المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Endogenous_MICAL-L1_is_recruited_by_mutant_LRRK2_to_lysosomes_/17221967

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s004

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Tf_recycling_in_iPSC-derived_microglia_/17221985

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s007

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Association_of_Rab8a_with_centrosomes_and_lysosomes_in_HEK293T_cells_expressing_G2019S_LRRK2_/17221961

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s003

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/LRRK2_genetic_variants_sequester_endogenous_Rab8a_to_lysosomes_in_a_kinase-dependent_manner_/17221955

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s002

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Characterization_of_iPSC-derived_microglia_/17221976

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s006

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Validation_of_Rab8a_antibodies_for_endogenous_detection_/17221946

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s001

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/media/Imaris_3D_surface_rendering_of_endogenous_transferrin_and_Lamp2_staining_in_G2019S_LRRK2_iPSC-derived_microglia_/17222033

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s012

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Mutant_LRRK2_induces_mistrafficking_of_TfR_/17221973

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s005

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/dataset/Individual_numerical_values_that_underlie_the_summary_data_displayed_in_the_following_figure_panels_Figs_1B_1C_1F_2B_3B_4B_4D_4G_4J_4K_6B_6F_7C_8B_8C_S2B_S2C_S3B_S3D_S4B_S4C_S5B_S5D_S5E_S6B_S6C_S6E_S7B_and_S7D_/17222009

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s009

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/media/Imaris_3D_surface_rendering_of_endogenous_transferrin_and_Lamp2_staining_in_WT_LRRK2_iPSC-derived_microglia_/17222015

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s010

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Uncropped_western_blots_of_figures_/17222000

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s008

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/media/Imaris_3D_surface_rendering_of_endogenous_transferrin_and_Lamp2_staining_in_WT_LRRK2_iPSC-derived_microglia_treated_with_100_ng_ml_LPS_for_16_hours_/17222024

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s011

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/media/Imaris_3D_surface_rendering_of_endogenous_transferrin_and_Lamp2_staining_in_G2019S_LRRK2_iPSC-derived_microglia_treated_with_100_ng_ml_LPS_for_16_hours_/17222042

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.s013

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/LRRK2_and_Rab8a_are_recruited_to_the_membrane_of_damaged_lysosomes_/17222063

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.g002

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Rab8a_phosphorylation_retains_interaction_with_MICAL-L1_that_is_corecruited_in_mutant_LRRK2_expressing_cells_/17222072

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.g003

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Pathogenic_mutations_of_LRRK2_sequester_endogenous_Rab8a_to_lysosomes_in_a_kinase-dependent_manner_/17222054

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.g001

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/A_model_of_the_recruitment_of_Rab8a_to_lysosomes_and_dysregulation_of_transferrin_recycling_by_mutant_LRRK2_/17222123

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.g009

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Mutant_LRRK2_sequesters_TfR_and_dysregulates_transferrin_recycling_/17222081

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.g004

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/Neuroinflammation_remodels_endolysosomal_gene_expression_in_microglia_in_vitro_and_in_vivo_/17222093

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.g005

المؤلفون: Adamantios Mamais (302600), Jillian H. Kluss (10333635), Luis Bonet-Ponce (336049), Natalie Landeck (414147), Rebekah G. Langston (5740400), Nathan Smith (341990), Alexandra Beilina (139251), Alice Kaganovich (347608), Manik C. Ghosh (11846063), Laura Pellegrini (694179), Ravindran Kumaran (4480765), Ioannis Papazoglou (11846066), George R. Heaton (11846069), Rina Bandopadhyay (302603), Nunziata Maio (11846072), Changyoun Kim (3479372), Matthew J. LaVoie (2287201), David C. Gershlick (11846075), Mark R. Cookson (139260)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Cancer, Biological Sciences not elsewhere classified, overexpression cell models, cellular responses downstream, modulating iron uptake, polymorphic lrrk2 variants, lrrk2 kinase substrate, common lrrk2 mutation, +mutations%22">xlink "> mutations, mediated iron uptake, lrrk2 induce sequestration, small gtpase rab8a, postmortem pd tissue, linked lrrk2 mutations, microglia , lrrk2 linked, iron deposition, mediated recycling, induce neurotoxicity, type mice, striatal accumulation, sporadic pd, significant increase, proinflammatory stimuli

Relation: https://figshare.com/articles/figure/G2019S_LRRK2_modulates_Tf_recycling_in_iPSC-derived_human_microglia_/17222102

الاتاحة: https://doi.org/10.1371/journal.pbio.3001480.g006