المؤلفون: Guillaume Mata (1685596), Dillon H. Miles (8962160), Samuel L. Drew (8682102), Jeremy Fournier (3594275), Kenneth V. Lawson (2391673), Artur K. Mailyan (1588903), Ehesan U. Sharif (6847676), Xuelei Yan (1698157), Joel W. Beatty (1328199), Jesus Banuelos (4036886), Jie Chen (5892), Elaine Ginn (2124058), Ada Chen (1698127), Kimberline Y. Gerrick (6061382), Amber T. Pham (8682105), Kent Wong (2160739), Divyank Soni (9383865), Puja Dhanota (6506090), Stefan G. Shaqfeh (9383868), Cesar Meleza (6899225), Nell Narasappa (11592941), Hema Singh (11592944), Xiaoning Zhao (184301), Lixia Jin (1570120), Ulrike Schindler (9383871), Matthew J. Walters (296691), Stephen W. Young (7022015), Nigel P. Walker (8682108), Manmohan Reddy Leleti (8682111), Jay P. Powers (1721107), Jenna L. Jeffrey (2029015)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, early lead series, tumor immune microenvironment, significant immune response, molecular docking studies, selective pi3kγ inhibitors, pyrazolopyrimidine amide inhibitors, 56 , immune cells, vitro <, studies indicate, pyrazolopyrimidine isoindolinones, optimal amide, metabolic stability, m1 macrophages, like properties, kinase γ, isoindolinone substituents, inflammatory phenotype, inflammatory mediators, increasing pro, highly potent, highly expressed, favorable drug

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Structure_Activity_Relationship_Optimization_of_Pyrazolopyrimidine_Amide_Inhibitors_of_Phosphoinositide_3_Kinase_PI3K_/16850249

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01153.s001

المؤلفون: Guillaume Mata (1685596), Dillon H. Miles (8962160), Samuel L. Drew (8682102), Jeremy Fournier (3594275), Kenneth V. Lawson (2391673), Artur K. Mailyan (1588903), Ehesan U. Sharif (6847676), Xuelei Yan (1698157), Joel W. Beatty (1328199), Jesus Banuelos (4036886), Jie Chen (5892), Elaine Ginn (2124058), Ada Chen (1698127), Kimberline Y. Gerrick (6061382), Amber T. Pham (8682105), Kent Wong (2160739), Divyank Soni (9383865), Puja Dhanota (6506090), Stefan G. Shaqfeh (9383868), Cesar Meleza (6899225), Nell Narasappa (11592941), Hema Singh (11592944), Xiaoning Zhao (184301), Lixia Jin (1570120), Ulrike Schindler (9383871), Matthew J. Walters (296691), Stephen W. Young (7022015), Nigel P. Walker (8682108), Manmohan Reddy Leleti (8682111), Jay P. Powers (1721107), Jenna L. Jeffrey (2029015)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, early lead series, tumor immune microenvironment, significant immune response, molecular docking studies, selective pi3kγ inhibitors, pyrazolopyrimidine amide inhibitors, 56 , immune cells, vitro <, studies indicate, pyrazolopyrimidine isoindolinones, optimal amide, metabolic stability, m1 macrophages, like properties, kinase γ, isoindolinone substituents, inflammatory phenotype, inflammatory mediators, increasing pro, highly potent, highly expressed, favorable drug

Relation: https://figshare.com/articles/dataset/Design_Synthesis_and_Structure_Activity_Relationship_Optimization_of_Pyrazolopyrimidine_Amide_Inhibitors_of_Phosphoinositide_3_Kinase_PI3K_/16850252

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01153.s002

المؤلفون: Guillaume Mata (1685596), Dillon H. Miles (8962160), Samuel L. Drew (8682102), Jeremy Fournier (3594275), Kenneth V. Lawson (2391673), Artur K. Mailyan (1588903), Ehesan U. Sharif (6847676), Xuelei Yan (1698157), Joel W. Beatty (1328199), Jesus Banuelos (4036886), Jie Chen (5892), Elaine Ginn (2124058), Ada Chen (1698127), Kimberline Y. Gerrick (6061382), Amber T. Pham (8682105), Kent Wong (2160739), Divyank Soni (9383865), Puja Dhanota (6506090), Stefan G. Shaqfeh (9383868), Cesar Meleza (6899225), Nell Narasappa (11592941), Hema Singh (11592944), Xiaoning Zhao (184301), Lixia Jin (1570120), Ulrike Schindler (9383871), Matthew J. Walters (296691), Stephen W. Young (7022015), Nigel P. Walker (8682108), Manmohan Reddy Leleti (8682111), Jay P. Powers (1721107), Jenna L. Jeffrey (2029015)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, early lead series, tumor immune microenvironment, significant immune response, molecular docking studies, selective pi3kγ inhibitors, pyrazolopyrimidine amide inhibitors, 56 , immune cells, vitro <, studies indicate, pyrazolopyrimidine isoindolinones, optimal amide, metabolic stability, m1 macrophages, like properties, kinase γ, isoindolinone substituents, inflammatory phenotype, inflammatory mediators, increasing pro, highly potent, highly expressed, favorable drug

Relation: https://figshare.com/articles/dataset/Design_Synthesis_and_Structure_Activity_Relationship_Optimization_of_Pyrazolopyrimidine_Amide_Inhibitors_of_Phosphoinositide_3_Kinase_PI3K_/16850255

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01153.s003