المؤلفون: Fumihito Hikage, Megumi Suzuki, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro, Megumi Watanabe

المصدر: Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

مصطلحات موضوعية: Three-dimensional (3D) cell culture, Graves’ orbitopathy, IGF-1, Orbital fibroblast, Linsitinib, M22, Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/b78fd5724ece4465be0586360b178b0f

المؤلفون: Maximilian Luffy, Anna-Lena Ganz, Stefanie Wagner, Jan Wolf, Julian Ropertz, Ryan Zeidan, Jeffrey D. Kent, Raymond S. Douglas, George J. Kahaly

المصدر: Frontiers in Immunology, Vol 15 (2024)

مصطلحات موضوعية: Linsitinib, small molecule kinase inhibitor, insulin-like growth factor 1 receptor, thyrotropin receptor, thyroid eye disease, apoptosis, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1488220/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/e92264e527924748b7fcf8e8d63e3420

المؤلفون: Diana Luísa Almeida-Nunes, João P. N. Silva, Mariana Nunes, Patrícia M. A. Silva, Ricardo Silvestre, Ricardo Jorge Dinis-Oliveira, Hassan Bousbaa, Sara Ricardo

المصدر: International Journal of Molecular Sciences ; Volume 25 ; Issue 22 ; Pages: 11935

مصطلحات موضوعية: ovarian cancer, linsitinib, IGF-1 signaling pathway, metformin, cell viability, apoptosis

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Oncology; https://dx.doi.org/10.3390/ijms252211935

الاتاحة: https://doi.org/10.3390/ijms252211935

المؤلفون: Sofia Catalina Heredia-Guerrero, Marietheres Evers, Sarah Keppler, Marlene Schwarzfischer, Viktoria Fuhr, Hilka Rauert-Wunderlich, Anne Krügl, Theodora Nedeva, Tina Grieb, Julia Pickert, Hanna Koch, Torsten Steinbrunn, Otto-Jonas Bayrhof, Ralf Christian Bargou, Andreas Rosenwald, Thorsten Stühmer, Ellen Leich

المصدر: Cancers, Vol 16, Iss 11, p 2139 (2024)

مصطلحات موضوعية: multiple myeloma, receptor tyrosine kinase signaling, IGF1R mutations, linsitinib, carfilzomib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Relation: https://www.mdpi.com/2072-6694/16/11/2139; https://doaj.org/toc/2072-6694; https://doaj.org/article/27eeda8cd3c64bb9a59f4fa9ae232270

الاتاحة: https://doi.org/10.3390/cancers16112139
https://doaj.org/article/27eeda8cd3c64bb9a59f4fa9ae232270

المؤلفون: Anne Gulbins, Mareike Horstmann, Simone Keitsch, Matthias Soddemann, Barbara Wilker, Gregory C. Wilson, Ryan Zeidan, Gary D. Hammer, Anke Daser, Nikolaos E. Bechrakis, Gina-Eva Görtz, Anja Eckstein

المصدر: Frontiers in Endocrinology, Vol 14 (2023)

مصطلحات موضوعية: bone marrow, linsitinib, autoimmunity, inflammation, small molecule IGF-1R antagonist GD: Graves’ disease, thyroid eye disease (TED), Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1252727/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/90c3d0dc549e442cbf551959731928f5

المؤلفون: Anne Gulbins, Mareike Horstmann, Anke Daser, Ulrich Flögel, Michael Oeverhaus, Nikolaos E. Bechrakis, J. Paul Banga, Simone Keitsch, Barbara Wilker, Gerd Krause, Gary D. Hammer, Andrew G. Spencer, Ryan Zeidan, Anja Eckstein, Svenja Philipp, Gina-Eva Görtz

المصدر: Frontiers in Endocrinology, Vol 14 (2023)

مصطلحات موضوعية: Graves’ disease (GD), thyroid eye disease (TED), autoimmune disorder, linsitinib, IGF-1R, inflammation, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1211473/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/917e1e39df624033b98a8d2e8cde1db7

المؤلفون: Jikui Guan, Marcus Borenäs, Junfeng Xiong, Wei-Yun Lai, Ruth H. Palmer, Bengt Hallberg

المصدر: Cancers; Volume 15; Issue 17; Pages: 4252

مصطلحات موضوعية: anaplastic lymphoma kinase, adaptor protein, lorlatinib, GSK1904529A, linsitinib

وصف الملف: application/pdf

Relation: Molecular Cancer Biology; https://dx.doi.org/10.3390/cancers15174252

الاتاحة: https://doi.org/10.3390/cancers15174252

المؤلفون: Murakami, Takashi, Singh, Arun S, Kiyuna, Tasuku, Dry, Sarah M, Li, Yunfeng, James, Aaron W, Igarashi, Kentaro, Kawaguchi, Kei, DeLong, Jonathan C, Zhang, Yong, Hiroshima, Yukihiko, Russell, Tara, Eckardt, Mark A, Yanagawa, Jane, Federman, Noah, Matsuyama, Ryusei, Chishima, Takashi, Tanaka, Kuniya, Bouvet, Michael, Endo, Itaru, Eilber, Fritz C, Hoffman, Robert M

المصدر: Oncotarget. 7(30)

مصطلحات موضوعية: Animals, Humans, Mice, Bone Neoplasms, Imidazoles, Piperazines, Pyrazines, Pyridines, Doxorubicin, Receptor, IGF Type 1, RNA-Binding Protein FUS, Oncogene Proteins, Fusion, Xenograft Model Antitumor Assays, Drug Resistance, Neoplasm, Female, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p18, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Molecular Targeted Therapy, Sarcoma, Ewing, Ewing’s sarcoma, PDOX, linsitinib, palbociclib, patient-derived orthotopic xenograft, Ewing's sarcoma, Pediatric, Pediatric Research Initiative, Orphan Drug, Cancer, Rare Diseases, Pediatric Cancer, Oncology and Carcinogenesis

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5dt3k9h8

المؤلفون: Ayelen Martin, María Celia Fernandez, Elizabeth R. Cattaneo, Claudio D. Schuster, Marcela Venara, Florencia Clément, Ariel Berenstein, Mercedes García Lombardi, Ignacio Bergadá, Mariana Gutierrez, Marcelo A. Martí, María R. Gonzalez-Baro, Patricia A. Pennisi

المصدر: Frontiers in Endocrinology, Vol 13 (2022)

مصطلحات موضوعية: OSI906, linsitinib, cell metabolism, nuclear IGF1R, high-grade glioma, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.849279/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/7510edb0b18e4e02b18bc3639f25903e

المؤلفون: Jia Kang, Zanzan Guo, Haoqi Zhang, Rongqi Guo, Xiaofei Zhu, Xiaofang Guo

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10382

مصطلحات موضوعية: dual inhibition, esophageal cancer, gefitinib, lapatinib, linsitinib

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Oncology; https://dx.doi.org/10.3390/ijms231810382

الاتاحة: https://doi.org/10.3390/ijms231810382

المؤلفون: Giulia Bresciani, Angeliki Ditsiou, Chiara Cilibrasi, Viviana Vella, Federico Rea, Marco Schiavon, Narciso Giorgio Cavallesco, Georgios Giamas, Maria Chiara Zatelli, Teresa Gagliano

المصدر: Endocrine Connections, Vol 8, Iss 6, Pp 680-690 (2019)

مصطلحات موضوعية: BP-NENs, sunitinib, IGF1R, EGFR, erlotinib, linsitinib, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: https://ec.bioscientifica.com/view/journals/ec/8/6/EC-19-0192.xml; https://doaj.org/toc/2049-3614

URL الوصول: https://doaj.org/article/bfba6096118e412693edee0a4ec7a5fb

المؤلفون: Yuki Ikeda, Ryuji Yasutake, Ryuzaburo Yuki, Youhei Saito, Yuji Nakayama

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 11; Pages: 5706

مصطلحات موضوعية: linsitinib, OSI-906, ZM447439, IGF1R, Aurora B, M phase, RO-3306

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biology; https://dx.doi.org/10.3390/ijms22115706

الاتاحة: https://doi.org/10.3390/ijms22115706

المؤلفون: Kruger, Dinja T., Alexi, Xanthippi, Opdam, Mark, Schuurman, Karianne, Voorwerk, Leonie, Sanders, Joyce, van der Noort, Vincent, Boven, Epie, Zwart, Wilbert, Linn, Sabine C.

المصدر: Kruger , D T , Alexi , X , Opdam , M , Schuurman , K , Voorwerk , L , Sanders , J , van der Noort , V , Boven , E , Zwart , W & Linn , S C 2020 , ' IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer ' , International Journal of Cancer , vol. 146 , no. 8 , pp. 2348-2359 . https://doi.org/10.1002/ijc.32668

مصطلحات موضوعية: adjuvant tamoxifen, breast cancer, IGF-1 receptor, linsitinib, PI3K/MAPK pathway, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://research.tue.nl/en/publications/7ba878ba-aaee-4e22-979a-5ec7219ba63f
https://doi.org/10.1002/ijc.32668
https://pure.tue.nl/ws/files/176397538/ijc.32668.pdf
http://www.scopus.com/inward/record.url?scp=85076555122&partnerID=8YFLogxK

المؤلفون: De Martino, Maria Cristina, van Koetsveld, Peter M., Feelders, Richard A., de Herder, Wouter W., Dogan, Fadime, Janssen, Joseph A.M.J.L., Hofste op Bruinink, Davine, Pivonello, Claudia, Waaijers, A. Marlijn, Colao, Annamaria, de Krijger, Ronald R., Pivonello, Rosario, Hofland, Leo J.

المساهمون: Pathologie Pathologen staf

مصطلحات موضوعية: Adrenal, Adrenocortical cancer, IGF, Insulin receptor, Linsitinib, Endocrinology, Diabetes and Metabolism

وصف الملف: image/pdf

Relation: https://dspace.library.uu.nl/handle/1874/392071

الاتاحة: https://dspace.library.uu.nl/handle/1874/392071

المؤلفون: Wei Li, Bing Liu, Jilin Dong, Xiaohua Lian, Yu Yu, Libin Xu, Yinying Lu, Na An, Lei Cao, Zhen Xie, Minzhen Tao, Baoxing Yang, Yajie Xu, Qiong Wu, Baoyu Le

المصدر: Cancer Biology & Medicine, Vol 19, Iss 2, Pp 229-252 (2022)

مصطلحات موضوعية: MAPK/ERK pathway, genetic interactions, cancer stemness, Cancer Research, Linsitinib, combinatorial therapy, mapki resistance, LGR5, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cilengitide, Biology, medicine.disease, chemistry.chemical_compound, Oncology, chemistry, pair-wise sgrna library, Cancer cell, medicine, Cancer research, Viability assay, RC254-282, Insulin-like growth factor 1 receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cd55576381032811280137ea1d03dc
http://www.cancerbiomed.org/index.php/cocr/article/view/1863

المؤلفون: Antelo Abeijón, Andrés

المساهمون: Araújo Vilar, David, Sánchez Iglesias, Sofía, Universidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía

مصطلحات موضوعية: Acantose nigricans, Inhibidores de IGF-1R, Acantosis nigricans, IGF1-R inhibitors, GSK3b inhibitors, Acanthosis nigricans, Insulin resistance, Rabson- Mendenhall, Resistencia á insulina, Expresión xénica, Resistencia a la insulina, Rabson-Mendenhall syndrome, Insulina, Cultivo celular, IGF-1, Inhibidores de GSK3b, Insulin, Cell culture, Gene expression, Síndrome de Rabson-Mendenhall, CHIR99021, IGF-1R, Linsitinib, Expresión génica

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1601::114458fc364c6b42f5d140cd01d988bf
https://hdl.handle.net/10347/29680

المؤلفون: Mingyue Chen, Juming Yu, Guohui Jiang, Shun-Xian Wang, Xiaoming Wang, Xiaomi Ding, Shenglin Wang, Wei-Wei He, Wang Li

المصدر: Acta Epileptologica, Vol 3, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: IGF-1 receptor, Linsitinib, medicine.medical_specialty, Glucose uptake, Context (language use), chemistry.chemical_compound, Internal medicine, medicine, Akt signaling, Receptor, RC346-429, Protein kinase B, General Environmental Science, Epilepsy, biology, Akt/PKB signaling pathway, Energy metabolism, Mitochondria, Insulin receptor, Endocrinology, chemistry, biology.protein, General Earth and Planetary Sciences, Epileptic seizure, Neurology. Diseases of the nervous system, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3bcfa6a2029b62c38fd467dcb5585d
https://doaj.org/article/31bfc93d254f4426bafa44e3385f6630

المؤلفون: Yonglu Wu, Zijun Xuan, Xianxi Chen, Shuitong Huang, Zhiqin Li, Guobin Tan, Aiming Wu, Zhijin Liang, Guangming Chen

المصدر: Transl Androl Urol

مصطلحات موضوعية: 0301 basic medicine, BAP1, Mutation, Linsitinib, Urology, Wild type, Cancer, Genomics, Biology, medicine.disease, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Reproductive Medicine, chemistry, 030220 oncology & carcinogenesis, medicine, Cancer research, Original Article, KEGG, Gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81bd6e9dc4836af87b20d7f5646bc64
https://doi.org/10.21037/tau-20-1079

المؤلفون: Tian-En Li, Jimeng Yang, Bei-Yuan Hu, Da Xu, Qiongzhu Dong, Chaoqun Wang, Ze Zhang, Feng Yang, Christiane Bruns, Shican Yan, Peter J. Nelson, Min Xue, Yan Zheng, Deliang Fu, Hu-Liang Jia, Yue Zhao, Lun-Xiu Qin, Xuan Wang, Chao Wu

المصدر: Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-14 (2020)
Signal Transduction and Targeted Therapy

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Linsitinib, endocrine system diseases, lcsh:Medicine, Article, Histone Deacetylases, Metastasis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Genetics, medicine, Humans, Insulin-Like Growth Factor I, Neoplasm Metastasis, Protein kinase B, lcsh:QH301-705.5, PI3K/AKT/mTOR pathway, Chemistry, lcsh:R, HDAC3, medicine.disease, Cancer metabolism, Neoplasm Proteins, Pancreatic Neoplasms, Enolase 2, 030104 developmental biology, PCAF, lcsh:Biology (General), Acetylation, Phosphopyruvate Hydratase, 030220 oncology & carcinogenesis, Cancer research, Female, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35816b03dd3b2fb9beebd921de216daf
http://link.springer.com/article/10.1038/s41392-020-0146-6

المؤلفون: Michaela Luconi, Massimo Mannelli, Andreea Liliana Serban, Rosa Catalano, Donatella Treppiedi, Francesca Elli, Erika Peverelli, Giovanna Mantovani, Anna Spada, Valentina Morelli, Elena Giardino, Maura Arosio, Federica Mangili

المصدر: Cancer letters. 497

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Linsitinib, medicine.medical_treatment, Filamins, Apoptosis, Filamin, Receptor, IGF Type 1, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin-Like Growth Factor II, medicine, Adrenocortical Carcinoma, Biomarkers, Tumor, Tumor Cells, Cultured, Gene silencing, FLNA, Humans, Pyrroles, Autocrine signalling, Insulin-like growth factor 1 receptor, Cell Proliferation, Cell growth, Growth factor, Imidazoles, Adrenal Cortex Neoplasms, Receptor, Insulin, body regions, Gene Expression Regulation, Neoplastic, Actin Cytoskeleton, 030104 developmental biology, adrenocortical carcinoma, growth factors, cytoskeleton, linsitinib, NVP-ADW742, Pyrimidines, Oncology, chemistry, 030220 oncology & carcinogenesis, Pyrazines, Cancer research, Mitogens, Adrenocortical carcinoma, Cytoskeleton, Growth factors, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6e4184d062de5492bf009f17dbf51d
https://pubmed.ncbi.nlm.nih.gov/33075426