المؤلفون: Justin H. Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F. T. Koehler, Christian N. Cunningham, R. Scott Lokey

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, single methylene group, single amino acid, peptoid hybrid scaffolds, optimal lipophilicity range, mer cyclic peptide, macrocyclic peptides would, like chemical space, existing physicochemical knowledge, affinity macrocyclic peptides, dielectric conformation shifted, compounds described herein, classically undruggable targets, 200 macrocyclic 10, poor membrane permeability, passive membrane permeability, highly permeable scaffold, membrane permeability, shaped conformation, parent compounds, intracellular targets, cyclized 10, permeability could, achieving permeability, work provides

Relation: https://figshare.com/articles/journal_contribution/Membrane_Permeability_in_a_Large_Macrocyclic_Peptide_Driven_by_a_Saddle-Shaped_Conformation/25193926

الاتاحة: https://doi.org/10.1021/jacs.3c10949.s001

المؤلفون: Justin H. Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F. T. Koehler, Christian N. Cunningham, R. Scott Lokey

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, single methylene group, single amino acid, peptoid hybrid scaffolds, optimal lipophilicity range, mer cyclic peptide, macrocyclic peptides would, like chemical space, existing physicochemical knowledge, affinity macrocyclic peptides, dielectric conformation shifted, compounds described herein, classically undruggable targets, 200 macrocyclic 10, poor membrane permeability, passive membrane permeability, highly permeable scaffold, membrane permeability, shaped conformation, parent compounds, intracellular targets, cyclized 10, permeability could, achieving permeability, work provides

Relation: https://figshare.com/articles/dataset/Membrane_Permeability_in_a_Large_Macrocyclic_Peptide_Driven_by_a_Saddle-Shaped_Conformation/25193929

الاتاحة: https://doi.org/10.1021/jacs.3c10949.s002
https://figshare.com/articles/dataset/Membrane_Permeability_in_a_Large_Macrocyclic_Peptide_Driven_by_a_Saddle-Shaped_Conformation/25193929

المؤلفون: Justin H. Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F. T. Koehler, Christian N. Cunningham, R. Scott Lokey

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, single methylene group, single amino acid, peptoid hybrid scaffolds, optimal lipophilicity range, mer cyclic peptide, macrocyclic peptides would, like chemical space, existing physicochemical knowledge, affinity macrocyclic peptides, dielectric conformation shifted, compounds described herein, classically undruggable targets, 200 macrocyclic 10, poor membrane permeability, passive membrane permeability, highly permeable scaffold, membrane permeability, shaped conformation, parent compounds, intracellular targets, cyclized 10, permeability could, achieving permeability, work provides

Relation: https://figshare.com/articles/dataset/Membrane_Permeability_in_a_Large_Macrocyclic_Peptide_Driven_by_a_Saddle-Shaped_Conformation/25193929

الاتاحة: https://doi.org/10.1021/jacs.3c10949.s002