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    المصدر: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13177

    مصطلحات موضوعية: interleukin 5, interleukin 9, IL5, IL9, ankylosing spondylitis, anti-TNF, SNP

    جغرافية الموضوع: agris

    وصف الملف: application/pdf

    Relation: Molecular Immunology; https://dx.doi.org/10.3390/ijms232113177

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    المساهمون: Hôpital Nord CHU - APHM, Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), CRP Clinique du Parc, Castelnau-Le-Lez, Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Plateforme F-CRIN, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Croix-Rousse CHU - HCL, Hospices Civils de Lyon (HCL), Inflammation et immunité de l'épithélium respiratoire, Université de Reims Champagne-Ardenne (URCA)-IFR53, Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Institut Pasteur de Lille, Pasteur Network (Réseau International des Instituts Pasteur), Université de Lille, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Aix Marseille Université (AMU), AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS)

    المصدر: ISSN: 1753-4658.

    Relation: info:eu-repo/semantics/altIdentifier/pmid/34629000; PUBMED: 34629000; WOS: 000706194500001

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    المصدر: PULMONOLOGIYA; Том 29, № 2 (2019); 216-228 ; Пульмонология; Том 29, № 2 (2019); 216-228 ; 2541-9617 ; 0869-0189 ; 10.18093/0869-0189-2019-29-2

    وصف الملف: application/pdf

    Relation: https://journal.pulmonology.ru/pulm/article/view/1148/912; Soriano J.B., Abajobir A.A., Abate K.H. et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir. Med. 2017; 5 (9): 691–706. DOI:10.1016/S2213-2600(17)30293-X.; Bousqet J., Mantzouranis E., Cruz A.A. et al. Uniform definition of asthma severity, control and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J. Allergy Clin. Immunol. 2010; 126 (5): 926–938. DOI:10.1016/j.jaci.2010.07.019.; Chung K.F., Wenzel S.E., Brozek J.L. et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur. Respir. J. 2014; 43 (2): 343–373. DOI:10.1183/09031936.00202013.; GINA 2018. Difficult-to-Treat & Severe Asthma in adolescent and adult patients: Diagnosis and management. A GINA Pocket Guide for Health Professionals. Available at: https://ginasthma.org/wp-content/uploads/2018/11/GINA-SA-FINAL-wms.pdf [Accessed: March 6, 2019].; Архипов В.В., Григорьева Е.В., Гавришина Е.В. Контроль над бронхиальной астмой в России: результаты многоцентрового наблюдательного исследования НИКА. Пульмонология. 2011; (6): 87–93.; Харитонс М.А., Рамазанова К.А. Современные представления о лечении бронхиальной астмы. Терра Медика Нова. 2001; (1). Доступно на: https://medi.ru/info/6513/ [Дата обращения: 06.03.19].; Астафьева Н.Г., Гамова И.В., Удовиченко Е.Н. и др. Клинические фенотипы бронхиальной астмы у подростков: трудности диагностики и терапии. Лечащий врач. 2015; (4): 20–23.; Куличенко Т.В. Омализумаб у детей с бронхиальной астмой: показания к применению. Педиатрическая фармакология. 2007; 4 (6): 51–55.; Busse W.W., Banks-Schlegel S., Wenzel S.E. Pathophysiology of severe asthma. J. Allergy Clin. Immunol. 2000; 106 (6): 1033–1042. DOI:10.1067/mai.2000.111307.; O'Byrne P.M., Naji N., Gauvreau G.M. Severe asthma: future treatments. Clin. Exp. Allergy. 2012; 42 (5): 706–711. DOI:10.1111/j.1365-2222.2012.03965.x.; Hekking P.P., Wener R.R., Amelink M. et al. The prevalence of severe refractory asthma. J. Allergy Clin. Immunol. 2015; 135 (4): 896–902. DOI:10.1016/j.jaci.2014.08.042.; Miller M.K., Lee J.H., Miller D.P., Wenzel S.E. Recent asthma exacerbations: a key predictor of future exacerbations. Respir. Med. 2007; 101 (3): 481–489. DOI:10.1016/j.rmed.2006.07.005.; Bai T.R., Vonk J.M., Postma D.S., Boezen H.M. Severe exacerbations predict excess lung function decline in asthma. Eur. Respir. J. 2007; 30 (3): 452–456. DOI:10.1183/09031936.00165106; Федеральные клинические рекомендации по диагностике и лечению бронхиальной астмы. М.: Российское респираторное общество, Российская ассоциация аллергологов и клинических иммунологов; 2018. Доступно на: http://spulmo.ru/obrazovatelnye-resursy/federalnye-klinicheskie-rekomendatsii/ [Дата обращения: 16.03.19].; Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Updated 2018. Available at: https://ginasthma.org/wp-content/uploads/2018/04/wms-GINA-2018-report-V1.3-002.pdf [Дата обращения: 16.03.19].; Ненашева Н.М. Бронхиальная астма. Современный взгляд на проблему. М.: ГЭОТАР-Медиа; 2018.; Anderson G.P. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008; 372 (9643): 1107–1019. DOI:10.1016/S0140-6736(08)61452-X.; Woodruff P.G., Modrek B., Choy D.F. et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 2009; 180 (5): 388–395. DOI:10.1164/rccm.200903-0392OC.; Bhakta N.R., Woodruff P.G. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol. Rev. 2011; 242 (1): 220–232. DOI:10.1111/j.1600-065X.2011.01032.x.; Brusselle G.G., Maes T., Bracke K.R. Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma. Nat. Med. 2013; 19 (8): 977–979. DOI:10.1038/nm.3300.; Wenzel S. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 2012; 18 (5): 716–725. DOI:10.1038/nm.2678.; Сергеева Г.Р., Емельянов А.В., Коровина О.В. и др. Тяжелая бронхиальная астма: характеристика пациентов в клинической практике. Терапевтический архив. 2015; 87 (12): 26–31. DOI:10.17116/terarkh2015871226-31.; Denlinger L.C., Phillips B.R., Ramrathan S. et al. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am. J. Respir. Crit. Care Med. 2017; 195 (3): 302–313. DOI:10.1164/rccm.201602-0419OC.; Kupczyk M., ten Brinke A., Sterk P.J. et al. Frequent exacerbators – a distinct phenotype of severe asthma. Clin. Exp. Allergy. 2013; 44 (2): 212–221. DOI:10.1111/cea.12179.; Price D., Wilson A.M., Chisholm A. et al. Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice. J. Asthma Allergy. 2016; 9: 1–12. DOI:10.2147/JAA.S97973.; Castro M., Zangrilli J., Wechlser M.E. et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicenter, parallel, double-blind, randomized, placebo-controlled, phase 3 trials. Lancet Respir. Med. 2015; 3 (5): 355–366. DOI:10.1016/S2213-2600(15)00042-9.; Pavord I.D., Korn S., Howarth P. et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012; 380 (9842): 651–659. DOI:10.1016/S0140-6736(12)60988-X.; Bleecker E.R., FitzGerald J.M., Chanez P. et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet. 2016; 388 (10056): 2115–2127. DOI:10.1016/S0140-6736(16)31324-1.; Hanania N.A., Alpan O., Hamilos D.L. et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. Ann. Intern. Med. 2011; 154 (9): 573–582. DOI:10.7326/0003-4819-154-9-201105030-00002.; Katial R.K., Bensch G.W., Busse W.W. et al. Changing paradigms in the treatment of severe asthma: The role of biologic therapies. J. Allergy Clin. Immunol. Pract. 2017; 5 (2, Suppl.): S1–S14. DOI:10.1016/j.jaip.2016.11.029.; Fajt M.L., Wenzel S.E. Development of new therapies for severe asthma. Allergy Asthma Immunol. Res. 2017; 9 (1): 3–14. DOI:10.4168/aair.2017.9.1.3.; Israel E., Reddel H.K. Severe and difficult-to-treat asthma in adults. N. Engl. J. Med. 2017; 377 (10): 965–976. DOI:10.1056/NEJMra1608969.; Li B.W., Hendriks R.W. Group 2 innate lymphoid cells in lung inflammation. Immunology. 2013; 140 (3): 281–287. DOI:10.1111/imm.12153.; Kim H.Y., Umetsu D.Т., Dekruyff R.Н. Innate lymphoid cells in asthma: Will they take your breath away? Eur. J. Immunol. 2016; 46 (4): 795–806. DOI:10.1002/eji.201444557.; Kau A.L., Korenblat P.E. Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes. Curr. Opin. Allergy Clin. Immunol. 2014; 14 (6): 570–575. DOI:10.1097/ACI.0000000000000108.; Gandhi N.A., Bennett B.L., Graham N.M. et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat. Rev. Drug Discov. 2016; 15 (1): 35–50. DOI:10.1038/nrd4624.; Coffman R.L. Converging discoveries: The first reports of IL-4. J. Immunol. 2013; 190 (3): 847–848. DOI:10.4049/jimmunol.1203368.; Wills-Karp M. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 2004; 202: 175–190. DOI:10.1111/j.0105-2896.2004.00215.x; Brusselle G., Kips J., Joos G. et al. Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am. J. Respir. Cell Mol. Biol. 1995; 12 (3): 254–259. DOI:10.1165/ajrcmb.12.3.7873190.; Gavett S.H., O’Hearn D.J., Karp C.L. et al. Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice. Am. J. Physiol. 1997; 272 (2, Pt 1): L253–L261. DOI:10.1152/ajplung.1997.272.2.L253.; Corry D.B., Folkesson H.G., Warnock M.L. et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 1996; 183 (1): 109–117. DOI:10.1084/jem.183.1.109.; Henderson W.R. Jr, Chi E.Y., Maliszewski C.R. Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma. J. Immunol. 2000; 164 (2): 1086–1095. DOI:10.4049/jimmunol.164.2.1086.; Dabbagh K., Takeyama K., Lee H.M. et al. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J. Immunol. 1999; 162 (10): 6233–6237.; Tepper R.I., Levinson D.А., Stanger B.Z. et al. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell. 1990; 62 (3): 457–467.; Wills-Karp M., Luyimbazi J., Xu X. et al. Interleukin-13: central mediator of allergic asthma. Science. 1998; 282 (5397): 2258–2261.; Grünig G., Warnock M., Wakil A. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998; 282 (5397): 2261–2263.; Zhu Z., Homer R.J., Wang Z. et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 1999; 103 (6): 779–788. DOI:10.1172/JCI5909.; Webb D.C., McKenzie A.N., Koskinen A.M. et al. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity. J. Immunol. 2000; 165 (1): 108–113. DOI:10.4049/jimmunol.165.1.108.; Kuperman D.A., Huang X., Koth L.L. et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 2002; 8 (8): 885–889. DOI:10.1038/nm734.; Gour N., Wills-Karp M. IL-4 and IL-13 signaling in allergic airway disease. Cytokine. 2015; 75 (1): 68–78. DOI:10.1016/j.cyto.2015.05.014.; Rosenberg H.F., Dyer K.D., Foster P.S. Eosinophils: changing perspectives in health and disease. Nat. Rev. Immunol. 2013; 13 (1): 9–22. DOI:10.1038/nri3341.; Louis R., Sele J., Henket M. et al. Sputum eosinophil count in a large population of patients with mild to moderate steroid-naive asthma: distribution and relationship with methacholine bronchial hyperresponsiveness. Allergy. 2002; 57 (10): 907–912.; Chung K.F. Personalised medicine in asthma: time for action. Eur. Respir. Rev. 2017; 26 (145): pii: 170064. DOI:10.1183/16000617.0064-2017.; Ненашева Н.М. Значение биомаркеров в диагностике и терапии бронхиальной астмы. Практическая пульмонология. 2017; (4): 3–9.; de Groot J.C., Storm H., Amelink M. et al. Clinical profile of patients with adult-onset eosinophilic asthma. ERJ Open Res. 2016; 2 (2): pii: 00100-2015. DOI:10.1183/23120541.00100-2015.; de Groot J.C., Ten Brinke A., Bel E.H. Management of the patient with eosinophilic asthma: a new era begins. ERJ Open Res. 2015; 1 (1): pii: 00024-2015. DOI:10.1183/23120541.00024-2015.; Haldar P., Brightling C.E., Hargadon B. et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N. Engl. J. Med. 2009; 360 (10): 973–984. DOI:10.1056/NEJMoa0808991.; Castro M., Mathur S., Hargreave F. et al. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am. J. Respir. Crit. Care Med. 2011; 184 (10): 1125–1132. DOI:10.1164/rccm.201103-0396OC.; Wenzel S., Ford L., Pearlman D. et al. Dupilumab in persistent asthma with elevated eosinophil levels. N. Engl. J. Med. 2013; 368 (26): 2455–2466. DOI:10.1056/NEJMoa1304048.; Castro M., Wenzel S.E., Bleecker E.R. et al. Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir. Med. 2014; 2 (11): 879–890. DOI:10.1016/S2213-2600(14)70201-2.; Castro M., Corren J., Pavord I.D. et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N. Engl. J. Med. 2018; 378 (26): 2486–2496. DOI:10.1056/NEJMoa1804092.; Fitzpatrick A.M. Biomarkers of asthma and allergic airway diseases. Ann. Allergy Asthma Immunol. 2015; 115 (5): 335–340. DOI:10.1016/j.anai.2015.09.003.; Dweik R.A., Boggs P.B., Erzurum S.C. et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am. J. Respir. Crit. Care Med. 2011; 184 (5): 602–615. DOI:10.1164/rccm.9120-11ST.; Smith A.D., Cowan J.O., Brasset K.P. et al. Exhaled nitric oxide: A predictor of steroid response. Am. J. Respir. Crit. Care Med. 2005; 172 (4): 453–459. DOI:10.1164/rccm.200411-1498OC.; Hanania N.A., Wenzel S., Rosén K. et al. Exploring the effect of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am. J. Respir. Crit. Care Med. 2013; 187 (8): 804–811. DOI:10.1164/rccm.201208-1414OC.; https://journal.pulmonology.ru/pulm/article/view/1148

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