المؤلفون: Chuan Zhou, Zisheng Fan, Yuejiao Gu, Zhiming Ge, Zhaofan Tao, Rongrong Cui, Yupeng Li, Guizhen Zhou, Ruifeng Huo, Mingshan Gao, Dan Wang, Wei He, Mingyue Zheng, Sulin Zhang, Tianfeng Xu

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, displayed favorable pharmacokinetic, complementary therapeutic strategy, selective protac degraders, mutant cancer cells, g12d , 8o , selective degradation, cancer therapy, structural modifications, representative compound, potently suppressed, pharmacodynamic properties, new chemotherapy, membrane permeability, mechanism studies, linker moiety, dependent manner, degradation activity

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Biological_Evaluation_of_Potent_and_Selective_PROTAC_Degraders_of_Oncogenic_KRAS_sup_G12D_sup_/24975430

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01622.s001
https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Biological_Evaluation_of_Potent_and_Selective_PROTAC_Degraders_of_Oncogenic_KRAS_sup_G12D_sup_/24975430

المؤلفون: Lanshu Xiao, Yi Liu, Hui Chen, Lisong Shen

المصدر: Cancer Biology & Therapy, Vol 24, Iss 1 (2023)

مصطلحات موضوعية: cdk9, small molecular inhibitors, protac degraders, tumor, targeted therapy, development, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1538-4047; https://doaj.org/toc/1555-8576

URL الوصول: https://doaj.org/article/28665abdc45943689696f56528246d74

المؤلفون: Xin Han, Yi Sun

المصدر: MedComm, Vol 4, Iss 3, Pp n/a-n/a (2023)

مصطلحات موضوعية: E3 ligase ligands, PROTAC degraders, targeted therapy, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2688-2663

URL الوصول: https://doaj.org/article/28e44c46c4af487ca19e8180dd7bea96

المؤلفون: Wuxiang Mao, Nathalie M. Vandecan, Christopher R. Bingham, Pui Ki Tsang, Peter Ulintz, Rachel Sexton, Daniel A. Bochar, Sofia D. Merajver, Matthew B. Soellner

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, e3 ligase ligands, cancer cell proliferation, src degradation compared, selective dual csk, identified pharmacological advantages, src protac degrader, potent protac degraders, src protacs, selective analogue, replaced dasatinib, high degree

Relation: https://figshare.com/articles/journal_contribution/Selective_and_Potent_PROTAC_Degraders_of_c_Src_Kinase/24868668

الاتاحة: https://doi.org/10.1021/acschembio.3c00548.s001
https://figshare.com/articles/journal_contribution/Selective_and_Potent_PROTAC_Degraders_of_c_Src_Kinase/24868668

المؤلفون: Qiuxia Chen (2477146), Chuan Liu (367528), Wei Wang (17594), Xiaoyun Meng (2353012), Xuemin Cheng (4042583), Xianyang Li (5891825), Longying Cai (14339445), Linfu Luo (14339448), Xu He (685343), Huan Qu (1872379), Jing Luo (146659), Hong Wei (334335), Sen Gao (6109205), Guansai Liu (2117938), Jinqiao Wan (2390107), David I. Israel (1463116), Jin Li (119007), Dengfeng Dou (8713674)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, proteolysis targeting chimera, potential protacs simultaneously, heterobifunctional degrader forms, parallel screening approach, possible protac molecules, utilizes dna barcodes, ternary complex formation, potent brd4 protacs, e3 ligase proteins, designed protac del, ternary complex, e3 ligase, approach evaluates, protac solubility, protac process, protac molecule, protac degraders, vast number, unwanted protein, tedious process

Relation: https://figshare.com/articles/journal_contribution/Optimization_of_PROTAC_Ternary_Complex_Using_DNA_Encoded_Library_Approach/21829680

الاتاحة: https://doi.org/10.1021/acschembio.2c00797.s001

المؤلفون: Kai Tang, Ya-Hong Wu, Yihui Song, Bin Yu

المصدر: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-21 (2021)

مصطلحات موضوعية: Immune escape, IDO1 inhibitors, PROTAC degraders, Cancer therapy, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1756-8722

URL الوصول: https://doaj.org/article/a297565415ca4d37b6367099fc347ceb

المؤلفون: Yuan Fang, Guochao Liao, Bin Yu

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 7, Pp 1253-1278 (2020)

مصطلحات موضوعية: MDM2/X–P53 interaction, MDM2/X inhibitors, PROTAC degraders, Cancer therapy, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383519312912; https://doaj.org/toc/2211-3835

URL الوصول: https://doaj.org/article/6c326b9530b741f5bc73ef0a79a7748e

المؤلفون: Xin Han (1329648), Lijie Zhao (721932), Weiguo Xiang (5536298), Chong Qin (2251120), Bukeyan Miao (1964026), Donna McEachern (573068), Yu Wang (12152), Hoda Metwally (11330594), Lu Wang (45927), Aleksas Matvekas (11330597), Bo Wen (207648), Duxin Sun (501117), Shaomeng Wang (88290)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Orally Bioavailable Proteolysis Tar., ARD -2128, Prostate Cancer Proteolysis, PROTAC degraders, E 3 ligase, PROTAC AR degrader, pharmacokinetic

Relation: https://figshare.com/articles/journal_contribution/Strategies_toward_Discovery_of_Potent_and_Orally_Bioavailable_Proteolysis_Targeting_Chimera_Degraders_of_Androgen_Receptor_for_the_Treatment_of_Prostate_Cancer/16438700

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00882.s001

المؤلفون: Bin Yu, Yihui Song, Ya-Hong Wu, Kai Tang

المصدر: Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-21 (2021)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_specialty, Kynurenine pathway, Cancer therapy, medicine.medical_treatment, Review, 03 medical and health sciences, 0302 clinical medicine, Cancer immunotherapy, Internal medicine, medicine, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Diseases of the blood and blood-forming organs, Indoleamine 2,3-dioxygenase, Molecular Biology, RC254-282, PROTAC degraders, Clinical Trials as Topic, Hematology, business.industry, Immune escape, Proteolysis targeting chimera, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, medicine.disease, Clinical trial, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, IDO1 inhibitors, Immunotherapy, RC633-647.5, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189fb71cd3945d7e7d56b729ec17fd75
http://europepmc.org/articles/PMC8061021

المؤلفون: Qi Chang, Jiayi Li, Yue Deng, Ruilin Zhou, Bingwei Wang, Yujie Wang, Mingming Zhang, Xun Huang, Yingxia Li

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, reported degrader dcbp, promising therapeutic targets, novel protac degraders, novel potent small, molecule protac degraders, conformational restriction strategy, common solid tumors, targeted hcc therapy, hcc ), one, 1 hcc cells, hcc cells, proteasome system, potential therapeutics, parental inhibitors, human cancer, hepatocellular carcinoma, dependent manner

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Novel_PROTAC_Degraders_of_p300_CBP_as_Potential_Therapeutics_for_Hepatocellular_Carcinoma/25148673

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01468.s001
https://figshare.com/articles/journal_contribution/Discovery_of_Novel_PROTAC_Degraders_of_p300_CBP_as_Potential_Therapeutics_for_Hepatocellular_Carcinoma/25148673