المؤلفون: Orhan Yilmaz, João Pedro Pinto, Tiago Torres

المصدر: Drugs in Context, Vol 13, Pp 1-24 (2024)

مصطلحات موضوعية: a3ar agonists, chronic inflammatory disease, il-17 inhibitors, il-23 inhibitors, oral microbiome, oral therapy, pde4 inhibitors, psoriasis, s1pr1 modulators, small molecules, tnf inhibitors, tyk2 inhibitors, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.drugsincontext.com/new-and-emerging-oral-therapies-for-psoriasis/; https://doaj.org/toc/1740-4398

URL الوصول: https://doaj.org/article/9560566152224b9383272fb94ad653ef

المؤلفون: Jie Zhu, Michael R. Edwards, Simon D. Message, Luminita A. Stanciu, Sebastian L. Johnston, Peter K. Jeffery

المصدر: Pharmaceuticals, Vol 17, Iss 11, p 1554 (2024)

مصطلحات موضوعية: cilomilast, PDE4 inhibitors, rhinovirus, bronchial epithelial cells, ICAM-1, IL-6, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/11/1554; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/2b9805374cee4e4198171d990aa6b946

المؤلفون: Chenming Gu, Jiayuan Liu, Fei Qian, Wenchao Yu, Doudou Huang, Jingshan Shen, Chenguo Feng, Kaixian Chen, Yiming Li, Xiangrui Jiang, Yechun Xu, Liuqiang Zhang

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, like mice model, induced atopic dermatitis, good skin permeability, binding mode similar, antiatopic dermatitis efficacy, antiatopic dermatitis agents, 26 ± 0, 19 ± 0, 17 ± 0, approved pde4 inhibitor, novel pde4 inhibitors, 50 , 1 , pde4 inhibitors, α activity, significant benefits, pharmacological intervention, moderate potency, magnolia biondii, localized eczema

Relation: https://figshare.com/articles/journal_contribution/Identification_of_Dihydrobenzofuran_Neolignans_as_Novel_PDE4_Inhibitors_and_Evaluation_of_Antiatopic_Dermatitis_Efficacy_in_DNCB-Induced_Mice_Model/25419267

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c02424.s001

المؤلفون: Andrew Blauvelt, Richard G. Langley, Kenneth B. Gordon, Jonathan I. Silverberg, Kilian Eyerich, Morten O. A. Sommer, Jakob Felding, Richard B. Warren

المصدر: Dermatology and Therapy, Vol 13, Iss 12, Pp 3031-3042 (2023)

مصطلحات موضوعية: PDE4 inhibitors, PDE4B, PDE4D, Nerandomilast, Orismilast, PF-07038124, Dermatology, RL1-803

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

URL الوصول: https://doaj.org/article/f2be335a118b4a2890d4421106a07e29

المؤلفون: Carmona Rocha, Elena, Rusiñol, Lluís, Puig Sanz, Lluís, Universitat Autònoma de Barcelona. Departament de Medicina

مصطلحات موضوعية: Psoriasis, Oral therapies, Topical therapies, Biologics, Jak inhibitors, PDE4 inhibitors, Systemic treatment, IL-17 inhibitors, IL-23 inhibitors, Tapinarof, Roflumilast

وصف الملف: application/pdf

Relation: Pharmaceutics; Vol. 16, Num. 2 (february 2024); https://ddd.uab.cat/record/290359; urn:10.3390/pharmaceutics16020239; urn:oai:ddd.uab.cat:290359; urn:pmcid:PMC10892104; urn:pmc-uid:10892104; urn:pmid:38399292; urn:oai:pubmedcentral.nih.gov:10892104; urn:oai:egreta.uab.cat:publications/7dfd1cb7-0235-4bd3-9fc8-dba4bf18f4dc

الاتاحة: https://ddd.uab.cat/record/290359

المؤلفون: Warren, Richard B., French, Lars E., Blauvelt, Andrew, Langley, Richard G., Egeberg, Alexander, Mrowietz, Ulrich, Hunter, Hamish J.A., Gooderham, Melinda, Soerensen, Per, Andres, Philippe, Sommer, Morten O.A., Carlsson, Anna, Kjøller, Kim D., Strober, Bruce E.

المصدر: Warren , R B , French , L E , Blauvelt , A , Langley , R G , Egeberg , A , Mrowietz , U , Hunter , H J A , Gooderham , M , Soerensen , P , Andres , P , Sommer , M O A , Carlsson , A , Kjøller , K D & Strober , B E 2024 , ' Orismilast in moderate-to-severe psoriasis : Efficacy and safety from a 16-week, randomized, double-blinded, placebo-controlled, dose-finding, and phase 2b trial (IASOS) ' , Journal of the American Academy of Dermatology , vol. 90 ....

مصطلحات موضوعية: Oral administration, PDE4 inhibitors, PDE4B, PDE4D, Psoriasis, Treatment efficacy

وصف الملف: application/pdf

Relation: https://orbit.dtu.dk/en/publications/1e2f42f5-f0a5-40a9-8eda-e3f464d0873f

الاتاحة: https://orbit.dtu.dk/en/publications/1e2f42f5-f0a5-40a9-8eda-e3f464d0873f
https://doi.org/10.1016/j.jaad.2023.11.005
https://backend.orbit.dtu.dk/ws/files/353614955/1-s2.0-S0190962223031870-main.pdf

المؤلفون: Elena Carmona-Rocha, Lluís Rusiñol, Lluís Puig

المصدر: Pharmaceutics, Vol 16, Iss 2, p 239 (2024)

مصطلحات موضوعية: psoriasis, oral therapies, topical therapies, biologics, Jak inhibitors, PDE4 inhibitors, Pharmacy and materia medica, RS1-441

Relation: https://www.mdpi.com/1999-4923/16/2/239; https://doaj.org/toc/1999-4923; https://doaj.org/article/44e4c44a767346fe95a014887f67db90

الاتاحة: https://doi.org/10.3390/pharmaceutics16020239
https://doaj.org/article/44e4c44a767346fe95a014887f67db90

المؤلفون: de Poel, E., Spelier, S., Hagemeijer, M. C., van Mourik, P., Suen, S. W.F., Vonk, A. M., Brunsveld, J. E., Ithakisiou, G. N., Kruisselbrink, E., Oppelaar, H., Berkers, G., de Winter de Groot, K. M., Heida-Michel, S., Jans, S. R., van Panhuis, H., Bakker, M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E. J.M., Koppelman, G. H., Blaazer, A. R., Muijlwijk-Koezen, J. E., van der Ent, C. K., Beekman, J. M.

المصدر: de Poel , E , Spelier , S , Hagemeijer , M C , van Mourik , P , Suen , S W F , Vonk , A M , Brunsveld , J E , Ithakisiou , G N , Kruisselbrink , E , Oppelaar , H , Berkers , G , de Winter de Groot , K M , Heida-Michel , S , Jans , S R , van Panhuis , H , Bakker , M , van der Meer , R , Roukema , J , Dompeling , E , Weersink , E J M , Koppelman ....

مصطلحات موضوعية: CFTR modulators, Drug screening, Organoids, PDE4 inhibitors, Rare mutations, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://research.vu.nl/en/publications/85a3ed9a-6f55-493f-8b12-8ab08b2a222b
https://doi.org/10.1016/j.jcf.2023.03.004
https://hdl.handle.net/1871.1/85a3ed9a-6f55-493f-8b12-8ab08b2a222b
https://research.vu.nl/ws/files/353806334/FDA-approved_drug_screening_in_patient-derived_organoids_demonstrates_potential_of_drug_repurposing_for_rare_cystic_fibrosis_genotypes.pdf
http://www.scopus.com/inward/record.url?scp=85156187712&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85156187712&partnerID=8YFLogxK

المؤلفون: Felisbela Gomes, Shih-Lung Cheng

المصدر: Biomolecules; Volume 13; Issue 3; Pages: 476

مصطلحات موضوعية: chronic obstructive pulmonary disease, inflammation, acetylcholine, muscarinic antagonists, β2 agonists, PDE4 inhibitors

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Medicine; https://dx.doi.org/10.3390/biom13030476

الاتاحة: https://doi.org/10.3390/biom13030476

المؤلفون: Jin, Jian, Mazzacuva, Francesca, Crocetti, Letizia, Giovannoni, Maria Paola, Cilibrizzi, Agostino

المصدر: Jin , J , Mazzacuva , F , Crocetti , L , Giovannoni , M P & Cilibrizzi , A 2023 , ' PDE4 Inhibitors : Profiling Hits through the Multitude of Structural Classes ' , International Journal of Molecular Sciences , vol. 24 , no. 14 , 11518 . https://doi.org/10.3390/ijms241411518

مصطلحات موضوعية: dual activity, PDE4 inhibitors, PDE4 selectivity, phosphodiesterases 4, respiratory diseases, structural analysis

الاتاحة: https://kclpure.kcl.ac.uk/portal/en/publications/83abbbd4-c954-4348-b70e-042033a67efb
https://doi.org/10.3390/ijms241411518
http://www.scopus.com/inward/record.url?scp=85166029697&partnerID=8YFLogxK

المؤلفون: Chuang Xia (11979456), Jia-Peng He (6332201), Kai-Wen Feng (4534645), Lu Liu (171341), Lei Zheng (106363), Hai-Tao Wang (561009), Jiang-Ping Xu (3216618), Zhong-Zhen Zhou (539126)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Physiology, Pharmacology, Biotechnology, Immunology, Mental Health, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, satisfactory bioavailability (<, obvious toxicological effect, low nanomolar potency, good developmental potentiality, displayed comparable activity, acute toxicological evaluation, roflumilast displayed emetogenicity, improved oral bioavailability, spatial memory impairments, realize pde4 inhibitors, model mice induced, cyclopropyl methoxy group, 9h , 9c , pde4 inhibitors, emetogenicity evaluation, f <, cyclopropyl methylamine, amide group

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Novel_3_Amino-4-alkoxyphenylketones_as_PDE4_Inhibitors_with_Improved_Oral_Bioavailability_and_Safety_against_Spatial_Memory_Impairments/18803100

الاتاحة: https://doi.org/10.1021/acschemneuro.1c00762.s001

المؤلفون: Hoang Oanh Nguyen, Tiziana Schioppa, Laura Tiberio, Fabrizio Facchinetti, Gino Villetti, Maurizio Civelli, Annalisa Del Prete, Francesca Sozio, Carolina Gaudenzi, Mauro Passari, Ilaria Barbazza, Silvano Sozzani, Valentina Salvi, Daniela Bosisio

المصدر: Frontiers in Immunology, Vol 12 (2022)

مصطلحات موضوعية: COVID-19, proinflammatory cytokines, cDCs, pDCs, phosphodiesterase 4 (PDE4) inhibitors, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.797390/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/40e0bf2dc169415384bee3348fb6ac74

المؤلفون: Letizia Crocetti, Giuseppe Floresta, Agostino Cilibrizzi, Maria Paola Giovannoni

المصدر: Molecules; Volume 27; Issue 15; Pages: 4964

مصطلحات موضوعية: phosphodiesterase 4, PDE4 inhibitors, clinical trials, respiratory diseases, skin diseases, rheumatoid arthritis, neurological disorders, COVID-19

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Chemical Biology; https://dx.doi.org/10.3390/molecules27154964

الاتاحة: https://doi.org/10.3390/molecules27154964

المؤلفون: Fernandes, Diogo Miguel Pereira

مصطلحات موضوعية: DPOC, Inibidores da PDE e PDE4, Roflumilast e Teofilina, Segurança e eficácia, Ensaios clínicos, COPD, PDE and PDE4 inhibitors, Roflumilast and Theophylline, Efficacy and safety, Clinical Trials

الاتاحة: https://hdl.handle.net/10316/82803

المؤلفون: Paes, D., Schepers, M., Rombaut, B., van den Hove, D., Vanmierlo, T., Prickaerts, J.

المصدر: Paes , D , Schepers , M , Rombaut , B , van den Hove , D , Vanmierlo , T & Prickaerts , J 2021 , ' The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors ' , Pharmacological Reviews , vol. 73 , no. 3 , pp. 1016-1049 . https://doi.org/10.1124/pharmrev.120.000273

مصطلحات موضوعية: CAMP-SPECIFIC PHOSPHODIESTERASE, AMP-SPECIFIC PHOSPHODIESTERASE, AFFINITY ROLIPRAM BINDING, CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES, N-TERMINAL REGION, 4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)-2-PYRROLIDONE ZK 62711, SIGNALING SCAFFOLD PROTEINS, AREA POSTREMA NEURONS, PDE4 INHIBITORS, SPLICE VARIANTS

وصف الملف: application/pdf

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/c39e791f-53bb-4abf-b124-1c1bcf521c30
https://doi.org/10.1124/pharmrev.120.000273
https://cris.maastrichtuniversity.nl/ws/files/75886398/Prickaerts_2021_The_Molecular_Biology_of_Phosphodiesterase.pdf

المؤلفون: Evgeny V. Pospelov, Ivan S. Golovanov, Sema L. Ioffe, Alexey Yu. Sukhorukov

المصدر: Molecules; Volume 25; Issue 16; Pages: 3613

مصطلحات موضوعية: C–H functionalization, total synthesis, pyrrolidines, anchimeric assistance, epimerization, PDE4 inhibitors

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Organic Chemistry; https://dx.doi.org/10.3390/molecules25163613

الاتاحة: https://doi.org/10.3390/molecules25163613

المؤلفون: Nelissen, Ellis, van Goethem, Nick P., Bonassoli, Vivian T., Heckman, Pim R. A., van Hagen, Britt T. J., Suay, Dila, Wouters, Caroline, Prickaerts, Jos

المصدر: Nelissen , E , van Goethem , N P , Bonassoli , V T , Heckman , P R A , van Hagen , B T J , Suay , D , Wouters , C & Prickaerts , J 2019 , ' Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats ' , Neuroscience Letters , vol. 699 , pp. 41-46 . https://doi.org/10.1016/j.neulet.2019.01.026

مصطلحات موضوعية: alpha 2 adrenergic receptor, Emesis, Ketamine, Xylazine, Phosphodiesterase, Nausea, CERULEUS NORADRENERGIC NEURONS, LOCUS-CERULEUS, PDE4 INHIBITORS, AREA POSTREMA, CLONIDINE, MECHANISMS, RECEPTOR, RELEASE

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/74633622-59f8-493f-a301-c2268c18fa24
https://doi.org/10.1016/j.neulet.2019.01.026

المؤلفون: Valeria Cavalloro, Marta Rui, Giacomo Rossino, Daniela Rossi, Federica Rapetti, Chiara Brullo, Olga Bruno, Simona Collina

المصدر: Proceedings, Vol 22, Iss 1, p 15 (2019)

مصطلحات موضوعية: Nerodegenerative diseases, PDE4 inhibitors, homochiral drugs, HPLC chiral resolution, General Works

Relation: https://www.mdpi.com/2504-3900/22/1/15; https://doaj.org/toc/2504-3900; https://doaj.org/article/c57217bcf2314546974088bf34cb8d3e

الاتاحة: https://doi.org/10.3390/proceedings2019022015
https://doaj.org/article/c57217bcf2314546974088bf34cb8d3e

المؤلفون: E. de Poel, S. Spelier, M.C. Hagemeijer, P. van Mourik, S.W.F. Suen, A.M. Vonk, J.E. Brunsveld, G.N. Ithakisiou, E. Kruisselbrink, H. Oppelaar, G. Berkers, K.M. de Winter de Groot, S. Heida-Michel, S.R. Jans, H. van Panhuis, M. Bakker, R. van der Meer, J. Roukema, E. Dompeling, E.J.M. Weersink, G.H. Koppelman, A.R. Blaazer, J.E. Muijlwijk-Koezen, C.K. van der Ent, J.M. Beekman

المساهمون: Medical Microbiology and Infection Prevention, AII - Infectious diseases, Pulmonology, Pulmonary Medicine

المصدر: Journal of cystic fibrosis. Elsevier
Journal of Cystic Fibrosis, 22, 548-559
Journal of Cystic Fibrosis, 22, 3, pp. 548-559
Journal of Cystic Fibrosis, 22(3), 548-559. Elsevier

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Genotype, Colforsin, Drug Repositioning, CFTR modulators, Phosphodiesterase 4 Inhibitors/therapeutic use, PDE4 inhibitors, Preclinical, Organoids, All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], SDG 3 - Good Health and Well-being, Drug screening, Rare mutations, Mutation, Pediatrics, Perinatology and Child Health, Humans, Cystic Fibrosis Transmembrane Conductance Regulator/genetics, Drug Evaluation, Cystic Fibrosis/drug therapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ec4ff876b41ac455bf427f708ef3b6
https://pure.amc.nl/en/publications/fdaapproved-drug-screening-in-patientderived-organoids-demonstrates-potential-of-drug-repurposing-for-rare-cystic-fibrosis-genotypes(d3d6bd49-ebfc-40f4-ab6c-0e87380d8a5f).html

المؤلفون: Jianyou Shi, Hengming Ke, Baowen Qi, Jun He, Ting Peng

المصدر: Journal of Medicinal Chemistry. 63:10594-10617

مصطلحات موضوعية: Protein Conformation, Vomiting, Pulmonary disease, Quinolones, Bioinformatics, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Phosphodiesterase-4, Drug Development, Drug Discovery, Animals, Humans, Cyclic adenosine monophosphate, PDE4 Inhibitors, 030304 developmental biology, 0303 health sciences, Molecular Structure, Cyclic nucleotide phosphodiesterase, Drug discovery, Cyclic Nucleotide Phosphodiesterases, Type 4, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Drug development, Molecular Medicine, Phosphodiesterase 4 Inhibitors, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ee4de327e23eee7a06a04226edd5ec
https://doi.org/10.1021/acs.jmedchem.9b02170