المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/journal_contribution/Summary_of_published_renal_dosing_guidelines_and_contraindications_for_metformin_/14056295

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.s001

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/journal_contribution/Determination_of_creatinine_clearance_and_eGFR_metrics_/14056304

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.s004

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/journal_contribution/Study_details_for_the_analysed_data_/14056298

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.s002

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/journal_contribution/Pharmacokinetic_analysis_of_the_metformin_data_/14056301

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.s003

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/journal_contribution/Evaluation_of_the_implemented_PK_model_/14056307

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.s005

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/journal_contribution/Regression_analysis_details_/14056310

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.s006

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/figure/Fig_1_-/14056313

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.g001

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/dataset/The_upper_and_lower_values_of_eGFR_or_CLcr_used_to_predict_metformin_clearance_/14056316

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.t001

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/dataset/Predicted_metformin_maintenance_doses_at_the_upper_and_lower_bounds_of_each_CKD_category_/14056322

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.t003

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/dataset/Demographics_of_the_study_subjects_used_in_the_analyses_/14056319

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.t002

المؤلفون: Isabelle H. S. Kuan (10164167), Luke C. Wilson (10164170), Jed C. Leishman (10164173), Samuel Cosgrove (10164176), Robert J. Walker (7207727), Tracey L. Putt (10164179), John B. W. Schollum (10164182), Daniel F. B. Wright (10164185)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Marine Biology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CKD, MDRD, kidney function levels, r 2, plasma metformin concentration, safety, lactic acidosis risk, metformin dosing strategy, metformin pharmacokinetic model, mg, metformin clearance, kidney function estimates, kidney function, efficacy, maintenance dose range

Relation: https://figshare.com/articles/dataset/The_fraction_of_predicted_metformin_C_sub_ss_ave_sub_and_C_sub_max_sub_concentrations_exceeding_the_safety_targets_/14056325

الاتاحة: https://doi.org/10.1371/journal.pone.0246247.t004