المؤلفون: Vishnu C. Damalanka, Victoria Banas, Paolo De Bona, Maithri M. Kashipathy, Kevin Battaile, Scott Lovell, James W. Janetka

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Inorganic Chemistry, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unexpected binding conformation, ray crystal structure, electrophilic ketone warhead, based macrocyclic inhibitors, linear acyclic peptides, improved protease selectivity, best pk properties, selective inhibitors, rational design, rapid clearance, phenyl ether, peptidomimetic side, oral permeability, obstacles presented, new strategy, metabolic stability, identified potent, cyclized macrocycles

Relation: https://figshare.com/articles/journal_contribution/Mechanism-Based_Macrocyclic_Inhibitors_of_Serine_Proteases/25399959

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c02388.s001

المؤلفون: Swapnil P. Bhujbal, Jung-Mi Hah

المصدر: Pharmaceuticals; Volume 16; Issue 7; Pages: 1009

مصطلحات موضوعية: kinases, human diseases, macrocyclic inhibitors, drug discovery

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/ph16071009

الاتاحة: https://doi.org/10.3390/ph16071009

المساهمون: Groutas, William [Wichita State Univ., KS (United States)]

المصدر: European Journal of Medicinal Chemistry; 127; C

وصف الملف: Medium: ED; Size: p. 41-61

URL الوصول: http://www.osti.gov/scitech/servlets/purl/1368274

المؤلفون: Xiaoling Song, Hui Zhong, Xiaojuan Qu, Linsong Yang, Biao Jiang

المصدر: MedComm, Vol 2, Iss 3, Pp 341-350 (2021)

مصطلحات موضوعية: ALK PROTACs, ALK‐TKIs, EML4‐ALK, macrocyclic inhibitors, non‐small cell lung cancer, resistance mechanisms, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2688-2663

URL الوصول: https://doaj.org/article/1b782881311144c59394f642d1b24a42

المؤلفون: Xi Xu (284242), Jubo Wang (3692899), Min Wang (21070), Xinyu Yuan (682492), Lei Li (29537), Chao Zhang (51048), Huidan Huang (5398352), Tian Jing (5683679), Chenchen Wang (12690), Chao Tong (389167), Liwen Zhou (8845190), Ying Meng (327793), Pengfei Xu (301785), Junping Kou (5644958), Zhixia Qiu (5535824), Zhiyu Li (10983), Jinlei Bian (1566253)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, SPR, 13 b, ROS, GLS 1 binding affinity, GLS 1 allosteric inhibitors, X-ray crystal structure, CB, vivo antitumor activity, ITC, Novel Macrocyclic Inhibitors Target., nM, LL, macrocyclic GLS 1 allosteric inhibitors, IC, candidate molecule 13 b

Relation: https://figshare.com/articles/journal_contribution/Structure-Enabled_Discovery_of_Novel_Macrocyclic_Inhibitors_Targeting_Glutaminase_1_Allosteric_Binding_Site/14357488

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02044.s001

المؤلفون: Hui Zhong, Biao Jiang, Xiaojuan Qu, Xiaoling Song, Linsong Yang

المصدر: MedComm, Vol 2, Iss 3, Pp 341-350 (2021)
MedComm

مصطلحات موضوعية: Drug, non‐small cell lung cancer, macrocyclic inhibitors, medicine.drug_class, media_common.quotation_subject, Reviews, Review, Drug resistance, EML4‐ALK, resistance mechanisms, Tyrosine-kinase inhibitor, hemic and lymphatic diseases, medicine, Anaplastic lymphoma kinase, Lung cancer, media_common, Kinase, Chemistry, ALK PROTACs, medicine.disease, Lorlatinib, ALK‐TKIs, Cancer cell, Cancer research, Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6d3b0193915cf58964844910e3a51f
https://doaj.org/article/1b782881311144c59394f642d1b24a42

المؤلفون: Bäck, Marcus, 1979

المساهمون: Sandström, Anja, Dr.

المصدر: Linköping Studies in Science and Technology. Thesis.

مصطلحات موضوعية: HCV, NS3 protease, Proline mimic, Cyclopentane-derived scaffold, Linear inhibitors, Macrocyclic inhibitors, NATURAL SCIENCES, Chemistry, Organic chemistry, Organic synthesis, NATURVETENSKAP, Kemi, Organisk kemi, Organisk syntes

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8395
https://liu.diva-portal.org/smash/get/diva2:23197/FULLTEXT01.pdf

المؤلفون: Rodriguez F, Saffon N, Sammartino JC, Degiacomi G, Pasca MR, Lherbet C.

المساهمون: Rodriguez, F, Saffon, N, Sammartino, Jc, Degiacomi, G, Pasca, Mr, Lherbet, C.

مصطلحات موضوعية: First triclosan-based macrocyclic inhibitors, InhA, TUBERCULOSIS

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/31855823; info:eu-repo/semantics/altIdentifier/wos/WOS:000512762900019; volume:95; firstpage:103498; numberofpages:10; journal:BIOORGANIC CHEMISTRY; http://hdl.handle.net/11571/1293346; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076337307

الاتاحة: http://hdl.handle.net/11571/1293346
https://doi.org/10.1016/j.bioorg.2019.103498

المؤلفون: Galasiti Kankanamalage, Anushka C., Weerawarna, Pathum M., Rathnayake, Athri D., Kim, Yunjeong, Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

مصطلحات موضوعية: Active site, Macrocyclic inhibitors, Norovirus 3CL protease, Structural rearrangement

Relation: Proteins: Structure, Function and Bioinformatics;2019; Galasiti Kankanamalage, AC, Weerawarna, PM, Rathnayake, AD, et al. Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease. Proteins. 2019; 1– 9; https://doi.org/10.1002/prot.25682; http://hdl.handle.net/10057/16148

الاتاحة: http://hdl.handle.net/10057/16148
https://doi.org/10.1002/prot.25682

المؤلفون: Damalanka, Vishnu C., Kim, Yunjeong, Kankanamalage, Anushka C. Galasiti, Rathnayake, Athri D., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Nguyen, Harry Nhat, Lushington, Gerald H., Chang, Kyeong-Ok, Groutas, William C.

مصطلحات موضوعية: Transition-state inhibitors, Data quality, Macromolecular crystallography, Macrocyclic inhibitors, Substrate-specificity, Norwalk-virus, Discovery, Therapeutics, Receptor, Targets

Relation: European Journal of Medicinal Chemistry;v.143; Damalanka, Vishnu C.; Kim, Yunjeong; Kankanamalage, Anushka C. Galasiti; Rathnayake, Athri D.; Mehzabeen, Nurjahan; Battaile, Kevin P.; Lovell, Scott; Nguyen, Harry Nhat; Lushington, Gerald H.; Chang, Kyeong-Ok; Groutas, William C. 2018. Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease. European Journal of Medicinal Chemistry, vol. 143:pp 881-890; WOS:000428216700072; http://dx.doi.org/10.1016/j.ejmech.2017.12.014; http://hdl.handle.net/10057/14949

الاتاحة: http://hdl.handle.net/10057/14949
https://doi.org/10.1016/j.ejmech.2017.12.014

المؤلفون: Manabu Aoki, Masayuki Amano, Melinda Steffey, Hiroaki Mitsuya, Johnson Agniswamy, W. Sean Fyvie, Margherita Brindisi, Irene T. Weber, Arun K. Ghosh, Yuan-Fang Wang

المساهمون: Ghosh, Arun K., Sean Fyvie, W., Brindisi, Margherita, Steffey, Melinda, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki

المصدر: Bioorganicmedicinal chemistry letters. 27(21)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Clinical Biochemistry, Heteroatom, Pharmaceutical Science, Crystallography, X-Ray, Ligands, Biochemistry, HIV-1 protease, HIV Protease, Drug Discovery, HIV Protease Inhibitor, Pyrrolidinones, Pyrrolidinone, Crystallography, biology, Chemistry, Molecular Medicine, P1'-P2' ligand, Macrocyclic Compound, Macrocyclic inhibitors, Protein Structure, Macrocyclic Compounds, Stereochemistry, 030106 microbiology, Structure-based design, Ligand, Molecular Dynamics Simulation, Article, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, medicine, Structure–activity relationship, Macrocyclic inhibitor, Binding site, Molecular Biology, IC50, Protease, Binding Sites, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Binding Site, Drug resistance, HIV protease, P1'-P2' ligands, HIV Protease Inhibitors, HIV-1, Mutation, Protein Structure, Tertiary, Drug Design, 3003, 030104 developmental biology, X-Ray, biology.protein, Tertiary

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f50fc5c218431cf9d4120d5e441dc54
https://pubmed.ncbi.nlm.nih.gov/28958624

المؤلفون: Damalanka, Vishnu C., Kim, Yunjeong, Kankanamalage, Anushka C. Galasiti, Lushington, Gerald H., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

مصطلحات موضوعية: Macrocyclic inhibitors, Norovirus, 3CLprotease

Relation: European Journal of Medicinal Chemistry;v.127; Damalanka, Vishnu C.; Kim, Yunjeong; Kankanamalage, Anushka C. Galasiti; Lushington, Gerald H.; Mehzabeen, Nurjahan; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. 2017. Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease. European Journal of Medicinal Chemistry, vol. 127:pp 41–61; WOS:000397172800004; http://dx.doi.org/10.1016/j.ejmech.2016.12.033; http://hdl.handle.net/10057/13011

الاتاحة: http://hdl.handle.net/10057/13011
https://doi.org/10.1016/j.ejmech.2016.12.033

المؤلفون: Weerawarna, Pathum M., Kim, Yunjeong, Kankanamalage, Anushka C. Galasiti, Damalanka, Vishnu C., Lushington, Gerald H., Alliston, Kevin R., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

مصطلحات موضوعية: Norovirus, Macrocyclic inhibitors, Beta-strand conformation, 3CL protease

Relation: European Journal of Medicinal Chemistry;v.119; Weerawarna, Pathum M.; Kim, Yunjeong; Kankanamalage, Anushka C. Galasiti; Damalanka, Vishnu C.; Lushington, Gerald H.; Alliston, Kevin R.; Mehzabeen, Nurjahan; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. 2016. Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies. European Journal of Medicinal Chemistry, vol. 119, 25 August 2016:pp 300–318; WOS:000378433600020; http://dx.doi.org/10.1016/j.ejmech.2016.04.013; http://hdl.handle.net/10057/12302

الاتاحة: http://hdl.handle.net/10057/12302
https://doi.org/10.1016/j.ejmech.2016.04.013

المؤلفون: Bäck, Marcus, Johansson, Per-Ola, Wångsell, Fredrik, Thorstensson, Fredrik, Kvarnström, Ingemar, Ayesa, Susana, Wähling, Horst, Pelcman, Mikael, Jansson, Katarina, Lindström, Stefan, Wallberg, Hans, Classon, Björn, Rydergård, Christina, Vrang, Lotta, Hamelink, Elizabeth, Hallberg, Anders, Rosenquist, Åsa, Samuelsson, Bertil

المصدر: Bioorganic & Medicinal Chemistry. 15(22):7184-7202

مصطلحات موضوعية: Cyclopentane and Cyclopentene derived P2 templates, HCV, Macrocyclic inhibitors, NS3 protease, PHARMACY, FARMACI

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-17095

المؤلفون: Mandadapu, Sivakoteswara Rao, Weerawarna, Pathum M., Prior, Allan M., Uy, Roxanne Adeline Z., Aravapalli, Sridhar, Alliston, Kevin R., Lushington, Gerald H., Kim, Yunjeong, Hua, Duy H., Chang, Kyeong-Ok, Groutas, William C.

المساهمون: ykim, duy, kchang

مصطلحات موضوعية: Proteases, Picornavirus, Norovirus, Coronavirus, Macrocyclic inhibitors

وصف الملف: application/pdf

Relation: http://doi.org/10.1016/j.bmcl.2013.05.021; http://hdl.handle.net/2097/16411

الاتاحة: http://hdl.handle.net/2097/16411

المؤلفون: Gallo, Mariana, Bottomley, Matthew James, Pennestri, Matteo, Eliseo, Tommaso, Paci, Maurizio, Koch, Uwe, Bazzo, Renzo, Summa V, Carfi, Andrea, Cicero, Daniel O

المساهمون: Gallo, Mariana, Bottomley, Matthew, Jame, Pennestri, Matteo, Eliseo, Tommaso, Paci, Maurizio, Koch, Uwe, Bazzo, Renzo, Summa, V, Carfi, Andrea, Cicero, Daniel, O

المصدر: Virology. (2):424-438

مصطلحات موضوعية: Models, Molecular, Proteases, Macrocyclic Compounds, Magnetic Resonance Spectroscopy, Genotype, Protein Conformation, Hepatitis C virus, medicine.medical_treatment, viruses, Molecular Sequence Data, Hepacivirus, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Viral Proteins, Protein structure, Models, Virology, medicine, Humans, Protease Inhibitors, Amino Acid Sequence, Settore BIO/10, 3a genotype, NS3, Cofactor binding, Protease, Intracellular Signaling Peptides and Proteins, Molecular, Surface Plasmon Resonance, Molecular biology, NMR, NS2-3 protease, Biochemistry, HCV, Macrocyclic inhibitors, Carrier Proteins, Protein Binding, NS3 protease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa90f74c8619b169189e8f250d3ed5d