المؤلفون: Manel BenAissa, Gregory R. J. Thatcher, Marton I. Siklos

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 6, Pp 506-519 (2015)

مصطلحات موضوعية: AD, Alzheimer׳s disease, APP/PS1, Aβ overexpressing mice APP (K670N/M671L) and PS1 (M146L) mutants, Review, Cdk5/p35, activator of cyclin-dependent kinase 5, NFT, neurofibrilliary tangles, Cathepsin B, Deubiquitinating enzyme, AppSwe, Swedish amyloid precursor protein mutation, APP (K670N/M671L), Aβ1-42, amyloid β, 42 amino acid protein, AppLon, London familial amyloid precursor protein mutation, APP (V717I), Met, methionine, GSH, glutathione, BACE-1, β-amyloid cleaving enzyme, General Pharmacology, Toxicology and Pharmaceutics, CREB, cyclic adenosine monophosphate response element binding protein, BBB, blood–brain barrier, Hsp70.1, heat shock protein 70.1, PD, Parkinson׳s disease, Caspase, Glu, glutamic acid, TNF, tumor necrosis factor, biology, Alzheimer׳s disease, Chemistry, Calpain, Enzyme inhibitors, ALS, amyotrophic lateral sclerosis, Cysteine protease, isoAsp, isoaspartate, PTP1B, protein-tyrosine phosphatase 1B, Biochemistry, SP, senile plaques, Gln, glutamine, Pro, proline, Val, valine, Phe, phenylalanine, Lys, lysine, Proteases, Aβ, amyloid β, pGlu, pyroglutamate, Thr, threonine, WRX, Trp-Arg containing epoxysuccinate cysteine protease inhibitor, CNS, central nervous system, PK, pharmacokinetic, CaMKII, Ca2+/calmodulin-dependent protein kinases II, TBI, traumatic brain injury, Leu, leucine, Cathepsin, Ala, alanine, MAP-2, microtubule-associated protein 2, APP, amyloid precursor protein, PKC, protein kinase C, WT, wildtype, pyroGluAβ, pyroglutamate-amyloid β, Neurodegeneration, Nle, norleucine, Ile, isoleucine, MMP-9, matrix metalloproteinase 9, Arg, arginine, KO, knockout, CANP, calcium-activated neutral protease, lcsh:RM1-950, Tyr, tyrosine, ERK1/2, extracellular signal-regulated kinase 1/2, EGFR, epidermal growth factor receptor, lcsh:Therapeutics. Pharmacology, biology.protein, DTT, dithioerythritol, Gly, glutamine, Cysteine

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