المؤلفون: Fabian Krutzek, Cornelius K. Donat, Martin Ullrich, Sven Stadlbauer

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, predominantly renal clearance, phosphonic acid groups, improved pharmacokinetic properties, time binding assay, highest binding affinity, 3 , cu -< b, 64 , 4 , l1 radioligands using, binding affinities, − 4, [< sup, >< sub, 64 complexation, investigated radioligands, based radioligands, therapy monitoring, specific uptake, promising candidate

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Biological_Evaluation_of_Small-Molecule-Based_Radioligands_with_Improved_Pharmacokinetic_Properties_for_Imaging_of_Programmed_Death_Ligand_1/24712704

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01355.s001
https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Biological_Evaluation_of_Small-Molecule-Based_Radioligands_with_Improved_Pharmacokinetic_Properties_for_Imaging_of_Programmed_Death_Ligand_1/24712704

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764310

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s001
https://figshare.com/articles/journal_contribution/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764310

المؤلفون: Fabian Krutzek, Cornelius K. Donat, Martin Ullrich, Sven Stadlbauer

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, predominantly renal clearance, phosphonic acid groups, improved pharmacokinetic properties, time binding assay, highest binding affinity, 3 , cu -< b, 64 , 4 , l1 radioligands using, binding affinities, − 4, [< sup, >< sub, 64 complexation, investigated radioligands, based radioligands, therapy monitoring, specific uptake, promising candidate

Relation: https://figshare.com/articles/dataset/Design_Synthesis_and_Biological_Evaluation_of_Small-Molecule-Based_Radioligands_with_Improved_Pharmacokinetic_Properties_for_Imaging_of_Programmed_Death_Ligand_1/24712707

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01355.s002
https://figshare.com/articles/dataset/Design_Synthesis_and_Biological_Evaluation_of_Small-Molecule-Based_Radioligands_with_Improved_Pharmacokinetic_Properties_for_Imaging_of_Programmed_Death_Ligand_1/24712707

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764316

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s003
https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764316

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764319

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s004
https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764319

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764328

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s007
https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764328

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764322

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s005
https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764322

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764313

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s002
https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764313

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764325

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s006
https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764325

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764331

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s008
https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764331

المؤلفون: Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao, Hongxia Wang, Wenbo Xu, Chenghao Wang, Yang Chen, Qiuyi Dong, Qihua Zhu, Yungen Xu, Yi Zou

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Chemical Sciences not elsewhere classified, strong antitumor effect, rigid constraint strategy, improved pharmacokinetic properties, 5 nm ), 60 %) compared, mediated immunity within, promising parp7 inhibitor, carboxamide derivatives based, 05 , 83 %), tumor immunity, tumor microenvironment, shown potential, profound effects, parp7 inhibitors, oral bioavailability, novel scaffold, novel indazole, molecular flexibility, immune response, future studies, crucial role, cancer immunity, attractive target

Relation: https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764334

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01764.s009
https://figshare.com/articles/dataset/Discovery_of_Highly_Selective_PARP7_Inhibitors_with_a_Novel_Scaffold_for_Cancer_Immunotherapy/24764334

المؤلفون: Deng, Feiyang, Zhang, Hua, Wang, Xing, Zhang, Yuan, Hu, Hongxiang, Song, Siyang, Dai, Wenbing, He, Bing, Zheng, Ying, Wang, Xueqing, Zhang, Qiang

المساهمون: Wang, XQ (reprint author), Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Delive, Sch Pharmaceut Sci, Beijing 100191, Peoples R China., Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Delive, Sch Pharmaceut Sci, Beijing 100191, Peoples R China., Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China., Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Coll Pharm, Kingston, RI 02881 USA., Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.

المصدر: SCI

مصطلحات موضوعية: nanocrystals, MDCK monolayer, endocytosis, intracellular transport, transcytosis, IMPROVED PHARMACOKINETIC PROPERTIES, CAVEOLAE-MEDIATED ENDOCYTOSIS, ORAL-DRUG DELIVERY, EPITHELIAL-CELLS, CELLULAR UPTAKE, HELA-CELLS, IN-VITRO, NANOPARTICLES, TRANSPORT, FORMULATION

Relation: ACS APPLIED MATERIALS & INTERFACES.2017,9(7),5803-5816.; 1909518; http://hdl.handle.net/20.500.11897/475044; WOS:000394829800017

الاتاحة: https://hdl.handle.net/20.500.11897/475044
https://doi.org/10.1021/acsami.6b15151

المؤلفون: Shenghua Gao, Letian Song, Katharina Sylvester, Beatrice Mercorelli, Arianna Loregian, Karoly Toth, Renato H. Weiße, Abibe Useini, Norbert Sträter, Mianling Yang, Bing Ye, Ann E. Tollefson, Christa E. Müller, Xinyong Liu, Peng Zhan

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, trisubstituted piperazine derivatives, spectrum anticoronaviral activity, somewhat enhanced compared, promising antiviral activity, prominent antiviral activity, molecular docking elucidated, improved antiviral activity, 38 μm ), improved pharmacokinetic properties, favorable pharmacokinetic profile, pro , hcl , 50 , pharmacokinetic properties, favorable druggability, 19 μm, three series, potential broad, ongoing transmission

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Biological_Evaluation_of_Trisubstituted_Piperazine_Derivatives_as_Noncovalent_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Main_Protease_Inhibitors_with_Improved_Antiviral_Activity_and_Favorable_Druggability/24627719

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01876.s001
https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Biological_Evaluation_of_Trisubstituted_Piperazine_Derivatives_as_Noncovalent_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Main_Protease_Inhibitors_with_Improved_Antiviral_Activity_and_Favorable_Druggability/24627719

المؤلفون: Xiaoyu Shi, Tong Zhao, Shuo Wang, Shujing Xu, Hui Liao, Shenghua Gao, Zhen Gao, Jian Zhang, Danhui Qi, Zhijiao Zhang, Fengxin Zheng, Youzhao Wang, Zhenqian Wang, Mingyu Yang, Qian Yang, Fan Yi, Jianxin Pang, Xinyong Liu, Peng Zhan

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, xanthine oxidase inhibitors, urate transporter 1, substituent modification strategies, metabolic diseases characterized, lower effective dosage, inhibiting urate reabsorption, glucose transporter 9, fused cyclic structures, favorable pharmacokinetic profiles, favorable druggability gout, extensive structural modifications, clinical practice due, apparent acute toxicity, improved pharmacokinetic properties, 21 μm ), novel thienopyrimidine compound, glut9 dual inhibitor, 50 , 29 , thienopyrimidine compound, vivo <, improved efficacy, 01 μm

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_a_Novel_Thienopyrimidine_Compound_as_a_Urate_Transporter_1_and_Glucose_Transporter_9_Dual_Inhibitor_with_Improved_Efficacy_and_Favorable_Druggability/25406817

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c00136.s001

المؤلفون: Shenghua Gao, Letian Song, Katharina Sylvester, Beatrice Mercorelli, Arianna Loregian, Karoly Toth, Renato H. Weiße, Abibe Useini, Norbert Sträter, Mianling Yang, Bing Ye, Ann E. Tollefson, Christa E. Müller, Xinyong Liu, Peng Zhan

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, trisubstituted piperazine derivatives, spectrum anticoronaviral activity, somewhat enhanced compared, promising antiviral activity, prominent antiviral activity, molecular docking elucidated, improved antiviral activity, 38 μm ), improved pharmacokinetic properties, favorable pharmacokinetic profile, pro , hcl , 50 , pharmacokinetic properties, favorable druggability, 19 μm, three series, potential broad, ongoing transmission

Relation: https://figshare.com/articles/dataset/Design_Synthesis_and_Biological_Evaluation_of_Trisubstituted_Piperazine_Derivatives_as_Noncovalent_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Main_Protease_Inhibitors_with_Improved_Antiviral_Activity_and_Favorable_Druggability/24627722

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01876.s002
https://figshare.com/articles/dataset/Design_Synthesis_and_Biological_Evaluation_of_Trisubstituted_Piperazine_Derivatives_as_Noncovalent_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Main_Protease_Inhibitors_with_Improved_Antiviral_Activity_and_Favorable_Druggability/24627722

المؤلفون: Xiaoyu Shi, Tong Zhao, Shuo Wang, Shujing Xu, Hui Liao, Shenghua Gao, Zhen Gao, Jian Zhang, Danhui Qi, Zhijiao Zhang, Fengxin Zheng, Youzhao Wang, Zhenqian Wang, Mingyu Yang, Qian Yang, Fan Yi, Jianxin Pang, Xinyong Liu, Peng Zhan

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, xanthine oxidase inhibitors, urate transporter 1, substituent modification strategies, metabolic diseases characterized, lower effective dosage, inhibiting urate reabsorption, glucose transporter 9, fused cyclic structures, favorable pharmacokinetic profiles, favorable druggability gout, extensive structural modifications, clinical practice due, apparent acute toxicity, improved pharmacokinetic properties, 21 μm ), novel thienopyrimidine compound, glut9 dual inhibitor, 50 , 29 , thienopyrimidine compound, vivo <, improved efficacy, 01 μm

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Novel_Thienopyrimidine_Compound_as_a_Urate_Transporter_1_and_Glucose_Transporter_9_Dual_Inhibitor_with_Improved_Efficacy_and_Favorable_Druggability/25406820

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c00136.s002