-
1Academic Journal
المؤلفون: Perez-de-Llano L, Scelo G, Canonica G.W, Chen W, Henley W, Larenas-Linnemann D, Peters M.J, Pfeffer P.E, Tran T.N, Ulrik C.S
المصدر: Universidad de La Sabana ; Intellectum Repositorio Universidad de La Sabana
مصطلحات موضوعية: Biological product, Corticosteroid, Immunoglobulin E Antibody, Interleukin 5 antibody, Antiasthmatic agent, Adolescent, Adult
وصف الملف: application/pdf
Relation: Annals of Allergy, Asthma and Immunology Vol. 132 N° 5; http://hdl.handle.net/10818/62184
-
2Academic Journal
المؤلفون: Correa-Borit, Jorge, Laorden, Daniel, Arnalich Montiel, Victoria, Quirce, Santiago, Domínguez-Ortega, Javier
المصدر: J Asthma ; ISSN:1532-4303
مصطلحات موضوعية: Mepolizumab, biologic, interleukin 5, long-term, real world, remission, severe asthma, treatment response
-
3
المؤلفون: Knutsson, Anki, Björkbacka, Harry, Dunér, Pontus, Engström, Gunnar, Binder, Christoph J., Nilsson, Anna Hultgårdh, Nilsson, Jan
المصدر: JACC: Basic to Translational Science EXODIAB: Excellence of Diabetes Research in Sweden EpiHealth: Epidemiology for Health. 4(8):891-902
مصطلحات موضوعية: atherosclerosis, interleukin 5, myocardial infarction, stroke, Medicin och hälsovetenskap, Klinisk medicin, Kardiologi, Medical and Health Sciences, Clinical Medicine, Cardiac and Cardiovascular Systems
-
4Academic Journal
المصدر: World Allergy Organization Journal, Vol 15, Iss 8, Pp 100676- (2022)
مصطلحات موضوعية: Eosinophil, Biologics, Interleukin 5, Treatment, Siglec-8, Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
-
5Academic Journal
المؤلفون: Sylwia Biały, Milena Iwaszko, Jerzy Świerkot, Bartosz Bugaj, Katarzyna Kolossa, Sławomir Jeka, Katarzyna Bogunia-Kubik
المصدر: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13177
مصطلحات موضوعية: interleukin 5, interleukin 9, IL5, IL9, ankylosing spondylitis, anti-TNF, SNP
جغرافية الموضوع: agris
وصف الملف: application/pdf
Relation: Molecular Immunology; https://dx.doi.org/10.3390/ijms232113177
-
6Academic Journal
المؤلفون: Mattei, Laura, Suehs, Carey, Alagha, Khuder, Bourdin, Arnaud, Brousse, Christophe, Charriot, Jérémy, Devouassoux, Gilles, Fry, Stephanie, Guilleminault, Laurent, Gouitaa, Marion, Taille, Camille, Chanez, Pascal, Pahus, Laurie
المساهمون: Hôpital Nord CHU - APHM, Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), CRP Clinique du Parc, Castelnau-Le-Lez, Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Plateforme F-CRIN, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Croix-Rousse CHU - HCL, Hospices Civils de Lyon (HCL), Inflammation et immunité de l'épithélium respiratoire, Université de Reims Champagne-Ardenne (URCA)-IFR53, Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Institut Pasteur de Lille, Pasteur Network (Réseau International des Instituts Pasteur), Université de Lille, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Aix Marseille Université (AMU), AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS)
المصدر: ISSN: 1753-4658.
مصطلحات موضوعية: anti-interleukin 5, anti-interleukin 5 receptor, failure, severe asthma, [SDV]Life Sciences [q-bio]
Relation: info:eu-repo/semantics/altIdentifier/pmid/34629000; PUBMED: 34629000; WOS: 000706194500001
-
7Academic JournalEosinophil Peroxidase: A Biomarker for Eosinophilic Chronic Rhinosinusitis Agnostic of Polyp Status.
المؤلفون: Idler, Beau M, Iijima, Koji, Ochkur, Sergei I, Jacobsen, Elizabeth A, Rank, Matthew A, Kita, Hirohito, Lal, Devyani
المصدر: Laryngoscope ; ISSN:1531-4995 ; Volume:134 ; Issue:1
مصطلحات موضوعية: IL-5, biomarker, chronic rhinosinusitis, eosinophil peroxidase, eosinophilia, interleukin 5, nasal polyps, sinusitis
Relation: https://doi.org/10.1002/lary.30787; https://pubmed.ncbi.nlm.nih.gov/37255054; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687314/
-
8Academic Journal
المؤلفون: Aydın, İ., Taşkın, R.B., Aytaç, G., Imamoglu, S., Tunçay, S.C., Bulut, İ.K., Karaca, N.E.
مصطلحات موضوعية: IgA vasculitis, polymerase chain reaction restriction fragment length polymorphism, real time polymerase chain reaction, Turk (people), young adult, anaphylactoid purpura, arthritis, gene expression, genetic polymorphism, genetic predisposition, genetics, single nucleotide polymorphism, ACE gene polymorphism, Proinflammatory cytokine gene polymorphisms, dipeptidyl carboxypeptidase, interleukin 1beta, interleukin 5, non receptor protein tyrosine phosphatase 22, transforming growth factor beta, messenger RNA, PTPN22 protein, human, adolescent, adult, allele specific polymerase chain reaction, Article, case control study, child, childhood, controlled study
Relation: Molecular Biology Reports; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11454/93200; https://doi.org/10.1007/s11033-023-08944-x; 51
-
9Academic Journal
المؤلفون: Renz, Harald, Bachert, Claus, Berek, Claudia, Hamelmann, Eckard, Levi-Schaffer, Francesca, Raap, Ulrike, Simon, Hans-Uwe, Ploetz, Sabine, Taube, Christian, Valent, Peter, Voehringer, David, Werfel, Thomas, Zhang, Nan, Ring, Johannes
المصدر: SCANDINAVIAN JOURNAL OF IMMUNOLOGY ; ISSN: 0300-9475 ; ISSN: 1365-3083
مصطلحات موضوعية: Medicine and Health Sciences, anti‐, interleukin 5, DNAzyme against GATA3, eosinophil, diseases, hypereosinophilic syndrome
وصف الملف: application/pdf
Relation: https://biblio.ugent.be/publication/8706288; http://hdl.handle.net/1854/LU-8706288; http://dx.doi.org/10.1111/sji.13032; https://biblio.ugent.be/publication/8706288/file/8706289
-
10Academic Journal
المؤلفون: Joanna Sarbinowska, Benita Wiatrak, Dorota Waśko-Czopnik
المصدر: Biomolecules; Volume 11; Issue 6; Pages: 890
مصطلحات موضوعية: eosinophilic esophagitis, eotaxin 3, interleukin 5, interleukin 13, major basic protein, transforming growth factor beta 1
جغرافية الموضوع: agris
وصف الملف: application/pdf
Relation: Chemical Biology; https://dx.doi.org/10.3390/biom11060890
الاتاحة: https://doi.org/10.3390/biom11060890
-
11Academic Journal
المؤلفون: Akram Miramin-Mohammadi, Amir Javadi, Seyed Ebrahim Eskandari, Hossein Mortazavi, Mahmoud Nateghi Rostami, Ali Khamesipour
المصدر: Iranian Journal of Microbiology, Vol 12, Iss 3 (2020)
مصطلحات موضوعية: Cutaneous leishmaniasis, Soluble Leishmania antigen (SLA), Immune response, Interferon gamma (IFNγ), Interleukin 10 (IL-10), Interleukin 5 (IL-5), Microbiology, QR1-502
وصف الملف: electronic resource
-
12Academic Journal
المصدر: Biomedical and Biotechnology Research Journal, Vol 3, Iss 3, Pp 156-161 (2019)
مصطلحات موضوعية: Bronchial asthma, eosinophil, interleukin 5, total IgE, Biotechnology, TP248.13-248.65
وصف الملف: electronic resource
-
13Academic JournalStudy of serum interleukin 5 level and factors that impact on this level in Iraqi asthmatic children
المؤلفون: Raghdah Maytham Hameed, Haidar Abdul Amir Najim Abood, Mohanad Mohsin Ahmed, Aqeel Mahdi Hussein
المصدر: Biomedical and Biotechnology Research Journal, Vol 3, Iss 4, Pp 249-252 (2019)
مصطلحات موضوعية: asthma, eosinophil, interleukin 5, total serum immunoglobulin e, Biotechnology, TP248.13-248.65
وصف الملف: electronic resource
-
14Academic Journal
المؤلفون: R. S. Fassakhov
المصدر: Медицинский совет, Vol 0, Iss 15, Pp 70-75 (2018)
مصطلحات موضوعية: severe bronchial asthma, eosinophilic inflammation, interleukin 5, reslisumab, Medicine
وصف الملف: electronic resource
-
15Academic Journal
المؤلفون: Andrea Matucci, Alessandra Vultaggio, Enrico Maggi, Ismail Kasujee
المصدر: Respiratory Research, Vol 19, Iss 1, Pp 1-10 (2018)
مصطلحات موضوعية: Immunoglobulin E, IgE, Eosinophil, Interleukin 5, IL-5, Asthma pathogenesis, anti-IgE, Diseases of the respiratory system, RC705-779
وصف الملف: electronic resource
-
16
المؤلفون: Hale ATEŞ, Kurtuluş AKSU, İlkay KOCA KALKAN, Musa TOPEL, Senay DEMİR, Selma YESİLKAYA, Sakine NAZİK BAHCECİOGLU
المصدر: Volume: 3, Issue: 3 275-279
Journal of Medicine and Palliative Careمصطلحات موضوعية: Health Care Sciences and Services, Astım kontrol testi, interlökin–5, kan eozinofil sayıları, kortikosteroid, Asthma control test, blood eosinophil counts, corticosteroid, interleukin – 5, Sağlık Bilimleri ve Hizmetleri
وصف الملف: application/pdf
-
17Academic Journal
المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1996 Mar . 93(6), 2436-2441.
URL الوصول: https://www.jstor.org/stable/38692
-
18Academic Journal
المؤلفون: Molano-González, Nicolas, Pacheco Nieva, Yovana, Rodríguez-Jímenez, Mónica, Rojas, Manuel, Monsalve, Diana M., Acosta-Ampudia, Yeny, Rodríguez, Yhojan, Ramirez-Santana, Carolina, Anaya, Juan-Manuel
المصدر: instname:Universidad del Rosario
مصطلحات موضوعية: Alpha interferon, Autoantibody, Gamma interferon, Granulocyte colony stimulating factor, Immunoglobulin g, Immunoglobulin m, Interleukin 10, Interleukin 12, Interleukin 13, Interleukin 17, Interleukin 1beta, Interleukin 2, Interleukin 4, Interleukin 5, Interleukin 6, Interleukin 8, Interleukin 9, Tumor necrosis factor, Adult, Antiphospholipid syndrome, Article, Autoimmune disease, Autoimmune hepatitis, Cluster analysis, Controlled study, Disease duration, Female, Human, Major clinical study, Myasthenia gravis
وصف الملف: application/pdf
Relation: https://repository.urosario.edu.co/handle/10336/22263; https://doi.org/10.1016/j.jaut.2018.11.002
-
19Academic Journal
المؤلفون: Natal'ya M. Nenasheva, Н. М. Ненашева
المصدر: PULMONOLOGIYA; Том 29, № 2 (2019); 216-228 ; Пульмонология; Том 29, № 2 (2019); 216-228 ; 2541-9617 ; 0869-0189 ; 10.18093/0869-0189-2019-29-2
مصطلحات موضوعية: биологическая терапия бронхиальной астмы, severe asthma, phenotype, endotype, interleukin 4, interleukin 5, interleukin 13, biomarkers of T2 inflammation, biological therapy for asthma, тяжелая бронхиальная астма, фенотип, эндотип, интерлейкины-4, биомаркеры Т2-воспаления
وصف الملف: application/pdf
Relation: https://journal.pulmonology.ru/pulm/article/view/1148/912; Soriano J.B., Abajobir A.A., Abate K.H. et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir. Med. 2017; 5 (9): 691–706. DOI:10.1016/S2213-2600(17)30293-X.; Bousqet J., Mantzouranis E., Cruz A.A. et al. Uniform definition of asthma severity, control and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J. Allergy Clin. Immunol. 2010; 126 (5): 926–938. DOI:10.1016/j.jaci.2010.07.019.; Chung K.F., Wenzel S.E., Brozek J.L. et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur. Respir. J. 2014; 43 (2): 343–373. DOI:10.1183/09031936.00202013.; GINA 2018. Difficult-to-Treat & Severe Asthma in adolescent and adult patients: Diagnosis and management. A GINA Pocket Guide for Health Professionals. Available at: https://ginasthma.org/wp-content/uploads/2018/11/GINA-SA-FINAL-wms.pdf [Accessed: March 6, 2019].; Архипов В.В., Григорьева Е.В., Гавришина Е.В. Контроль над бронхиальной астмой в России: результаты многоцентрового наблюдательного исследования НИКА. Пульмонология. 2011; (6): 87–93.; Харитонс М.А., Рамазанова К.А. Современные представления о лечении бронхиальной астмы. Терра Медика Нова. 2001; (1). Доступно на: https://medi.ru/info/6513/ [Дата обращения: 06.03.19].; Астафьева Н.Г., Гамова И.В., Удовиченко Е.Н. и др. Клинические фенотипы бронхиальной астмы у подростков: трудности диагностики и терапии. Лечащий врач. 2015; (4): 20–23.; Куличенко Т.В. Омализумаб у детей с бронхиальной астмой: показания к применению. Педиатрическая фармакология. 2007; 4 (6): 51–55.; Busse W.W., Banks-Schlegel S., Wenzel S.E. Pathophysiology of severe asthma. J. Allergy Clin. Immunol. 2000; 106 (6): 1033–1042. DOI:10.1067/mai.2000.111307.; O'Byrne P.M., Naji N., Gauvreau G.M. Severe asthma: future treatments. Clin. Exp. Allergy. 2012; 42 (5): 706–711. DOI:10.1111/j.1365-2222.2012.03965.x.; Hekking P.P., Wener R.R., Amelink M. et al. The prevalence of severe refractory asthma. J. Allergy Clin. Immunol. 2015; 135 (4): 896–902. DOI:10.1016/j.jaci.2014.08.042.; Miller M.K., Lee J.H., Miller D.P., Wenzel S.E. Recent asthma exacerbations: a key predictor of future exacerbations. Respir. Med. 2007; 101 (3): 481–489. DOI:10.1016/j.rmed.2006.07.005.; Bai T.R., Vonk J.M., Postma D.S., Boezen H.M. Severe exacerbations predict excess lung function decline in asthma. Eur. Respir. J. 2007; 30 (3): 452–456. DOI:10.1183/09031936.00165106; Федеральные клинические рекомендации по диагностике и лечению бронхиальной астмы. М.: Российское респираторное общество, Российская ассоциация аллергологов и клинических иммунологов; 2018. Доступно на: http://spulmo.ru/obrazovatelnye-resursy/federalnye-klinicheskie-rekomendatsii/ [Дата обращения: 16.03.19].; Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Updated 2018. Available at: https://ginasthma.org/wp-content/uploads/2018/04/wms-GINA-2018-report-V1.3-002.pdf [Дата обращения: 16.03.19].; Ненашева Н.М. Бронхиальная астма. Современный взгляд на проблему. М.: ГЭОТАР-Медиа; 2018.; Anderson G.P. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008; 372 (9643): 1107–1019. DOI:10.1016/S0140-6736(08)61452-X.; Woodruff P.G., Modrek B., Choy D.F. et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 2009; 180 (5): 388–395. DOI:10.1164/rccm.200903-0392OC.; Bhakta N.R., Woodruff P.G. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol. Rev. 2011; 242 (1): 220–232. DOI:10.1111/j.1600-065X.2011.01032.x.; Brusselle G.G., Maes T., Bracke K.R. Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma. Nat. Med. 2013; 19 (8): 977–979. DOI:10.1038/nm.3300.; Wenzel S. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 2012; 18 (5): 716–725. DOI:10.1038/nm.2678.; Сергеева Г.Р., Емельянов А.В., Коровина О.В. и др. Тяжелая бронхиальная астма: характеристика пациентов в клинической практике. Терапевтический архив. 2015; 87 (12): 26–31. DOI:10.17116/terarkh2015871226-31.; Denlinger L.C., Phillips B.R., Ramrathan S. et al. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am. J. Respir. Crit. Care Med. 2017; 195 (3): 302–313. DOI:10.1164/rccm.201602-0419OC.; Kupczyk M., ten Brinke A., Sterk P.J. et al. Frequent exacerbators – a distinct phenotype of severe asthma. Clin. Exp. Allergy. 2013; 44 (2): 212–221. DOI:10.1111/cea.12179.; Price D., Wilson A.M., Chisholm A. et al. Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice. J. Asthma Allergy. 2016; 9: 1–12. DOI:10.2147/JAA.S97973.; Castro M., Zangrilli J., Wechlser M.E. et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicenter, parallel, double-blind, randomized, placebo-controlled, phase 3 trials. Lancet Respir. Med. 2015; 3 (5): 355–366. DOI:10.1016/S2213-2600(15)00042-9.; Pavord I.D., Korn S., Howarth P. et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012; 380 (9842): 651–659. DOI:10.1016/S0140-6736(12)60988-X.; Bleecker E.R., FitzGerald J.M., Chanez P. et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet. 2016; 388 (10056): 2115–2127. DOI:10.1016/S0140-6736(16)31324-1.; Hanania N.A., Alpan O., Hamilos D.L. et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. Ann. Intern. Med. 2011; 154 (9): 573–582. DOI:10.7326/0003-4819-154-9-201105030-00002.; Katial R.K., Bensch G.W., Busse W.W. et al. Changing paradigms in the treatment of severe asthma: The role of biologic therapies. J. Allergy Clin. Immunol. Pract. 2017; 5 (2, Suppl.): S1–S14. DOI:10.1016/j.jaip.2016.11.029.; Fajt M.L., Wenzel S.E. Development of new therapies for severe asthma. Allergy Asthma Immunol. Res. 2017; 9 (1): 3–14. DOI:10.4168/aair.2017.9.1.3.; Israel E., Reddel H.K. Severe and difficult-to-treat asthma in adults. N. Engl. J. Med. 2017; 377 (10): 965–976. DOI:10.1056/NEJMra1608969.; Li B.W., Hendriks R.W. Group 2 innate lymphoid cells in lung inflammation. Immunology. 2013; 140 (3): 281–287. DOI:10.1111/imm.12153.; Kim H.Y., Umetsu D.Т., Dekruyff R.Н. Innate lymphoid cells in asthma: Will they take your breath away? Eur. J. Immunol. 2016; 46 (4): 795–806. DOI:10.1002/eji.201444557.; Kau A.L., Korenblat P.E. Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes. Curr. Opin. Allergy Clin. Immunol. 2014; 14 (6): 570–575. DOI:10.1097/ACI.0000000000000108.; Gandhi N.A., Bennett B.L., Graham N.M. et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat. Rev. Drug Discov. 2016; 15 (1): 35–50. DOI:10.1038/nrd4624.; Coffman R.L. Converging discoveries: The first reports of IL-4. J. Immunol. 2013; 190 (3): 847–848. DOI:10.4049/jimmunol.1203368.; Wills-Karp M. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 2004; 202: 175–190. DOI:10.1111/j.0105-2896.2004.00215.x; Brusselle G., Kips J., Joos G. et al. Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am. J. Respir. Cell Mol. Biol. 1995; 12 (3): 254–259. DOI:10.1165/ajrcmb.12.3.7873190.; Gavett S.H., O’Hearn D.J., Karp C.L. et al. Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice. Am. J. Physiol. 1997; 272 (2, Pt 1): L253–L261. DOI:10.1152/ajplung.1997.272.2.L253.; Corry D.B., Folkesson H.G., Warnock M.L. et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 1996; 183 (1): 109–117. DOI:10.1084/jem.183.1.109.; Henderson W.R. Jr, Chi E.Y., Maliszewski C.R. Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma. J. Immunol. 2000; 164 (2): 1086–1095. DOI:10.4049/jimmunol.164.2.1086.; Dabbagh K., Takeyama K., Lee H.M. et al. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J. Immunol. 1999; 162 (10): 6233–6237.; Tepper R.I., Levinson D.А., Stanger B.Z. et al. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell. 1990; 62 (3): 457–467.; Wills-Karp M., Luyimbazi J., Xu X. et al. Interleukin-13: central mediator of allergic asthma. Science. 1998; 282 (5397): 2258–2261.; Grünig G., Warnock M., Wakil A. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998; 282 (5397): 2261–2263.; Zhu Z., Homer R.J., Wang Z. et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 1999; 103 (6): 779–788. DOI:10.1172/JCI5909.; Webb D.C., McKenzie A.N., Koskinen A.M. et al. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity. J. Immunol. 2000; 165 (1): 108–113. DOI:10.4049/jimmunol.165.1.108.; Kuperman D.A., Huang X., Koth L.L. et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 2002; 8 (8): 885–889. DOI:10.1038/nm734.; Gour N., Wills-Karp M. IL-4 and IL-13 signaling in allergic airway disease. Cytokine. 2015; 75 (1): 68–78. DOI:10.1016/j.cyto.2015.05.014.; Rosenberg H.F., Dyer K.D., Foster P.S. Eosinophils: changing perspectives in health and disease. Nat. Rev. Immunol. 2013; 13 (1): 9–22. DOI:10.1038/nri3341.; Louis R., Sele J., Henket M. et al. Sputum eosinophil count in a large population of patients with mild to moderate steroid-naive asthma: distribution and relationship with methacholine bronchial hyperresponsiveness. Allergy. 2002; 57 (10): 907–912.; Chung K.F. Personalised medicine in asthma: time for action. Eur. Respir. Rev. 2017; 26 (145): pii: 170064. DOI:10.1183/16000617.0064-2017.; Ненашева Н.М. Значение биомаркеров в диагностике и терапии бронхиальной астмы. Практическая пульмонология. 2017; (4): 3–9.; de Groot J.C., Storm H., Amelink M. et al. Clinical profile of patients with adult-onset eosinophilic asthma. ERJ Open Res. 2016; 2 (2): pii: 00100-2015. DOI:10.1183/23120541.00100-2015.; de Groot J.C., Ten Brinke A., Bel E.H. Management of the patient with eosinophilic asthma: a new era begins. ERJ Open Res. 2015; 1 (1): pii: 00024-2015. DOI:10.1183/23120541.00024-2015.; Haldar P., Brightling C.E., Hargadon B. et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N. Engl. J. Med. 2009; 360 (10): 973–984. DOI:10.1056/NEJMoa0808991.; Castro M., Mathur S., Hargreave F. et al. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am. J. Respir. Crit. Care Med. 2011; 184 (10): 1125–1132. DOI:10.1164/rccm.201103-0396OC.; Wenzel S., Ford L., Pearlman D. et al. Dupilumab in persistent asthma with elevated eosinophil levels. N. Engl. J. Med. 2013; 368 (26): 2455–2466. DOI:10.1056/NEJMoa1304048.; Castro M., Wenzel S.E., Bleecker E.R. et al. Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir. Med. 2014; 2 (11): 879–890. DOI:10.1016/S2213-2600(14)70201-2.; Castro M., Corren J., Pavord I.D. et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N. Engl. J. Med. 2018; 378 (26): 2486–2496. DOI:10.1056/NEJMoa1804092.; Fitzpatrick A.M. Biomarkers of asthma and allergic airway diseases. Ann. Allergy Asthma Immunol. 2015; 115 (5): 335–340. DOI:10.1016/j.anai.2015.09.003.; Dweik R.A., Boggs P.B., Erzurum S.C. et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am. J. Respir. Crit. Care Med. 2011; 184 (5): 602–615. DOI:10.1164/rccm.9120-11ST.; Smith A.D., Cowan J.O., Brasset K.P. et al. Exhaled nitric oxide: A predictor of steroid response. Am. J. Respir. Crit. Care Med. 2005; 172 (4): 453–459. DOI:10.1164/rccm.200411-1498OC.; Hanania N.A., Wenzel S., Rosén K. et al. Exploring the effect of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am. J. Respir. Crit. Care Med. 2013; 187 (8): 804–811. DOI:10.1164/rccm.201208-1414OC.; https://journal.pulmonology.ru/pulm/article/view/1148
-
20Academic Journal
المصدر: Majalah Kesehatan FKUB; Vol. 6 No. 2 (2019): Majalah Kesehatan; pp.86-95 ; 2548-7698 ; 1907-8803
مصطلحات موضوعية: asma, interleukin 5, CD4, CD8
وصف الملف: application/pdf
Relation: https://majalahfk.ub.ac.id/index.php/mkfkub/article/view/305/170; https://majalahfk.ub.ac.id/index.php/mkfkub/article/view/305