المؤلفون: Yang, Dongxiao, Alphey, Magnus S., MacNeill, Stuart

المصدر: Yang , D , Alphey , M S & MacNeill , S 2022 , ' Non‐canonical binding of the Chaetomium thermophilum PolD4 N‐terminal PIP motif to PCNA involves Q‐pocket and compact 2‐fork plug interactions but no 3 10 helix ' , FEBS Journal , vol. Early View , 16590 . https://doi.org/10.1111/febs.16590

مصطلحات موضوعية: PCNA, DNA polymerase zeta, DNA replication, Chaetomium thermophilum, PolD4

وصف الملف: application/pdf

الاتاحة: https://risweb.st-andrews.ac.uk/portal/en/researchoutput/noncanonical-binding-of-the-chaetomium-thermophilum-pold4-nterminal-pip-motif-to-pcna-involves-qpocket-and-compact-2fork-plug-interactions-but-no-310-helix(a84ae62b-3220-4992-a874-f7eea69fcdef).html
https://doi.org/10.1111/febs.16590
https://research-repository.st-andrews.ac.uk/bitstream/10023/25871/1/Yang_2022_Non_canonical_binding_FEBSJ_16590_CCBY.pdf

المؤلفون: Genome Aggregation Database Prod T, Genome Aggregation Database Consor, Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B., MacArthur, Daniel G., Groop, Leif, Färkkilä, Martti, Palotie, Aarno, Remes, Anne M., Ripatti, Samuli, Salomaa, Veikko, Soininen, Hilkka, Suvisaari, Jaana, Tuomi, Tiinamaija, Vartiainen, Erkki, Wessman, Maija

المساهمون: Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Department of Medicine, Clinicum, Gastroenterologian yksikkö, Helsinki University Hospital Area, Research Programs Unit, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, Department of Public Health, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Biostatistics Helsinki, Biosciences

مصطلحات موضوعية: DNA-POLYMERASE-ZETA, DE-NOVO MUTATIONS, WHOLE-GENOME, FRAMEWORK, SLIPPAGE, ELEMENTS, REPEATS, SIGNATURES, EVOLUTION, PATTERNS, Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: We would like to thank the many individuals whose sequence data are aggregated in gnomAD for their contributions to research, and for making this work possible. The results published here are in part based upon data: (1) generated by The Cancer Genome Atlas managed by the NCI and NHGRI (accession: phs000178.v10.p8). Information about TCGA can be found at http://cancergenome.nih.gov, (2) generated by the Genotype-Tissue Expression Project (GTEx) managed by the NIH Common Fund and NHGRI (accession: phs000424.v7.p2), (3) generated by the Exome Sequencing Project, managed by NHLBI, (4) generated by the Alzheimer's Disease Sequencing Project (ADSP), managed by the NIA and NHGRI (accession: phs000572.v7.p4). We would like to thank the Hail team for developing tools essential for the large-scale computation in this work. We would like to thank the analysis team of the Broad's Rare Disease Group for their manual inspection of MNVs in rare disease cohorts. This work was funded by NIDDK U54 DK105566, NIGMS R01 GM104371, and NHGRI UM1 HG008900-01. Q. W. was supported by the Nakajima Foundation Scholarship. K.J.K. was supported by NIGMS F32 GM115208. A.O.D.L. was supported by NICHD K12 HD052896.; Genome Aggregation Database Prod T , Genome Aggregation Database Consor , Wang , Q , Pierce-Hoffman , E , Cummings , B B , MacArthur , D G , Groop , L , Färkkilä , M , Palotie , A , Remes , A M , Ripatti , S , Salomaa , V , Soininen , H , Suvisaari , J , Tuomi , T , Vartiainen , E & Wessman , M 2020 , ' Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes ' , Nature Communications , vol. 11 , no. 1 , 2539 . https://doi.org/10.1038/s41467-019-12438-5; ORCID: /0000-0002-0250-8559/work/87349990; ORCID: /0000-0002-8306-6202/work/87350194; ORCID: /0000-0002-2527-5874/work/97266432; http://hdl.handle.net/10138/325078; 03bf4b14-32bd-4b51-8ac6-2343a619e908; 000538031600001

الاتاحة: http://hdl.handle.net/10138/325078

المؤلفون: Lawrence, Christopher W., Maher, Veronica M.

المصدر: Philosophical Transactions: Biological Sciences, 2001 Jan . 356(1405), 41-46.

URL الوصول: https://www.jstor.org/stable/3066954

المؤلفون: Diaz, Marilyn, Flajnik, Martin F., Klinman, Norman

المصدر: Philosophical Transactions: Biological Sciences, 2001 Jan . 356(1405), 67-72.

URL الوصول: https://www.jstor.org/stable/3066958

المؤلفون: Milena Denkiewicz-Kruk, Malgorzata Jedrychowska, Shizuko Endo, Hiroyuki Araki, Piotr Jonczyk, Michal Dmowski, Iwona J. Fijalkowska

المصدر: International Journal of Molecular Sciences; Volume 21; Issue 24; Pages: 9484

مصطلحات موضوعية: CMGE helicase-polymerase complex, GINS complex, PSF1 / GINS1, DNA polymerase epsilon, Pol ε, polymerase zeta, Pol ζ, recombination, DRIM, DNA replication fidelity, genetic instability, repeat tracts instability

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Genetics and Genomics; https://dx.doi.org/10.3390/ijms21249484

الاتاحة: https://doi.org/10.3390/ijms21249484

المؤلفون: Schreier, Heike

المساهمون: Wiesmüller, Lisa, Gebhardt, Christof, Ricchetti, Miria

مصطلحات موضوعية: Base excision repair, Mitochondrial DNA replication, Endonuclease G, Replikation, DNA replication, DNA, Mitochondrial, Mitochondrial DNA, Compensatory replication, DNA repair enzymes, Oxidative stress, Oxidativer Stress, Oxidative damage, Mitochondriale DNS, Mitochondrial DNA degradation, ddc:610, Polymerase zeta, DDC 610 / Medicine & health

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dec41f329c976b2be3f9dd5a9c8f259

المؤلفون: Yang, Dongxiao, Alphey, Magnus S., MacNeill, Stuart

المساهمون: University of St Andrews. Institute of Behavioural and Neural Sciences, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. School of Biology

مصطلحات موضوعية: QH301, QH301 Biology, PCNA, DAS, QD, Chaetomium thermophilum, DNA replication, QD Chemistry, PolD4, DNA polymerase zeta

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______901::d556798e4b1947b9c1cf7e5e014445c3
https://hdl.handle.net/10023/25871

المؤلفون: Martín-Pardillos, Ana, Tsaalbi-Shtylik, Anastasia, Chen, Si, Lazare, Seka, van Os, Ronald P, Dethmers-Ausema, Albertina, Fakouri, Nima Borhan, Bosshard, Matthias, Aprigliano, Rossana, van Loon, Barbara, Salvatori, Daniela C F, Hashimoto, Keiji, Dingemanse-van der Spek, Celia, Moriya, Masaaki, Rasmussen, Lene Juel, de Haan, Gerald, Raaijmakers, Marc H G P, de Wind, Niels

المصدر: Martín-Pardillos , A , Tsaalbi-Shtylik , A , Chen , S , Lazare , S , van Os , R P , Dethmers-Ausema , A , Fakouri , N B , Bosshard , M , Aprigliano , R , van Loon , B , Salvatori , D C F , Hashimoto , K , Dingemanse-van der Spek , C , Moriya , M , Rasmussen , L J , de Haan , G , Raaijmakers , M H G P & de Wind , N 2017 , ' Genomic and functional integrity of the hematopoietic system requires tolerance of ....

مصطلحات موضوعية: STEM-CELL FUNCTION, CLONAL HEMATOPOIESIS, REPLICATION STRESS, POLYMERASE-ZETA, BONE-MARROW, TRANSLESION SYNTHESIS, DAMAGE RESPONSE, MICE, CANCER, REPAIR

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/aa9f02d3-22fc-43b4-8020-b72d57383feb
https://research.rug.nl/en/publications/aa9f02d3-22fc-43b4-8020-b72d57383feb
https://doi.org/10.1182/blood-2017-01-764274
https://pure.rug.nl/ws/files/49396539/1523.full.pdf

المؤلفون: Ruth Loos, Qingbo Wang, Anne O'Donnell-Luria, Benjamin Glaser, James Ware, John D. Rioux, ROBERTO ELOSUA, Kristian Cibulskis, Laurent Francioli, E Shyong Tai, Terho Lehtimäki, Daniel MacArthur, Irina Armean, Matthew Bown, Tiinamaija Tuomi, Jeanette Erdmann, Matthew Solomonson, Harry Sokol, Aarno Palotie, Martti Färkkilä, Ronald Ma, Olle Melander, Emilia Solinas

المساهمون: Tampere University, Clinical Medicine, Department of Clinical Chemistry, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Department of Medicine, Clinicum, Gastroenterologian yksikkö, Helsinki University Hospital Area, Research Programs Unit, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, Department of Public Health, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Biostatistics Helsinki, Biosciences, Rosetrees Trust

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
2020, ' Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes ', Nature Communications, vol. 11, no. 1, 2539 . https://doi.org/10.1038/s41467-019-12438-5
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Mutation rate, Science, Nonsense mutation, General Physics and Astronomy, Computational biology, Genome, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Protein sequencing, 0302 clinical medicine, DNA Mutational Analysis, Genetic variation, ELEMENTS, lcsh:Science, Exome, SIGNATURES, Exome sequencing, Polymerase, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, Haplotype, 1184 Genetics, developmental biology, physiology, Genome Aggregation Database Production Team, Genomics, General Chemistry, FRAMEWORK, EVOLUTION, SLIPPAGE, 030104 developmental biology, Haplotypes, CpG site, DE-NOVO MUTATIONS, Genome Aggregation Database Consortium, 030220 oncology & carcinogenesis, Mutation (genetic algorithm), WHOLE-GENOME, PATTERNS, biology.protein, DNA-POLYMERASE-ZETA, REPEATS, lcsh:Q, 3111 Biomedicine, 030217 neurology & neurosurgery

وصف الملف: fulltext; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6888bcf12b71f1b1b238d4a8d4e562d2
https://doaj.org/article/053a200a4cea4fb997d382b7e041c377

المؤلفون: Raykov, V., Marvin, Marcus E., Louis, Edward J., Maringele, L.

مصطلحات موضوعية: Dnl4, Rad51, Rad52, Rev3, palindrome, polymerase zeta, telomere

Relation: http://www.ncbi.nlm.nih.gov/pubmed/27334270; Genetics, 2016, 203 (4), pp. 1659-1668; http://www.genetics.org/content/203/4/1659; http://hdl.handle.net/2381/38695; genetics.115.183020

الاتاحة: http://www.genetics.org/content/203/4/1659
http://hdl.handle.net/2381/38695
https://doi.org/10.1534/genetics.115.183020

المؤلفون: V. Raykov, Marcus E. Marvin, Edward J. Louis, L. Maringele

مصطلحات موضوعية: Uncategorized, Dnl4, Rad51, Rad52, Rev3, palindrome, polymerase zeta, telomere

Relation: 2381/38695; https://figshare.com/articles/journal_contribution/Telomere_Dysfunction_Triggers_Palindrome_Formation_Independently_of_Double-Strand_Break_Repair_Mechanisms_/10122206

الاتاحة: https://figshare.com/articles/journal_contribution/Telomere_Dysfunction_Triggers_Palindrome_Formation_Independently_of_Double-Strand_Break_Repair_Mechanisms_/10122206

المؤلفون: Wojtaszek, Jessica Louise

Thesis Advisors: Zhou, Pei

مصطلحات موضوعية: Biochemistry, Biophysics, Chemistry, FAAP20, interstrand crosslink, Polymerase kappa, Polymerase zeta, Rev1 CTD, translesion synthesis

الاتاحة: http://hdl.handle.net/10161/9936

المؤلفون: Hiroyuki Araki, Shizuko Endo, Piotr Jonczyk, Milena Denkiewicz-Kruk, Malgorzata Jedrychowska, Michał Dmowski, Iwona J. Fijalkowska

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9484, p 9484 (2020)
Volume 21
Issue 24

مصطلحات موضوعية: DRIM, DNA-Directed DNA Polymerase, lcsh:Chemistry, DNA polymerase epsilon, PSF1/GINS1, Mutation Rate, lcsh:QH301-705.5, Spectroscopy, Polymerase, Recombination, Genetic, biology, Minichromosome Maintenance Proteins, Chemistry, Nuclear Proteins, genetic instability, General Medicine, Computer Science Applications, Cell biology, DNA-Binding Proteins, G2 Phase Cell Cycle Checkpoints, Protein Binding, DNA Replication, Saccharomyces cerevisiae Proteins, DNA replication initiation, Cell Survival, DNA replication fidelity, Saccharomyces cerevisiae, CMGE helicase-polymerase complex, Catalysis, Article, Inorganic Chemistry, Pol ε, Pol ζ, Physical and Theoretical Chemistry, Molecular Biology, CMG complex, Organic Chemistry, DNA replication, DNA Helicases, Helicase, Frameshifting, Ribosomal, DNA Polymerase II, GINS complex, GINS, recombination, repeat tracts instability, Rad52 DNA Repair and Recombination Protein, lcsh:Biology (General), lcsh:QD1-999, polymerase zeta, Mutagenesis, Mutation, biology.protein, Homologous recombination, Synthetic Lethal Mutations

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499424c6cb3c4cff325a05297c36506d
http://europepmc.org/articles/PMC7762974

المؤلفون: Song, Liang, McNeil, Ewan M., Ritchie, Ann-Marie, Astell, Katy R, Gourley, Charlie, Melton, David W.

المصدر: BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
Song, L, McNeil, E M, Ritchie, A-M, Astell, K R, Gourley, C & Melton, D W 2017, ' Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA Polymerase ζ ', BMC Cancer . https://doi.org/10.1186/s12885-017-3864-6

مصطلحات موضوعية: cisplatin, DNA repair, chemotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, synthetic lethality, PARP inhibitor, DNA repiar, Chemotherapy, RAD51, translesion synthesis, Cisplatin, Translesion synthesis, Melanoma, DNA polymerase zeta

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4989e918fff146096c562a3533c4086a
http://link.springer.com/article/10.1186/s12885-017-3864-6

المؤلفون: Iwona J. Fijalkowska, Catherine Suski, Ewa Szwajczak

المصدر: Current Genetics

مصطلحات موضوعية: 0301 basic medicine, Saccharomyces cerevisiae Proteins, CysB motif, DNA polymerase, DNA damage, viruses, Protein subunit, DNA-Directed DNA Polymerase, Saccharomyces cerevisiae, Review, 03 medical and health sciences, chemistry.chemical_compound, Biopolymers, Genetics, Protein Interaction Maps, Translesion synthesis, Polymerase, biology, DNA polymerase zeta (Pol ζ), Mutagenesis, DNA replication, General Medicine, Heterotetramer, Cell biology, 030104 developmental biology, chemistry, biology.protein, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185c86aee181f5c327877861edd229d8
https://doi.org/10.1007/s00294-017-0789-1

المؤلفون: Iwona J. Fijalkowska, Ewa Szwajczak, Catherine Suski

المصدر: Molecular Microbiology. 106:659-672

مصطلحات موضوعية: 0301 basic medicine, biology, DNA polymerase, viruses, Protein subunit, DNA polymerase zeta, Mutant, Eukaryotic DNA replication, Microbiology, Molecular biology, Yeast, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Induced mutagenesis, 030220 oncology & carcinogenesis, biology.protein, Replisome, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::442e8f9ec49cd2067d5bbaa65d1df044
https://doi.org/10.1111/mmi.13846

المؤلفون: Anastasia Tsaalbi-Shtylik, Rossana Aprigliano, Niels de Wind, Daniela C.F. Salvatori, Matthias Bosshard, Marc H.G.P. Raaijmakers, Ronald van Os, Celia Dingemanse-van der Spek, Albertina Dethmers-Ausema, Barbara van Loon, Gerald de Haan, Keiji Hashimoto, Masaaki Moriya, Si Chen, Nima Borhan Fakouri, Seka Lazare, Lene Juel Rasmussen, Ana Martín-Pardillos

المساهمون: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), Hematology

المصدر: Blood, 130(13), 1523-1534. AMER SOC HEMATOLOGY
Blood, 130(13), 1523-1534
Blood, 130(13), 1523-1534. American Society of Hematology

مصطلحات موضوعية: 0301 basic medicine, Senescence, DNA Repair, DNA damage, DNA repair, Hematopoietic System, BONE-MARROW, Immunology, Apoptosis, TRANSLESION SYNTHESIS, DNA-Directed DNA Polymerase, Biology, Biochemistry, 03 medical and health sciences, Bone Marrow, medicine, Animals, POLYMERASE-ZETA, DAMAGE RESPONSE, Aplastic anemia, Cellular Senescence, Cell Proliferation, REPAIR, Genome, STEM-CELL FUNCTION, CLONAL HEMATOPOIESIS, Cell Biology, Hematology, medicine.disease, Hematopoietic Stem Cells, Molecular biology, Nucleotidyltransferases, CANCER, Cell biology, Oxidative Stress, REPLICATION STRESS, MICE, 030104 developmental biology, medicine.anatomical_structure, REV1, Bone marrow, Stem cell, Erratum, Nucleotide excision repair, DNA Damage

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303237965cefbec89cd518ec17b7d33
https://research.rug.nl/en/publications/aa9f02d3-22fc-43b4-8020-b72d57383feb

المؤلفون: Kovich, Joshua

المصدر: West Chester University Master’s Theses

مصطلحات موضوعية: DNA Polymerase Zeta, Translesion Synthesis, Morpholinos, Apoptosis, Zebrafish, Molecular Genetics

وصف الملف: application/pdf

Relation: https://digitalcommons.wcupa.edu/all_theses/94; https://digitalcommons.wcupa.edu/cgi/viewcontent.cgi?article=1110&context=all_theses

الاتاحة: https://digitalcommons.wcupa.edu/all_theses/94
https://digitalcommons.wcupa.edu/cgi/viewcontent.cgi?article=1110&context=all_theses

المؤلفون: Hiroyuki Araki, Karolina Makiela-Dzbenska, Iwona J. Fijalkowska, Piotr Jonczyk, Krzysztof Flis, Anna E. Zawada, Marta A. Garbacz, Anna Bebenek

المصدر: DNA Repair. 29:23-35

مصطلحات موضوعية: DNA Replication, Saccharomyces cerevisiae Proteins, Chromosomal Proteins, Non-Histone, Ribonucleoprotein, U4-U6 Small Nuclear, DNA polymerase, DNA polymerase II, DNA polymerase epsilon, DNA-Directed DNA Polymerase, Saccharomyces cerevisiae, DNA polymerase delta, Biochemistry, DNA, Fungal, Molecular Biology, DNA polymerase zeta, Ribonucleoprotein, U5 Small Nuclear, Fidelity of replication, DNA clamp, biology, DNA replication, DNA leading strand, DNA Polymerase II, Cell Biology, Processivity, GINS complex, Molecular biology, Mutation, biology.protein, DNA polymerase I

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddce5a72d53bac4b91f4f83f6931f20
https://doi.org/10.1016/j.dnarep.2015.02.007

المؤلفون: Liang, Song, Ewan M, McNeil, Ann-Marie, Ritchie, Katy R, Astell, Charlie, Gourley, David W, Melton

المصدر: BMC Cancer

مصطلحات موضوعية: DNA Replication, Synthetic lethality, DNA repair, Apoptosis, DNA-Directed DNA Polymerase, Poly(ADP-ribose) Polymerase Inhibitors, Piperazines, Gene Expression Regulation, Neoplastic, PARP inhibitor, Cell Line, Tumor, Gene Knockdown Techniques, Humans, Phthalazines, Chemotherapy, RAD51, Rad51 Recombinase, Cisplatin, Homologous Recombination, Translesion synthesis, Melanoma, DNA polymerase zeta, DNA Damage, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::4b7bfea655eacfad054a3bef55a6d971
https://pubmed.ncbi.nlm.nih.gov/29254481