المؤلفون: Aaron M. Fleming (1314534), Nicole J. Mathewson (11437354), Shereen A. Howpay Manage (6927761), Cynthia J. Burrows (1314543)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Evolutionary Biology, Inorganic Chemistry, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, pseudouridine synthase 1, 2 rna taken, sequencing unknown samples, less context bias, data analysis approach, epitranscriptomic modification pseudouridine, helicase brake produced, calling rna modifications, helicase brake, would result, vitro assay, two sites, synthetic rnas, slowly feed, providing validation, modification identification, ionic current, dwell time, conformational assignment, cell culture

Relation: https://figshare.com/articles/journal_contribution/Nanopore_Dwell_Time_Analysis_Permits_Sequencing_and_Conformational_Assignment_of_Pseudouridine_in_SARS-CoV_2/16624462

الاتاحة: https://doi.org/10.1021/acscentsci.1c00788.s001

المؤلفون: Moon Young Yang (473061), Soo-Kyung Kim (1632286), Donghwa Kim (252081), Stephen B. Liggett (9606087), William A. Goddard (1235154)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biological Sciences not elsewhere classified, using computational approaches, two polar residues, receptor signaling coefficients, many extraoral tissues, activated tas2r5 coupled, agonists activate tas2r5, based drug design, agonist binding sites, agonists bind, 19 agonists, treating asthma, taste perception, tas2r5s expressed, providing validation, obstructive diseases, induce bronchodilation, hindered efforts, gi protein, experimental results, also expressed, active ligands

Relation: https://figshare.com/articles/journal_contribution/Structures_and_Agonist_Binding_Sites_of_Bitter_Taste_Receptor_TAS2R5_Complexed_with_Gi_Protein_and_Validated_against_Experiment/16645872

الاتاحة: https://doi.org/10.1021/acs.jpclett.1c02162.s001

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/Schematic_of_data_workflow_/16648691

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s001

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/SNP_genetic_variants_are_common_and_their_gene_targets_are_associated_with_B-lymphocyte_activity_/16648694

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s002

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/Workflow_schematic_of_applying_the_SNP_Prioritization_Pipeline_to_B-lymphocyte_data_/16648697

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s003

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/SNP_Pipeline_output_with_cohesin_HiChIP_input_is_a_subset_of_the_H3K27ac_HiChIP_output_/16648700

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s004

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/SNP_Prioritization_Pipeline_produces_similar_results_to_the_Sharp_et_al_/16648703

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s005

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/Four_types_of_genetic_variant_gene_regulatory_network_component_structures_/16648706

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s006

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/The_HLA_locus_is_the_top_candidate_region_identified_by_the_SNP_prioritization_pipeline_/16648709

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s007

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/IKZF3_is_a_top_pipeline_identified_candidate_for_T1D-associated_genes_/16648712

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s008

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/IKZF1_identified_as_a_candidate_for_T1D-associated_genes_by_the_pipeline_/16648718

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s009

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/dataset/Main_Biomedical_Data_Commons_entity_types_/16648721

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s010

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/dataset/Main_Biomedical_Data_Commons_edges_/16648724

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s011

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/dataset/Ranked_list_of_genetic_variant_and_genes_ordered_by_closeness_centrality_score_calculated_from_their_gene_regulatory_networks_for_GM12878_cells_with_H3K27ac_HiChIP_connectome_data_/16648727

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s012

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/dataset/Genetic_variants_in_close_proximity_to_HLA-DQB1_or_HLA-DRB1_/16648730

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s013

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/dataset/The_entities_along_with_their_subclass_and_description_that_are_uniquely_defined_by_Biomedical_Data_Commons_schema_to_represent_the_data_in_the_knowledge_graph_/16648736

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s015

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/dataset/ENCODE_ChIP-seq_datasets_GEO_accession_numbers_/16648733

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s014

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/dataset/The_properties_along_with_their_domain_range_and_description_that_are_uniquely_defined_by_Biomedical_Data_Commons_schema_to_represent_the_data_in_the_knowledge_graph_/16648739

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s016

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/dataset/The_enumeration_subclass_along_with_their_description_and_their_subclass_types_of_plus_associated_descriptions_that_are_uniquely_defined_by_Biomedical_Data_Commons_schema_to_represent_the_data_in_the_knowledge_graph_/16648742

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.s017

المؤلفون: Samantha N. Piekos (11457947), Sadhana Gaddam (11457950), Pranav Bhardwaj (11457953), Prashanth Radhakrishnan (11457956), Ramanathan V. Guha (11457959), Anthony E. Oro (11457962)

مصطلحات موضوعية: Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unknown clinical significance, studied disease genes, single queryable format, requires redundant investment, remain relatively understudied, mice providing validation, diverse applications including, clinical validation studies, specific disease alleles, type 1 diabetes, assess genetic variants, biomedical data commons, t1d ), one, pipeline using b, coding genetic variants, type specific, genetic contributions, biomedical data, biomedical information, bmdc )

Relation: https://figshare.com/articles/figure/Biomedical_Data_Commons_is_a_knowledge_graph_that_integrates_multiple_data_types_/16648745

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009382.g001