المؤلفون: Ghosh, Sreya, De Smedt, Jonathan, Tricot, Tine, Proença, Susana, Kumar, Manoj, Nami, Fatemeharefeh, Vanwelden, Thomas, Vidal, Niels, Jennings, Paul, Kramer, Nynke I., Verfaillie, Catherine M.

المصدر: Ghosh , S , De Smedt , J , Tricot , T , Proença , S , Kumar , M , Nami , F , Vanwelden , T , Vidal , N , Jennings , P , Kramer , N I & Verfaillie , C M 2022 , ' Hipsc-derived hepatocyte-like cells can be used as a model for transcriptomics-based study of chemical toxicity ' , Toxics , vol. 10 , no. 1 , 1 , pp. 1-18 . https://doi.org/10.3390/toxics10010001

مصطلحات موضوعية: ER stress, Hepatocytes, In vitro toxicology, Mechanistic toxicity, Stem cell derived, Transcriptomics

الاتاحة: https://research.vu.nl/en/publications/dbec4197-d750-4a3f-9fd6-b55dfc1a4cf3
https://doi.org/10.3390/toxics10010001
https://hdl.handle.net/1871.1/dbec4197-d750-4a3f-9fd6-b55dfc1a4cf3
http://www.scopus.com/inward/record.url?scp=85121610848&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85121610848&partnerID=8YFLogxK

مصطلحات موضوعية: toxicology, systems toxicology, computational models, synthetic biology, mechanistic toxicity data, apical effects, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.journals.elsevier.com/current-research-in-toxicology; https://www.journals.elsevier.com/current-research-in-toxicology/; https://www.elsevier.com/authors/open-access/choice#waivers; https://www.elsevier.com/journals/current-research-in-toxicology/2666-027x/open-access-journal; https://www.elsevier.com/journals/current-research-in-toxicology/2666-027x/guide-for-authors

URL الوصول: https://doaj.org/toc/2666-027X

المؤلفون: Iman Jafarian, Kamaleddin Haj Mohammad Ebrahim Tehrani, Mohammad Reza Eskandari, Morteza Ahadpour, Mir-Jamal Hosseini, Parvaneh Naserzadeh, Vida Mashayekhi

المصدر: Drug and Chemical Toxicology, 39(2), 224. Informa Healthcare

مصطلحات موضوعية: Male, 0301 basic medicine, Health, Toxicology and Mutagenesis, Antitubercular Agents, Mitochondria, Liver, Pharmacology, Mitochondrion, isolated mitochondria, Toxicology, medicine.disease_cause, Rats, Sprague-Dawley, Lipid peroxidation, chemistry.chemical_compound, Isoniazid (INH), heterocyclic compounds, Membrane Potential, Mitochondrial, chemistry.chemical_classification, biology, mechanistic toxicity, Cytochrome c, Brain, General Medicine, respiratory system, Mitochondria, Mitochondrial toxicity, Mitochondrial respiratory chain, Liver, Biochemistry, In Vitro Techniques, 03 medical and health sciences, Isoniazid, medicine, Animals, Reactive oxygen species, Chemical Health and Safety, Public Health, Environmental and Occupational Health, Glutathione, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, respiratory tract diseases, Oxidative Stress, 030104 developmental biology, chemistry, biology.protein, Lipid Peroxidation, Mitochondrial Swelling, Reactive Oxygen Species, Oxidative stress

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06724c172ace36d81c23f32f65bf5ba4
https://doi.org/10.3109/01480545.2015.1092039

المؤلفون: Ahadpour, Morteza, Eskandari, Mohammad Reza, Mashayekhi, Vida, Hajmohammadebrahimtehrani, K., Jafarian, Iman, Naserzadeh, Parvaneh, Hosseini, Mir-Jamal

مصطلحات موضوعية: isolated mitochondria, Isoniazid (INH), mechanistic toxicity

وصف الملف: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/322944

الاتاحة: https://dspace.library.uu.nl/handle/1874/322944

المؤلفون: Franco, Marco E., 1991

المساهمون: Lavado, Ramon.

مصطلحات موضوعية: Ecotoxicology. In vitro. Fish. Metabolism. Biotransformation. Endocrine disruption. Mechanistic toxicity, envir, socio

Relation: https://hdl.handle.net/2104/11698

الاتاحة: https://hdl.handle.net/2104/11698

المؤلفون: Franco, Marco E., 1991-

المساهمون: Lavado, Ramon.

مصطلحات موضوعية: Ecotoxicology. In vitro. Fish. Metabolism. Biotransformation. Endocrine disruption. Mechanistic toxicity

وصف الملف: application/pdf

Relation: https://hdl.handle.net/2104/11698

الاتاحة: https://hdl.handle.net/2104/11698

المؤلفون: McCanna, David

مصطلحات موضوعية: in vitro, Alternative Methods, alamarBlue, rhodamine, tight junctions, bovine lens, viability, toxicity, mitochondria, mitochondria integrity, benzalkonium chloride, sodium dodecyl sulphate, sodium lauryl sulfate, scanning electron microscopy, Draize, Draize maximal average scores, zonula occludens, cosmetic directive, PETA, humane society, animal league, people for the ethical treatment of animals, interagency coordinating committee on the validation of alternative methods, ICCVAM, ECVAM, JaCVAM, BCOP, bovine cornea, ocular irritants, ocular irritation, ocular toxicity, human corneal epithelial cells, vitro, confocal, confocal microscopy, metabolic activity, optical quality, reactive oxygen species, contact lens, contact lens care solutions, barrier function, microbial keratitis, mulitipurpose solutions, tight junction, cell damage, claudin, ZO-1, occludin, MDCK, Madin, Madin-Darby, canine kidney cells, cornea, human cornea, human corneal epithelium, epithelial cell line, human corneal epithelial cell line, sodium fluorescein, sodium fluorescein permeability, fluorescein permeability, ocular surface, cell monolayer, Araki-Sasaki, cell physiology, risk assessment, safety assessment, ScanTox, scanning laser, lens epithelium, corneal cells, in vitro model, ophthalmic formulations, multiple instillation, back vertex, animal testing, rabbit testing, alternatives to animal testing, cultured bovine lens, toxicity of chemicals, irritation, irritants, laser scanner, organ culture, delayed toxicity, toxins, hydrogen peroxide, cornea toxicity, cornea toxicity models, prediction of human toxicity, no observable adverse effect level, lowest observable adverse effect level, NOAEL, LOAEL, toxicity thresholds, safety factors, uncertainty factors, preservatives, disinfectants, ophthalmic products, preclinical, preclinical testing, epithelial barrier, drug penetration, clinical confocal microscopy, animal rights, rabbit cornea, human clinical effects, toxic, animal rights activist, sensitive measures, toxic effect, toxicity threshold, agar overlay, agar diffusion, agar overlay method, agar diffusion method, cytochrome, cytochrome c, apoptosis, necrotic, apoptotic, necrosis, caspase, rhodamine 123, resazuran, resorufin, cell death, cell viability, metabolic dye, microsomal, microsomal enzymes, cytotoxicity, cytotoxic, cytotoxic effect, MTT, XTT, WST-1, plasma membrane, mitochondrial, mitochondrial morphology, ocular toxicity potential, human corneal epithelial, cell line, confocal analysis, corneal epithelium, cell fluorescence, alamarBlue assay, rhodamine dye, animal welfare, toxic injury, degraded mitochondria, epithelial monolayer, membrane integrity, eye toxicity, eye, viability dye, toxicity in humans, human toxicity, effects on the mitochondria, mitochondrial toxicity, in vitro battery, in vitro test battery, ophthalmic eye drop, direct contact, product safety, cytotoxicity potential, molecular, molecular biology, refine reduce replace, sensitivity and relevance, sensitivity, relevance, rabbit ocular irritation test, product development, cytotoxicity models, cytotoxicity alternative methods, replacements for animal testing, three r's, beagle, tiered testing, tiered testing strategy, replacements animal testing, mechanistic toxicity, cornea mitochondria, dose response, threshold, Vision Science and Biology

الاتاحة: http://hdl.handle.net/10012/4338

Degree: School of Optometry
Doctor of Philosophy