المؤلفون: Kai-Po Chen, Kuo-Feng Hua, Fu-Ting Tsai, Ting-Yu Lin, Chih-Yuan Cheng, Ding-I. Yang, Hsien-Ta Hsu, Tz-Chuen Ju

المصدر: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)

مصطلحات موضوعية: Huntington’s disease (HD), Interleukin‐1β (IL‐1β), Mutated huntingtin (mHTT), Nucleotide oligomerization domain-like receptor protein 3 inflammasome (NLRP3 inflammasome), Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1742-2094

URL الوصول: https://doaj.org/article/f2d8f3d48b8b49b1a403ac4aecb9c14a

المؤلفون: Solis Chiriboga, Ariel, Bustillos, Alberto

المصدر: Salud, Ciencia y Tecnología - Serie de Conferencias, ISSN 2953-4860, Nº. 3, 2024 (Ejemplar dedicado a: Salud, Ciencia y Tecnología - Serie de Conferencias)

مصطلحات موضوعية: Antisense Oligonucleotides, Huntington's Disease, Mutated Huntingtin, Wild-Type Huntingtin, Modulation, Clinical Trials

وصف الملف: application/pdf

Relation: https://dialnet.unirioja.es/servlet/oaiart?codigo=9872365

الاتاحة: https://dialnet.unirioja.es/servlet/oaiart?codigo=9872365

المؤلفون: Solis Chiriboga, Ariel, Bustillos, Alberto

المصدر: Salud, Ciencia y Tecnología - Serie de Conferencias, ISSN 2953-4860, Nº. 3, 2024 (Ejemplar dedicado a: Salud, Ciencia y Tecnología - Serie de Conferencias)

مصطلحات موضوعية: Antisense Oligonucleotides, Huntington's Disease, Mutated Huntingtin, Wild-Type Huntingtin, Modulation, Clinical Trials

وصف الملف: application/pdf

Relation: https://dialnet.unirioja.es/servlet/oaiart?codigo=9872251

الاتاحة: https://dialnet.unirioja.es/servlet/oaiart?codigo=9872251

المؤلفون: Fiorillo A., Morea V., Colotti G., Ilari A.

المساهمون: Fiorillo, A., Morea, V., Colotti, G., Ilari, A.

مصطلحات موضوعية: E3 ligase, huntingtin, mutated huntingtin clearance, PROTAC, ubiquitination

Relation: info:eu-repo/semantics/altIdentifier/pmid/34945781; info:eu-repo/semantics/altIdentifier/wos/WOS:000738237500001; volume:11; issue:12; firstpage:1309; journal:JOURNAL OF PERSONALIZED MEDICINE; https://hdl.handle.net/11573/1617233; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85121616450

الاتاحة: https://hdl.handle.net/11573/1617233
https://doi.org/10.3390/jpm11121309

المؤلفون: Austin Folger, Yanchang Wang

المصدر: Cells; Volume 10; Issue 11; Pages: 2835

مصطلحات موضوعية: protein misfolding, mutated Huntingtin, ubiquitin-proteasome system (UPS), Cdc48, autophagy

وصف الملف: application/pdf

Relation: Cellular Aging; https://dx.doi.org/10.3390/cells10112835

الاتاحة: https://doi.org/10.3390/cells10112835

المؤلفون: Ryan Higgins, Marie-Helene Kabbaj, Delaney Sherwin, Lauren A. Howell, Alexa Hatcher, Robert J. Tomko, Jr., Yanchang Wang

المصدر: Cell Reports, Vol 32, Iss 2, Pp 107898- (2020)

مصطلحات موضوعية: proteotoxicity, Cdc48, San1/Ubr1 E3 ligases, ubiquitin homeostasis, mutated Huntingtin, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124720308792; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/64665d8392944950b3c1f13929211b39

المؤلفون: Silvia Rea, David Della-Morte, Francesca Pacifici, Barbara Capuani, Donatella Pastore, Andrea Coppola, Roberto Arriga, Aikaterini Andreadi, Giulia Donadel, Nicola Di Daniele, Alfonso Bellia, Davide Lauro

المصدر: Frontiers in Pharmacology, Vol 11 (2020)

مصطلحات موضوعية: Huntington disease, neuronal survival, insulin, exendin-4, mutated huntingtin, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2020.00779/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/c4d9183791e444b1ab49d9b2831f39bc

المؤلفون: Higgins, Ryan, Kabbaj, Marie-Helene, Sherwin, Delaney, Howell, Lauren A., Hatcher, Alexa, Tomko, Robert J., Wang, Yanchang

المساهمون: Pathology and Laboratory Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: proteotoxicity, Cdc48, San1/Ubr1 E3 ligases, ubiquitin homeostasis, mutated Huntingtin

وصف الملف: application/pdf

Relation: Cell Reports; Higgins, R., Kabbaj, M.-H., Sherwin, D., Howell, L. A., Hatcher, A., Tomko, R. J., & Wang, Y. (2020). The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis. Cell Reports, 32(2), 107898. https://doi.org/10.1016/j.celrep.2020.107898; https://hdl.handle.net/1805/24424

الاتاحة: https://hdl.handle.net/1805/24424

المؤلفون: Veronica Morea, Andrea Ilari, Gianni Colotti, Annarita FIORILLO

المصدر: Journal of Personalized Medicine, Vol 11, Iss 1309, p 1309 (2021)
Journal of Personalized Medicine

مصطلحات موضوعية: E3 ligases, huntingtin, mutated huntingtin clearance, PROTACs, ubiquitination, Medicine (miscellaneous), Medicine, Review

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29ddb8948ea113f829c317c76cd4595
http://hdl.handle.net/11573/1617233

المؤلفون: J. Sassone, A. Ciammola, A. Maraschi, F. Sassone, V. Silani

المساهمون: J. Sassone, A. Maraschi, F. Sassone, V. Silani, A. Ciammola

مصطلحات موضوعية: Bcl-2 family protein, Huntington's disease model, Mutated huntingtin, Settore MED/26 - Neurologia, Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica

Relation: info:eu-repo/semantics/altIdentifier/pmid/23949221; info:eu-repo/semantics/altIdentifier/wos/WOS:000324146000029; volume:4; issue:8; firstpage:1; lastpage:9; numberofpages:9; journal:CELL DEATH & DISEASE; http://hdl.handle.net/2434/226480; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84882664898

الاتاحة: http://hdl.handle.net/2434/226480
https://doi.org/10.1038/cddis.2013.300

المؤلفون: Robert J. Tomko, Ryan Higgins, Delaney Sherwin, Yanchang Wang, Alexa Hatcher, Lauren A. Howell, Marie-Helene Miquel Kabbaj

المصدر: Cell Reports, Vol 32, Iss 2, Pp 107898-(2020)
Cell Rep

مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Protein Folding, Huntingtin, Saccharomyces cerevisiae Proteins, Proteolysis, Ubiquitin-Protein Ligases, Saccharomyces cerevisiae, General Biochemistry, Genetics and Molecular Biology, Article, Cdc48, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Valosin Containing Protein, ubiquitin homeostasis, medicine, Homeostasis, lcsh:QH301-705.5, Huntingtin Protein, biology, medicine.diagnostic_test, Cell Death, Chemistry, mutated Huntingtin, Temperature, Ubiquitination, Ubiquitin homeostasis, proteotoxicity, Ubiquitinated Proteins, Protein ubiquitination, Ubiquitin ligase, Cell biology, Cytosol, 030104 developmental biology, Proteotoxicity, lcsh:Biology (General), Mutation, biology.protein, Mutant Proteins, 030217 neurology & neurosurgery, San1/Ubr1 E3 ligases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48c65d6cb9606a3e8b91f52dbaffa57
http://www.sciencedirect.com/science/article/pii/S2211124720308792

المؤلفون: Sekáč, Dávid

Thesis Advisors: Ellederová, Zdeňka, Hanzlíková, Hana

مصطلحات موضوعية: primární fibroblasty, poškození DNA, mutovaný huntingtin, oxidativní stres, velký zvířecí model, Huntingtonova choroba, oxidative stress - DNA damage - mutated huntingtin - Huntington's disease -large animal model -primary fibroblasts

الاتاحة: http://www.nusl.cz/ntk/nusl-436405

المؤلفون: Sekáč, Dávid

المساهمون: Ellederová, Zdeňka, Hanzlíková, Hana

مصطلحات موضوعية: primární fibroblasty, poškození DNA, mutovaný huntingtin, oxidativní stres, velký zvířecí model, Huntingtonova choroba, oxidative stress - DNA damage - mutated huntingtin - Huntington's disease -large animal model -primary fibroblasts

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2186::459a517c34827ee4ee1a857ae0c8edc1
http://www.nusl.cz/ntk/nusl-436405

المؤلفون: Abjean, Laurene

Thesis Advisors: Université Paris-Saclay (ComUE), Escartin, Carole

مصطلحات موضوعية: Agrégats de huntingtine mutées, Maladie de Huntington, Astrocytes réactifs, Protéostasie, Voie JAK2-STAT3, Vecteurs viraux, Mutated huntingtin aggregates, Huntington's disease, Reactive astrocytes, Proteostasis, Viral vectors, JAK2-STAT3 pathway

الاتاحة: http://www.theses.fr/2019SACLS088

المؤلفون: Sekáč, Dávid

المساهمون: Ellederová, Zdeňka, Hanzlíková, Hana

مصطلحات موضوعية: oxidative stress - DNA damage - mutated huntingtin - Huntington's disease -large animal model -primary fibroblasts, oxidativní stres, poškození DNA, mutovaný huntingtin, Huntingtonova choroba, velký zvířecí model, primární fibroblasty

وصف الملف: application/pdf

Relation: http://hdl.handle.net/20.500.11956/122690; 208940; 990023874070106986

الاتاحة: https://hdl.handle.net/20.500.11956/122690

المؤلفون: Šmatlíková, Petra

Thesis Advisors: Motlík, Jan, Trejbalová, Kateřina, Reiniš, Milan

مصطلحات موضوعية: primární fibroblasty, Huntington's disease, large animal model, MSCs, primary fibroblasts, mutated huntingtin, velký zvířecí model, Huntingtonova choroba, mutovaný huntingtín

الاتاحة: http://www.nusl.cz/ntk/nusl-397731

المؤلفون: Abjean, Laurene

المساهمون: STAR, ABES, Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN), Service MIRCEN (MIRCEN), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Université Paris Saclay (COmUE), Carole Escartin, Centre National de la Recherche Scientifique (CNRS)-Service MIRCEN (MIRCEN), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

المصدر: Neurosciences [q-bio.NC]. Université Paris Saclay (COmUE), 2019. Français. ⟨NNT : 2019SACLS088⟩

مصطلحات موضوعية: Viral vectors, JAK2-STAT3 pathway, Huntington's disease, Agrégats de huntingtine mutées, Astrocytes réactifs, Maladie de Huntington, Proteostasis, Vecteurs viraux, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Reactive astrocytes, Voie JAK2-STAT3, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Mutated huntingtin aggregates, Protéostasie

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::87762389ed3d9ccbbf397e2c3208ce55
https://theses.hal.science/tel-02562821

المؤلفون: Šmatlíková, Petra

المساهمون: Motlík, Jan, Trejbalová, Kateřina, Reiniš, Milan

مصطلحات موضوعية: primární fibroblasty, Huntington's disease, large animal model, MSCs, primary fibroblasts, mutated huntingtin, velký zvířecí model, Huntingtonova choroba, mutovaný huntingtín

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2186::802d69d627202049ee70ea83445d5d16
http://www.nusl.cz/ntk/nusl-397731

المؤلفون: Šmatlíková, Petra

المساهمون: Motlík, Jan, Trejbalová, Kateřina, Reiniš, Milan, Ellederová, Zdeňka

مصطلحات موضوعية: Huntington's disease, mutated huntingtin, large animal model, primary fibroblasts, MSCs, Huntingtonova choroba, mutovaný huntingtín, velký zvířecí model, primární fibroblasty

وصف الملف: application/pdf; application/zip

Relation: http://hdl.handle.net/20.500.11956/107130; 115186; 002282503

الاتاحة: https://hdl.handle.net/20.500.11956/107130

المؤلفون: Abjean, Laurene

المساهمون: Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN), Molecular Imaging Research Center Fontenay-aux-Roses (MIRCEN), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Université Paris Saclay (COmUE), Carole Escartin

المصدر: https://theses.hal.science/tel-02562821 ; Neurosciences [q-bio.NC]. Université Paris Saclay (COmUE), 2019. Français. ⟨NNT : 2019SACLS088⟩.

مصطلحات موضوعية: Mutated huntingtin aggregates, Huntington's disease, Reactive astrocytes, Proteostasis, Viral vectors, JAK2-STAT3 pathway, Agrégats de huntingtine mutées, Maladie de Huntington, Astrocytes réactifs, Protéostasie, Voie JAK2-STAT3, Vecteurs viraux, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

Relation: NNT: 2019SACLS088; tel-02562821; https://theses.hal.science/tel-02562821; https://theses.hal.science/tel-02562821/document; https://theses.hal.science/tel-02562821/file/74361_ABJEAN_2019_archivage.pdf

الاتاحة: https://theses.hal.science/tel-02562821
https://theses.hal.science/tel-02562821/document
https://theses.hal.science/tel-02562821/file/74361_ABJEAN_2019_archivage.pdf