المؤلفون: Meng Shi, Wei Xiong, Jie Feng, Lihe Wu, Jing Yang, Yudie Lu, Xuanyi Lu, Qingdeng Fan, Hemin Nie, Yunlu Dai, Chenggong Yan, Ye Tian, Zheyu Shen

المصدر: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)

مصطلحات موضوعية: Contrast agents (CAs), Kilogram scale facile synthesis, Remarkable relaxivity, Magnetic resonance imaging (MRI), Excellent biocompatibility, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1477-3155

URL الوصول: https://doaj.org/article/26466d6c6212429f975df70f55fc70a1

المؤلفون: Yongda Zhang, Eugene Chong, Jada A. H. White, Suttipol Radomkit, Yibo Xu, Stephanie C. Kosnik, Qi Jiang, Jon C. Lorenz

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Molecular Biology, Pharmacology, Immunology, Developmental Biology, Computational Biology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, telescopic chemical process, scale chemical process, achieve process sustainability, multiple kilogram scale, chiral spirocyclic isoxazolone, 1 , spirocyclic isoxazolone, scalable process, 1 er, simple operation, ray analysis, overall yield, four steps, facile synthesis, crystalline solid, crystal x, 160 kg

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_Kilogram-Scale_Chemical_Process_for_a_Chiral_Spirocyclic_Isoxazolone/25260802

الاتاحة: https://doi.org/10.1021/acs.oprd.4c00008.s001
https://figshare.com/articles/journal_contribution/Development_of_a_Kilogram-Scale_Chemical_Process_for_a_Chiral_Spirocyclic_Isoxazolone/25260802

المؤلفون: Gen-Qiang Chen, Renwei Xiao, Xiaobing Ding, Jiang Wang, Baode Ma, Qiwei Lang, Xumu Zhang

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, showed excellent reactivity, resulting ruthenium catalyst, step coupling protocol, step synthesis, kilogram scale, key intermediate, industrial scale, highly practical, asymmetric hydrogenation, >- sdp

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_One-Step_Synthesis_of_oxa-Spirocyclic_Diphosphine_Ligands_Driven_by_Their_Application_in_the_Industrial_Synthesis_of_Sacubitril/25008640

الاتاحة: https://doi.org/10.1021/acs.orglett.3c03536.s001
https://figshare.com/articles/journal_contribution/Development_of_a_One-Step_Synthesis_of_oxa-Spirocyclic_Diphosphine_Ligands_Driven_by_Their_Application_in_the_Industrial_Synthesis_of_Sacubitril/25008640

المؤلفون: Rajashri B. Jundale, Bhagavatula L. V. Prasad, R. Nandini Devi, Amol A. Kulkarni

مصطلحات موضوعية: Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Ecology, Inorganic Chemistry, Infectious Diseases, Virology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, numerous morphological aspects, mesoporous silica particles, kilogram scale using, 1000 nm produced, pore swelling agent, continuous flow synthesis, large scale production, high yield production, narrow size distribution, pore diameter, continuous process, variable size, tunable size, particle size, way toward, tubular reactor, surfactant concentration, surface area

Relation: https://figshare.com/articles/journal_contribution/Continuous_Flow_Synthesis_of_Mesoporous_Silica_Particles_with_Tunable_Size_and_Structure/25015944

الاتاحة: https://doi.org/10.1021/acs.iecr.3c03304.s001
https://figshare.com/articles/journal_contribution/Continuous_Flow_Synthesis_of_Mesoporous_Silica_Particles_with_Tunable_Size_and_Structure/25015944

المؤلفون: Jing-Jing Xiang, Bi-Bo Jiang, Wen-Qing Sun, Fu-Li Zhang, Jun Yu

المصدر: Pharmaceutical Fronts, Vol 05, Iss 02, Pp e84-e90 (2023)

مصطلحات موضوعية: cangrelor, 2-thioadenosine monohydrate, a kilogram scale, impurities, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2628-5088; https://doaj.org/toc/2628-5096

URL الوصول: https://doaj.org/article/84ac302ac52342e18adca1845399ef69

المؤلفون: Katie Brown, Yun Huang, Kevin Knopf, Bryan Li, Martha A. Ornelas, Rebecca B. Watson

مصطلحات موضوعية: Biophysics, Medicine, Ecology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, production process constraints, operating temperature range, internal demand facilitated, developing synthetic methods, continuous flow procedure, 120 ° c, dibromopyrazole multiple methods, − 20, vendor pool, regioselective dehalogenation, readily available, pot saponification, lowering cost, kilogram scale, carboxylate ester, alternative method

Relation: https://figshare.com/articles/journal_contribution/Evaluation_and_Removal_of_Production_Process_Constraints_in_the_Synthesis_of_3_5-Dibromopyrazole/24877786

الاتاحة: https://doi.org/10.1021/acs.oprd.3c00309.s001
https://figshare.com/articles/journal_contribution/Evaluation_and_Removal_of_Production_Process_Constraints_in_the_Synthesis_of_3_5-Dibromopyrazole/24877786

المؤلفون: W. David Hong (1283970), Paul M. O’Neill (1283988), Mark J. Taylor (7252553), Joseph D. Turner (7252550), Stephen A. Ward (250279), Fabian Gusovsky (6755774), Farid Benayoud (2664238), Nao Shibuguchi (14373555), Dixit Girish (11436246), Francis Gerard Fang (14373558), Ravi Kumar Talabhakthla (14373561), Anand Vaddi (11436258), Chiranjeevi Challa (14373564), Karri Satya Ammi Reddy (14373567), Vijay Kalla (11436270), Sugandham Srinivasa Rao (14373570), Durga Mahesh Kumar Nagireddi (14373573), Jayesh Patel (14373576), Anil Shahaji Khile (11436249)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Neuroscience, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Computational Biology, Information Systems not elsewhere classified, optimized production route, active pharmaceutical ingredient, process development work, ongoing clinical development, filariasis anti -<, drug candidate developed, clinical development, drug candidate, clinical candidate, 3 -<, scalable process, manufacturing process, lymphatic filariasis, human filariasis, safe approach, presented herein, kilogram scale, delivering high, clinically proven

Relation: https://figshare.com/articles/journal_contribution/Transformation_of_the_Manufacturing_Process_from_Discovery_to_Kilogram_Scale_for_AWZ1066S_A_Highly_Specific_Anti-_i_Wolbachia_i_Drug_Candidate_for_a_Short-Course_Treatment_of_Filariasis/21859392

الاتاحة: https://doi.org/10.1021/acs.oprd.2c00167.s001

المؤلفون: Stephen P. Lathrop (2174966), Laurie B. Mlinar (14259520), Onkar N. Manjrekar (14259523), Yong Zhou (23772), Kaid C. Harper (1990219), Eric R. Sacia (1930018), Molly Higgins (14259526), Andrew R. Bogdan (2178564), Zhe Wang (41178), Steven M. Richter (1867810), Wei Gong (112494), Eric A. Voight (2243263), Jeremy Henle (7905863), Moiz Diwan (6900881), Jeffrey M. Kallemeyn (1479613), Jack C. Sharland (8196453), Bo Wei (188204), Huw M. L. Davies (8082566)

مصطلحات موضوعية: Genetics, Evolutionary Biology, Inorganic Chemistry, Infectious Diseases, Computational Biology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, − 729 j, maintain water levels, efficiently removed via, catalyzed enantioselective cyclopropanation, also minimizing accumulation, 30 ° c, organic soluble base, final aryldiazoacetate solution, enables direct use, generating flow process, 100 g scale, onset , direct use, organic layer, kilogram scale, g ), flow process, 100 ppm, >< sub, , wider application

Relation: https://figshare.com/articles/journal_contribution/Continuous_Process_to_Safely_Manufacture_an_Aryldiazoacetate_and_Its_Direct_Use_in_a_Dirhodium-Catalyzed_Enantioselective_Cyclopropanation/21726886

الاتاحة: https://doi.org/10.1021/acs.oprd.2c00288.s001

المؤلفون: Xiaogen Yang (8763636), Zhiwen Li (1349109), Wenwen Xu (175846), Guanming Zhu (14307546), Xiantong Feng (14307549), Jun Zhang (48506), Hongbin Zhao (3210261), Yuyin Chen (1315206), Jianshe Kong (1670494), Wanping Mai (4738713), Lian-Sheng Li (2676301), Daniel J. Pippel (1562482), Pingda Ren (2983428), Xiaohu Deng (1490398)

مصطلحات موضوعية: Biochemistry, Neuroscience, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, “ early cross, global deprotection followed, generation covalent kras, effective chiral resolution, coupling ” strategy, atropisomeric covalent kras, subsequent diastereomeric crystallization, g12c , diastereomeric enrichment, successfully executed, scaleup route, kilogram scale, key intermediate, inhibitor ars, free sequence, excellent yield

Relation: https://figshare.com/articles/journal_contribution/Hindered_Biaryl_Bond_Construction_and_Subsequent_Diastereomeric_Crystallization_to_Produce_an_Atropisomeric_Covalent_KRAS_sup_G12C_sup_Inhibitor_ARS-2102/21787311

الاتاحة: https://doi.org/10.1021/acs.oprd.2c00335.s001

المؤلفون: Yulei Ma (4031771), Xuecheng Jiao (11977732), Zujian Wang (3740038), Huiyan Mu (11977735), Kaihua Sun (11977738), Xiang Li (114679), Tong Zhao (17215), Xufeng Liu (292685), Na Zhang (333280)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, poor substrate acceptance, >- cyclohepta ­[<, detectable trace activity, detectable activity toward, difluorophenyl )- 6, difluorophenyl )- 9, 6 -( 2, >, whole sequence, random mutagenesis, pharmaceutical intermediates, major drawback, kilogram scale, key loop, key intermediate, industrial application, increasingly utilized, hplc purity, gram scale, enzyme variant

Time: 6, 9

Relation: https://figshare.com/articles/journal_contribution/Engineering_a_Transaminase_for_the_Efficient_Synthesis_of_a_Key_Intermediate_for_Rimegepant/18769840

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00376.s001

المؤلفون: Arul Pundi, Chi-Jung Chang

المصدر: Polymers; Volume 14; Issue 11; Pages: 2153

مصطلحات موضوعية: carbon dot, doped, kilogram-scale fabrication, photoluminescence, electron transfer, NEXAFS, sensor, photocatalyst, bioimaging

وصف الملف: application/pdf

Relation: Polymer Processing and Engineering; https://dx.doi.org/10.3390/polym14112153

الاتاحة: https://doi.org/10.3390/polym14112153

المؤلفون: Cheng-Wei Li, Cai Wang, Chao Guo, Bin-Hua Lv, You-Fu Luo

المصدر: Pharmaceutical Fronts, Vol 03, Iss 02, Pp e56-e64 (2021)

مصطلحات موضوعية: obeticholic acid, four-step process, amide intermediate, kilogram-scale production, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2628-5088; https://doaj.org/toc/2628-5096

URL الوصول: https://doaj.org/article/eb759f86d1414c6fa586cd7430102e6a

المؤلفون: Jianpeng Yin (2112994), Desheng Zhan (11485020), Hui Ma (290168), Huanan Liu (10644772), Lifang Yu (10525814), Yangming Zhang (11485023), Fajun Nan (1426045)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Immunology, Developmental Biology, Infectious Diseases, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, treat metabolic diseases, mild reaction conditions, effective impurities purging, activated protein kinase, 0 – 3, scalable process, residual solvents, reperfusion injury, process successfully, process features, preclinical study, potent amp, myocardial ischemia, miri ), low levels, kilogram scale, api ), 17 kg

Relation: https://figshare.com/articles/journal_contribution/Optimization_and_Development_of_a_Scalable_Palladium-Catalyzed_C_H_Activation_Process_for_the_Geometry-Selective_Preparation_of_Kilograms_of_YLF466D_a_Potent_AMP-Activated_Protein_Kinase_Activator/16685451

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00150.s001

المؤلفون: Seong Taek Kim (11835091), Yongseo Park (11835094), Namhyeon Kim (3336699), Jaeun Gu (11835097), Wongyoung Son (11835100), Jisu Hur (11835103), KangHee Lee (11835106), Areum Baek (9570743), Ju Young Song (11835109), U Bin Kim (1997866), Kee-Young Lee (2374432), Chang-Young Oh (561130), Seokhwi Park (9869171), Hyunik Shin (2117641)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Molecular Biology, Neuroscience, Ecology, Marine Biology, Mental Health, Infectious Diseases, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, vinyl epoxide provides, mediated 6 -<, crystalline tetrahydropyran intermediate, tet <, precedent sequence, lactol intermediate, kilogram scale, improved kilogram, endo <, bicyclic motif

Relation: https://figshare.com/articles/journal_contribution/Synthesis_of_the_C1_C13_Fragment_of_Eribulin_on_a_Kilogram_Scale/17197972

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00295.s001

المؤلفون: Helong Liang (6861425), Ganzhong Li (6861428), Lei Zhang (38117), Gefei Wang (498248), Mingyu Song (9182187), Heng Li (6476), Bingxin Yuan (1345323)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Ecology, Developmental Biology, Infectious Diseases, Chemical Sciences not elsewhere classified, workup procedure, unsymmetrical, acyl isocyanate, amidine, Strategy, production cost, Chlorination, variety, Scalable, Unsymmetrical Trisubstituted, method, Triazine, scalability, trisubstituted, multi-kilogram-scale synthesis, substituent, nucleophile, amide, triazinone

Relation: https://figshare.com/articles/journal_contribution/Scalable_Synthetic_Strategy_for_Unsymmetrical_Trisubstituted_i_s_i_Triazines/14980443

الاتاحة: https://doi.org/10.1021/acs.orglett.1c01970.s001

المؤلفون: Yasinalli Tamboli (9293172), Bharat B. Kashid (10270553), Ram Prasad Yadav (9293178), Mohammad Rafeeq (832467), Ravindra Yeole (5125163), Arvind Y. Merwade (10826253)

مصطلحات موضوعية: Biochemistry, Genetics, Ecology, Developmental Biology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, chromatography-free process, purge triphenylphosphine oxide, reaction mixture, Wittig reactions, Triphenylphosphine Oxide Removal, pilot plant, TPPO, crude product, physicochemical properties, kilogram scale

Relation: https://figshare.com/articles/journal_contribution/Triphenylphosphine_Oxide_Removal_from_Reactions_The_Role_of_Solvent_and_Temperature/14621067

الاتاحة: https://doi.org/10.1021/acsomega.1c01996.s001

المؤلفون: Aaron F. Baldwin (10531615), Michaella A. Caporello (10531618), Guoyong Chen (2629909), Adam E. Goetz (1309353), Weifeng Hu (1372167), Chengfeng Jin (10517273), Kevin M. Knopf (6620207), Zhifeng Li (1776799), Cuong V. Lu (2999454), Sebastien Monfette (1608055), Angela L. A. Puchlopek-Dermenci (3865009), Feng Shi (305643)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sequence, alternative route, nitro reduction, viability, genotoxic impurities, copper-catalyzed amidation, hydrogenation equipment, target compound, Copper-Catalyzed Aryl Amidation, impurity, ammonia, intermediate, nitration, Kilogram-Scale Preparation, scalable method, acetamide, Aminopyrazole Building Block, kg, procedure

Relation: https://figshare.com/articles/journal_contribution/Kilogram-Scale_Preparation_of_an_Aminopyrazole_Building_Block_via_Copper-Catalyzed_Aryl_Amidation/14378737

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00066.s001

المؤلفون: Yuanchao Xie (1730734), Tianwen Hu (3278730), Yan Zhang (8098), Daibao Wei (10324033), Wei Zheng (25452), Fuqiang Zhu (2937369), Guanghui Tian (2012824), Haji A. Aisa (8269605), Jingshan Shen (1601962)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Neuroscience, Ecology, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, health crisis, Practical Synthesis, Weinreb amidation, Weinreb amide approach, scalable production, Adequate supplies, remdesivir, Grignard addition, Key Remdesivir Intermediate, TMS protection, glycosylation step, kilogram scale, sequential steps, overaddition side reactions, COVID -19 treatment

Relation: https://figshare.com/articles/journal_contribution/Weinreb_Amide_Approach_to_the_Practical_Synthesis_of_a_Key_Remdesivir_Intermediate/14237116

الاتاحة: https://doi.org/10.1021/acs.joc.0c02986.s001

المؤلفون: Aminul Islam (446588), Biswajyoti Mukherjee (6238949), Krishna Kant Pandey (6911321), Anup Kumar Keshri (6238952)

مصطلحات موضوعية: Biophysics, Physiology, Developmental Biology, Marine Biology, Science Policy, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, quality graphene, High Quality Exfoliated Graphene, sub-kilogram scale, plasma spray technique, quality graphene sheets, two-stage shear, ultrafast exfoliation, Mass Production, energy storage devices, exfoliated graphene, conductive coatings, New discoveries face, basal defect, plasma spray exfoliated graphene

Relation: https://figshare.com/articles/journal_contribution/Ultra-Fast_Chemical-Free_Mass_Production_of_High_Quality_Exfoliated_Graphene/13581195

الاتاحة: https://doi.org/10.1021/acsnano.0c09451.s001

المؤلفون: Giuseppina Sabatino (1383063), Annunziata D’Ercole (9909666), Lorenzo Pacini (9909669), Matteo Zini (9909672), Arianna Ribecai (2265907), Alfredo Paio (1738870), Paolo Rovero (1344753), Anna Maria Papini (694904)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Automated Solid-Phase Microwave-Ass., on-resin strategies, kilogram-scale manufacturing, microwave-assisted solid-phase pept., solution, optimized scalable, reactor procedure, disulfide-bridged cyclo-heptapeptid., oxidation byproducts, MPA, antithrombotic agent, CH 3 CN, thiol side-chain, MW-SPPS, latter strategy, Eptifibatide ring, disulfide formation, cysteine side-chain amide bond form., C-terminal Cys residue, disulfide formation procedure, solid-phase microwave-assisted cGMP.

Relation: https://figshare.com/articles/online_resource/An_Optimized_Scalable_Fully_Automated_Solid-Phase_Microwave-Assisted_cGMP-Ready_Process_for_the_Preparation_of_Eptifibatide/13584709

الاتاحة: https://doi.org/10.1021/acs.oprd.0c00490.ls01