المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Characterization_of_possible_binding_of_loxapine_to_the_EV-D68_2C_hexamer_/25403257

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.s004

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Antiviral_effect_of_loxapine_succinate_on_the_propagation_of_EV-D68_dengue_virus_DV_and_hepatitis_C_virus_HCV_/25403084

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.s001

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Effect_of_loxapine_treatment_on_HAV_assembly_release_steps_/25403251

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.s002

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/dataset/Supporting_information_tables_/25403263

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.s006

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/dataset/Supporting_information_tables_/25403266

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.s007

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Morphological_effects_of_expression_of_HAV_2C_in_293T_cells_/25403254

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.s003

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Electropherograms_showing_the_sequences_on_Day_14_of_the_inoculated_virus_and_of_HAV_RNA_extracted_from_feces_of_mice_administered_once_daily_with_15_mg_kg_loxapine_/25403260

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.s005

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Loxapine_succinate_inhibits_HAV_infection_via_an_RNA_replication_step_/25403272

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.g002

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Loxapine_succinate_inhibits_HAV_propagation_in_Huh7_5_1_cells_/25403269

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.g001

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Loxapine-resistant_mutations_in_HAV_following_blind_passage_/25403275

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.g003

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Characterization_of_possible_binding_of_loxapine_to_the_HAV_2C_hexamer_/25403278

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.g004

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Efficacy_of_loxapine_succinate_treatment_in_HAV-infected_female_i_Ifnar1_i_sup_-_-_sup_mice_/25403284

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.g006

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/figure/Effects_on_HAV_replication_of_antipsychotic_compounds_that_share_the_tricyclic_structure_of_loxapine_/25403281

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.g005

المؤلفون: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, viruses containing mutations, viral rna replication, resistant mutations impede, provide novel insights, molecular dynamics simulations, inhibit viral entry, exhibited strong inhibition, div >< p, >< sup ><, loxapine inhibits replication, intrahepatic hav rna, fecal hav rna, antiviral drugs currently, loxapine succinate resulted, hav protein 2c, loxapine succinate, >, loxapine suggested, loxapine binds

Relation: https://figshare.com/articles/dataset/Summary_of_nucleotide_and_amino_acid_sequence_differences_between_the_parent_virus_and_virus_passaged_in_the_presence_of_loxapine_succinate_p8L_/25403287

الاتاحة: https://doi.org/10.1371/journal.ppat.1012091.t001