofilm_communities_from_river_and_pre-established_biofilms_of_i_Hydrogenophaga_i_F14_i_Brevundimonas_i_F16_and_i_Acidovorax_i_F19_at_8_hours_incubation_/24554335

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/NMDS_ANOSIM_and_PERMANOVA_analyses_of_biofilm_communities_from_river_and_pre-established_biofilms_of_i_Hydrogenophaga_i_F14_i_Brevundimonas_i_F16_and_i_Acidovorax_i_F19_at_4_hours_incubation_/24554332

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.s004
https://figshare.com/articles/figure/NMDS_ANOSIM_and_PERMANOVA_analyses_of_biofilm_communities_from_river_and_pre-established_biofilms_of_i_Hydrogenophaga_i_F14_i_Brevundimonas_i_F16_and_i_Acidovorax_i_F19_at_4_hours_incubation_/24554332

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/Taxa_S_and_Chao_1_diversity_indices_and_evenness_of_river_biofilms_at_4_8_and_24_hours_in_the_presence_and_absence_of_preestablished_isolate_biofilms_/24554326

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.s002
https://figshare.com/articles/figure/Taxa_S_and_Chao_1_diversity_indices_and_evenness_of_river_biofilms_at_4_8_and_24_hours_in_the_presence_and_absence_of_preestablished_isolate_biofilms_/24554326

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/Resilience_of_single_and_double_isolate_biofilms_to_filtered_and_unfiltered_river_water_as_measured_with_crystal_violet_/24554344

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.g003
https://figshare.com/articles/figure/Resilience_of_single_and_double_isolate_biofilms_to_filtered_and_unfiltered_river_water_as_measured_with_crystal_violet_/24554344

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/Ordination_statistical_analyses_and_diversity_measures_of_the_river_and_river_biofilm_communities_/24554338

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.g001
https://figshare.com/articles/figure/Ordination_statistical_analyses_and_diversity_measures_of_the_river_and_river_biofilm_communities_/24554338

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/Top_25_river_and_river_biofilm_populations_/24554341

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.g002
https://figshare.com/articles/figure/Top_25_river_and_river_biofilm_populations_/24554341

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/Resilience_of_established_biofilm_to_challenge_with_river_bacterial_populations_as_determined_by_16S_amplicon_sequencing_/24554347

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.g004
https://figshare.com/articles/figure/Resilience_of_established_biofilm_to_challenge_with_river_bacterial_populations_as_determined_by_16S_amplicon_sequencing_/24554347

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/The_fate_of_river_populations_when_colonizing_established_biofilms_/24554356

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.g007
https://figshare.com/articles/figure/The_fate_of_river_populations_when_colonizing_established_biofilms_/24554356

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/Cluster_analysis_of_biofilms_communities_at_4_8_and_24_hours_T4_T8_T24_/24554350

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.g005
https://figshare.com/articles/figure/Cluster_analysis_of_biofilms_communities_at_4_8_and_24_hours_T4_T8_T24_/24554350

المؤلفون: Roshan Angoshtari, Kim T. Scribner, Terence L. Marsh

مصطلحات موضوعية: Microbiology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, relatively simple measures, relatively rapid way, perhaps offer protection, investigations reported herein, aquatic milieu develop, sturgeon eggs influence, specifically blocked populations, blocking invading populations, tested strains altered, minimizing microbial infections, natural river populations, abundance river populations, pelagic river community, div >< p, microbial populations, microbial community, river biofilm, bacterial populations, several strains, community composition, biofilm community, two strains, top 25, specific manner

Relation: https://figshare.com/articles/figure/NMDS_ANOSIM_and_PERMANOVA_analyses_of_biofilm_communities_from_river_and_pre-established_biofilms_of_i_Hydrogenophaga_i_F14_i_Brevundimonas_i_F16_and_i_Acidovorax_i_F19_at_24_hours_incubation_/24554353

الاتاحة: https://doi.org/10.1371/journal.pone.0288040.g006
https://figshare.com/articles/figure/NMDS_ANOSIM_and_PERMANOVA_analyses_of_biofilm_communities_from_river_and_pre-established_biofilms_of_i_Hydrogenophaga_i_F14_i_Brevundimonas_i_F16_and_i_Acidovorax_i_F19_at_24_hours_incubation_/24554353

المؤلفون: Suttipat Srisutham (3934988), Wanassanan Madmanee (14271661), Jindarat Kouhathong (14271664), Kreepol Sutawong (14271667), Rupam Tripura (731049), Thomas J. Peto (3157794), Rob W. van der Pluijm (6390596), James J. Callery (8716128), Lek Dysoley (2577217), Mayfong Mayxay (132900), Paul N. Newton (132889), Tiengkham Pongvongsa (244713), Bouasy Hongvanthong (3436124), Nicholas P. J. Day (7305209), Nicholas J. White (35779), Arjen M. Dondorp (7305212), Mallika Imwong (151642)

مصطلحات موضوعية: Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Evolutionary Biology, Infectious Diseases, Virology, Physical Sciences not elsewhere classified, three asian countries, investigated using real, southeast asia due, single nucleotide polymorphisms, several study sites, 59 distinct haplotypes, sulfonamide resistance markers, relatively rapid evolution, laos decades ago, antimalarial drug sulfadoxine, plasmodium falciparum <, clinical drug resistance, irn , g , age , northeast thailand close, falciparum <, study assessed, required due, numerous haplotypes, including single

Relation: https://figshare.com/articles/figure/Frequencies_of_i_pfdhfr_i_and_i_pfdhps_i_mutations_in_Thailand_Cambodia_and_Lao_PDR_between_2008_and_2018_/21742513

الاتاحة: https://doi.org/10.1371/journal.pone.0278928.g001

المؤلفون: Suttipat Srisutham (3934988), Wanassanan Madmanee (14271661), Jindarat Kouhathong (14271664), Kreepol Sutawong (14271667), Rupam Tripura (731049), Thomas J. Peto (3157794), Rob W. van der Pluijm (6390596), James J. Callery (8716128), Lek Dysoley (2577217), Mayfong Mayxay (132900), Paul N. Newton (132889), Tiengkham Pongvongsa (244713), Bouasy Hongvanthong (3436124), Nicholas P. J. Day (7305209), Nicholas J. White (35779), Arjen M. Dondorp (7305212), Mallika Imwong (151642)

مصطلحات موضوعية: Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Evolutionary Biology, Infectious Diseases, Virology, Physical Sciences not elsewhere classified, three asian countries, investigated using real, southeast asia due, single nucleotide polymorphisms, several study sites, 59 distinct haplotypes, sulfonamide resistance markers, relatively rapid evolution, laos decades ago, antimalarial drug sulfadoxine, plasmodium falciparum <, clinical drug resistance, irn , g , age , northeast thailand close, falciparum <, study assessed, required due, numerous haplotypes, including single

Relation: https://figshare.com/articles/figure/Changes_in_IRNL-SGKGA_and_IRNI-AGEAA_frequencies_of_i_pfdhfr_i_and_i_pfdhps_i_haplotypes_between_2008_and_2018_/21742516

الاتاحة: https://doi.org/10.1371/journal.pone.0278928.g002