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1Academic Journal
المؤلفون: Gary M. Chinigo, Emma L. McInturff, Scott W. Bagley, Richard W. Barnhart, David C. Blakemore, Lu Han, Taegyo Lee, Javier Magano, J. Christopher McWilliams, Sebastien Monfette, James J. Mousseau, Senliang Pan, Dylan Pedro, Hahdi H. Perfect, Jeffrey W. Raggon, Peter R. Rose, John Sagal, John I. Trujillo, Jared Van Haitsma, Michael G. Vetelino, Xiaojing Helen Yang
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Sociology, Immunology, Computational Biology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, two elaborated amines, sulfinimine addition reaction, sterically congested amine, low yield due, highlighted improvements made, early process development, target molecule, subsequent enablement, sequential substitution, previously suffered, poor regioselectivity, original synthesis, kilogram manufacture, key iodopyrazole, high stereocontrol, enablement efforts, efficient construction, diethyl squarate, crystalline api, campaign include
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2Academic Journal
المؤلفون: S. Ya. Skachilova, G. A. Ermakova, N. K. Zheltukhin, E. F. Zueva, N. K. Davydova
المصدر: Разработка и регистрация лекарственных средств, Vol 8, Iss 1, Pp 7-13 (2019)
مصطلحات موضوعية: original synthesis, import substituion, chemical purity, original drugs, industrial production, Pharmaceutical industry, HD9665-9675
وصف الملف: electronic resource
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3Dissertation/ Thesis
المؤلفون: Fournier, Louise
المساهمون: Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Université Paris Cité, Cédric Chauvierre
المصدر: https://theses.hal.science/tel-04607283 ; Chemical Sciences. Université Paris Cité, 2023. English. ⟨NNT : 2023UNIP5040⟩.
مصطلحات موضوعية: Microbubbles, Original synthesis, Thrombotic diseases, Ultrasound, Targeted fibrinolysis, Fucoidan, Sonothrombolysis, Microbulles, Synthèse originale, Maladies thrombotiques, Ultrasons, Fibrinolyse ciblée, Fucoïdane, Sonothrombolyse, [CHIM]Chemical Sciences
Relation: NNT: 2023UNIP5040
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4Academic Journal
المؤلفون: Nadji-Boukrouche, Aïda R., Khoumeri, Omar, Terme, Thierry, Liacha, Messaoud, Vanelle, Patrice
المساهمون: Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Département de Génie des Procédés, جامعة 8 مايو 45، قالمة الجزائر = Université du 8 mai 1945 Guelma Algérie = University 8 mai 1945 Guelma Algeria, Laboratoire de Synthèse et de Biocatalyse Organique (LSBO), Université Badji Mokhtar Annaba (UBMA)
المصدر: ISSN: 1420-3049 ; Molecules ; https://amu.hal.science/hal-01234886 ; Molecules, 2015, 20, pp.1262-1276. ⟨10.3390/molecules20011262⟩.
مصطلحات موضوعية: TDAE, benzoxazolone, benzoxazolinonic anion, benzylic alcohols, oxiranes, ORIGINAL SYNTHESIS, DERIVATIVES, ALDEHYDES, LIGANDS, 2(3H)-BENZOXAZOLONE, METHODOLOGY, RING, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Relation: hal-01234886; https://amu.hal.science/hal-01234886; https://amu.hal.science/hal-01234886/document; https://amu.hal.science/hal-01234886/file/molecules-20-01262.pdf
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5
المؤلفون: Romano Silvestri, Antonio Coluccia, Manon Roche, Patrice Vanelle, Laurène Da Costa, Thierry Terme, Johan Neyts, Els Scheers, Pieter Leyssen
المساهمون: Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Rega Institute for Medical Research [Leuven, België], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], This work was supported by the Centre National de la Recherche Scientifique., We express our thanks to Youssef Kabri, and Omar Khoumeri which were an enormous help in my everyday work and to Vincent Remusat for 1H and 13C NMR spectra recording. The antiviral work was performed by Els Scheers, Ph.D. in Rega Institute for Medical Research., Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 115, pp.453--462. ⟨10.1016/j.ejmech.2016.03.049⟩
European Journal of Medicinal Chemistry, 2016, 115, pp.453--462. ⟨10.1016/j.ejmech.2016.03.049⟩مصطلحات موضوعية: 0301 basic medicine, Serotype, Models, Molecular, Rhinovirus, compound, design, MESH: Antiviral Agents/pharmacology, Pharmacology, medicine.disease_cause, 01 natural sciences, HeLa, Drug Discovery, Benzene Derivatives, media_common, capsid inhibitors, HRV14, in silico design, TDAE, VP1 protein, drug discovery3003 pharmaceutical science, organic chemistry, pharmacology, MESH: Benzene Derivatives/pharmacology, In silico design, original synthesis, biology, Chemistry, Common cold, General Medicine, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Toxicity, hrv14, 3c protease, strategy, MESH: Models, Molecular, Drug, replication, media_common.quotation_subject, Antiviral Agents, 03 medical and health sciences, tdae methodology, MESH: Benzene Derivatives/chemistry, tdae, medicine, Potency, Humans, [CHIM]Chemical Sciences, MESH: Rhinovirus/chemistry, attachment, Asthma, MESH: Humans, 010405 organic chemistry, MESH: Antiviral Agents/chemistry, Organic Chemistry, biology.organism_classification, medicine.disease, Virology, common cold, Capsid inhibitors, 0104 chemical sciences, 030104 developmental biology, MESH: HeLa Cells, derivatives, HeLa Cells
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6Academic Journal
المؤلفون: da Costa, Laurene, Roche, Manon, Scheers, Els, Coluccia, Antonio, Neyts, Johan, Terme, Thierry, Leyssen, Pieter, Silvestri, Romano, Vanelle, Patrice
المساهمون: Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Rega Institute for Medical Research Leuven, België, Catholic University of Leuven = Katholieke Universiteit Leuven (KU Leuven), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA), This work was supported by the Centre National de la Recherche Scientifique., We express our thanks to Youssef Kabri, and Omar Khoumeri which were an enormous help in my everyday work and to Vincent Remusat for 1H and 13C NMR spectra recording. The antiviral work was performed by Els Scheers, Ph.D. in Rega Institute for Medical Research.
المصدر: ISSN: 0223-5234.
مصطلحات موضوعية: hrv14, design, derivatives, compound, replication, In silico design, original synthesis, 3c protease, attachment, Capsid inhibitors, common cold, strategy, tdae, tdae methodology, VP1 protein, MESH: Antiviral Agents/chemistry, MESH: Antiviral Agents/pharmacology, MESH: Benzene Derivatives/chemistry, MESH: Benzene Derivatives/pharmacology, MESH: HeLa Cells, MESH: Humans, MESH: Models, Molecular, MESH: Rhinovirus/chemistry, [CHIM]Chemical Sciences, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Relation: info:eu-repo/semantics/altIdentifier/pmid/27049678; hal-01460664; https://hal.science/hal-01460664; PUBMED: 27049678