المؤلفون: Christopher J. Morris, Michael G. Rolf, Linda Starnes, Inmaculada C. Villar, Amy Pointon, Holly Kimko, Giovanni Y. Di Veroli

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: hemodynamic drug safety, clinical translation, quantitative systems toxicology, rat, dog, secondary pharmacology, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1402462/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/8cc8e9c9676f413cbf55bed31991df2d

المؤلفون: James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead

المصدر: Frontiers in Pharmacology, Vol 13 (2023)

مصطلحات موضوعية: drug discovery, quantitative systems toxicology modeling, computational biology, bile duct, DILI (drug-induced liver injury), drug development, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1085621/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/854fa12f4fac4c6c81044b54a6766df4

المؤلفون: Meghna Verma, Louis Gall, Jacopo Biasetti, Giovanni Y. Di Veroli, Cesar Pichardo-Almarza, Megan A. Gibbs, Holly Kimko

المصدر: Frontiers in Systems Biology, Vol 2 (2023)

مصطلحات موضوعية: Quantitative systems pharmacology, systems modeling, model informed drug development, quantitative systems toxicology, Computational modeling, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fsysb.2022.1063308/full; https://doaj.org/toc/2674-0702

URL الوصول: https://doaj.org/article/a29bf6f3327e4d3dbd071eaa8fdd58e1

المؤلفون: James J. Beaudoin, Lara Clemens, Mark T. Miedel, Albert Gough, Fatima Zaidi, Priya Ramamoorthy, Kari E. Wong, Rangaprasad Sarangarajan, Christina Battista, Lisl K. M. Shoda, Scott Q. Siler, D. Lansing Taylor, Brett A. Howell, Lawrence A. Vernetti, Kyunghee Yang

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9692

مصطلحات موضوعية: human liver microphysiology system, quantitative systems toxicology (QST) modeling, macromolecule, hepatotoxicity

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pharmacology; https://dx.doi.org/10.3390/ijms24119692

الاتاحة: https://doi.org/10.3390/ijms24119692

المؤلفون: Smith, Brenda, Rowe, Josh, Watkins, Paul B., Ashina, Messoud, Woodhead, Jeffrey L., Sistare, Frank D., Goadsby, Peter J.

المصدر: Smith , B , Rowe , J , Watkins , P B , Ashina , M , Woodhead , J L , Sistare , F D & Goadsby , P J 2020 , ' Mechanistic Investigations Support Liver Safety of Ubrogepant ' , Toxicological sciences : an official journal of the Society of Toxicology , vol. 177 , no. 1 , pp. 84-93 . https://doi.org/10.1093/toxsci/kfaa093

مصطلحات موضوعية: calcitonin gene-related peptide receptor antagonist, DILI, DILIsym, headache, migraine, quantitative systems toxicology

Relation: https://kclpure.kcl.ac.uk/portal/en/publications/2005d6c9-3f37-4c0e-935e-3c4ac4d44395

الاتاحة: https://kclpure.kcl.ac.uk/portal/en/publications/2005d6c9-3f37-4c0e-935e-3c4ac4d44395
https://doi.org/10.1093/toxsci/kfaa093
http://www.scopus.com/inward/record.url?scp=85091127122&partnerID=8YFLogxK

المؤلفون: Beaudoin, James J., Yang, Kyunghee, Adiwidjaja, Jeffry, Taneja, Guncha, Watkins, Paul B., Siler, Scott Q., Howell, Brett A., Woodhead, Jeffrey L.

المصدر: Frontiers in Pharmacology, 13

مصطلحات موضوعية: drug development, computational biology, drug discovery, quantitative systems toxicology modeling, bile duct, DILI (drug-induced liver injury)

Relation: https://cdr.lib.unc.edu/downloads/w0892m842?file=thumbnail; https://cdr.lib.unc.edu/downloads/w0892m842

الاتاحة: https://doi.org/10.17615/4c8j-4f97
https://cdr.lib.unc.edu/downloads/w0892m842?file=thumbnail
https://cdr.lib.unc.edu/downloads/w0892m842

المؤلفون: James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, drug discovery, quantitative systems toxicology modeling, computational biology, bile duct, DILI (drug-induced liver injury), drug development

Relation: https://figshare.com/articles/dataset/DataSheet1_Investigating_bile_acid-mediated_cholestatic_drug-induced_liver_injury_using_a_mechanistic_model_of_multidrug_resistance_protein_3_MDR3_inhibition_docx/21906993

الاتاحة: https://doi.org/10.3389/fphar.2022.1085621.s001
https://figshare.com/articles/dataset/DataSheet1_Investigating_bile_acid-mediated_cholestatic_drug-induced_liver_injury_using_a_mechanistic_model_of_multidrug_resistance_protein_3_MDR3_inhibition_docx/21906993

المؤلفون: Patel, Nikunjkumar, Wiśniowska, Barbara, Jamei, Masoud, Polak, Sebastian

مصطلحات موضوعية: citalopram, cardiotoxicity, QT prolongation, cardiac safety simulator, simcyp, hERG, personalised medicine, quantitative systems toxicology, virtual twin

Relation: The AAPS Journal, T. 20, nr 1; https://ruj.uj.edu.pl/xmlui/handle/item/141983

الاتاحة: https://ruj.uj.edu.pl/xmlui/handle/item/141983
https://doi.org/10.1208/s12248-017-0155-8

المؤلفون: Patel, Nikunjkumar, Hatley, Oliver, Berg, Alexander, Romero, Klaus, Wiśniowska, Barbara, Hanna, Debra, Hermann, David, Polak, Sebastian

مصطلحات موضوعية: hERG, moxifloxacin, torsade de pointes, quantitative systems toxicology, QT prolongation

Relation: The AAPS Journal, T. 20, nr 3; https://ruj.uj.edu.pl/xmlui/handle/item/143025

الاتاحة: https://ruj.uj.edu.pl/xmlui/handle/item/143025
https://doi.org/10.1208/s12248-018-0199-4

المؤلفون: Simone H. Stahl, Christina Battista, Paul B. Watkins, Scott Q. Siler, Jerome T. Mettetal, Kyunghee Yang, Brett A. Howell

المصدر: Toxicological Sciences

مصطلحات موضوعية: Male, 0301 basic medicine, Indoles, Carboxylic Acids, Pharmacology, Mitochondrion, Toxicology, medicine.disease_cause, 030226 pharmacology & pharmacy, 0302 clinical medicine, Liver Function Tests, Tissue Distribution, Receptor, education.field_of_study, Membrane Glycoproteins, Bile acid, medicine.diagnostic_test, Hep G2 Cells, Middle Aged, Systems Toxicology and Cka-Mediated Hepatotoxicity, Dose–response relationship, Female, Receptors, Chemokine, Chemical and Drug Induced Liver Injury, drug-induced liver injury, systems pharmacology, Adult, hepatotoxicity, medicine.drug_class, Population, Biology, Models, Biological, 03 medical and health sciences, Double-Blind Method, Species Specificity, CKA, medicine, Animals, Humans, Rats, Wistar, education, Dose-Response Relationship, Drug, Transporter, quantitative systems toxicology, Oxidative Stress, 030104 developmental biology, quantitative systems pharmacology, Carrier Proteins, Liver function tests, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b978f96547347f1557add929a62dd55e
https://doi.org/10.1093/toxsci/kfy191

المؤلفون: Brett A. Howell, L. Pellegrini, Jeffrey L. Woodhead, Lisl K.M. Shoda

المصدر: Pharmaceutical Research

مصطلحات موضوعية: Drug-Related Side Effects and Adverse Reactions, medicine.drug_class, Autosomal dominant polycystic kidney disease, Tolvaptan, Pharmaceutical Science, Pharmacology, Liver injury, Lower risk, medicine.disease_cause, 030226 pharmacology & pharmacy, 03 medical and health sciences, autosomal-dominant polycystic kidney disease, 0302 clinical medicine, medicine, Polycystic kidney disease, Humans, Pharmacology (medical), Pyrroles, 030304 developmental biology, bile acids, 0303 health sciences, Bile acid, business.industry, Organic Chemistry, Models, Theoretical, medicine.disease, Polycystic Kidney, Autosomal Dominant, Lixivaptan, quantitative systems toxicology, mitochondria, Benzamides, Molecular Medicine, Chemical and Drug Induced Liver Injury, business, Oxidative stress, Biotechnology, medicine.drug, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadb95190e28a387f75c56345d9e195b
https://pubmed.ncbi.nlm.nih.gov/31909447

المؤلفون: Nikunjkumar Patel, Barbara Wiśniowska, Sebastian Polak, Masoud Jamei

المصدر: The AAPS Journal

مصطلحات موضوعية: ERG1 Potassium Channel, Desmethylcitalopram, simcyp, virtual twin, hERG, cardiotoxicity, Pharmaceutical Science, QT prolongation, Citalopram, Pharmacology, Toxicology, Risk Assessment, 030226 pharmacology & pharmacy, QT interval, Ion Channels, Electrocardiography, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, citalopram, Didesmethylcitalopram, Active metabolite, Cardiotoxicity, biology, Cardiac electrophysiology, business.industry, Systems Biology, personalised medicine, Heart, quantitative systems toxicology, chemistry, 030220 oncology & carcinogenesis, biology.protein, cardiac safety simulator, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa36a7eca4fe8a1926c520705a67b9e
https://ruj.uj.edu.pl/xmlui/handle/item/124563

المؤلفون: Debra Hanna, Alexander Berg, Klaus Romero, Barbara Wisniowska, Sebastian Polak, David Hermann, Oliver Hatley, Nikunjkumar Patel

مصطلحات موضوعية: ERG1 Potassium Channel, Physiologically based pharmacokinetic modelling, medicine.medical_specialty, Long QT syndrome, Moxifloxacin, hERG, Pharmaceutical Science, Torsades de pointes, QT prolongation, 030204 cardiovascular system & hematology, Models, Biological, Risk Assessment, 030226 pharmacology & pharmacy, QT interval, Translational Research, Biomedical, 03 medical and health sciences, 0302 clinical medicine, Torsades de Pointes, Internal medicine, medicine, Humans, biology, business.industry, Cardiac arrhythmia, Heart, medicine.disease, Anti-Bacterial Agents, quantitative systems toxicology, Long QT Syndrome, Drug development, biology.protein, Cardiology, torsade de pointes, moxifloxacin, business, Risk assessment, Algorithms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf71c15489a439f9e1ead155171224f2
https://ruj.uj.edu.pl/xmlui/handle/item/103421

المؤلفون: Shuklinova, Olha

مصطلحات موضوعية: Fizjologiczne modelowanie farmakokinetyczne, flecainid, tocainid, torsade de pointes, podejście ilościowe do badań toksykologii i bezpieczeństwa, bezpieczeństwo kardiologiczne, Simcyp, Cardiac Safety Simulator, Physiologically based pharmacokinetic modelling, flecainide, tocainide, Quantitative Systems Toxicology and Safety, cardiac safety

Relation: https://ruj.uj.edu.pl/xmlui/handle/item/239913

الاتاحة: https://ruj.uj.edu.pl/xmlui/handle/item/239913