المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/journal_contribution/ITC_results_summary_/16596401

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s009

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/journal_contribution/Cryo-EM_data_collection_and_refinement_statistics_of_PfFNT_/16596395

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s008

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Sequence_alignment_of_PfFNT_and_homologs_in_pathogenic_i_Plasmodium_i_parasites_and_prokaryotic_FNT_family_members_/16596365

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s003

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Cryo-EM_structural_determination_of_PfFNT_/16596353

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s001

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Cryo-EM_analysis_of_the_PfFNT_structure_/16596359

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s002

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/dataset/The_individual_numerical_values_for_the_ITC_results_in_Fig_2A_2F_2G_and_2H_/16596407

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s010

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Cryo-EM_structural_determination_of_PfFNT_MMV007839_/16596371

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s004

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Cryo-EM_analysis_of_the_PfFNT_MMV007839_structure_/16596377

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s005

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Fitting_of_the_hemiketal_form_of_MMV007839_and_inhibitor_docking_results_/16596383

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s006

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Structural_comparison_of_PfFNT_proteins_/16596389

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s007

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Molecular_docking_of_MMV007839_and_BH267_meta_in_the_wild-type_PfFNT_or_G107S_resistant_mutant_/16596437

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.g003

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/dataset/The_individual_numerical_values_for_the_FSC_curves_in_S2A_and_S5A_Figs_/16596419

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.s012

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Overall_structure_of_PfFNT_/16596425

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.g001

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Inhibition_of_PfFNT_by_MMV007839_/16596431

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.g002

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Structural_comparison_between_apo_form_and_inhibitor-bound_PfFNT_/16596443

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.g004

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Intracellular_region_of_PfFNT_/16596449

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.g005

المؤلفون: Xi Peng (406437), Nan Wang (21935), Angqi Zhu (8681169), Hanwen Xu (6332030), Jialu Li (506281), Yanxia Zhou (1447465), Chen Wang (88408), Qingjie Xiao (9226140), Li Guo (171454), Fei Liu (21082), Zhi-jun Jia (11413904), Huaichuan Duan (6458477), Jianping Hu (287208), Weidan Yuan (10711212), Jia Geng (1708321), Chuangye Yan (554009), Xin Jiang (6348), Dong Deng (8202849)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, raise urgent demands, novel antimalarial agents, deadliest causal agent, 3 å resolution, present 2 cryogenic, plasmodium falciparum <, plasmodium <, falciparum <, p <, submicromolar concentrations, study provides, structural characterization, resolution structures, molecular basis, lead compound, lactate transport, lactate efflux, kills parasites

Relation: https://figshare.com/articles/figure/Structural_comparison_between_PfFNT_and_prokaryotic_FocA_/16596455

الاتاحة: https://doi.org/10.1371/journal.pbio.3001386.g006