المؤلفون: Cyclerion Therapeutics

المصدر: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of IW-1973 in Patients With Type 2 Diabetes With Albuminuria Treated With Renin-Angiotensin System Inhibitors
Hanrahan JP, de Boer IH, Bakris GL, Wilson PJ, Wakefield JD, Seferovic JP, Chickering JG, Chien YT, Carlson K, Cressman MD, Currie MG, Milne GT, Profy AT. Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial. Clin J Am Soc Nephrol. 2020 Dec 31;16(1):59-69. doi: 10.2215/CJN.08410520. Epub 2020 Dec 16.

المؤلفون: Cyclerion Therapeutics

المصدر: A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 2 Study Evaluating the Safety and Efficacy of Different Doses of IW-1973 Over 12 Weeks in Patients With Heart Failure With Preserved Ejection Fraction
Udelson JE, Lewis GD, Shah SJ, Zile MR, Redfield MM, Burnett J Jr, Parker J, Seferovic JP, Wilson P, Mittleman RS, Profy AT, Konstam MA. Effect of Praliciguat on Peak Rate of Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: The CAPACITY HFpEF Randomized Clinical Trial. JAMA. 2020 Oct 20;324(15):1522-1531. doi: 10.1001/jama.2020.16641.
Udelson JE, Lewis GD, Shah SJ, Zile MR, Redfield MM, Burnett J Jr, Mittleman RS, Profy AT, Seferovic JP, Reasner D, Konstam MA. Rationale and design for a multicenter, randomized, double-blind, placebo-controlled, phase 2 study evaluating the safety and efficacy of the soluble guanylate cyclase stimulator praliciguat over 12 weeks in patients with heart failure with preserved ejection fraction (CAPACITY HFpEF). Am Heart J. 2020 Apr;222:183-190. doi: 10.1016/j.ahj.2020.01.009. Epub 2020 Jan 21.

المصدر: A Phase 2 Study to Compare the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of 2 Dose Regimens of IW-1973 in Patients With Stable Type 2 Diabetes and Hypertension
Hanrahan JP, Seferovic JP, Wakefield JD, Wilson PJ, Chickering JG, Jung J, Carlson KE, Zimmer DP, Frelinger AL 3rd, Michelson AD, Morrow L, Hall M, Currie MG, Milne GT, Profy AT. An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension. Diabetologia. 2020 Apr;63(4):733-743. doi: 10.1007/s00125-019-05062-x. Epub 2019 Dec 19.

المصدر: An Open-label, Phase 2a Trial to Evaluate the Effect of Escalating Doses of IW-1973 on Tolerability, Endothelial Function, and Hemodynamics in Patients With Stable Type 2 Diabetes and Hypertension

المصدر: A Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-Praliciguat ([14C]-IW-1973) Following a Single Oral Dose in Healthy Male Subjects

المصدر: An Open-label, 2-Period, Fixed-sequence, Phase 1 Study in Healthy Volunteers to Evaluate the Effect of Itraconazole, a Potent CYP3A Inhibitor, on the Pharmacokinetics of IW-1973

المصدر: A 2-stage Phase 1 Study of Safety, Tolerability, PK, and PD of IW-1973 Tablet in Healthy Volunteers in an Open-label, Single-dose Stage, and a Randomized, Double Blind, Placebo-controlled, Multiple-ascending-dose Stage

المؤلفون: Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Peter Germano, Julien Roux, Courtney M. Shea, Emmanuel S. Buys, Juli E. Jones

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: praliciguat, cGMP (cyclic GMP), nitric oxide, metabolic disease, thermoneutrality, obesity, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.852080/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/276425e92d2143c0a1202416a49b9492

المؤلفون: Ataei Ataabadi, Ehsan, Golshiri, Keivan, Juttner, Annika, Krenning, Guido, Danser, A. H. Jan, Roks, Anton J. M.

المصدر: Ataei Ataabadi , E , Golshiri , K , Juttner , A , Krenning , G , Danser , A H J & Roks , A J M 2020 , ' Nitric Oxide-cGMP Signaling in Hypertension : Current and Future Options for Pharmacotherapy ' , Hypertension , vol. 76 , no. 4 , pp. 1055-1068 . https://doi.org/10.1161/HYPERTENSIONAHA.120.15856

مصطلحات موضوعية: hypertension, mitochondria, nitric oxide, oxidoreductase, soluble guanylyl cyclase, SOLUBLE GUANYLATE-CYCLASE, KINASE G I, ACETYLCHOLINE-INDUCED HYPOTENSION, ELECTRONIC CIGARETTE-SMOKING, REACTIVE OXYGEN, BLOOD-PRESSURE, ENDOTHELIAL DYSFUNCTION, STIMULATOR PRALICIGUAT, HEART-FAILURE, ORGAN DAMAGE

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/20e6ea62-9652-4d54-97e4-a594264af4eb
https://research.rug.nl/en/publications/20e6ea62-9652-4d54-97e4-a594264af4eb
https://doi.org/10.1161/HYPERTENSIONAHA.120.15856
https://pure.rug.nl/ws/files/168960551/HYPERTENSIONAHA.120.15856_1_.pdf

المصدر: Hypertension. 76(4):1055-1068

مصطلحات موضوعية: hypertension, ACETYLCHOLINE-INDUCED HYPOTENSION, ELECTRONIC CIGARETTE-SMOKING, soluble guanylyl cyclase, BLOOD-PRESSURE, KINASE G I, ORGAN DAMAGE, mitochondria, nitric oxide, ENDOTHELIAL DYSFUNCTION, SOLUBLE GUANYLATE-CYCLASE, HEART-FAILURE, REACTIVE OXYGEN, STIMULATOR PRALICIGUAT, oxidoreductase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dris___01423::390e45cebb0591100cfdae6428d71dda
https://research.rug.nl/en/publications/20e6ea62-9652-4d54-97e4-a594264af4eb

المؤلفون: Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Peter Germano, Julien Roux, Courtney M. Shea, Emmanuel S. Buys, Juli E. Jones

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, praliciguat, cGMP (cyclic GMP), nitric oxide, metabolic disease, thermoneutrality, obesity, soluble guanylate cyclase (sGC)

Relation: https://figshare.com/articles/figure/Image1_Beneficial_Metabolic_Effects_of_Praliciguat_a_Soluble_Guanylate_Cyclase_Stimulator_in_a_Mouse_Diet-Induced_Obesity_Model_TIF/19304636

الاتاحة: https://doi.org/10.3389/fphar.2022.852080.s001
https://figshare.com/articles/figure/Image1_Beneficial_Metabolic_Effects_of_Praliciguat_a_Soluble_Guanylate_Cyclase_Stimulator_in_a_Mouse_Diet-Induced_Obesity_Model_TIF/19304636

المؤلفون: Annika Jüttner, Guido Krenning, Keivan Golshiri, A.H. Jan Danser, Anton J.M. Roks, Ehsan Ataei Ataabadi

المساهمون: Internal Medicine

المصدر: Hypertension, 76(4), 1055-1068. Lippincott Williams & Wilkins

مصطلحات موضوعية: 0301 basic medicine, Drug, ACETYLCHOLINE-INDUCED HYPOTENSION, media_common.quotation_subject, ELECTRONIC CIGARETTE-SMOKING, BLOOD-PRESSURE, 030204 cardiovascular system & hematology, Pharmacology, Nitric Oxide, Nitric oxide, ORGAN DAMAGE, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacotherapy, Soluble Guanylyl Cyclase, Guanosine monophosphate, Internal Medicine, medicine, SOLUBLE GUANYLATE-CYCLASE, Humans, Endothelial dysfunction, oxidoreductase, Cyclic GMP, Antihypertensive Agents, media_common, business.industry, Phosphodiesterase, medicine.disease, KINASE G I, mitochondria, 030104 developmental biology, chemistry, ENDOTHELIAL DYSFUNCTION, Hypertension, HEART-FAILURE, REACTIVE OXYGEN, STIMULATOR PRALICIGUAT, Soluble guanylyl cyclase, business, cGMP-dependent protein kinase, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4886961b192fa43b4be75f0272de5ee3
https://doi.org/10.1161/hypertensionaha.120.15856

المؤلفون: Guang Liu, Katherine C. Hall, Sarah Jacobson, Mark G. Currie, Renee Sarno, Sylvie G. Bernier, Victoria Catanzano, Ping Y. Zhang, Jaime L. Masferrer

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: 0301 basic medicine, soluble guanylate cyclase, praliciguat, Anti-Inflammatory Agents, Enzyme Activators, Inflammation, Nitric Oxide, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Soluble Guanylyl Cyclase, Fibrosis, Non-alcoholic Fatty Liver Disease, medicine, Hepatic Stellate Cells, Animals, Humans, Cells, Cultured, Pharmacology, Multidisciplinary, business.industry, AMPK, Biological Sciences, medicine.disease, NASH fibrosis, Coculture Techniques, 030104 developmental biology, Pyrimidines, chemistry, 030220 oncology & carcinogenesis, Hepatic stellate cell, Cancer research, Pyrazoles, Steatosis, medicine.symptom, Signal transduction, business, Myofibroblast, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c65ebd93360b967319371168329084
http://europepmc.org/articles/PMC6561202

المؤلفون: Jenny Tobin, Albert T. Profy, Ali R. Banijamali, Mark G. Currie, James Wakefield, Jaime L. Masferrer, G. Todd Milne, Daniel P. Zimmer, Andrew Carvalho, Peter Germano, Barden Timothy Claude

المصدر: Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)

مصطلحات موضوعية: Male, medicine.medical_specialty, sGC, Metabolite, praliciguat, Glucuronidation, Adipose tissue, RM1-950, 030226 pharmacology & pharmacy, Excretion, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Feces, 0302 clinical medicine, Soluble Guanylyl Cyclase, Pharmacokinetics, Oral administration, nitric oxide, Internal medicine, QWBA, medicine, Animals, Bile, Rats, Long-Evans, Tissue Distribution, General Pharmacology, Toxicology and Pharmaceutics, Original Articles, Bioavailability, cGMP, Endocrinology, Pyrimidines, Neurology, chemistry, 030220 oncology & carcinogenesis, Pyrazoles, Original Article, excretion, Therapeutics. Pharmacology, absorption, metabolism, pharmacokinetics, Drug metabolism, mass balance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3e4df24159164c127118e8e21c0b4
http://europepmc.org/articles/PMC7171252

المؤلفون: Andreas Friebe, Peter Sandner, Achim Schmidtko

المصدر: Naunyn-Schmiedeberg's Archives of Pharmacology

مصطلحات موضوعية: Review, sGC stimulators, Nitric oxide, chemistry.chemical_compound, Vericiguat, Animals, Humans, Natriuretic peptides, Receptor, Cyclic guanosine monophosphate, Cyclic GMP, Pharmacology, Riociguat, Chemistry, Effector, Phosphodiesterase, Guanylyl cyclases, General Medicine, Cell biology, cGMP, Crosstalk (biology), sGC activators, Phosphodiesterases, Second messenger system, Soluble guanylyl cyclase, Signal Transduction, Praliciguat

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0a6c356bd419fd8073f8b52fc2500b
https://pubmed.ncbi.nlm.nih.gov/31853617