المؤلفون: Karolina Maciejewska, Kamila Czarnecka, Paweł Kręcisz, Dorota Niedziałek, Grzegorz Wieczorek, Robert Skibiński, Paweł Szymański

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 5876

مصطلحات موضوعية: Alzheimer’s disease, multitarget small molecules, biological activity

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pharmacology; https://dx.doi.org/10.3390/ijms23115876

الاتاحة: https://doi.org/10.3390/ijms23115876

المؤلفون: Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M. Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 163-170 (2019)

مصطلحات موضوعية: alzheimer disease, kojic acid, multitarget small molecules, tacrine, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/e3c0e08c463645d08a8cc7dd58a4bda9

المؤلفون: Winnie Deuther-Conrad, Isabel Iriepa, Michael Gütschow, Francisco López-Muñoz, Maria Angeles Martinez-Grau, Daniel Diez-Iriepa, José Marco-Contelles

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
RSC Medicinal Chemistry 12(2021)6, 1000-1004

مصطلحات موضوعية: Stereochemistry, receptor binding, Pharmaceutical Science, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, radioligand assay, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Receptor, Butyrylcholinesterase, 030304 developmental biology, Pharmacology, 0303 health sciences, chromenones, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, sigma 1/2 receptors, multitarget small molecules, Acetylcholinesterase, Small molecule, 0104 chemical sciences, ADME, docking, Molecular Medicine, Monoamine oxidase B, Selectivity

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c9ddbbaab5176df0c44aca1aede0a3
https://doi.org/10.1039/d1md00105a

المؤلفون: do Carmo Carreiras, María, Marco-Contelles, José

مصطلحات موضوعية: Alzheimer’s disease, acetyl(butyryl)cholinesterase en-zymes, acetyl(butyryl)cholinesterase inhibitors, Friedländer reactions, Tacrines, Multitarget small molecules

Relation: http://dx.doi.org/10.1055/s-0040-1719823; Sí; Synlett 32: 1987-2012 (2021); http://hdl.handle.net/10261/260859

الاتاحة: http://hdl.handle.net/10261/260859
https://doi.org/10.1055/s-0040-1719823

المؤلفون: José Marco-Contelles, Maria do Carmo Carreiras

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Anti alzheimer, Chemistry, Aché, Organic Chemistry, Friedländer reactions, Pharmacology, Ring (chemistry), Neuroprotection, language.human_language, Multitarget small molecules, Tacrines, Tacrine, medicine, language, acetyl(butyryl)cholinesterase en-zymes, Viability assay, IC50, Alzheimer’s disease, acetyl(butyryl)cholinesterase inhibitors, EC50, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533a9197361ddae9543834cc4f5262ff
http://hdl.handle.net/10261/260859

المؤلفون: Dgachi, Youssef, Martin, H., Martin, Hélène, Malek, R, Jun, D., Janockova, Jana, Sepsova, Vendula, Soukup, Ondrej, Iriepa, Isabel, Moraleda, Ignacio, Maalej, Enma, Carreiras, M. Carmo, Refouvelet, B., Chabchoub, Fakher, Marco-Contelles, José, Ismaili, Lhassane

المساهمون: Ministerio de Economía, Industria y Competitividad (España), European Commission

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 163-170 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, medicine.drug_class, Short Communication, tacrine, Pharmacology, 01 natural sciences, Neuroprotection, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Kojic acid, Drug Discovery, medicine, alzheimer disease, Humans, Structure–activity relationship, IC50, Dose-Response Relationship, Drug, Molecular Structure, kojic acid, 010405 organic chemistry, business.industry, lcsh:RM1-950, General Medicine, multitarget small molecules, medicine.disease, Acetylcholinesterase, Multitarget small molecules, 0104 chemical sciences, Neuroprotective Agents, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, chemistry, Acetylcholinesterase inhibitor, Drug Design, Tacrine, Cholinesterase Inhibitors, Alzheimer's disease, Alzheimer disease, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f01cc1d23157fa3d81d0133cfe5701
http://hdl.handle.net/10261/175021

المؤلفون: Bartolini, Manuela, Marco-Contelles, José

مصطلحات موضوعية: Tacripyrines, Tacripyrimedones, Tacripyrimidines, Hupertacrines, Multitarget small molecules

Relation: http://dx.doi.org/10.1002/tcr.201800155; Sí; e-issn: 1528-0691; Chemical Record 19: 927-937 (2019); http://hdl.handle.net/10261/184685

الاتاحة: http://hdl.handle.net/10261/184685
https://doi.org/10.1002/tcr.201800155

المؤلفون: Marco-Contelles, José

المساهمون: Universidad Camilo José Cela, Ministerio de Economía y Competitividad (España)

مصطلحات موضوعية: Alzheimer’s disease, Aβ hypothesis, Tau hypothesis, Multitarget small molecules, Symptomatic-disease approach, Disease-modifying therapy approach

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-65586-R; http://dx.doi.org/10.1021/acschemneuro.9b00034; Sí; e-issn: 1948-7193; ACS Chemical Neuroscience (2019); http://hdl.handle.net/10261/177935; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/501100008742

الاتاحة: http://hdl.handle.net/10261/177935
https://doi.org/10.1021/acschemneuro.9b00034
https://doi.org/10.13039/501100003329
https://doi.org/10.13039/501100008742

المؤلفون: José Marco-Contelles

المساهمون: Universidad Camilo José Cela, Ministerio de Economía y Competitividad (España)

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Biomedical Research, Physiology, Computer science, Cognitive Neuroscience, education, tau Proteins, Biochemistry, Aβ hypothesis, Alzheimer's disease research, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Animals, Humans, Tau hypothesis, health care economics and organizations, 030304 developmental biology, 0303 health sciences, Biological data, Symptomatic-disease approach, Amyloid beta-Peptides, Management science, Cell Biology, General Medicine, Multitarget small molecules, Order (business), Cholinesterase Inhibitors, Serotonin Antagonists, Alzheimer’s disease, 030217 neurology & neurosurgery, Disease-modifying therapy approach

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5a1a9d8ce4b715ed5a884effdeac94
http://hdl.handle.net/10261/177935

المؤلفون: Oset-Gasque, M. J., Marco-Contelles, José

مصطلحات موضوعية: Multitarget-small molecules, Selective drugs, Alzheimer disease

Relation: http://dx.doi.org/10.1021/acschemneuro.8b00069; Sí; e-issn: 1948-7193; ACS Chemical Neuroscience 9: 401-403 (2018); http://hdl.handle.net/10261/166510

الاتاحة: http://hdl.handle.net/10261/166510
https://doi.org/10.1021/acschemneuro.8b00069

المؤلفون: María Jesús Oset-Gasque, José Marco-Contelles

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Physiology, Cognitive Neuroscience, Computational biology, Multitarget-small molecules, Ligands, 01 natural sciences, Biochemistry, Alzheimer Disease, Drug Discovery, Molecule, Humans, Receptor, 010405 organic chemistry, Chemistry, Drug discovery, Ligand, Cell Biology, General Medicine, Selective drugs, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, Cholinesterase Inhibitors, Alzheimer disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ecbddab633bc1878d6bc8b13a1e457
https://pubmed.ncbi.nlm.nih.gov/29465220

المؤلفون: (0000-0003-3168-3062) Deuther-Conrad, W., Diez-Iriepa, D., Iriepa, I., López-Muñoz, F., Martínez-Grau, A. M., (0000-0002-9376-7897) Gütschow, M., (0000-0003-0690-0328) Marco-Contelles, J.

المصدر: RSC Medicinal Chemistry 12(2021)6, 1000-1004

مصطلحات الفهرس: ADME, chromenones, docking, multitarget small molecules, radioligand assay, receptor binding, sigma 1/2 receptors, info:eu-repo/semantics/publishedVersion, doc-type:article, Text

URL: https://www.hzdr.de/publications/Publ-31302-2
info:eu-repo/semantics/reference/doi/10.1039/D1MD00105A
info:eu-repo/semantics/altIdentifier/purl/https://www.hzdr.de/publications/Publ-31302-2

المؤلفون: Oset-Gasque, María Jesús, Marco-Contelles, José

مصطلحات الفهرس: Multitarget-small molecules, Selective drugs, Alzheimer disease, artículo

URL: http://hdl.handle.net/10261/166510
http://dx.doi.org/10.1021/acschemneuro.8b00069
Sí