المؤلفون: Tomoki Yamashita, Tatsuya Inui, Jumpei Yokota, Kentaro Kawakami, Gaku Morinaga, Masahito Takatani, Daisuke Hirayama, Ryuga Nomoto, Kohei Ito, Yunhai Cui, Stephanie Ruez, Kazuo Harada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 263-278 (2021)

مصطلحات موضوعية: intestinal organoids, small intestine, intestinal first-pass effect, monolayer culture, CYP3A4, P-glycoprotein, Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050121000899; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/de9ad83ff8c848cf81d09de556e3ec5e

المؤلفون: Ji Sang Lee, So Hee Kim

المصدر: Pharmaceutics; Volume 11; Issue 7; Pages: 318

مصطلحات موضوعية: tofacitinib, dose-dependent pharmacokinetics, hepatic and intestinal first-pass effect, rats

وصف الملف: application/pdf

Relation: Pharmacokinetics and Pharmacodynamics; https://dx.doi.org/10.3390/pharmaceutics11070318

الاتاحة: https://doi.org/10.3390/pharmaceutics11070318

المؤلفون: Gaku Morinaga, Masahito Takatani, Daisuke Hirayama, Kentaro Kawakami, Ryuga Nomoto, Tatsuya Inui, Stephanie Ruez, Jumpei Yokota, Tomoki Yamashita, Kohei Ito, Wataru Kishimoto, Hiroyuki Mizuguchi, Hiroshi Nakase, Kazuo Harada, Yunhai Cui

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 263-278 (2021)
Molecular Therapy. Methods & Clinical Development

مصطلحات موضوعية: CYP3A4, P-glycoprotein, QH426-470, intestinal first-pass effect, Pharmacokinetics, Monolayer, Organoid, medicine, Genetics, CES1, PEPT1, CES2, Pharmaceutical sciences, Molecular Biology, biology, Tight junction, QH573-671, Chemistry, monolayer culture, Cytochrome P450, Small intestine, Cell biology, medicine.anatomical_structure, intestinal organoids, biology.protein, Molecular Medicine, Original Article, Cytology, microarray, small intestine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7c6d5772e15a71a1724e3dfc727a2f
http://www.sciencedirect.com/science/article/pii/S2329050121000899

المؤلفون: Tomoki Yamashita, Seiichi Ishida, Hiroshi Yamada, Hiroyuki Mizuguchi, Kazuo Harada, Moe Ichikawa, Kazuo Takayama, Kazumasa Hirata, Kanae Kawai, Noriyuki Nakatsu, Ryosuke Negoro, Yoshiyuki Yamaura, Takanori Mori, Sumito Ito

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 513-526 (2019)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, CYP3A4, TF, transcription factor, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Cell Culture Techniques, SI, sucrose isomerase, Intestinal absorption, IEC, intestinal epithelial cell, Papp, apparent permeability coefficient, ZO-1, zonula occludens-1, Food-Drug Interactions, 0302 clinical medicine, Transduction, Genetic, BIO, 6-Bromoindirubin-3′-oxime, Adenovirus, Cytochrome P-450 CYP3A, CDX2 Transcription Factor, Drug Interactions, VP, vector particle, Induced pluripotent stem cell, CDX2, Cells, Cultured, Original Research, LY, Lucifer yellow, Chemistry, Gastroenterology, Cell Differentiation, FD-4, FITC-Dextran 4 kDa, Cell biology, Fruit and Vegetable Juices, Intestines, RIF, rifampicin, medicine.anatomical_structure, Fa, fraction absorbed, Differentiation, MDZ, midazolam, 030211 gastroenterology & hepatology, Rifampin, Ad-TF, transcription factor–expressing Ad vector, iPSC, induced pluripotent stem cell, Intestinal First-Pass Effect, RT-PCR, reverse transcription-polymerase chain reaction, IECM, intestinal epithelial cell monolayer, Induced Pluripotent Stem Cells, CHGA, chromogranin A, Fg, fraction passing the gut wall, TEER, transepithelial electrical resistance, 03 medical and health sciences, Pharmacokinetics, GFJ, grapefruit juice, medicine, Humans, HBSS, Hank's Balanced Salt Solution, Progenitor cell, lcsh:RC799-869, MRM, multiple-reaction monitoring, Hepatology, LYZ, lysozyme, Epithelial Cells, Epithelium, Small intestine, MUC2, mucin 2, 030104 developmental biology, Intestinal Absorption, Cell culture, UPLC-MS/MS, ultra-performance liquid chromatography tandem mass spectrometry, VD3, 1,25-dihydroxyvitamin D3, lcsh:Diseases of the digestive system. Gastroenterology, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836b9fc4e81bc0f2d53e50d6ad87bcd2
http://www.sciencedirect.com/science/article/pii/S2352345X19300827

المؤلفون: 신지현

المساهمون: 이명걸, 약학과 약물학전공

مصطلحات موضوعية: Itraconazole, 용량 의존적 약물 역학, Dose-dependent pharmacokinetics, 장 초회통과 효과, Intestinal first-pass effect, 랫트, Rats

وصف الملف: v, 57 leaves

Relation: http://dcollection.snu.ac.kr:80/jsp/common/DcLoOrgPer.jsp?sItemId=000000054221; http://hdl.handle.net/10371/18501

الاتاحة: http://hdl.handle.net/10371/18501
http://dcollection.snu.ac.kr:80/jsp/common/DcLoOrgPer.jsp?sItemId=000000054221