المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/journal_contribution/Additional_methods_information_/16618347

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s001

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/journal_contribution/Supporting_information_for_animals_/16618383

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s012

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/journal_contribution/Additional_lens_sample_information_/16618350

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s002

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/Comparison_of_frozen_and_fixed_tissue_for_mouse_lenses_/16618365

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s007

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/Comparison_of_fixed_lens_anharmonicity_values_/16618380

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s011

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/2DIR_contour_plots_for_data_shown_in_Fig_2_/16618356

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s004

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/Wild_type_mouse_lens_data_chart_/16618368

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s008

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/A_2DIR_and_TEM_comparison_of_B-crystallin_and_B-R120G-crystallin_with_acid_treatment_/16618359

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s005

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/Comparison_of_frozen_dried_and_fixed_paraffin_embedded_tissue_for_human_lenses_/16618362

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s006

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/2DIR_contour_plots_for_data_shown_in_Fig_4_/16618377

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s010

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/_i_Cryab_i_-R120G_mutant_mouse_lenses_have_more_amyloid-like_secondary_structure_features_than_wild-_type_mouse_lenses_by_2DIR_image_analysis_/16618392

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.g003

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/_i_Cryab_i_-R120G_mouse_lens_data_chart_/16618371

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.s009

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/_B-R120G-crystallin_has_more_amyloid-like_secondary_structure_than_wild-type_B-crystallin_proteins_i_in_vitro_i_by_2DIR_and_TEM_/16618389

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.g002

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/An_example_of_a_2DIR_contour_plot_/16618386

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.g001

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/2DIR_cross_peak_intensity_reveals_significant_amyloid-like_secondary_structure_presence_in_i_Cryab_i_-R120G_mouse_lenses_as_compared_to_wild_type_lenses_/16618398

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.g005

المؤلفون: Ariel M. Alperstein (8722125), Kathleen S. Molnar (3094308), Sidney S. Dicke (11432466), Kieran M. Farrell (11432469), Leah N. Makley (2041579), Martin T. Zanni (1280187), Usha P. Andley (354477)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, measure uv radiation, div >< p, developing pharmacological treatments, cross peak frequency, also widely distributed, ordered secondary structure, like secondary structure, cross peak changes, mutant mouse lenses, related cataract disease, protein structural relevance, diagonal peak frequencies, form amorphous aggregates, >- r120g knock, wt mouse lenses, mouse lens model, human hereditary cataracts, dimensional infrared spectroscopy, human lenses, dimensional infrared, mouse model

Relation: https://figshare.com/articles/figure/An_FFPE_age-related_cataract_human_lens_tissue_contains_more_amyloid-like_secondary_structure_features_than_an_FFPE_juvenile_human_lens_tissue_by_2DIR_image_analysis_/16618395

الاتاحة: https://doi.org/10.1371/journal.pone.0257098.g004