المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/journal_contribution/Description_of_models_and_their_simulation_using_i_COPASI_i_/14383336

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.s004

المؤلفون: Kerr, Katelyn A, Kaur, Nirmal, Jafri, Syed-Mohammed

المصدر: Gastroenterology Meeting Abstracts

مصطلحات موضوعية: adalimumab, endogenous compound, infliximab, prednisone, tacrolimus, tumor necrosis factor, vedolizumab, adult, apoptosis, autoimmune disease, case report, chronic inflammation, clinical article, conference abstract, diagnosis, diarrhea, drug megadose, drug therapy, duodenitis, erosion, esophagogastroduodenoscopy, female, hospitalization, human, human cell, human tissue, hyperplasia, intestine cell, intestine villus atrophy, metaplasia

Relation: https://scholarlycommons.henryford.com/gastroenterology_mtgabstracts/157; https://sladenlibrary.hfhs.org/login?url=https://www.embase.com/search/results?subaction=viewrecord&id=L636473036&from=export

الاتاحة: https://scholarlycommons.henryford.com/gastroenterology_mtgabstracts/157
https://sladenlibrary.hfhs.org/login?url=https://www.embase.com/search/results?subaction=viewrecord&id=L636473036&from=export

المؤلفون: Zupancic T., Stojan J., Lane E.B., Komel R., Bedina-Zavec A., Liovic M.

المساهمون: PATHOLOGY

المصدر: Unpaywall 20191101

مصطلحات موضوعية: claudin 4, cytokeratin 18, cytokeratin 8, protein ZO1, cell extract, amino acid substitution, article, cell function, cell membrane permeability, controlled study, cytokeratin 18 gene, cytokeratin 8 gene, dissociation constant, gene mutation, genetic association, growth rate, heat stress, human, human cell, in vitro study, inflammatory bowel disease, intestine cell, molecular model, permeability barrier, protein localization, cell proliferation, chemical structure, genetics, heat shock response, hydrogen bond

Relation: Zupancic T., Stojan J., Lane E.B., Komel R., Bedina-Zavec A., Liovic M. (2014). Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease. PLoS ONE 9 (6) : e99398. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0099398; https://scholarbank.nus.edu.sg/handle/10635/161405

الاتاحة: https://scholarbank.nus.edu.sg/handle/10635/161405

المؤلفون: Werf, C.S. (Christine) van der, Hsiao, N.H. (Nai-Hua), Conroy, S. (Siobhan), Paredes, J. (Joana), Ribeiro, A.S. (Ana), Sribudiani, Y. (Yunia), Seruca, R. (Raquel), Hofstra, R.M.W. (Robert), Westers, H. (Helga), IJzendoorn, S.C.D. (Sven) van

المصدر: PLoS ONE vol. 8 no. 2

مصطلحات موضوعية: animal cell, article, cell adhesion, cell aggregation, cell maturation, cell migration, cell proliferation, cell viability, controlled study, epithelium cell, flow cytometry, human, human cell, intestine cell, missense mutation, nonhuman, organogenesis, plasmid, polymerase chain reaction, protein analysis, protein function, signal transduction

وصف الملف: application/pdf

Relation: http://repub.eur.nl/pub/40862; urn:hdl:1765/40862

الاتاحة: http://repub.eur.nl/pub/40862
https://doi.org/10.1371/journal.pone.0054649

المؤلفون: Qing Chu, Weiwei Zheng, Tianjun Xu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, PRR, pattern recognition receptor, Regulator, Gene Expression, Apoptosis, MDP, muramyl dipeptide, Biochemistry, chemistry.chemical_compound, Nod1 Signaling Adaptor Protein, ceRNA, competing endogenous RNA, NOD1, NLR, nucleotide-binding oligomerization domain-like receptor, microRNA, Pattern recognition receptor, NF-kappa B, RIP, RNA immunoprecipitation, Cell biology, RNA, Long Noncoding, MIC, M. miiuy intestine cell, Signal Transduction, Research Article, China, NARL, NOD1 antibacterial and antiviral-related lncRNA, NF-κB, nuclear factor-κB, Biology, 03 medical and health sciences, Downregulation and upregulation, EPC, Epithelioma papulosum cyprinid, Animals, long noncoding RNA, Molecular Biology, Cell Proliferation, Innate immune system, 030102 biochemistry & molecular biology, Competing endogenous RNA, NOD1, nucleotide oligomerization domain 1, NF-κB, Cell Biology, ceRNA, Immunity, Innate, immune responses, Perciformes, body regions, MicroRNAs, 030104 developmental biology, chemistry, Gene Expression Regulation, bacteria, LPS, lipopolysaccharides, SCRV, Siniperca chuatsi rhabdovirus, Interferon Regulatory Factor-3, lncRNA, long noncoding RNA, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fac645ca72615a90187f4787db1734
https://pubmed.ncbi.nlm.nih.gov/33581111

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/dataset/Metformin_concentration_time-series_data_for_nine_healthy_individuals_from_Zaharenko_et_al_2016_/14383333

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.s003

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Distribution_of_metformin_amount_over_tissues_that_contain_more_than_2_of_the_absorbed_amount_of_metformin_at_PO_dose_500_mg_/14383357

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g006

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Metformin_concentration_time-courses_in_major_compartments_of_metformin_action_/14383354

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g005

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/dataset/Human_and_mice_model_files_in_SBML_and_COPASI_formats_equations_and_experimental_data_files_for_parameter_fitting_and_validation_/14383339

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.s005

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Metformin_pharmacokinetics_/14383345

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g002

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/dataset/List_of_human_model_parameters_and_their_description_/14383330

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.s002

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/dataset/List_of_mice_model_parameters_and_their_description_/14383327

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.s001

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Metformin_pharmacokinetics_in_plasma_model_validation_results_for_250mg_A_36_500mg_B_37_750mg_C_38_and_500mg_D_39_PO_doses_in_humans_/14383351

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g004

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Metformin_pharmacokinetics_in_major_compartments_of_metformin_action_/14383342

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g001

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Fig_8_-/14383363

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g008

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Metformin_time-course_comparison_of_experimental_data_and_model_simulations_for_tissues_/14383348

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g003

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Schematic_representation_of_a_physiologically_based_pharmacokinetic_model_for_metformin_in_mice_and_humans_/14383366

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g009

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/figure/Intestine_and_kidney_model_structures_for_permeability_rate-limited_kinetics_/14383369

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.g010

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/dataset/Metformin_pharmacokinetic_parameter_comparison_of_experimental_data_1_and_model_simulations_in_plasma_portal_vein_intestine_liver_kidney_heart_muscle_adipose_tissues_and_brain_following_a_single_50mg_kg_PO_dose_in_mice_/14383372

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.t001

المؤلفون: Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model

Relation: https://figshare.com/articles/dataset/Metformin_pharmacokinetic_parameters_for_different_tissues_following_a_twice-daily_dosing_regimen_of_500mg_1000mg_and_1500mg_PO_dose_in_humans_/14383390

الاتاحة: https://doi.org/10.1371/journal.pone.0249594.t007