المؤلفون: Guo, Chun-Jun, Chang, Fang-Yuan, Wyche, Thomas P, Backus, Keriann M, Acker, Timothy M, Funabashi, Masanori, Taketani, Mao, Donia, Mohamed S, Nayfach, Stephen, Pollard, Katherine S, Craik, Charles S, Cravatt, Benjamin F, Clardy, Jon, Voigt, Christopher A, Fischbach, Michael A

المصدر: Cell. 168(3)

مصطلحات موضوعية: Feces, Animals, Humans, Bacteria, Bacillus subtilis, Escherichia coli, Pyrazines, Peptide Synthases, Phylogeny, Microbiota, Gastrointestinal Microbiome, biosynthetic gene cluster, metagenomics, microbiome, natural products, peptide aldehyde, protease inhibitor, synthetic biology, Developmental Biology, Biological Sciences, Medical and Health Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/70n9x6vn

المؤلفون: Leahy, Darren, Grant, Cameron, Jackson, Alex, Duff, Alex, Tardiota, Nicolas, Van Haeften, Jessica, Chen, Xingchen, Peake, Jonathan M., Kruppa, Michael D., Smith, Eliot T., Johnson, David A., Lott, William B., Harris, Jonathan M.

المصدر: Molecules

مصطلحات موضوعية: Human neutrophil elastase, Methi-onine oxidation, Methionine sulfone, Peptide aldehyde, Substrate guided inhibitor design, Substrate selectivity

وصف الملف: application/pdf

Relation: https://eprints.qut.edu.au/226042/1/101391247.pdf; Leahy, Darren, Grant, Cameron, Jackson, Alex, Duff, Alex, Tardiota, Nicolas, Van Haeften, Jessica, Chen, Xingchen, Peake, Jonathan M., Kruppa, Michael D., Smith, Eliot T., Johnson, David A., Lott, William B., & Harris, Jonathan M. (2021) Discrimination of methionine sulfoxide and sulfone by human neutrophil elastase. Molecules, 26(17), Article number: 5344.; https://eprints.qut.edu.au/226042/; Faculty of Science; School of Chemistry & Physics; Faculty of Health; School of Biomedical Sciences

الاتاحة: https://eprints.qut.edu.au/226042/

المؤلفون: Darren Leahy, Cameron Grant, Alex Jackson, Alex Duff, Nicholas Tardiota, Jessica Van Haeften, Xingchen Chen, Jonathan M. Peake, Michael D. Kruppa, Eliot T. Smith, David A. Johnson, William B. Lott, Jonathan M. Harris

المصدر: Molecules; Volume 26; Issue 17; Pages: 5344

مصطلحات موضوعية: human neutrophil elastase, peptide aldehyde, substrate guided inhibitor design, methionine oxidation, methionine sulfone, substrate selectivity

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Chemical Biology; https://dx.doi.org/10.3390/molecules26175344

الاتاحة: https://doi.org/10.3390/molecules26175344

المؤلفون: Hiroyuki Konno, Kenichi Akaji, 今野 博行, 赤路 健一

المصدر: 有機合成化学協会誌 / Journal of Synthetic Organic Chemistry, Japan. 2021, 79(1):2

المساهمون: Nathan, C

المصدر: Archives of Biochemistry and Biophysics; 501; 2

وصف الملف: Medium: X; Size: 214 - 220

URL الوصول: http://www.osti.gov/scitech/biblio/1040566

المؤلفون: Akira Sanjo, Hironori Mitsui, Hiroyuki Konno, Kazuto Nosaka, Kenichi Akaji, Mari Onozuka, Masami Kusunoki, Takeshi Ozaki, 三井 寛法, 三城 明, 今野 博行, 小野塚 真理, 尾崎 健, 楠木 正己, 赤路 健一, 野坂 和人

المصدر: Proceedings of the Symposium on Progress in Organic Reactions and Syntheses. 2009, :19

المؤلفون: Timothy M. Acker, Thomas P. Wyche, Fang-Yuan Chang, Mohamed S. Donia, Charles S. Craik, Chun-Jun Guo, Michael A. Fischbach, Katherine S. Pollard, Jon Clardy, Keriann M. Backus, Mao Taketani, Funabashi Masanori, Benjamin F. Cravatt, Christopher A. Voigt, Stephen Nayfach

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Synthetic Biology Center, Chang, Fang-Yuan, Voigt, Christopher A.

المصدر: Guo, CJ; Chang, FY; Wyche, TP; Backus, KM; Acker, TM; Funabashi, M; et al.(2017). Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell, 168(3), 517-526.e18. doi: 10.1016/j.cell.2016.12.021. UCSF: Retrieved from: http://www.escholarship.org/uc/item/70n9x6vn
Cell, vol 168, iss 3
PMC

مصطلحات موضوعية: 0301 basic medicine, natural products, medicine.medical_treatment, peptide aldehyde, microbiome, Gut flora, medicine.disease_cause, 01 natural sciences, Medical and Health Sciences, Feces, Gene cluster, 2.1 Biological and endogenous factors, Aetiology, Peptide Synthases, Phylogeny, chemistry.chemical_classification, biology, biosynthetic gene cluster, Microbiota, Biological Sciences, Pyrazines, HIV/AIDS, Infection, Bacillus subtilis, Proteases, General Biochemistry, Genetics and Molecular Biology, Microbiology, protease inhibitor, 03 medical and health sciences, Nonribosomal peptide, medicine, Genetics, Escherichia coli, Animals, Humans, Microbiome, metagenomics, Protease, Bacteria, 010405 organic chemistry, Human Genome, biology.organism_classification, 0104 chemical sciences, Gastrointestinal Microbiome, 030104 developmental biology, chemistry, synthetic biology, Human Microbiome Project, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f48518e8a650d1dc30bcf0ac048b38
http://www.escholarship.org/uc/item/70n9x6vn

المؤلفون: Diness, Frederik, Meldal, Morten Peter

المصدر: Diness , F & Meldal , M P 2015 , ' Fmox : a base-labile aldehyde protecting group ' , European Journal of Organic Chemistry , vol. 2015 , no. 7 , pp. 1433-1436 . https://doi.org/10.1002/ejoc.201403643

مصطلحات موضوعية: Fmoc, Amino aldehydes, Peptide aldehyde, Oxidation, Protecting groups

الاتاحة: https://curis.ku.dk/portal/da/publications/fmox(9d5d9724-3d85-4a53-8f8c-eece620ef998).html
https://doi.org/10.1002/ejoc.201403643

المؤلفون: Catherine Lange, Corinne Buré, Agnès F. Delmas, Guy Le Falher

المساهمون: Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Asymétrie, hétérocycles, hétérochimie et bio-organique (AHHBO), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)

المصدر: International Journal of Mass Spectrometry
International Journal of Mass Spectrometry, Elsevier, 2004, 39 (7), pp.817-823. ⟨10.1002/jms.661⟩

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Serine Proteinase Inhibitors, Collision-induced dissociation, Stereochemistry, Molecular Sequence Data, Peptide, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Aldehyde, in-source collision-induced dissociation, chemistry.chemical_compound, Acetals, Fragmentation (mass spectrometry), Nucleophile, Amino Acid Sequence, Spectroscopy, chemistry.chemical_classification, Aldehydes, fragmentation mechanism, 010401 analytical chemistry, Acetal, 0104 chemical sciences, peptide acetal, hydrated peptide aldehyde, chemistry, Amine gas treating, Methanol, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ae0fa6c901cbfb484a87d492e19a22
https://doi.org/10.1002/jms.661

المؤلفون: Buré, Corinne, Marceau, Philippe, Meudal, Hervé, Delmas, Agnès F

المساهمون: Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1075-2617.

مصطلحات موضوعية: peptide aldehyde, peptide ketone, ESI, mass spectrometry, NMR, oxime ligation, HPLC kinetic, SOLID-PHASE SYNTHESIS, COLLISION-INDUCED DISSOCIATION, TOTAL CHEMICAL-SYNTHESIS, CHEMOSELECTIVE LIGATION, EFFICIENT SYNTHESIS, SEGMENT LIGATION, BUILDING-BLOCKS, HYDRAZONE, PROTEIN, FRAGMENTATION, MESH: Aldehydes, MESH: Ketones, MESH: Oximes, MESH: Peptides, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

Relation: info:eu-repo/semantics/altIdentifier/pmid/22065463; hal-00721799; https://hal.science/hal-00721799; PUBMED: 22065463

الاتاحة: https://hal.science/hal-00721799
https://doi.org/10.1002/psc.1429

المؤلفون: Shpak-Kraievskyi, Pavlo, Yin, Biaolin, Martel, Arnaud, Dhal, Robert, Dujardin, Gilles, Laurent, Mathieu Y.

المساهمون: Unité de chimie organique moléculaire et macromoléculaire (UCO2M), Le Mans Université (UM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0040-4020 ; Tetrahedron ; https://hal.science/hal-00700165 ; Tetrahedron, 2012, 68 (9), pp.2179-2188. ⟨10.1016/j.tet.2012.01.002⟩.

مصطلحات موضوعية: Peptide coupling, Transacetalization, peptide aldehyde, β-amino acetal, Maraviroc, [CHIM.ORGA]Chemical Sciences/Organic chemistry

Relation: hal-00700165; https://hal.science/hal-00700165

الاتاحة: https://hal.science/hal-00700165
https://doi.org/10.1016/j.tet.2012.01.002

المؤلفون: Kazuto Nosaka, Manabu Ishii, Yasunao Hattori, Hiroyuki Konno, Yoshihiro Sema, Kenichi Akaji

المصدر: Tetrahedron Letters

مصطلحات موضوعية: chemistry.chemical_classification, Acetal, Peptide aldehyde, Chemistry, Stereochemistry, Organic Chemistry, Thioacetal, Peptide, Biochemistry, Aldehyde, Article, Transformation (genetics), chemistry.chemical_compound, Terminal (electronics), Drug Discovery, Cysteine protease inhibitor, ComputingMethodologies_COMPUTERGRAPHICS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7a9d9279ec71febcf9bdb8e311396a
https://pubmed.ncbi.nlm.nih.gov/32287443

المؤلفون: Robert Dhal, Pavlo Shpak-Kraievskyi, Biaolin Yin, Mathieu Y. Laurent, Arnaud Martel, Gilles Dujardin

المساهمون: Unité de chimie organique moléculaire et macromoléculaire (UCO2M), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

المصدر: Tetrahedron
Tetrahedron, Elsevier, 2012, 68 (9), pp.2179-2188. ⟨10.1016/j.tet.2012.01.002⟩

مصطلحات موضوعية: medicine.drug_class, Stereochemistry, peptide aldehyde, Peptide, Carboxamide, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, Chemical synthesis, Maraviroc, chemistry.chemical_compound, β-amino acetal, Drug Discovery, Peptide synthesis, medicine, Enantiomeric excess, Peptide coupling, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Acetal, 0104 chemical sciences, chemistry, Transacetalization, Amine gas treating

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7159e81bf8a9e9cb5ec8b65bda19ea0c
https://hal.archives-ouvertes.fr/hal-00700165

المؤلفون: Kazuto Nosaka, Hiroyuki Saito, Mari Onozuka, Kenichi Akaji, Ayumi Makino, Hiroyuki Konno

المصدر: Bioorganic & Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Proteolysis, medicine.medical_treatment, Clinical Biochemistry, Mutant, Molecular Sequence Data, Pharmaceutical Science, Peptide, medicine.disease_cause, Severe Acute Respiratory Syndrome, Biochemistry, Article, Substrate Specificity, 3CL protease, Viral Proteins, Drug Discovery, medicine, Virus maturation, Humans, Protease Inhibitors, Amino Acid Sequence, Molecular Biology, Coronavirus 3C Proteases, Coronavirus, chemistry.chemical_classification, SARS, Aldehydes, Protease, Binding Sites, medicine.diagnostic_test, Tetrapeptide, Molecular Structure, Peptide aldehyde, Chemistry, Hydrolysis, Organic Chemistry, Cysteine Endopeptidases, Enzyme, Severe acute respiratory syndrome-related coronavirus, Protease inhibitor, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Mutation, Molecular Medicine, Protein Processing, Post-Translational

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25705593df29aeaccc7968e7a00af306
https://pubmed.ncbi.nlm.nih.gov/18845442

المؤلفون: 邹晓民, 赵宏, 傅翌秋, 张欣, 徐萍

المساهمون: 北京大学药学院药物化学系,北京,100083

المصدر: 万方 ; 知网 ; http://d.g.wanfangdata.com.cn/Periodical_zgyx-e200303002.aspx

مصطلحات موضوعية: Weinreb酰胺 天冬氨酸肽醛 Boc保护基 活化酯 Weinreb amide aspartyl peptide aldehyde Boc protecting group activated ester

Relation: 中国药学（英文版）.2003,12,(3),123-126.; 766875; http://hdl.handle.net/20.500.11897/209836

الاتاحة: https://hdl.handle.net/20.500.11897/209836

المؤلفون: Gros, Christel, Boulègue, Cyril, Galéotti, Nathalie, Niel, Gilles, Jouin, Patrick

المساهمون: Institut de Génomique Fonctionnelle (IGF), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0040-4020 ; Tetrahedron ; https://hal.science/hal-00162707 ; Tetrahedron, 2002, 58 (13), pp.2673-2680. ⟨10.1016/S0040-4020(02)00115-1⟩.

مصطلحات موضوعية: N-trityl, thiazolidine, peptide aldehyde, solid phase, ligation, [CHIM.ORGA]Chemical Sciences/Organic chemistry

Relation: hal-00162707; https://hal.science/hal-00162707

الاتاحة: https://hal.science/hal-00162707
https://doi.org/10.1016/S0040-4020(02)00115-1

المؤلفون: Cyril Boulègue, Nathalie Galéotti, Christel Gros, Patrick Jouin, Gilles Niel

المساهمون: Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)

المصدر: Tetrahedron
Tetrahedron, Elsevier, 2002, 58 (13), pp.2673-2680. ⟨10.1016/S0040-4020(02)00115-1⟩

مصطلحات موضوعية: chemistry.chemical_classification, inorganic chemicals, Caspase inhibitors, Carbon atom, 010405 organic chemistry, Thiazolidines, Stereochemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Thiazolidine, peptide aldehyde, Peptide, N-trityl, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, 0104 chemical sciences, 3. Good health, thiazolidine, chemistry.chemical_compound, chemistry, Drug Discovery, solid phase, ligation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39461e0e8355d5b1a8a79281c151d3d9
https://hal.archives-ouvertes.fr/hal-00162707

المؤلفون: Hideaki Hamazaki

المصدر: FEBS letters. 424(3)

مصطلحات موضوعية: Serine Proteinase Inhibitors, Leupeptins, medicine.medical_treatment, p-Chloromercuribenzoic Acid, Biophysics, Peptide, Carboxypeptidases, Biochemistry, Calpain inhibitor, Carboxypeptidase activity, chemistry.chemical_compound, Structural Biology, Pepstatins, Genetics, medicine, Animals, Antipain, Proteasome inhibitor, Amino Acids, Molecular Biology, Edetic Acid, chemistry.chemical_classification, Serine protease, Protease, Amyloid beta-Peptides, Peptide aldehyde, biology, Brain, Cell Biology, Alzheimer's disease, Carboxypeptidase, Peptide Fragments, Amino acid, Rats, Phenylmethylsulfonyl Fluoride, chemistry, Lysosomal carboxypeptidase, biology.protein, β-Amyloid, Chloromercuribenzoates

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e057925e00a41cf04c17c572727c244a
https://pubmed.ncbi.nlm.nih.gov/9539136

المؤلفون: Irmgard Assfalg-Machleidt, Norbert Schaschke, Hans-Jürgen Musiol, Werner Machleidt, Luis Moroder, Sabine Rudolph-Böhner

المصدر: FEBS letters. 391(3)

مصطلحات موضوعية: Carbohydrate chemistry, Stereochemistry, Leupeptins, medicine.medical_treatment, Molecular Sequence Data, Biophysics, Peptide, Cysteine Proteinase Inhibitors, Biochemistry, Cathepsin B, Structural Biology, Genetics, medicine, Moiety, Molecular Biology, chemistry.chemical_classification, Cyclodextrins, Protease, Cyclodextrin, Peptide aldehyde, Chemistry, Calpain, Circular Dichroism, beta-Cyclodextrins, Cell Biology, Protease inhibitor (biology), Kinetics, Protease inhibitor, Carbohydrate Sequence, β-Cylodextrin conjugation, medicine.drug, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad024e450fdc5bd7e7be26dce530bf6
https://pubmed.ncbi.nlm.nih.gov/8764993

المؤلفون: E. Sarubbi, M. R. Angelastro, N. P. Peet, M. Denaro, K. Islam, P. Seneci

المساهمون: E. Sarubbi, P. Seneci, M.R. Angelastro, N.P. Peet, M. Denaro, K. Islam

مصطلحات موضوعية: Aspartic protease, Human immunodeficiency viru, Microbial alkaline protease inhibitor, Peptide aldehyde, Transition state analogue, Settore CHIM/06 - Chimica Organica

Relation: info:eu-repo/semantics/altIdentifier/pmid/8458418; info:eu-repo/semantics/altIdentifier/wos/WOS:A1993KT49400011; volume:319; issue:3; firstpage:253; lastpage:256; journal:FEBS LETTERS; http://hdl.handle.net/2434/170324; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0027465626

الاتاحة: http://hdl.handle.net/2434/170324
https://doi.org/10.1016/0014-5793(93)80557-B