المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661547

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s016

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661502

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s001

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661505

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s002

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661508

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s003

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661511

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s004

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661514

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s005

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661517

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s006

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661523

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s008

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661520

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s007

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661526

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s009

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661529

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s010

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661532

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s011

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661535

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s012

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661538

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s013

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661541

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s014

المؤلفون: Zhijie Wang (283745), Jiongheng Cai (11467041), Jiwei Ren (9256994), Yun Chen (279569), Yingli Wu (1772014), Jie Cheng (294193), Kun Jia (747683), Fei Huang (9205), Zitian Cheng (11467044), Tiancheng Sheng (11467047), Shiyu Song (733585), Hao Heng (9161263), Yifan Zhu (417526), Weifang Tang (1478896), Hongmei Li (51944), Tao Lu (39406), Yadong Chen (621664), Shuai Lu (158723)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, strongly inhibited phosphorylation, significant clinical challenge, selective inhibitory activities, possessed equivalent potency, downstream signaling factors, 11 xenograft models, flt3 inhibitor resistance, transformed baf3 cells, 67 , potent flt3 inhibitor, exhibited potent, 11 cells, flt3 could, taken together, secondary mutations, ribose region, results demonstrated, main mechanism

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Potent_FLT3_Inhibitor_LT-850-166_with_the_Capacity_of_Overcoming_a_Variety_of_FLT3_Mutations/16661544

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01196.s015