المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/journal_contribution/Numbers_of_reads_library_size_and_HTSeq_gene_count_for_samples_from_CHL1_and_A375_cells_/24489815

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s001
https://figshare.com/articles/journal_contribution/Numbers_of_reads_library_size_and_HTSeq_gene_count_for_samples_from_CHL1_and_A375_cells_/24489815

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/journal_contribution/Numbers_of_differential_splicing_events_of_each_type_detected_by_rMATs_at_each_time_point_post-treatment_for_CHL1_and_A375_cells_/24489821

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s003
https://figshare.com/articles/journal_contribution/Numbers_of_differential_splicing_events_of_each_type_detected_by_rMATs_at_each_time_point_post-treatment_for_CHL1_and_A375_cells_/24489821

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/journal_contribution/Number_of_differentially_expressed_genes_in_CHL1_cells_under_different_treatments_/24489818

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s002
https://figshare.com/articles/journal_contribution/Number_of_differentially_expressed_genes_in_CHL1_cells_under_different_treatments_/24489818

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/journal_contribution/MDM4_skipped_exon_events_of_exon_number_6_detected_by_rMATS_/24489824

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s004
https://figshare.com/articles/journal_contribution/MDM4_skipped_exon_events_of_exon_number_6_detected_by_rMATS_/24489824

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/Schematic_of_the_single_contrast_analyses_solid_lines_comparing_each_treatment_to_the_control_and_multi-contrast_analyses_dashed_lines_comparing_differentially_expressed_genes_or_differentially_spliced_events_obtained_from_the_single_contra/24489827

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s005
https://figshare.com/articles/figure/Schematic_of_the_single_contrast_analyses_solid_lines_comparing_each_treatment_to_the_control_and_multi-contrast_analyses_dashed_lines_comparing_differentially_expressed_genes_or_differentially_spliced_events_obtained_from_the_single_contra/24489827

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/S3_Fig_-/24489833

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s007
https://figshare.com/articles/figure/S3_Fig_-/24489833

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/S5_Fig_-/24489839

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s009
https://figshare.com/articles/figure/S5_Fig_-/24489839

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/S2_Fig_-/24489830

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s006
https://figshare.com/articles/figure/S2_Fig_-/24489830

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/S4_Fig_-/24489836

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s008
https://figshare.com/articles/figure/S4_Fig_-/24489836

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/S6_Fig_-/24489842

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s010
https://figshare.com/articles/figure/S6_Fig_-/24489842

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/S7_Fig_-/24489845

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s011
https://figshare.com/articles/figure/S7_Fig_-/24489845

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/Number_of_differentially_spliced_events_and_differentially_spliced_genes_across_treatments_with_the_p-value_0_05_threshold_/24489854

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s013
https://figshare.com/articles/figure/Number_of_differentially_spliced_events_and_differentially_spliced_genes_across_treatments_with_the_p-value_0_05_threshold_/24489854

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/S10_Fig_-/24489857

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s014
https://figshare.com/articles/figure/S10_Fig_-/24489857

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/Number_of_selected_GO_terms_related_to_the_cell_cycle_translation_DNA_repair_and_splicing_in_all_treatments_/24489860

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s015
https://figshare.com/articles/figure/Number_of_selected_GO_terms_related_to_the_cell_cycle_translation_DNA_repair_and_splicing_in_all_treatments_/24489860

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/Prolonged_CDK4_6_inhibition_response_of_gene_expression_and_splicing_in_A375_and_CHL1_/24489866

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.g001
https://figshare.com/articles/figure/Prolonged_CDK4_6_inhibition_response_of_gene_expression_and_splicing_in_A375_and_CHL1_/24489866

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/Significance_of_gene_sets_detected_accommodate_all_samples_in_both_differentially_expressed_and_spliced_genes_/24489863

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s016
https://figshare.com/articles/figure/Significance_of_gene_sets_detected_accommodate_all_samples_in_both_differentially_expressed_and_spliced_genes_/24489863

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/Differential_gene_expression_in_response_to_CDK4_6_and_PRMT5_inhibition_/24489872

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.g002
https://figshare.com/articles/figure/Differential_gene_expression_in_response_to_CDK4_6_and_PRMT5_inhibition_/24489872

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/Functional_responses_in_differentially_expressed_and_spliced_genes_/24489878

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.g004
https://figshare.com/articles/figure/Functional_responses_in_differentially_expressed_and_spliced_genes_/24489878

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/Differential_splicing_in_response_to_CDK4_6_and_PRMT5_inhibition_/24489875

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.g003
https://figshare.com/articles/figure/Differential_splicing_in_response_to_CDK4_6_and_PRMT5_inhibition_/24489875

المؤلفون: Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Marine Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new treatments, length mrna sequencing, important downstream component, 6 inhibitor resistance, 6 inhibitor palbociclib, gene expression profiles, prmt5 inhibitor gsk3326595, findings indicate cdk4, dependent kinases 4, regulate alternative splicing, mrna splicing induced, differential gene expression, 6 inhibition result, although prmt5 inhibition, melanoma , gene expression, alternative splicing

Relation: https://figshare.com/articles/figure/PCR_products_showing_the_expression_patterns_of_MDM4-FL_and_MDM4-SL_mRNA_in_CHL1_and_A375_/24489848

الاتاحة: https://doi.org/10.1371/journal.pone.0292278.s012
https://figshare.com/articles/figure/PCR_products_showing_the_expression_patterns_of_MDM4-FL_and_MDM4-SL_mRNA_in_CHL1_and_A375_/24489848