المؤلفون: Sahil Arora (6069491), Gaurav Joshi (282488), Anuhar Chaturvedi (615698), Michael Heuser (615701), Santoshkumar Patil (11635330), Raj Kumar (214626)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Computational Biology, Chemical Sciences not elsewhere classified, pyruvate kinase m2, metabolically energetic cells, medicinal chemistry approaches, including cancer cells, dimeric form ), attractive target due, thus activating pkm2, discover pkm2 inhibitors, compounds targeting pkm2, present perspective focuses, low catalytic state, pkm2 protein, tetrameric formation, metabolic dysfunction, lactate production, interrelated conditions, chiefly active, better efficacy, allow atp, allosteric site, allosteric regulation

Relation: https://figshare.com/articles/journal_contribution/A_Perspective_on_Medicinal_Chemistry_Approaches_for_Targeting_Pyruvate_Kinase_M2/16917766

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00981.s001