يعرض 1 - 20 نتائج من 99 نتيجة بحث عن '"naïve b cells"', وقت الاستعلام: 0.59s تنقيح النتائج
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    المساهمون: The work was carried out with the financial support of the Russian Foundation for Basic Research (project no. № 19-315-90090)., Исследование выполнено при финансовой поддержке Российского фонда фундаментальных исследований в рамках научного проекта № 19-315-90090.

    المصدر: Modern Rheumatology Journal; Том 16, № 1 (2022); 38-45 ; Современная ревматология; Том 16, № 1 (2022); 38-45 ; 2310-158X ; 1996-7012

    وصف الملف: application/pdf

    Relation: https://mrj.ima-press.net/mrj/article/view/1250/1206; Насонов ЕЛ. Проблемы иммунопатологии ревматоидного артрита: эволюция болезни. Научно-практическая ревматология. 2017;55(3):277-94.; Silverman GJ, Carson DA. Roles of B cells in rheumatoid arthritis. Arthritis Res Ther. 2003;5 Suppl 4(Suppl 4):S1-6. doi:10.1186/ar1010. Epub 2003 Dec 2.; Krishnamurthy A, Joshua V, Haj Hensvold A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibodymediated bone loss. Ann Rheum Dis. 2016 Apr;75(4):721-9. doi:10.1136/annrheumdis-2015-208093.; Ford JA, Liu X, Marshall AA, et al. Impact of Cyclic Citrullinated Peptide Antibody Level on Progression to Rheumatoid Arthritis in Clinically Tested Cyclic Citrullinated Peptide Antibody-Positive Patients Without Rheumatoid Arthritis. Arthritis Care Res (Hoboken).2019 Dec;71(12):1583-92.; Mellado M, Martinez-Munoz L, Cascio G, et al. T Cell Migration in Rheumatoid Arthritis. Front Immunol. 2015 Jul 27;6:384. doi:10.3389/fimmu.2015.00384.eCollection 2015.; Petrelli A , van Wijk F . CD8(+) T cells in human autoimmune arthritis: the unusual suspects. Nat Rev Rheumatol. 2016 Jul;12(7): 421-8. doi:10.1038/nrrheum.2016.74. Epub 2016 Jun 3.; Kang YM , Zhang X , Wagner UG , et al . CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. J Exp Med. 2002 May 20;195(10): 1325-36. doi:10.1084/jem.20011565.; Furst DE, Emery P. Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets. Rheumatology (Oxford). 2014 Sep;53(9): 1560-9. doi:10.1093/rheumatology/ket414. Epub 2014 Jan 8.; Wong P, Quinn J, Sims N, et al. Interleukin-6 modulates production of T lymphocytederived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis Rheum. 2006 Jan;54(1): 158-68. doi:10.1002/art.21537.; Yamin R, Berhani O, Peleg H, et al. High percentages and activity of synovial fluid NK cells present in patients with advanced stage active Rheumatoid Arthritis. Sci Rep. 2019 Feb 4;9(1):1351. doi:10.1038/s41598-018-37448-z.; Shegarfi H, Naddafi F, Irshafiey A. Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe? Scientific World Journal. 2012;2012:491974. doi:10.1100/2012/491974. Epub 2012 Apr 1.; Ahern DJ, Brennan FM. The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: Major contributors or essential homeostatic modulators? Immunol Lett. 2011 May;136(2):115-21. doi:10.1016/j.imlet.2010.11.001. Epub 2010 Nov 10.; Qu CH, Hou Y, Bi YF, et al. Values of serum IL-10 and IL-17 in rheumatoid arthritis. Eur Rev Med Pharmacol Sci. 2019 Mar; 23(5):1899-1906. doi:10.26355/eurrev_201903_17227.; Jung J, Choe J, Li L, Choi YS. Regulation of CD27 expression in the course of germinal center B cell differentiation: the pivotal role of IL-10. Eur J Immunol. 2000 Aug;30(8):2437-43. doi:10.1002/1521-4141(2000)30:8< 2437::AID-IMMU2437>3.0.CO;2-M.; Li Y, Li Z, Hu F. Double negative (DN) B cells: an under recognized effector memory B cell subset in autoimmunity. Clin Exp Immunol. 2021 Aug;205(2):119-127. doi:10.1111/cei.13615. Epub 2021 Jun 6.; Герасимова EВ, Попкова ТВ, Алексанкин АП и др. Субпопуляции В-лимфоцитов у больных ревматоидным артритом и влияние на них ингибитора рецепторов интерлейкина 6. Научно-практическая ревматология. 2018;56(6):731-8.; Cope AP, Schulze-Koops H, Aringer M. The central role of T cells in rheumatoid arthritis. Clin Exp Rheumatol. Sep-Oct 2007;25(5 Suppl 46):S4-11.; Scheeren FA, Nagasawa M, Weijer K, et al. T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells. J Exp Med. 2008 Sep 1;205(9):2033-42. doi:10.1084/jem.20070447. Epub 2008 Aug 11.; Weller S, Faili A, Garcia C, et al. CD40- CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1166-70. doi:10.1073/pnas.98.3.1166.; Sanz I, Wei C, Lee FE, Anolik J. Phenotypic and functional heterogeneity of human memory B cells. SeminImmunol. 2008;20(1): 67-82. doi:10.1016/j.smim.2007.12.006; Mahmood Z, Muhammad K, Schmalzing M, et al. CD27-IgD- memory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis. Arthritis Res Ther. 2015 Mar 14;17(1):61. doi:10.1186/s13075-015-0580-y.; Lemoine S, Morva A, Youinou P, Jamin C. Human T cells induce their own regulation through activation of B cells. J Autoimmun. 2011 May;36(3-4):228-38. doi:10.1016/j.jaut.2011.01.005. Epub 2011 Feb 12.; Blair PA, Noreсa LY, Flores-Borja F, et al. CD19+CD24hi CD38 hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity. 2010 Jan 29; 32(1):129-40. doi:10.1016/j.immuni.2009.11.009. Epub 2010 Jan 14.; Flores-Borja F, Bosma А, Ng D, et al. CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation. Sci Transl Med. 2013 Feb 20; 5(173):173ra23. doi:10.1126/scitranslmed.3005407.; Palanichamy A, Barnard J, Zheng B, et al. Novel human transitional B cell populations revealed by B cell depletion therapy. J Immunol. 2009 May 15;182(10):5982-93. doi:10.4049/jimmunol.0801859.; Wang Y, Lloyd KA, Melas I, et al. Rheumatoid arthritis patients display B-cell dysregulation already in the naпve repertoire consistent with defects in B-cell tolerance. Sci Rep. 2019 Dec 27;9(1):19995. doi:10.1038/s41598-019-56279-0.; Meffre E, O'Connor KC. Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies. Immunol Rev. 2019 Nov;292(1): 90-101. doi:10.1111/imr.12821. Epub 2019 Nov 12.; Vital EM, Dass S, Rawstron AC, et al. Management of nonresponse to rituximab in rheumatoid arthritis: predictors and outcome of re-treatment. Arthritis Rheum. 2010 May; 62(5):1273-9. doi:10.1002/art.27359.; Hofmann K, Clauder AK, Manz RА. Targeting B Cells and Plasma Cells in Autoimmune Diseases. Front Immunol. 2018 Apr 23;9:835. doi:10.3389/fimmu.2018.00835.eCollection 2018.; https://mrj.ima-press.net/mrj/article/view/1250

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    المساهمون: S. Mati, M. Rossi, L. Brondolo, M. Cardillo, D. Reverberi, R. Massara, M. Colombo, A. Ibatici, E. Angelucci, T. Vaisitti, S. Bruno, S. Fabri, A. Neri, M. Gentile, F. Morabito, G. Cutrona, P. Briata, R. Gherzi, F. Fais

    Relation: info:eu-repo/semantics/altIdentifier/pmid/34679195; info:eu-repo/semantics/altIdentifier/wos/WOS:000712111600001; journal:HEMATOLOGICAL ONCOLOGY; http://hdl.handle.net/2434/877511; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118210991

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    المساهمون: The research was carried out with the financial support of the Russian Foundation for Basic Research within scientific project № 19-315-90090, Исследование выполнено при финансовой поддержке Российского фонда фундаментальных исследований в рамках научного проекта № 19-315-90090

    المصدر: Modern Rheumatology Journal; Том 15, № 2 (2021); 17-22 ; Современная ревматология; Том 15, № 2 (2021); 17-22 ; 2310-158X ; 1996-7012

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    Relation: https://mrj.ima-press.net/mrj/article/view/1117/1076; https://mrj.ima-press.net/mrj/article/view/1117/1094; Насонов ЕЛ. Проблемы иммунопатологии ревматоидного артрита: эволюция болезни. Научно-практическая ревматология. 2017.55(3):277-94.; Harre U, Georgess D, Bang H, et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012 May;122(5):1791-802. doi:10.1172/JCI60975. Epub 2012 Apr 16.; Krishnamurthy A, Joshua V, Haj Hensvold A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis. 2016 Apr;75(4):721-9. doi:10.1136/annrheumdis-2015-208093. Epub 2015 Nov 26.; Holers V, Banda N. Complement in the Initiation and Evolution of Rheumatoid Arthritis. Front Immunol. 2018 May 28;9:1057. doi:10.3389/fimmu.2018.01057. eCollection 2018.; Weyand C, Goronzy J. Ectopic germinal center formation in rheumatoid synovitis. Ann N Y Acad Sci. 2003 Apr;987:1-8. doi:10.1111/j.1749-6632.2003.tb06027.x.; Shi K, Hayashida K. Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles Within the Synovium of Chronic Arthritis Patients. J Immunol. 2001 Jan 1;166(1):650-5. doi:10.4049/jimmunol.166.1.650.; Mellado M, Martinez-Munoz L, Cascio G, et al. T Cell Migration in Rheumatoid Arthritis. Front Immunol. 2015 Jul 27;6:384. doi:10.3389/fimmu.2015.00384. eCollection 2015.; Lino A, Dorner T, Bar-Or A, Fillatreau S. Cytokine-producing B cells: a translational view on their roles in human and mouse autoimmune diseases. Immunol Rev. 2016 Jan;269(1):130-44. doi:10.1111/imr.12374.; Wong P, Quinn J, Sims N, et al. Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis Rheum. 2006 Jan;54(1):158-68. doi:10.1002/art.21537.; Abbas A, Janeway C Jr. Immunology: improving on nature in the twenty first century. Cell. 2000 Jan 7;100(1):129-38. doi:10.1016/s0092-8674(00)81689-x.; Насонов ЕЛ, Александрова ЕН, Авдеева АС, Рубцов ЮП. Т-регуляторные клетки при ревматических заболеваниях. Научно-практическая ревматология. 2014;52(4):430-7.; Авдеева АС, Рубцов ЮП, Дыйканов ДТ, Насонов ЕЛ. Клинико-патогенетическое значение Foxp3+ регуляторных Т-клеток при ревматоидном артрите. Научно-практическая ревматология. 2016;54(4):442-55.; Alvarez-Quiroga C, Abud-Mendoza C, DonizPadilla L, et al. CTLA-4-Ig therapy diminishes the frequency but enhances the function of treg cells in patients with rheumatoid arthritis. J Clin Immunol. 2011 Aug;31(4):588-95. doi:10.1007/s10875-011-9527-5. Epub 2011 Apr 13.; Pieper J, Herrath J, Raghavan S, et al. CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients. BMC Immunol. 2013 Aug 5;14:34. doi:10.1186/1471-2172-14-34.; Bugatti S, Vitolo B, Caporali R, et al. B Cells in Rheumatoid Arthritis: From Pathogenic Players to Disease Biomarkers. Biomed Res Int. 2014;2014:681678. doi:10.1155/2014/681678. Epub 2014 Apr 29.; Hu F, Zhang W, Shi L, et al. Impaired CD27+IgD+ B Cells With Altered Gene Signature in Rheumatoid Arthritis. Front Immunol. 2018 Mar 23;9:626. doi:10.3389/fimmu.2018.00626. eCollection 2018.; Wang Y, Lloyd K, Melas I, et al. Rheumatoid arthritis patients display B-cell dysregulation already in the naive repertoire consistent with defects in B-cell tolerance. Sci Rep. 2019 Dec 27;9(1):19995. doi:10.1038/s41598-019-56279-0.; Moura R, Weinmann P, Pereira P, et al. Alterations on peripheral blood B-cell subpopulations in very early arthritis patients. Rheumatology (Oxford). 2010 Jun;49(6):1082-92. doi:10.1093/rheumatology/keq029. Epub 2010 Mar 7.; Nakayamada S, Kubo S, Yoshikawa M, et al. Differential effects of biological DMARDs on peripheral immune cell phenotypes in patients with rheumatoid arthritis. Rheumatology (Oxford). 2018 Jan 1;57(1):164-74. doi:10.1093/rheumatology/kex012.; Lü bbers J, van Beers-Tas M, Vosslamber S, et al. Changes in peripheral blood lymphocyte subsets during arthritis development in arthralgia patients. Arthritis Res Ther. 2016 Sep 14;18(1):205. doi:10.1186/s13075-016-1102-2.; Souto-Carneiro M, Mahadevan V, Takada K, et al. Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor. Arthritis Res Ther. 2009;11(3):R84. doi:10.1186/ar2718. Epub 2009 Jun 5.; Reddy V, Klein C, Isenberg D, et al. Obinutuzumab induces superior B-cell cytotoxicity to rituximab in rheumatoid arthritis and systemic lupus erythematosus patient samples. Rheumatology (Oxford). 2017 Jul 1;56(7):1227-1237. doi:10.1093/rheumatology/kex067.; Vital E, Rawstron A, Dass S, et al. Reduceddose rituximab in rheumatoid arthritis: Efficacy depends on degree of B cell depletion. Arthritis Rheum. 2011 Mar;63(3):603-8. doi:10.1002/art.30152.; Cambridge G, Leandro M, Teodorescu M, et al. B cell depletion therapy in systemic lupus erythematosus: Effect on autoantibody and antimicrobial antibody profiles. Arthritis Rheum. 2006 Nov;54(11): 3612-22. doi:10.1002/art.22211.; Calero I, Nieto J, Sanz I. B Cell Therapies for Rheumatoid Arthritis: Beyond B cell Depletion. Rheum Dis Clin North Am. 2010 May;36(2):325-43. doi:10.1016/j.rdc.2010.02.003.; https://mrj.ima-press.net/mrj/article/view/1117

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    المصدر: Rheumatology Science and Practice; Vol 56, No 6 (2018); 731-738 ; Научно-практическая ревматология; Vol 56, No 6 (2018); 731-738 ; 1995-4492 ; 1995-4484

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    Relation: https://rsp.mediar-press.net/rsp/article/view/2650/1780; Насонов ЕЛ. Проблемы иммунопатологии ревматоидного артрита: эволюция болезни. Научно-практическая ревматология. 2017;55(3):277-94 [Nasonov EL. Рroblems of rheumatoid arthritis immunopathology: evolution of the disease. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2017;55(3):277-94 (In Russ.)]. doi:10.14412/1995-4484-2017-277-294; Leslie D, Lipsky P, Notkins AL. Autoantibodies as predictors of disease. J Clin Invest. 2001;108:1417-22. doi:10.1172/JCI14452; Leandro M. B cells and rheumatoid factors in autoimmunity. Int J Rheum Dis. 2015;18:379-81. doi:10.1111/1756-185X.12690; Lino AC, Dorner T, Bar-Or A, Fillatreau S. Cytokine-producing B cells: a translational view on their roles in human and mouse autoimmune diseases. Immunol Rev. 2016;269:130-44. doi:10.1111/imr.12374; Насонов ЕЛ, Лила АМ. Ингибиция интерлейкина 6 при иммуновоспалительных ревматических заболеваниях: достижения, перспективы и надежды. Научно-практическая ревматология. 2017;55(6):590-9 [Nasonov EL, Lila AM. Inhibition of interleukin 6 in immune inflammatory rheumatic diseases: achievements, prospects, and hopes. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2017;55(6):590-9 (In Russ.)]. doi:10.14412/1995-4484-2017-590-599; Scott LJ. Tocilizumab: A Review in Rheumatoid Arthritis. Drugs. 2017 Nov;77(17):1865-79. doi:10.1007/s40265-017-0829-7; Yeo L, Toellner KM, Salmon M, et al. Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis. Ann Rheum Dis. 2011 Nov;70(11):2022-8. doi:10.1136/ard.2011.153312; Mihara M, Hashizume M, Yoshida H, et al. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond). 2012 Feb;122(4):143-59. doi:10.1042/CS20110340; Burmester GR, Feist E, Dö rner T. Emerging cell and cytokine targets in rheumatoid arthritis. Nat Rev Rheumatol. 2014 Feb;10(2):77-88. doi:10.1038/nrrheum.2013.168; Roll P, Muhammad K, Schumann M, et al. In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment. Arthritis Rheum. 2011 May;63(5):1255-64. doi:10.1002/art.30242; Moura RA, Quaresma C, Vieira AR, et al. B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis. PLoS One. 2017 Sep 8;12(9):e0182927. doi:10.1371/journal.pone.0182927; Lubbers J, Vosslamber S, van de Stadt LA, et al. B cell signature contributes to the prediction of RA development in patients with arthralgia. Ann Rheum Dis. 2015;74:1786-8. doi:10.1136/annrheumdis-2015-207324; Van Baarsen LGM, de Hair MJH, Ramwadhdoebe TH, et al. The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis. Ann Rheum Dis. 2013;72:1420-4. doi:10.1136/annrheumdis-2012-202990; Amara K, Steen J, Murray F, et al. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition. J Exp Med. 2013;210:445-55. doi:10.1084/jem.20121486; Li S, Yu Y, Yue Y, et al. Autoantibodies from single circulating plasmablasts react with citrullinated antigens and Porphyromonas gingivalis in rheumatoid arthritis. Arthritis Rheum. 2016;68:614-26. doi:10.1002/art.39455; Muhammad K, Roll P, Einsele H, et al. Delayed acquisition of somatic hypermutations in repopulated IGD+CD27+ memory B cell receptors after rituximab treatment. Arthritis Rheum. 2009;60:2284-93. doi:10.1002/art.24722; Adlowitz DG, Barnard J, Biear J, et al. Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response. PLoS One. 2015 Jun 5;10(6):e0128269. doi:10.1371/journal.pone.0128269; Fekete A, Soos L, Szekanecz Z, et al. Disturbances in B- and T-cell homeostasis in rheumatoid arthritis: suggested relationships with antigen-driven immune responses. J Autoimmun. 2007;29:154-63. doi:10.1016/j.jaut.2007.07.002; Moura RA, Graca L, Fonseca JE. To B or not to B the conductor of rheumatoid arthritis orchestra. Clin Rev Allergy Immunol. 2012 Dec;43(3):281-91. doi:10.1007/s12016-012-8318-y; Супоницкая ЕВ, Алексанкин АП, Александрова ЕН и др. Определение субпопуляций В-лимфоцитов периферической крови методом проточной цитофлуорометрии у здоровых лиц и больных ревматическими заболеваниями. Клиническая лабораторная диагностика. 2015;60(6):30-33 [Suponitskaya EV, Aleksankin AP, Alexandrova EN, et al. Characterization of peripheral blood b-cell subset in patients with systemic lupus erythematosus. Klinicheskaya Laboratornaya Diagnostika. 2015;60(6):30-3 (In Russ.)].; Nakayamada S, Kubo S, Yoshikawa M, et al. Differential effects of biological DMARDs on peripheral immune cell phenotypes in patients with rheumatoid arthritis. Rheumatology (Oxford). 2018 Jan 1;57(1):164-74. doi:10.1093/rheumatology/kex012; Lü bbers J, van Beers-Tas MH, Vosslamber S, et al. Changes in peripheral blood lymphocyte subsets during arthritis development in arthralgia patients. Arthritis Res Ther. 2016;18(1):205. doi:10.1186/s13075-016-1102-2; Moura RA, Weinmann P, Pereira PA, et al. Alterations on peripheral blood B-cell subpopulations in very early arthritis patients. Rheumatology (Oxford). 2010;49:1082-92. doi:10.1093/rheumatology/keq029; Mahmood Z, Muhammad K, Schmalzing M, et al. CD27-IgDmemory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis. Arthritis Res Ther. 2015 Mar 14;17:61. doi:10.1186/s13075-015-0580-y; Illei GG, Shirota Y, Yarboro CH, et al. Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. Arthritis Rheum. 2010;62:542-52. doi:10.1002/art.27221; Меснянкина АА, Соловьев СК, Александрова ЕН и др. Динамика субпопуляции В-лимфоцитов у больных системной красной волчанкой на фоне терапии генно-инженерными биологическими препаратами. Научно-практическая ревматология. 2017;55(3):252-60 [Mesnyankina AA, Solovyev SK, Aleksandrova EN, et al. The time course of changes in B lymphocyte subpopulations in patients with systemic lupus erythematosus during therapy with biological agents. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2017;55(3):252-60 (In Russ.)]. doi:10.14412/1995-4484-2017-252-260; Marie-Cardine A, Divay F, Dutot I, et al. Transitional B cells in humans: characterization and insight from B lymphocyte reconstitution after hematopoietic stem cell transplantation. Clin Immunol. 2008;127:14-25. doi:10.1016/j.clim.2007.11.013; Fonseca JE, Santos MJ, Canhao H, Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev. 2009;8:538-42. doi:10.1016/j.autrev.2009.01.012; Jourdan M, Cren M, Robert N, et al. IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors. Leukemia. 2014 Aug;28(8):1647-56. doi:10.1038/leu.2014.61; Muhammad K, Roll P, Seibold T, et al. Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells. Ann Rheum Dis. 2011;70:1507-10. doi:10.1136/ard.2010.141325; Kikuchi J, Hashizume M, Kaneko Y, et al. Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response. Arthritis Res Ther. 2015 Jan 21;17:10. doi:10.1186/s13075-015-0526-4; Fleischer S, Ries S, Shen P, et al. Anti-interleukin-6 signalling therapy rebalances the disrupted cytokine production of B cells from patients with active rheumatoid arthritis. Eur J Immunol. 2018 Jan;48(1):194-203. doi:10.1002/eji.201747191; Alivernini S, Kurowska-Stolarska M, Tolusso B, et al. MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nat Commun. 2016 Sep 27;7:12970. doi:10.1038/ncomms12970; Wu Y, El Shikh ME, El Sayed RM, et al. IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation. Int Immunol. 2009;21:745-56. doi:10.1093/intimm/dxp041; https://rsp.mediar-press.net/rsp/article/view/2650

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