المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/journal_contribution/Supplemental_methods_S1_Methods-S5_Methods_/24931609

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s002
https://figshare.com/articles/journal_contribution/Supplemental_methods_S1_Methods-S5_Methods_/24931609

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/Active_place_avoidance_APA_test_protocol_performed_for_3_days_consecutively_/24931618

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s005
https://figshare.com/articles/figure/Active_place_avoidance_APA_test_protocol_performed_for_3_days_consecutively_/24931618

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/Schematic_diagram_showing_the_experimental_timeline_/24931612

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s003
https://figshare.com/articles/figure/Schematic_diagram_showing_the_experimental_timeline_/24931612

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/Fourteen_days_after_tMCAo_surgery_mice_with_RNS60_treatment_show_a_decrease_in_microglial_activation_Iba1_in_the_CA3_region_of_the_ipsilateral_hippocampus_/24931642

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s011
https://figshare.com/articles/figure/Fourteen_days_after_tMCAo_surgery_mice_with_RNS60_treatment_show_a_decrease_in_microglial_activation_Iba1_in_the_CA3_region_of_the_ipsilateral_hippocampus_/24931642

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/Schematic_diagram_showing_the_experimental_timeline_to_test_whether_RNS60_treatment_reduces_hypoxia_/24931615

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s004
https://figshare.com/articles/figure/Schematic_diagram_showing_the_experimental_timeline_to_test_whether_RNS60_treatment_reduces_hypoxia_/24931615

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/Cerebral_microvascular_perfusion_MVP_was_measured_by_high_resolution_laser_speckle_contrast_imaging_HR-LSCI_in_motor_cortex_MC_and_parietal_cortex_PC_with_real_time_recording_/24931621

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s006
https://figshare.com/articles/figure/Cerebral_microvascular_perfusion_MVP_was_measured_by_high_resolution_laser_speckle_contrast_imaging_HR-LSCI_in_motor_cortex_MC_and_parietal_cortex_PC_with_real_time_recording_/24931621

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/Motor_skills_are_not_a_factor_in_behavioral_differences_observed_in_tMCAo_animals_with_different_treatments_/24931645

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s012
https://figshare.com/articles/figure/Motor_skills_are_not_a_factor_in_behavioral_differences_observed_in_tMCAo_animals_with_different_treatments_/24931645

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/tMCAo_mice_treated_with_RNS60_had_a_significantly_smaller_infarct_area_/24931630

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s008
https://figshare.com/articles/figure/tMCAo_mice_treated_with_RNS60_had_a_significantly_smaller_infarct_area_/24931630

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/Motor_performance_is_affected_24_h_after_left_tMCAo_/24931627

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s007
https://figshare.com/articles/figure/Motor_performance_is_affected_24_h_after_left_tMCAo_/24931627

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/RNS60_treatment_decreases_A_aggregation_and_neurodegeneration_in_the_stratum_pyramidale_in_the_CA3_region_of_the_hippocampus_of_tMCAo_animals_14_days_after_stroke_/24931633

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.s009
https://figshare.com/articles/figure/RNS60_treatment_decreases_A_aggregation_and_neurodegeneration_in_the_stratum_pyramidale_in_the_CA3_region_of_the_hippocampus_of_tMCAo_animals_14_days_after_stroke_/24931633

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/RNS60_treatment_of_tMCAo_mice_decreased_microglial_activation_in_the_CA3_region_of_the_ipsilateral_hippocampus_/24931663

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.g006
https://figshare.com/articles/figure/RNS60_treatment_of_tMCAo_mice_decreased_microglial_activation_in_the_CA3_region_of_the_ipsilateral_hippocampus_/24931663

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/RNS60_treatment_decreased_expression_of_hypoxia_inducible_factor_1_HIF1_in_the_peri_infarct_cortical_area_of_tMCAo_mice_4_days_after_onset_of_daily_dose_of_RNS60_/24931666

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.g007
https://figshare.com/articles/figure/RNS60_treatment_decreased_expression_of_hypoxia_inducible_factor_1_HIF1_in_the_peri_infarct_cortical_area_of_tMCAo_mice_4_days_after_onset_of_daily_dose_of_RNS60_/24931666

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/RNS60_treatment_decreased_A_aggregation_and_neurodegeneration_in_the_stratum_pyramidale_in_the_CA3_region_of_the_hippocampus_of_tMCAo_animals_14_days_after_stroke_/24931660

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.g005
https://figshare.com/articles/figure/RNS60_treatment_decreased_A_aggregation_and_neurodegeneration_in_the_stratum_pyramidale_in_the_CA3_region_of_the_hippocampus_of_tMCAo_animals_14_days_after_stroke_/24931660

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/RNS60_protected_against_hemispheric_loss_in_mice_subjected_to_left_tMCAo_/24931648

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.g001
https://figshare.com/articles/figure/RNS60_protected_against_hemispheric_loss_in_mice_subjected_to_left_tMCAo_/24931648

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/RNS60_treatment_of_tMCAo_mice_reduced_alterations_of_myelin_basic_protein_MBP_in_corpus_callosum_contiguous_to_the_CA1_of_the_hippocampus_/24931657

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.g004
https://figshare.com/articles/figure/RNS60_treatment_of_tMCAo_mice_reduced_alterations_of_myelin_basic_protein_MBP_in_corpus_callosum_contiguous_to_the_CA1_of_the_hippocampus_/24931657

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/RNS60_treatment_improved_performance_in_cognitive_evaluation_tests_/24931651

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.g002
https://figshare.com/articles/figure/RNS60_treatment_improved_performance_in_cognitive_evaluation_tests_/24931651

المؤلفون: Gloria Patricia Baena-Caldas, Jie Li, Lina Pedraza, Supurna Ghosh, Andreas Kalmes, Frank C. Barone, Herman Moreno, A. Iván Hernández

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Evolutionary Biology, Mental Health, white matter damage, several animal models, public health problems, neurological severity score, multiple neurobehavioral tests, mechanical thrombectomy without, improved neurobehavioral functioning, g ., anova, endovascular clot removal, cortical microvascular perfusion, improved cognitive flexibility, chronic neuroprotective treatments, +stroke%22">xlink "> stroke, +rns60%22">xlink "> rns60, increased neuronal survival, sham surgery mice, neuroprotective effect, cognitive function, 6j mice, increased memory, stroke compared

Relation: https://figshare.com/articles/figure/RNS60_treatment_increased_the_cortical_cerebral_blood_flow_in_mice_subjected_to_tMCAo_60-min_followed_by_14_days_treatment_/24931654

الاتاحة: https://doi.org/10.1371/journal.pone.0295504.g003
https://figshare.com/articles/figure/RNS60_treatment_increased_the_cortical_cerebral_blood_flow_in_mice_subjected_to_tMCAo_60-min_followed_by_14_days_treatment_/24931654