المؤلفون: Biswas, Subarna, Hilser, James, Woodward, Nicholas, Wang, Zeneng, Gukasyan, Janet, Nemet, Ina, Schwartzman, William, Huang, Pin, Han, Yi, Fouladian, Zachary, Charugundla, Sarada, Spencer, Neal, Pan, Calvin, Tang, W, Lusis, Aldons, Hazen, Stanley, Hartiala, Jaana, Allayee, Hooman

المصدر: Nutrients. 17(1)

مصطلحات موضوعية: Mendelian randomization, atherosclerosis, coronary artery disease, dietary supplementation, genome-wide association study, glycine, mice, Glycine, Animals, Humans, Coronary Artery Disease, Genome-Wide Association Study, Mice, Male, Female, Middle Aged, Disease Models, Animal, Mendelian Randomization Analysis, Aged, Atherosclerosis, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease, Dietary Supplements, United Kingdom

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3h8368wp
https://escholarship.org/content/qt3h8368wp/qt3h8368wp.pdf

المؤلفون: Rallabandi, Harikrishna, Singh, Manish, Looger, Loren, Nath, Swapan

المصدر: International Journal of Molecular Sciences. 26(1)

مصطلحات موضوعية: CLEC16A, autophagy, enhancer, lupus, post-GWAS, Lectins, C-Type, Humans, Lupus Erythematosus, Systemic, Genetic Predisposition to Disease, Monosaccharide Transport Proteins, Polymorphism, Single Nucleotide, Alleles, Autophagy, Genome-Wide Association Study, Gene Editing, STAT3 Transcription Factor, CRISPR-Cas Systems, B-Lymphocytes, Chromosomes, Human, Pair 16

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/25v3g6x9
https://escholarship.org/content/qt25v3g6x9/qt25v3g6x9.pdf

المؤلفون: Tihagam, Rachisan Djiake, Lou, Song, Zhao, Yuanji, Liu, Kammi Song-Yan, Singh, Arjun Tushir, Koo, Bon Il, Przanowski, Piotr, Li, Jie, Huang, Xiaosong, Li, Hong, Tushir-Singh, Jogender, Fejerman, Laura, Bhatnagar, Sanchita

المصدر: EMBO Reports. 26(1)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Cancer, Prevention, Social Determinants of Health, Breast Cancer, Human Genome, Genetics, Clinical Research, Health Disparities, Minority Health, Women's Health, 2.1 Biological and endogenous factors, Humans, Triple Negative Breast Neoplasms, Female, Ubiquitin-Protein Ligases, Tripartite Motif Proteins, Black or African American, Promoter Regions, Genetic, Gene Expression Regulation, Neoplastic, Polymorphism, Single Nucleotide, Cell Line, Tumor, Genetic Predisposition to Disease, Biomarkers, Tumor, Black People, White People, White, Triple-negative Breast Cancer, TRIM37, Black Women, SNP, NRF1, Developmental Biology, Biochemistry and cell biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3k67x1b9
https://escholarship.org/content/qt3k67x1b9/qt3k67x1b9.pdf

المؤلفون: Kachuri, Linda, Guerra, Geno A, Nakase, Taishi, Wendt, George A, Hansen, Helen M, Molinaro, Annette M, Bracci, Paige, McCoy, Lucie, Rice, Terri, Wiencke, John K, Eckel-Passow, Jeanette E, Jenkins, Robert B, Wrensch, Margaret, Francis, Stephen S

المصدر: Nature Communications. 16(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Rare Diseases, Brain Disorders, Clinical Research, Brain Cancer, Neurosciences, Cancer, Genetics, 2.1 Biological and endogenous factors, Good Health and Well Being, Blood Cells, Blood Platelets, Neutrophils, Lymphocytes, Humans, Glioma, Brain Neoplasms, Genetic Predisposition to Disease, Isocitrate Dehydrogenase, Risk Factors, Case-Control Studies, Homeostasis, Mutation, Adult, Aged, Middle Aged, Female, Male

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7wj446k5
https://escholarship.org/content/qt7wj446k5/qt7wj446k5.pdf

المؤلفون: Li, Dan, Zhong, Chenhan, Yang, Mengyuan, He, Li, Chang, Hang, Zhu, Ning, Celniker, Susan E, Threadgill, David W, Snijders, Antoine M, Mao, Jian-Hua, Yuan, Ying

المصدر: Gut Microbes. 16(1)

مصطلحات موضوعية: Microbiology, Biological Sciences, Genetics, Cancer Genomics, Prevention, Colo-Rectal Cancer, Cancer, Microbiome, Digestive Diseases, Human Genome, 2.1 Biological and endogenous factors, Animals, Colorectal Neoplasms, Azoxymethane, Humans, Mice, Polymorphism, Single Nucleotide, Gastrointestinal Microbiome, Collaborative Cross Mice, Dual Oxidases, Genetic Predisposition to Disease, Male, Bacteria, Disease Models, Animal, Female, Colorectal tumor susceptibility, azoxymethane, genome-wide association study, gut microbiome, conditional knockout mouse, DUOX2

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/01d2b6fp
https://escholarship.org/content/qt01d2b6fp/qt01d2b6fp.pdf

المؤلفون: Yiangou, Kristia, Mavaddat, Nasim, Dennis, Joe, Zanti, Maria, Wang, Qin, Bolla, Manjeet, Abubakar, Mustapha, Ahearn, Thomas, Andrulis, Irene, Anton-Culver, Hoda, Antonenkova, Natalia, Arndt, Volker, Aronson, Kristan, Augustinsson, Annelie, Baten, Adinda, Behrens, Sabine, Bermisheva, Marina, de Gonzalez, Amy, Białkowska, Katarzyna, Boddicker, Nicholas, Bodelon, Clara, Bogdanova, Natalia, Bojesen, Stig, Brantley, Kristen, Brauch, Hiltrud, Brenner, Hermann, Camp, Nicola, Canzian, Federico, Castelao, Jose, Cessna, Melissa, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Chung, Wendy, Colonna, Sarah, Couch, Fergus, Cox, Angela, Cross, Simon, Czene, Kamila, Daly, Mary, Devilee, Peter, Dörk, Thilo, Dunning, Alison, Eccles, Diana, Eliassen, A, Engel, Christoph, Eriksson, Mikael, Evans, D, Fasching, Peter, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gago-Dominguez, Manuela, Gentry-Maharaj, Aleksandra, González-Neira, Anna, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher, Hamann, Ute, Hartikainen, Jaana, Ho, Vikki, Hodge, James, Hollestelle, Antoinette, Honisch, Ellen, Hooning, Maartje, Hoppe, Reiner, Hopper, John, Howell, Sacha, Howell, Anthony, Jakovchevska, Simona, Jakubowska, Anna, Jernström, Helena, Johnson, Nichola, Kaaks, Rudolf, Khusnutdinova, Elza, Kitahara, Cari, Koutros, Stella, Kristensen, Vessela, Lacey, James, Lambrechts, Diether, Lejbkowicz, Flavio, Lindblom, Annika, Lush, Michael, Mannermaa, Arto, Mavroudis, Dimitrios, Menon, Usha, Murphy, Rachel, Nevanlinna, Heli, Obi, Nadia, Offit, Kenneth, Park-Simon, Tjoung-Won, Patel, Alpa, Peng, Cheng, Peterlongo, Paolo, Pita, Guillermo, Plaseska-Karanfilska, Dijana, Pylkäs, Katri, Radice, Paolo, Rashid, Muhammad, Rennert, Gad, Roberts, Eleanor

المصدر: Breast Cancer Research. 26(1)

مصطلحات موضوعية: Breast cancer, Polygenic risk scores, Risk calibration, Risk prediction, Humans, Female, Breast Neoplasms, Genetic Predisposition to Disease, Multifactorial Inheritance, White People, Risk Assessment, Risk Factors, Europe, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Middle Aged, Genotype

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1qb074nk
https://escholarship.org/content/qt1qb074nk/qt1qb074nk.pdf

المؤلفون: Kim, Youngwon, Godino, Job, Cheung, Flora, Multhaup, Michael, Chan, Derwin, Chen, Ziyuan, Ho, Harrison, Tse, Tsz, Au Yeung, Shiu, Lou, Shan, Zhang, Joni, Wang, Mengyao, Chung, Brian, Griffin, Simon

المصدر: BMJ Open. 14(12)

مصطلحات موضوعية: Behavior, GENETICS, General diabetes, Protocols & guidelines, Randomized Controlled Trial, Adult, Female, Humans, Male, Middle Aged, Diabetes Mellitus, Type 2, East Asian People, Exercise, Fitness Trackers, Genetic Predisposition to Disease, Obesity, Overweight, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Wearable Electronic Devices

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3v31r2q6
https://escholarship.org/content/qt3v31r2q6/qt3v31r2q6.pdf

المؤلفون: Lai, Dongbing, Zhang, Michael, Abreu, Marco, Schwantes-An, Tae-Hwi, Chan, Grace, Dick, Danielle M, Kamarajan, Chella, Kuang, Weipeng, Nurnberger, John I, Plawecki, Martin H, Rice, John, Schuckit, Marc, Porjesz, Bernice, Liu, Yunlong, Foroud, Tatiana

المصدر: JAMA Network Open. 7(12)

مصطلحات موضوعية: Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Prevention, Alcoholism, Alcohol Use and Health, Substance Misuse, Brain Disorders, Human Genome, Genetics, Mental health, Good Health and Well Being, Humans, Female, Male, Alcohol Dehydrogenase, Adult, Alcoholism, Middle Aged, Genetic Predisposition to Disease, Multifactorial Inheritance, White People, Polymorphism, Single Nucleotide, Genome-Wide Association Study, White, Biomedical and clinical sciences, Health sciences

URL الوصول: https://escholarship.org/uc/item/6zx9h9ch

المؤلفون: Bellos, Evangelos, Santillo, Dilys, Vantourout, Pierre, Jackson, Heather, Duret, Amedine, Hearn, Henry, Seeleuthner, Yoann, Talouarn, Estelle, Hodeib, Stephanie, Patel, Harsita, Powell, Oliver, Yeoh, Sophya, Mustafa, Sobia, Habgood-Coote, Dominic, Nichols, Samuel, Estramiana Elorrieta, Leire, DSouza, Giselle, Wright, Victoria, Estrada-Rivadeneyra, Diego, Tremoulet, Adriana, Dummer, Kirsten, Netea, Stejara, Condino-Neto, Antonio, Lau, Yu, Núñez Cuadros, Esmeralda, Toubiana, Julie, Holanda Pena, Marisol, Rieux-Laucat, Frédéric, Luyt, Charles-Edouard, Haerynck, Filomeen, Mège, Jean, Chakravorty, Samya, Haddad, Elie, Morin, Marie-Paule, Metin Akcan, Özge, Keles, Sevgi, Emiroglu, Melike, Alkan, Gulsum, Tüter Öz, Sadiye, Elmas Bozdemir, Sefika, Morelle, Guillaume, Volokha, Alla, Kendir-Demirkol, Yasemin, Sözeri, Betul, Coskuner, Taner, Yahsi, Aysun, Gulhan, Belgin, Kanik-Yuksek, Saliha, Bayhan, Gulsum, Ozkaya-Parlakay, Aslinur, Yesilbas, Osman, Hatipoglu, Nevin, Ozcelik, Tayfun, Belot, Alexandre, Chopin, Emilie, Barlogis, Vincent, Sevketoglu, Esra, Menentoglu, Emin, Gayretli Aydin, Zeynep, Bloomfield, Marketa, AlKhater, Suzan, Cyrus, Cyril, Stepanovskiy, Yuriy, Bondarenko, Anastasiia, Öz, Fatma, Polat, Meltem, Fremuth, Jiří, Lebl, Jan, Geraldo, Amyrath, Jouanguy, Emmanuelle, Carter, Michael, Wellman, Paul, Peters, Mark, Pérez de Diego, Rebeca, Edwards, Lindsey, Chiu, Christopher, Noursadeghi, Mahdad, Bolze, Alexandre, Shimizu, Chisato, Kaforou, Myrsini, Hamilton, Melissa, Herberg, Jethro, Schmitt, Erica, Rodriguez-Palmero, Agusti, Pujol, Aurora, Kim, Jihoon, Cobat, Aurélie, Abel, Laurent, Zhang, Shen-Ying, Casanova, Jean-Laurent, Kuijpers, Taco, Burns, Jane, Levin, Michael, Hayday, Adrian, Sancho-Shimizu, Vanessa

المصدر: Journal of Experimental Medicine. 221(12)

مصطلحات موضوعية: Humans, COVID-19, Child, Systemic Inflammatory Response Syndrome, Male, Female, Butyrophilins, SARS-CoV-2, Child, Preschool, Heterozygote, Adolescent, Genetic Predisposition to Disease, Infant

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1570s2ms
https://escholarship.org/content/qt1570s2ms/qt1570s2ms.pdf

المؤلفون: Roe, James M, Vidal-Piñeiro, Didac, Sørensen, Øystein, Grydeland, Håkon, Leonardsen, Esten H, Iakunchykova, Olena, Pan, Mengyu, Mowinckel, Athanasia, Strømstad, Marie, Nawijn, Laura, Milaneschi, Yuri, Andersson, Micael, Pudas, Sara, Bråthen, Anne Cecilie Sjøli, Kransberg, Jonas, Falch, Emilie Sogn, Øverbye, Knut, Kievit, Rogier A, Ebmeier, Klaus P, Lindenberger, Ulman, Ghisletta, Paolo, Demnitz, Naiara, Boraxbekk, Carl-Johan, Drevon, Christian A, Penninx, Brenda, Bertram, Lars, Nyberg, Lars, Walhovd, Kristine B, Fjell, Anders M, Wang, Yunpeng

المصدر: Nature Communications. 15(1)

مصطلحات موضوعية: Biological Psychology, Biological Sciences, Genetics, Psychology, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Aging, Brain Disorders, Alzheimer's Disease, Neurosciences, Acquired Cognitive Impairment, Neurodegenerative, Prevention, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies, 1.1 Normal biological development and functioning, Neurological, Mental health, Humans, Alzheimer Disease, Aged, Brain, Male, Female, Middle Aged, Aged, 80 and over, Adult, Memory Disorders, Longitudinal Studies, Genetic Variation, Neuroimaging, Genetic Predisposition to Disease, Risk Factors, Apolipoproteins E, Magnetic Resonance Imaging, Atrophy, Machine Learning, Alzheimer’s Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8839z90r
https://escholarship.org/content/qt8839z90r/qt8839z90r.pdf

المؤلفون: Álvarez Jerez, Pilar, Wild Crea, Peter, Ramos, Daniel M, Gustavsson, Emil K, Radefeldt, Mandy, Damianov, Andrey, Makarious, Mary B, Ojo, Oluwadamilola O, Billingsley, Kimberley J, Malik, Laksh, Daida, Kensuke, Bromberek, Sarah, Hu, Fangle, Schneider, Zachary, Surapaneni, Aditya L, Stadler, Julia, Rizig, Mie, Morris, Huw R, Pantazis, Caroline B, Leonard, Hampton L, Screven, Laurel, Qi, Yue A, Nalls, Mike A, Bandres-Ciga, Sara, Hardy, John, Houlden, Henry, Eng, Celeste, Burchard, Esteban González, Kachuri, Linda, Lin, Chia-Ho, Black, Douglas L, Singleton, Andrew B, Fischer, Steffen, Bauer, Peter, Reed, Xylena, Ryten, Mina, Beetz, Christian, Ward, Michael, Okubadejo, Njideka U, Blauwendraat, Cornelis

المصدر: Nature Structural & Molecular Biology. 31(12)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Neurodegenerative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Prevention, Biotechnology, Acquired Cognitive Impairment, Dementia, Aging, Brain Disorders, Neurosciences, Parkinson's Disease, 2.1 Biological and endogenous factors, Neurological, Glucosylceramidase, Humans, Introns, Parkinson Disease, Genetic Predisposition to Disease, Black People, Polymorphism, Single Nucleotide, RNA Splicing, Global Parkinson’s Genetics Program, Chemical Sciences, Medical and Health Sciences, Biophysics, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3668224k
https://escholarship.org/content/qt3668224k/qt3668224k.pdf

المصدر: Robotic Nipple-Sparing Mastectomy With Immediate Prosthetic Breast Reconstruction: Prospective Study of Feasibility, Safety and Patient Satisfaction, Toronto Experience.
Toesca A, Peradze N, Manconi A, Galimberti V, Intra M, Colleoni M, Bonanni B, Curigliano G, Rietjens M, Viale G, Sacchini V, Veronesi P. Robotic nipple-sparing mastectomy for the treatment of breast cancer: Feasibility and safety study. Breast. 2017 Feb;31:51-56. doi: 10.1016/j.breast.2016.10.009. Epub 2016 Nov 2.
Sarfati B, Struk S, Leymarie N, Honart JF, Alkhashnam H, Tran de Fremicourt K, Conversano A, Rimareix F, Simon M, Michiels S, Kolb F. Robotic Prophylactic Nipple-Sparing Mastectomy with Immediate Prosthetic Breast Reconstruction: A Prospective Study. Ann Surg Oncol. 2018 Sep;25(9):2579-2586. doi: 10.1245/s10434-018-6555-x. Epub 2018 Jun 29.

المصدر: Registro Mono-istituzionale Di Individui Sottoposti a Valutazione Del Rischio Genetico Oncologico

المصدر: Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition Across Diverse Patient Populations in Gynecology Practices at Penn Medicine
Srivastava SK, Ahmad A, Miree O, Patel GK, Singh S, Rocconi RP, Singh AP. Racial health disparities in ovarian cancer: not just black and white. J Ovarian Res. 2017 Sep 21;10(1):58. doi: 10.1186/s13048-017-0355-y.
Menon U, Gentry-Maharaj A, Burnell M, Singh N, Ryan A, Karpinskyj C, Carlino G, Taylor J, Massingham SK, Raikou M, Kalsi JK, Woolas R, Manchanda R, Arora R, Casey L, Dawnay A, Dobbs S, Leeson S, Mould T, Seif MW, Sharma A, Williamson K, Liu Y, Fallowfield L, McGuire AJ, Campbell S, Skates SJ, Jacobs IJ, Parmar M. Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. 2021 Jun 5;397(10290):2182-2193. doi: 10.1016/S0140-6736(21)00731-5. Epub 2021 May 12.
Reid S, Cadiz S, Pal T. Disparities in Genetic Testing and Care among Black women with Hereditary Breast Cancer. Curr Breast Cancer Rep. 2020 Sep;12(3):125-131. doi: 10.1007/s12609-020-00364-1. Epub 2020 May 19.
Jatoi I, Sung H, Jemal A. The Emergence of the Racial Disparity in U.S. Breast-Cancer Mortality. N Engl J Med. 2022 Jun 23;386(25):2349-2352. doi: 10.1056/NEJMp2200244. Epub 2022 Jun 18. No abstract available.
Domchek SM, Robson ME. Update on Genetic Testing in Gynecologic Cancer. J Clin Oncol. 2019 Sep 20;37(27):2501-2509. doi: 10.1200/JCO.19.00363. Epub 2019 Aug 12. No abstract available.
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC; Karlan BY, Khan S, Klein C, Kohlmann W; CGC; Kurian AW, Laronga C, Litton JK, Mak JS; LCGC; Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC; Senter-Jamieson L; CGC; Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA. Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001.
Smith-Uffen M, Bartley N, Davies G, Best M. Motivations and barriers to pursue cancer genomic testing: A systematic review. Patient Educ Couns. 2021 Jun;104(6):1325-1334. doi: 10.1016/j.pec.2020.12.024. Epub 2020 Dec 25.
Kurian AW, Ward KC, Howlader N, Deapen D, Hamilton AS, Mariotto A, Miller D, Penberthy LS, Katz SJ. Genetic Testing and Results in a Population-Based Cohort of Breast Cancer Patients and Ovarian Cancer Patients. J Clin Oncol. 2019 May 20;37(15):1305-1315. doi: 10.1200/JCO.18.01854. Epub 2019 Apr 9.
McBride CM, Pathak S, Johnson CE, Alberg AJ, Bandera EV, Barnholtz-Sloan JS, Bondy ML, Cote ML, Moorman PG, Peres LC, Peters ES, Schwartz AG, Terry PD, Schildkraut JM. Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: Results from the African American Cancer Epidemiology Study. Cancer. 2022 Mar 15;128(6):1252-1259. doi: 10.1002/cncr.34053. Epub 2021 Dec 9.
Hamilton JG, Symecko H, Spielman K, Breen K, Mueller R, Catchings A, Trottier M, Salo-Mullen EE, Shah I, Arutyunova A, Batson M, Gebert R, Pundock S, Schofield E, Offit K, Stadler ZK, Cadoo K, Carlo MI, Narayan V, Reiss KA, Robson ME, Domchek SM. Uptake and acceptability of a mainstreaming model of hereditary cancer multigene panel testing among patients with ovarian, pancreatic, and prostate cancer. Genet Med. 2021 Nov;23(11):2105-2113. doi: 10.1038/s41436-021-01262-2. Epub 2021 Jul 13.
Lau-Min KS, Guerra CE, Nathanson KL, Bekelman JE. From Race-Based to Precision Oncology: Leveraging Behavioral Economics and the Electronic Health Record to Advance Health Equity in Cancer Care. JCO Precis Oncol. 2021 Feb 17;5:PO.20.00418. doi: 10.1200/PO.20.00418. eCollection 2021. No abstract available.
Kukafka R, Pan S, Silverman T, Zhang T, Chung WK, Terry MB, Fleck E, Younge RG, Trivedi MS, McGuinness JE, He T, Dimond J, Crew KD. Patient and Clinician Decision Support to Increase Genetic Counseling for Hereditary Breast and Ovarian Cancer Syndrome in Primary Care: A Cluster Randomized Clinical Trial. JAMA Netw Open. 2022 Jul 1;5(7):e2222092. doi: 10.1001/jamanetworkopen.2022.22092.

المؤلفون: National Cancer Institute (NCI)

المصدر: Genetic Susceptibility to Bladder Cancer: A Molecular Epidemiology Approach

المصدر: Genetic Newborn Screening for Rare Diseases Within the Screen4Care Project: the French Participation

المصدر: Genetic Susceptibility to Radiation Induced Thyroid Cancer

المصدر: EVALUATION OF CANCER RISK BY MEASUREMENT OF CIRCULATING MUTATIONAL BURDEN IN CARRIERS OF A GENETIC PREDISPOSITION

المصدر: Vascular Disease Discovery Protocol

المساهمون: Ai-Ling Lin, PhD, Professor

المصدر: Short Term Apolipoprotein E (ApoE)-dependent Cerebral Blood Flow and Lung Perfusion Response to Sirolimus in Cognitively Normal Adults
Ficke AJ, Owens WF Jr. Femoral shaft fractures and the above-knee amputee: use of the compression plate. A report of three cases. Clin Orthop Relat Res. 1972 Sep;87:200-3. No abstract available.
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Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Physician. 2007 Aug 1;76(3):391-6.
Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond JAL, Kellogg DL Jr. A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. Exp Gerontol. 2018 May;105:53-69. doi: 10.1016/j.exger.2017.12.026. Epub 2018 Feb 3.
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M, Kappos L, Goedert M, Tolnay M, Winkler DT. Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS One. 2013 May 7;8(5):e62459. doi: 10.1371/journal.pone.0062459. Print 2013.
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010 Apr 1;5(4):e9979. doi: 10.1371/journal.pone.0009979. Erratum In: PLoS One. 2011;6(11). doi:10.1371/annotation/05c1b976-7eab-4154-808d-0526e604b8eb.
Ross C, Salmon A, Strong R, Fernandez E, Javors M, Richardson A, Tardif S. Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus). Aging (Albany NY). 2015 Nov;7(11):964-73. doi: 10.18632/aging.100843.
Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A. Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. J Gerontol A Biol Sci Med Sci. 2015 May;70(5):577-87. doi: 10.1093/gerona/glu101. Epub 2014 Jul 19.
Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB. Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Am J Primatol. 2019 Feb;81(2):e22927. doi: 10.1002/ajp.22927. Epub 2018 Oct 12.
Lelegren M, Liu Y, Ross C, Tardif S, Salmon AB. Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate. Pathobiol Aging Age Relat Dis. 2016 Jun 23;6:31793. doi: 10.3402/pba.v6.31793. eCollection 2016.
Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiol Dis. 2020 Jun;139:104834. doi: 10.1016/j.nbd.2020.104834. Epub 2020 Mar 12.
Lin AL, Jahrling JB, Zhang W, DeRosa N, Bakshi V, Romero P, Galvan V, Richardson A. Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab. 2017 Jan;37(1):217-226. doi: 10.1177/0271678X15621575. Epub 2015 Dec 31.
Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21. doi: 10.1038/jcbfm.2013.82. Epub 2013 Jun 26.
Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB. mTOR inhibition improves immune function in the elderly. Sci Transl Med. 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892.