المؤلفون: Mesoey, Susanne

المساهمون: Lummis, Sarah

مصطلحات موضوعية: pLGIC, Cys-loop receptor, 5-HT3, Serotonin receptor, nicotinic acetylcholine receptor

URL الوصول: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.857190

المؤلفون: Catherine Van Renterghem, Ákos Nemecz, Karima Medjebeur, Pierre‐Jean Corringer

المصدر: Physiological Reports, Vol 12, Iss 3, Pp n/a-n/a (2024)

مصطلحات موضوعية: GLIC, Loop Ω, orthotopic site, pLGIC, pre‐β5 strand, vestibular site, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2051-817X

URL الوصول: https://doaj.org/article/f797f6b13a9d453e9028762a82198a87

المؤلفون: Anders A. Jensen

المصدر: Frontiers in Molecular Biosciences, Vol 10 (2023)

مصطلحات موضوعية: pentameric ligand-gated ion channel (pLGIC), Zinc-Activated Channel (ZAC), two-electrode voltage-clamp electrophysiology (TEVC), mammalian, evolutionary conservation, zinc, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1265429/full; https://doaj.org/toc/2296-889X

URL الوصول: https://doaj.org/article/d9e4a751df1d469699c18d4f5edec2b2

المؤلفون: van Renterghem, Catherine, Nemecz, Ákos, Delarue-Cochin, Sandrine, Joseph, Delphine, Corringer, Pierre‐Jean

المساهمون: Récepteurs Canaux - Channel Receptors, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie - CNRS Chimie (INC-CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), CNRS, MESRI, Université Paris-Saclay and ANR (ANR-13-BSV8-0020) are gratefully acknowledged for financial support., The authors wish to thank Nicolas Bocquet, Virginie Dufresne, Zaineb Fourati, Christèle Huon and Karima Medjebeur for some molecular biology constructs and DNA production, as well as Chantal Jan, Colette Jean and Corinne Balayira for technical assistance with labware. They thank Karine Leblanc for HPLC and HRMS analyses, Laurie Peverini for two 1H NMR spectra at the end of patch-clamp experiments, Nicolas Lenovère for formerly providing a multi-alignment of pLGICs amino acid sequences, and Jean-Marie Biansan for the free software Dozzzaqueux. CVR thanks Frédéric Poitevin, Ludovic Sauguet, Hugues Nury and Marc Delarue for useful discussions at the beginning of this work (starting from 2010)., ANR-13-BSV8-0020,Pentagate,Mécanismes d'activation et de désensibilisation d'un récepteur-canal pentamérique(2013)

المصدر: ISSN: 0022-3751.

مصطلحات موضوعية: pLGIC, GLIC, fumarate, succinate, ligand-gated ion channel, positive allosteric modulator, orthosteric site, orthotopic site, allotopic site, vestibular site, intracellular pH, [CHIM]Chemical Sciences

Relation: info:eu-repo/semantics/altIdentifier/pmid/37026398; PUBMED: 37026398

الاتاحة: https://pasteur.hal.science/pasteur-04093140
https://pasteur.hal.science/pasteur-04093140v1/document
https://pasteur.hal.science/pasteur-04093140v1/file/Catherine%20article.pdf
https://doi.org/10.1113/JP283765

المؤلفون: Marc A. Dämgen (10131695), Philip C. Biggin (122818)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Inorganic Chemistry, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, membrane Pentameric ligand-gated io., lipid-protein interactions, protein-lipid interaction sites, transmembrane domain, protein-lipid interactions, communication interface, lipid-like allosteric drugs, binding site, State-dependent protein-lipid inter., receptor state, pLGIC, lipid binding sites, receptor proteins, allosteric modulator ivermectin, dynamics simulations, glycine receptor, membrane environment, pentameric ligand-gated ion channel

Relation: https://figshare.com/articles/journal_contribution/Probability_densities_of_cholesterol_for_each_individual_simulation_repeat_around_the_receptor_in_the_extracellular_and_intracellular_leaflet_for_the_inactive_and_active_state_/13920281

الاتاحة: https://doi.org/10.1371/journal.pcbi.1007856.s003

المؤلفون: Marc A. Dämgen (10131695), Philip C. Biggin (122818)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Inorganic Chemistry, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, membrane Pentameric ligand-gated io., lipid-protein interactions, protein-lipid interaction sites, transmembrane domain, protein-lipid interactions, communication interface, lipid-like allosteric drugs, binding site, State-dependent protein-lipid inter., receptor state, pLGIC, lipid binding sites, receptor proteins, allosteric modulator ivermectin, dynamics simulations, glycine receptor, membrane environment, pentameric ligand-gated ion channel

Relation: https://figshare.com/articles/journal_contribution/Comparison_of_lipid_binding_sites_to_other_pLGIC_members_/13920275

الاتاحة: https://doi.org/10.1371/journal.pcbi.1007856.s001

المؤلفون: Marc A. Dämgen (10131695), Philip C. Biggin (122818)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Inorganic Chemistry, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, membrane Pentameric ligand-gated io., lipid-protein interactions, protein-lipid interaction sites, transmembrane domain, protein-lipid interactions, communication interface, lipid-like allosteric drugs, binding site, State-dependent protein-lipid inter., receptor state, pLGIC, lipid binding sites, receptor proteins, allosteric modulator ivermectin, dynamics simulations, glycine receptor, membrane environment, pentameric ligand-gated ion channel

Relation: https://figshare.com/articles/journal_contribution/Mean_duration_of_protein-lipid_contact_per_residue_for_inactive_and_active_state_/13920284

الاتاحة: https://doi.org/10.1371/journal.pcbi.1007856.s004

المؤلفون: Marc A. Dämgen (10131695), Philip C. Biggin (122818)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Inorganic Chemistry, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, membrane Pentameric ligand-gated io., lipid-protein interactions, protein-lipid interaction sites, transmembrane domain, protein-lipid interactions, communication interface, lipid-like allosteric drugs, binding site, State-dependent protein-lipid inter., receptor state, pLGIC, lipid binding sites, receptor proteins, allosteric modulator ivermectin, dynamics simulations, glycine receptor, membrane environment, pentameric ligand-gated ion channel

Relation: https://figshare.com/articles/journal_contribution/Trajectories_of_single_DOPS_molecules_in_the_membrane_plane_for_the_inactive_state_/13920278

الاتاحة: https://doi.org/10.1371/journal.pcbi.1007856.s002

المؤلفون: Marc A. Dämgen (10131695), Philip C. Biggin (122818)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Inorganic Chemistry, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, membrane Pentameric ligand-gated io., lipid-protein interactions, protein-lipid interaction sites, transmembrane domain, protein-lipid interactions, communication interface, lipid-like allosteric drugs, binding site, State-dependent protein-lipid inter., receptor state, pLGIC, lipid binding sites, receptor proteins, allosteric modulator ivermectin, dynamics simulations, glycine receptor, membrane environment, pentameric ligand-gated ion channel

Relation: https://figshare.com/articles/journal_contribution/Overlay_of_phospholipid_densities_at_the_ECD-TMD_interface_with_experimental_structures_/13920290

الاتاحة: https://doi.org/10.1371/journal.pcbi.1007856.s005

المؤلفون: Marc A. Dämgen (10131695), Philip C. Biggin (122818)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Inorganic Chemistry, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, membrane Pentameric ligand-gated io., lipid-protein interactions, protein-lipid interaction sites, transmembrane domain, protein-lipid interactions, communication interface, lipid-like allosteric drugs, binding site, State-dependent protein-lipid inter., receptor state, pLGIC, lipid binding sites, receptor proteins, allosteric modulator ivermectin, dynamics simulations, glycine receptor, membrane environment, pentameric ligand-gated ion channel

Relation: https://figshare.com/articles/journal_contribution/C_-RMSD_of_inactive_and_active_state_homology_models_in_fully_atomistic_simulations_/13920293

الاتاحة: https://doi.org/10.1371/journal.pcbi.1007856.s006

المؤلفون: Marc A. Dämgen (10131695), Philip C. Biggin (122818)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Inorganic Chemistry, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, membrane Pentameric ligand-gated io., lipid-protein interactions, protein-lipid interaction sites, transmembrane domain, protein-lipid interactions, communication interface, lipid-like allosteric drugs, binding site, State-dependent protein-lipid inter., receptor state, pLGIC, lipid binding sites, receptor proteins, allosteric modulator ivermectin, dynamics simulations, glycine receptor, membrane environment, pentameric ligand-gated ion channel

Relation: https://figshare.com/articles/journal_contribution/Probability_densities_of_cholesterol_around_the_receptor_in_the_extracellular_and_intracellular_leaflet_for_the_inactive_and_active_state_obtained_with_position-restrained_approach_and_elastic_network_approach_/13920296

الاتاحة: https://doi.org/10.1371/journal.pcbi.1007856.s007

المؤلفون: Pavan V. Payghan, Indrani Bera, Dhananjay Bhattacharyya, Nanda Ghoshal

المصدر: Frontiers in Physics, Vol 6 (2018)

مصطلحات موضوعية: pLGIC, GPCRs, GABA A receptor, structure based drug design, MD simulations, CNS drug discovery, Physics, QC1-999

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphy.2018.00052/full; https://doaj.org/toc/2296-424X

URL الوصول: https://doaj.org/article/76f121833279465ead131a54dc978d5e

المؤلفون: Stevens, Alexander

مصطلحات موضوعية: Applied Physics, Biophysics, Molecular Biophysics, GABA(A)R, LGIC, pLGIC, Tillämpad Fysik, Biofysik, Molekylär Biofysik, Physical Sciences, Fysik

وصف الملف: application/pdf

Relation: TRITA-SCI-GRU ; 2023:007

الاتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-323235

المؤلفون: Catherine Van Renterghem, Ákos Nemecz, Sandrine Delarue‐Cochin, Delphine Joseph, Pierre‐Jean Corringer

المساهمون: Récepteurs Canaux - Channel Receptors, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), CNRS, MESRI, Université Paris-Saclay and ANR (ANR-13-BSV8-0020) are gratefully acknowledged for financial support., The authors wish to thank Nicolas Bocquet, Virginie Dufresne, Zaineb Fourati, Christèle Huon and Karima Medjebeur for some molecular biology constructs and DNA production, as well as Chantal Jan, Colette Jean and Corinne Balayira for technical assistance with labware. They thank Karine Leblanc for HPLC and HRMS analyses, Laurie Peverini for two 1H NMR spectra at the end of patch-clamp experiments, Nicolas Lenovère for formerly providing a multi-alignment of pLGICs amino acid sequences, and Jean-Marie Biansan for the free software Dozzzaqueux. CVR thanks Frédéric Poitevin, Ludovic Sauguet, Hugues Nury and Marc Delarue for useful discussions at the beginning of this work (starting from 2010)., ANR-13-BSV8-0020,Pentagate,Mécanismes d'activation et de désensibilisation d'un récepteur-canal pentamérique(2013)

المصدر: The Journal of Physiology
The Journal of Physiology, In press, ⟨10.1113/JP283765⟩

مصطلحات موضوعية: pLGIC, vestibular site, fumarate, ligand-gated ion channel, Physiology, allotopic site, positive allosteric modulator, intracellular pH, [CHIM]Chemical Sciences, GLIC, orthosteric site, succinate, orthotopic site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516ad60c6a99572869deff9a768838b1
https://hal-pasteur.archives-ouvertes.fr/pasteur-04093140

المؤلفون: Avstrikova, Mariia

المساهمون: Strasbourg, Cecchini, Marco, Corringer, Pierre-Jean, Changeux, Jean-Pierre

مصطلحات موضوعية: Dynamique moléculaire, Récepteurs de neurotransmetteurs, Récepteur nicotinique de l'acétylcholine α7, PLGIC, Désensibilisation, Modulation allostérique, Etudes Structurales, Molecular dynamics, Neurotransmitter receptors, Nicotinic Acetylcholine Receptor α7, Desensitization, Allosteric Modulation, Structural studies, 541.2

Relation: http://www.theses.fr/2023STRAF061/document

الاتاحة: http://www.theses.fr/2023STRAF061/document

المؤلفون: Stevens, Alexander

مصطلحات موضوعية: Applied Physics, Biophysics, Molecular Biophysics, GABA(A)R, LGIC, pLGIC, Tillämpad Fysik, Biofysik, Molekylär Biofysik, Physical Sciences, Fysik

وصف الملف: application/pdf

Relation: TRITA-SCI-GRU; 2023:007

الاتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-323235

المؤلفون: Gielen, Marc, Corringer, Pierre-Jean

المساهمون: Récepteurs Canaux - Channel Receptors, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0022-3751.

مصطلحات موضوعية: ECD, half maximal effective concentration, EC 50, two-electrode voltage clamp, pLGIC, SAM, silent allosteric modulator, NAM, nicotinic acetylcholine receptors, nAChR, DHA, docosahexaenoic acid, TMD, transmembrane domain, negative allosteric modulator, PAM, TEVC, Abbreviations: 5HT 3 R, 5HT 3 serotonin receptor, DAM, extracellular domain, ELIC, Erwinia ligand-gated ion channel, Aminobutyric acid, GABA A R, GABA A receptor, GlyR, glycine receptor, GLIC, Gloeobacter ligand-gated ion channel

Relation: info:eu-repo/semantics/altIdentifier/pmid/29484660; pasteur-01721186; https://hal-pasteur.archives-ouvertes.fr/pasteur-01721186; https://hal-pasteur.archives-ouvertes.fr/pasteur-01721186/document; https://hal-pasteur.archives-ouvertes.fr/pasteur-01721186/file/Gielen%26Corringer_JPhysiol_2018_combined.pdf; PUBMED: 29484660

الاتاحة: https://hal-pasteur.archives-ouvertes.fr/pasteur-01721186
https://hal-pasteur.archives-ouvertes.fr/pasteur-01721186/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-01721186/file/Gielen%26Corringer_JPhysiol_2018_combined.pdf
https://doi.org/10.1113/JP275100

المؤلفون: Mesoy, Susanne

مصطلحات موضوعية: pLGIC, Cys-loop receptor, 5-HT3, nicotinic acetylcholine receptor, Serotonin receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e25ff28a474e26864e03f774abe2c074

المؤلفون: Marijke Brams, Diletta Pasini, Akshay Sridhar, Chris Ulens, Sarah C. R. Lummis, Kumiko Kambara, Rebecca J. Howard, Aujan Mehregan, Erik Lindahl, Daniel Bertrand

المساهمون: Lummis, Sarah [0000-0001-9410-9805], Apollo - University of Cambridge Repository

المصدر: The Journal of Biological Chemistry
Journal of Biological Chemistry

مصطلحات موضوعية: DYNAMICS, MECHANISM, 0301 basic medicine, Models, Molecular, POPG, palmitoyloleoylphosphatidylglycerol, TMD, transmembrane domain, DOTAP, dipalmitoyl-3-trimethylammonium-propane, PG, phosphatidylglycerol, Crystallography, X-Ray, Biochemistry, ACTIVATION, chemistry.chemical_compound, PC, phosphatidylcholine, Xenopus laevis, Chemistry, GABAA receptor, Editors' Pick, Lipids, Transmembrane domain, VSD, voltage-sensor domain, K+ CHANNEL, Ligand-gated ion channel, Protein Structural Elements, Signal transduction, site-directed mutagenesis, Life Sciences & Biomedicine, Research Article, Protein Binding, STRUCTURAL BASIS, Biochemistry & Molecular Biology, SOFTWARE NEWS, Protein subunit, ICD, intracellular domain, Cys-loop receptor, POPC, palmitoyloleoylphosphatidylcholine, PE, phosphatidylethanolamine, Cell Line, 03 medical and health sciences, pLGIC, pentameric ligand-gated ion channel, Cations, Animals, Humans, Molecular Biology, POPC, Ion channel, G protein-coupled receptor, GPCR, G-protein-coupled receptor, Science & Technology, RECEPTOR, 030102 biochemistry & molecular biology, RMSD, root-mean-squared deviation, Cell Biology, Ligand-Gated Ion Channels, electrophysiology, nAChR, nicotinic acetylcholine receptor, ECD, extracellular domain, WT, wild-type, molecular dynamics, PROTEIN INTERACTIONS, 030104 developmental biology, GENERAL-ANESTHETICS, Biophysics, Oocytes, ELIC, pentameric ligand-gated ion channel, X-RAY-STRUCTURE

وصف الملف: application/pdf; Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b160ea3186d551ffde4ccf17635eb8
http://europepmc.org/articles/PMC8327344

المؤلفون: Lucia G. Sivilotti, Hongtao Zhu, Jie Yu, Vid Jazbec, Remigijus Lape, Josip Ivica, Matthew G. Gold, Eric Gouaux

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Agonist, Patch-Clamp Techniques, GABA Agents, Taurine, medicine.drug_class, Protein subunit, ICD, intracellular domain, Glycine, Gating, zf, zebrafish, Biochemistry, DMEM, Dulbecco’s modified Eagle’s medium, Structure-Activity Relationship, 03 medical and health sciences, Receptors, Glycine, Protein Domains, PDB, Protein Data Bank, medicine, Animals, Humans, Homomeric, 5-HT3, 5-hydroxytryptamine type 3, Amino Acid Sequence, Molecular Biology, Glycine receptor, Cells, Cultured, Zebrafish, gamma-Aminobutyric Acid, Ion channel, pLGIC, pentameric ligand-gated ion channels, 030102 biochemistry & molecular biology, Chemistry, Glycine Agents, Cell Biology, GlyR, glycine receptor, ECD, extracellular domain, Transmembrane protein, Transmembrane domain, 030104 developmental biology, beta-Alanine, Biophysics, Popen, open probability, Research Article, TM, transmembrane

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5e62e52b02e33fb60a4766d31b3107
http://europepmc.org/articles/PMC7995613