المؤلفون: Estévez-Silva, Héctor M., Mediavilla, Tomás, Giacobbo, Bruno Lima, Liu, Xijia, Sultan, Fahad R., Marcellino, Daniel

المصدر: European Journal of Neuroscience. 55(5):1356-1372

مصطلحات موضوعية: motor function, neuroprotection, preclinical research, pridopidine, sigma-1 receptor, SOD1G93A

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192663
https://doi.org/10.1111/ejn.15608
https://umu.diva-portal.org/smash/get/diva2:1639371/FULLTEXT02.pdf

المؤلفون: Borje Darpo, Michal Geva, Georg Ferber, Yigal Paul Goldberg, Andres Cruz-Herranz, Munish Mehra, Richard Kovacs, Michael R. Hayden

المصدر: Neurology and Therapy, Vol 12, Iss 2, Pp 597-617 (2023)

مصطلحات موضوعية: Concentration-QTc analysis, Huntington’s disease (HD), Pridopidine, QT prolongation, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2193-8253; https://doaj.org/toc/2193-6536

URL الوصول: https://doaj.org/article/8aac3a828618475eb11cb8502f0f5d75

المؤلفون: Darpo, Borje, Geva, Michal, Ferber, Georg, Goldberg, Yigal Paul, Cruz-Herranz, Andres, Mehra, Munish, Kovacs, Richard, Hayden, Michael R.

المساهمون: Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Concentration-QTc analysis, Huntington’s disease (HD), Pridopidine, QT prolongation

وصف الملف: application/pdf

Relation: Neurology and Therapy; Darpo B, Geva M, Ferber G, et al. Pridopidine Does Not Significantly Prolong the QTc Interval at the Clinically Relevant Therapeutic Dose. Neurol Ther. 2023;12(2):597-617. doi:10.1007/s40120-023-00449-w; https://hdl.handle.net/1805/36940

الاتاحة: https://hdl.handle.net/1805/36940

المؤلفون: Sophie Lenoir, Romane A. Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux, Laetitia Capellano, Aurélie Genoux, Noga Gershoni-Emek, Michal Geva, Michael R. Hayden, Frédéric Saudou

المصدر: Neurobiology of Disease, Vol 173, Iss , Pp 105857- (2022)

مصطلحات موضوعية: Huntington disease, Huntingtin, Pridopidine, Sigma-1 receptor, Neuroprotection, BDNF/TrkB trafficking, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996122002492; https://doaj.org/toc/1095-953X

URL الوصول: https://doaj.org/article/fd15b7293989424cb83b9058a66155a8

المؤلفون: Thomas Klopstock, Deborah Hall, Steven Frucht, Emmanuel Flamand-Roze

المصدر: Frontiers in Neurology, Vol 13 (2022)

مصطلحات موضوعية: hyperkinetic, dystonia, pridopidine, epilepsy, Tourette, NBIA, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2022.853084/full; https://doaj.org/toc/1664-2295

URL الوصول: https://doaj.org/article/dde00fddf08b49028ae1e2ed203b8169

المؤلفون: Chelsy R. Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R. Hayden, Christopher A. Ross

المصدر: Neurobiology of Disease, Vol 129, Iss , Pp 118-129 (2019)

مصطلحات موضوعية: Neuroprotection, Huntingtin toxicity, Huntington's disease, Mutant-huntingtin, Pridopidine, 3PPP, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996118306120; https://doaj.org/toc/1095-953X

URL الوصول: https://doaj.org/article/6c7c6a1004604c76b60f2b97bd104cc6

المؤلفون: Shujun Chen, Tianyu Liang, Tao Xue, Shouru Xue, Qun Xue

المصدر: Frontiers in Neurology, Vol 12 (2021)

مصطلحات موضوعية: pridopidine, Huntington's disease, TMS, MMS, meta-analysis, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2021.658123/full; https://doaj.org/toc/1664-2295

URL الوصول: https://doaj.org/article/0fa9ad13f0054ce3aa119c82da8a4c83

المؤلفون: Daniel Ryskamp, Jun Wu, Michal Geva, Rebecca Kusko, Iris Grossman, Michael Hayden, Ilya Bezprozvanny

المصدر: Neurobiology of Disease, Vol 97, Iss , Pp 46-59 (2017)

مصطلحات موضوعية: Huntington disease, Pridopidine, 3-PPP, Sigma-1 receptor, Medium spiny neurons, YAC128 mice, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996116302479; https://doaj.org/toc/1095-953X

URL الوصول: https://doaj.org/article/9663a4e2c25e4386a5bcd97f7b718930

المؤلفون: Michal Geva, Karl Kieburtz, Andrew McGarry, Mika Leinonen, Michael R. Hayden, C. Warren Olanow

المصدر: Journal of Huntington's Disease

مصطلحات موضوعية: 0301 basic medicine, Research Report, Adult, Male, medicine.medical_specialty, Placebo, Severity of Illness Index, Pharmacological treatment, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Huntington's disease, Piperidines, Internal medicine, Activities of Daily Living, medicine, pridopidine, Humans, Receptors, sigma, Stage (cooking), Beneficial effects, business.industry, Repeated measures design, clinical trial, Middle Aged, medicine.disease, total functional capacity, Pridopidine, Clinical trial, 030104 developmental biology, Functional Status, Huntington Disease, chemistry, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Huntington’s disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3c11384e608a711f1801f09f6f7bd9
http://europepmc.org/articles/PMC7836066

المؤلفون: Michael R. Hayden, Osama Sabri, Mark Forrest Gordon, Laura Rabinovich, Marianne Patt, Henryk Barthel, Michael Rullmann, Andreas Kluge, Gina Pastino, Georg Becker, Doug Marsteller, Swen Hesse, Helena Knebel, Peter Brust, Thilo Gerhards, Juha-Matti Savola, Marcus Bronzel, Philipp Meyer, Ole Voges, Michal Geva, Igor D. Grachev, Franziska Zientek, Maria Strauss, Bernhard Sattler

المصدر: European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging 48(2021), 1103-1115

مصطلحات موضوعية: 0301 basic medicine, Male, 18F-fallypride, Sigma-1 receptor occupancy, Dopamine, [18F]fluspidine, Pharmacology, Dopamine D2/D3 receptor occupancy, Pridopidine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Dopamine receptor D3, Dopamine receptor D2, Healthy volunteers, medicine, pridopidine, Humans, Radiology, Nuclear Medicine and imaging, sigma-1 receptor occupancy, Benzofurans, dopamine D2/D3 receptor occupancy, business.industry, Receptors, Dopamine D2, Receptors, Dopamine D3, Brain, General Medicine, Huntington disease, Healthy Volunteers, 030104 developmental biology, PET, Fallypride, chemistry, Positron-Emission Tomography, Benzamides, Original Article, Fluspidine, business, 030217 neurology & neurosurgery, medicine.drug

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4137f555b5abb99b82655a00e1f0ced7
http://europepmc.org/articles/PMC8041674

المؤلفون: Wang, Shao-Ming, Wu, Hsiang-En, Yasui, Yuko, Geva, Michal, Hayden, Michael, Maurice, Tangui, Cozzolino, Mauro, Su, Tsung-Ping

المساهمون: National Institute on Drug Abuse NIH, Bethesda, USA (NIDA), National Institutes of Health Bethesda, MD, USA (NIH), Department of Neurology, National Taiwan University Hospital, China Medical University Taichung, Prilenia Therapeutics (Herzliya), BC Children's Hospital Research Institute Vancouver, BC, Canada (BCCHR), University of British Columbia Canada (UBC), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL), Institute of Translational Pharmacology - Istituto di Farmacologia Traslazionale Roma (IFT), National Research Council of Italy

المصدر: ISSN: 1554-8627.

مصطلحات موضوعية: ALS/FTD, c9orf72, Chaperone, KPNB1/ importinβ1, Nucleocytoplasmic transport, Nucleoporin POM121, Pridopidine, SIGMAR1, Sigma-1 receptor, TFEB, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences

Relation: info:eu-repo/semantics/altIdentifier/pmid/35507432; PUBMED: 35507432; PUBMEDCENTRAL: PMC9809944

الاتاحة: https://hal.umontpellier.fr/hal-04591681
https://doi.org/10.1080/15548627.2022.2063003

المؤلفون: Héctor M. Estévez‐Silva, Tomás Mediavilla, Bruno Lima Giacobbo, Xijia Liu, Fahad R. Sultan, Daniel J. Marcellino

المصدر: The European journal of neuroscience. 55(5)

مصطلحات موضوعية: Cachexia, Muscle Weakness, Neurologi, Superoxide Dismutase, General Neuroscience, motor function, Amyotrophic Lateral Sclerosis, Neurosciences, Mice, Transgenic, Neurodegenerative Diseases, SOD1G93A, Disease Models, Animal, Mice, Phenotype, Superoxide Dismutase-1, sigma-1 receptor, Neurology, Piperidines, pridopidine, Animals, neuroprotection, preclinical research, Neurovetenskaper

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500ba64c546e0bb6031c26d25872fde4
https://pubmed.ncbi.nlm.nih.gov/35080077

المؤلفون: Ana Cristina Rego, Philip T. T. Ly, Noga Gershoni-Emek, Leonard A. Levin, Luana Naia, Sandra I. Mota, Michael R. Hayden, Michal Geva

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

مصطلحات موضوعية: Retinal degeneration, Agonist, Retinal Ganglion Cells, genetic structures, medicine.drug_class, Science, Retinal ganglion, Neuroprotection, Article, chemistry.chemical_compound, Piperidines, medicine, Animals, Receptors, sigma, Retina, Multidisciplinary, Sigma-1 receptor, Dose-Response Relationship, Drug, Chemistry, Glaucoma, Translational research, medicine.disease, eye diseases, Pridopidine, Mitochondria, Rats, Disease Models, Animal, medicine.anatomical_structure, Neuroprotective Agents, Retinal ganglion cell, Medicine, sense organs, Reactive Oxygen Species, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fbaa1641b4fc0aca8c1421678d599b
http://europepmc.org/articles/PMC8578336

المؤلفون: C. Warren Olanow, Munish Mehra, Andrew McGarry, Noga Gershoni Emek, Michael R. Hayden, Karl Kieburtz, Michal Geva

المصدر: F: Clinical studies: case reports, observational studies and trials.

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, business.industry, Medicine, Clinical efficacy, Pharmacology, business, Exposure response, Pridopidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c4b2ad504d64b2b2fce49e940584f595
https://doi.org/10.1136/jnnp-2021-ehdn.85

المؤلفون: Jennifer Dreymann, Michael R. Hayden, Deniz Akinc Abdulhayoglu, Noga Gershoni Emek, Michal Geva, Y. Paul Goldberg, Bruno Boulanger, Charles Li

المصدر: F: Clinical studies: case reports, observational studies and trials.

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Neurofilament light, Biophysics, Pridopidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cdbabfd735b90805044680ce2561c732
https://doi.org/10.1136/jnnp-2021-ehdn.86

المؤلفون: Carla Lopes, Sandra I. Mota, Michael R. Hayden, Marina Shenkman, Gerardo Z Lederkreme, Michal Geva, Noga Gershoni Emek, Luana Naia, A. Cristina Rego, Philip T. T. Ly, Maria Ankarcrona

المصدر: I: Experimental therapeutics – preclinical.

مصطلحات موضوعية: chemistry.chemical_classification, Reactive oxygen species, Programmed cell death, Endoplasmic reticulum, Mitochondrion, medicine.disease_cause, Neuroprotection, Pridopidine, Cell biology, chemistry.chemical_compound, chemistry, Unfolded protein response, medicine, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::68f88ce1d0f2488cc10642d6e717970b
https://doi.org/10.1136/jnnp-2021-ehdn.127

المؤلفون: Michael R. Hayden, Yael C Cohen, Ralf Reilmann, C. Warren Olanow, Karl Kieburtz, Sandra K. Kostyk, Michal Geva, Andrew Feigin, Munish Mehra, Andrew McGarry, Anne Elizabeth Rosser, Noga Gershoni-Emek

المصدر: F: Clinical studies: case reports, observational studies and trials.

مصطلحات موضوعية: chemistry.chemical_compound, medicine.medical_specialty, Physical medicine and rehabilitation, chemistry, business.industry, Phases of clinical research, Medicine, Function (mathematics), Disease, business, Outcome (game theory), Pridopidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad09aa52a3fdcc724e9b3c4bce3320aa
https://doi.org/10.1136/jnnp-2021-ehdn.84

المؤلفون: Waters, Susanna, Tedroff, J., Ponten, Henrik, Klamer, Daniel, 1976, Sonesson, C., Waters, N.

المصدر: Journal of Huntingtons Disease. 7(1):1-16

مصطلحات موضوعية: Pharmacology and Toxicology, Farmakologi och toxikologi, Huntington's disease, pridopidine, prefrontal cortex, striatum, motor control, dopamine, stabilizer, dopaminergic stabilizer pridopidine, placebo-controlled trial, rat, immediate-early gene, arc messenger-rna, r6/2 mouse, model, in-vivo, movement-disorders, basal ganglia, antipsychotic-drugs

URL الوصول: https://gup.ub.gu.se/publication/265295

المؤلفون: Sahlholm, Kristoffer, Sijbesma, Jurgen W. A., Maas, Bram, Kwizera, Chantal, Marcellino, Daniel, Kuzhuppilly Ramakrishnan, Nisha, Dierckx, Rudi A. J. O., Elsinga, Philip H., van Waarde, Aren

المصدر: Sahlholm , K , Sijbesma , J W A , Maas , B , Kwizera , C , Marcellino , D , Kuzhuppilly Ramakrishnan , N , Dierckx , R A J O , Elsinga , P H & van Waarde , A 2015 , ' Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses ' , Psychopharmacology , vol. 232 , no. 18 , pp. 3443-3453 . https://doi.org/10.1007/s00213-015-3997-8

مصطلحات موضوعية: MicroPET, Kinetic analysis, C-11-SA4503, C-11-raclopride, Receptor occupancy, POSITRON-EMISSION-TOMOGRAPHY, IN-VIVO, STABILIZERS PRIDOPIDINE, (-)-OSU6162, ACR16, BINDING, PET, BRAIN, ANTAGONISM, RATS

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/280319d1-6a84-4485-bcf0-6a8ba3f7924a

الاتاحة: https://hdl.handle.net/11370/280319d1-6a84-4485-bcf0-6a8ba3f7924a
https://research.rug.nl/en/publications/280319d1-6a84-4485-bcf0-6a8ba3f7924a
https://doi.org/10.1007/s00213-015-3997-8
https://pure.rug.nl/ws/files/42647430/art_3A10.1007_2Fs00213_015_3997_8.pdf

المؤلفون: Jun Wu, Michael R. Hayden, Dabin Kim, Ilya Bezprozvanny, Daniel A. Ryskamp, Michal Geva, Gerhard Rammes, Lili Wu

المصدر: Neurobiology of Disease, Vol 124, Iss, Pp 489-504 (2019)

مصطلحات موضوعية: 0301 basic medicine, Agonist, Mushroom spines, Calcium dysregulation, medicine.drug_class, Dendritic Spines, Hippocampal formation, Pharmacology, Hippocampus, Neuroprotection, Article, lcsh:RC321-571, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Alzheimer Disease, mental disorders, medicine, Animals, Receptors, sigma, Presenilin-1-M146 V knock-in mice, Cognitive decline, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 3-PPP, Sigma-1 receptor, Excitatory Postsynaptic Potentials, Long-term potentiation, Alzheimer's disease, Pridopidine, Mice, Inbred C57BL, Disease Models, Animal, Neuroprotective Agents, 030104 developmental biology, Neurology, chemistry, nervous system, Synapses, Synaptic plasticity, APP knock-in mice, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7647fe9f7df6f9cef5365db057e19224
http://www.sciencedirect.com/science/article/pii/S0969996118305953