المؤلفون: Zeren Sun, Lanjie Li, Bingxin Zhai, Mengxuan Hu, Lei Huang, Shihui Huang, Liu Ye, Xiangying Kong, Jie Xu, Jie Bai, Jingjie Yan, Qichen Zhou, Zheqi Hu, Yuchen Zhang, Yuhan Jiang, Yan Zhang, Zhou Qiao, Yi Zou, Yungen Xu, Qihua Zhu

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Astronomical and Space Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, present study describes, hct116or xenograft models, current therapeutic challenge, 2 nm ), met inhibitor crizotinib, parp1 inhibitor olaparib, met dual inhibitors, 50 , 16 , parp1 inhibitors poses, parp1 inhibitors, small molecules, novel strategies, findings highlight, either alone, 3 nm

Relation: https://figshare.com/articles/journal_contribution/Rational_Design_of_PARP1_c-Met_Dual_Inhibitors_for_Overcoming_PARP1_Inhibitor_Resistance_Induced_by_c_Met_Overexpression/25399313

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c00077.s001

المؤلفون: Kathryn M. Pflug, Dong W. Lee, Ashutosh Tripathi, Vytas A. Bankaitis, Kevin Burgess, Raquel Sitcheran

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, preclinical rodent model, inducing kinase activity, highly aggressive form, glioma progression glioblastoma, heptamethine cyanine dye, blood brain barrier, observed increased ir, newly diagnosed gbm, limited treatment options, impaired tumor growth, met inhibitor crizotinib, tumor localization, novel inhibitor, infrared dye, gbm growth, brain cancer, vivo <, vitro <, unconjugated crizotinib, poor prognosis, poor penetration, nuclear factor

Relation: https://figshare.com/articles/journal_contribution/Cyanine_Dye_Conjugation_Enhances_Crizotinib_Localization_to_Intracranial_Tumors_Attenuating_NF-_B-Inducing_Kinase_Activity_and_Glioma_Progression/24528455

الاتاحة: https://doi.org/10.1021/acs.molpharmaceut.3c00496.s001
https://figshare.com/articles/journal_contribution/Cyanine_Dye_Conjugation_Enhances_Crizotinib_Localization_to_Intracranial_Tumors_Attenuating_NF-_B-Inducing_Kinase_Activity_and_Glioma_Progression/24528455

المؤلفون: Zeren Sun, Lanjie Li, Bingxin Zhai, Mengxuan Hu, Lei Huang, Shihui Huang, Liu Ye, Xiangying Kong, Jie Xu, Jie Bai, Jingjie Yan, Qichen Zhou, Zheqi Hu, Yuchen Zhang, Yuhan Jiang, Yan Zhang, Zhou Qiao, Yi Zou, Yungen Xu, Qihua Zhu

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Astronomical and Space Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, present study describes, hct116or xenograft models, current therapeutic challenge, 2 nm ), met inhibitor crizotinib, parp1 inhibitor olaparib, met dual inhibitors, 50 , 16 , parp1 inhibitors poses, parp1 inhibitors, small molecules, novel strategies, findings highlight, either alone, 3 nm

Relation: https://figshare.com/articles/dataset/Rational_Design_of_PARP1_c-Met_Dual_Inhibitors_for_Overcoming_PARP1_Inhibitor_Resistance_Induced_by_c_Met_Overexpression/25399316

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c00077.s002