المؤلفون: Li, Wenlong, Tibben, Matthijs, Wang, Yaogeng, Lebre, Maria C, Rosing, Hilde, Beijnen, Jos H, Schinkel, Alfred H

المساهمون: Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

مصطلحات موضوعية: galunisertib, P-glycoprotein, brain accumulation, intestinal disposition, cytochrome P450-3A, oral availability, Oatp1a/1b, Taverne

وصف الملف: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/390157

الاتاحة: https://dspace.library.uu.nl/handle/1874/390157

المؤلفون: Li, Wenlong, Tibben, Matthijs, Wang, Yaogeng, Lebre, Maria C, Rosing, Hilde, Beijnen, Jos H, Schinkel, Alfred H, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

المصدر: International Journal of Cancer, 146(6), 1631. Wiley-Liss Inc.

مصطلحات موضوعية: Genetically modified mouse, Cancer Research, ATP Binding Cassette Transporter, Subfamily B, Abcg2, CYP3A, Herb-Drug Interactions, Organic Anion Transporters, P-glycoprotein, Pharmacology, Madin Darby Canine Kidney Cells, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Pharmacokinetics, Transforming Growth Factor beta, Tetrahydroisoquinolines, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Cytochrome P-450 CYP3A, Humans, Galunisertib, Tissue Distribution, cytochrome P450-3A, Receptor, biology, CYP3A4, Chemistry, Brain, Oatp1a/1b, Neoplasm Proteins, brain accumulation, galunisertib, Oncology, oral availability, 030220 oncology & carcinogenesis, Quinolines, biology.protein, Acridines, Pyrazoles, Female, intestinal disposition, Signal Transduction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce90e3ddebbd0e2bc1b7872e31bd5917
https://doi.org/10.1002/ijc.32568

المؤلفون: Nancy H.C. Loos, Margarida L. Ferreira Martins, Jamie Rijmers, Daniëlle de Jong, Maria C. Lebre, Matthijs Tibben, Jos H. Beijnen, Alfred H. Schinkel

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Physiology, Pharmacology, Biotechnology, Mental Health, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, therefore study determinants, pharmacodynamic mouse studies, parameters showed rescue, oral formulation would, orally applied cabazitaxel, humanized mouse strains, >< sup ><, orally boosted cabazitaxel, boosted oral cabazitaxel, increased plasma auc, intestinal drug disposition, plasma auc, boosted setting, intestinal disposition, ablated strains, >, plasma ratio, plasma carboxylesterase

Relation: https://figshare.com/articles/journal_contribution/Interplay_of_Ritonavir-Boosted_Oral_Cabazitaxel_with_the_Organic_Anion-Transporting_Polypeptide_OATP_Uptake_Transporters_and_Carboxylesterase_1_in_Mice/25321868

الاتاحة: https://doi.org/10.1021/acs.molpharmaceut.3c01205.s001
https://figshare.com/articles/journal_contribution/Interplay_of_Ritonavir-Boosted_Oral_Cabazitaxel_with_the_Organic_Anion-Transporting_Polypeptide_OATP_Uptake_Transporters_and_Carboxylesterase_1_in_Mice/25321868