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المؤلفون: Takeshi Tada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Yasuyuki Hayashi, Hideaki Okuyama, Tsunetaro Morino, Yoshiyuki Kasai, Hiromi Kojima, Koichi Omori
المصدر: Regenerative Therapy
Regenerative Therapy, Vol 19, Iss, Pp 77-87 (2022)مصطلحات موضوعية: Medicine (General), ET, Eustachian tube, CPM, carboxypeptidase M, Middle ear, PBS, phosphate-buffered saline, Biomedical Engineering, KRT5, cytokeratin5, NBRP, National BioResource Project, Ac-TUB, acetylated α-tubulin, Biomaterials, R5-920, X-SCID, x-linked severe combined immunodeficient, hiPSC, human induced pluripotent stem cell, OCT, optimal cutting temperature, PET, polyethylene terephthalate, Cholesteatoma, AEC, airway epithelial cell, Otitis media, Transplantation, QH573-671, EDTA, ethylenediaminetetraacetic acid, HNA, human nuclear antigen, Induced pluripotent stem cell, respiratory system, MUC5AC, mucin5AC, Original Article, PFA, paraformaldehyde, Cytology, DAPI, 4′,6-diamidino-2-phenylindole, Developmental Biology
وصف الملف: application/pdf
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المؤلفون: Ryota Tabei, Yujiro Kawai, Kazuaki Nakajima, Satoshi Kunita, Shota Someya, Jun Fujita, Hidenori Tani, Keiichi Fukuda, Yoshikazu Kishino, Hideaki Kanazawa, Shugo Tohyama, Takumi Teratani, Akira Ito, Noriko Handa, Akinori Hirano, Rei Shibata, Sho Tanosaki, Eiji Kobayashi, Shuji Hishikawa, Marina Okada, Hideyuki Shimizu, Masataka Yamazaki, Shigeo Okuda, Yoshitake Yamada, Yusuke Soma, Yasuhiko Tabata, Yuika Morita, Shinji Kawaguchi, Toyoaki Murohara
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: 0301 basic medicine, Cardiac function curve, medicine.medical_specialty, LVEDV, left ventricular end-diastolic volume, Cell, heart failure, cardiomyocyte, 030204 cardiovascular system & hematology, HF, heart failure, human iPS cells, 03 medical and health sciences, 0302 clinical medicine, sCM, single cardiomyocyte, CMR, cardiac magnetic resonance, Internal medicine, hiPSC, human induced pluripotent stem cell, medicine, dp/dtmax, maximum rate of left ventricular pressure rise, EF, ejection fraction, CM, cardiomyocyte, Induced pluripotent stem cell, cell transplantation, LV, left ventricular, Ejection fraction, business.industry, Spheroid, medicine.disease, FAC, fractional area change, VEGF, vascular endothelial growth factor, Transplantation, 030104 developmental biology, medicine.anatomical_structure, GH, gelatin hydrogel, hPSC, human pluripotent stem cell, cardiac spheroids, Heart failure, Cardiology, LVESV, left ventricular end-systolic volume, ECG, electrocardiogram, Teratoma, Preclinical Research, Cardiology and Cardiovascular Medicine, business, CS, cardiac spheroid
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المؤلفون: David J. Mooney, Andrew S. Khalil, Rudolf Jaenisch
المصدر: Advanced Drug Delivery Reviews
مصطلحات موضوعية: Drug Evaluation, Preclinical, Preclinical studies, Pharmaceutical Science, 02 engineering and technology, hESC, human embryonic stem cell, NTD, neural tube closure defect, GEM, genetically engineered mouse, NIH, United States National Institutes of Health, Neoplasms, hiPSC, human induced pluripotent stem cell, Drug Discovery, DMPK, drug metabolism and pharmacokinetics studies, 2D, two-dimensional, media_common, Stem cell engineering, PKPD, Pharmacokinetic-pharmacodynamic studies, Vaccines, 0303 health sciences, Neurodegenerative Diseases, HTS, high-throughput screen, 021001 nanoscience & nanotechnology, MPS, microphysiological system, ECM, extracellular matrix, Disease modeling, Risk analysis (engineering), Drug development, Microphysiological systems, Models, Animal, 0210 nano-technology, FDA, United States Food and Drug Administration, Drug, BBB, blood-brain barrier, media_common.quotation_subject, Bioengineering, ADME, absorption, distribution, metabolism, and excretion studies, In Vitro Techniques, Models, Biological, Article, PK, drug pharmacokinetics, 03 medical and health sciences, Lack of efficacy, Animals, Humans, Engineering tool, Tissue engineering, Obesity, 030304 developmental biology, 3D, three-dimensional, HCT, human clinical trials, Clinical trial, DARPA, United States Defense Advanced Research Projects Agency, hPSC, human pluripotent stem cell, PD, drug pharmacodynamics
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المؤلفون: Karl J. Wahlin, Jun Wan, Ravi Chakra Turaga, Cynthia A. Berlinicke, Jiang Qian, Joseph L. Mertz, Melissa M. Liu, Ming-Wen Hu, Donald J. Zack, Srinivasa R. Sripathi, Julien Maruotti
المصدر: Molecular & Cellular Proteomics : MCP
مصطلحات موضوعية: retina, SLC, solute carrier, UR, upstream regulator, Proteome, Carcinogenesis, DIA, data-independent acquisition, Retinal Pigment Epithelium, Tandem mass tag, Proteomics, Biochemistry, Analytical Chemistry, Transcriptome, transcriptomics, Data-independent acquisition, AMD, age-related macular degeneration, Induced pluripotent stem cell, Cells, Cultured, EMT, PSM, peptide-spectrum match, Cell biology, ECM, extracellular matrix, medicine.anatomical_structure, embryonic structures, proteogenomics, RT, room temperature, hiPSC, human-induced pluripotent stem cell, FGFR, fibroblast growth factor receptor, RPE, retinal pigment epithelium, TEABC, triethylammonium bicarbonate, URA, upstream regulator analysis, Epithelial-Mesenchymal Transition, FDR, false discovery rate, Induced Pluripotent Stem Cells, hiPS/ES–RPE, hRPE, human stem cell–derived RPE, Biology, proteomics, STY, phosphoserine, threonine, and tyrosine, GO, Gene Ontology, medicine, Humans, Epithelial–mesenchymal transition, Molecular Biology, Embryonic Stem Cells, Retinal pigment epithelium, Research, TMT, tandem mass tag, MS, ACN, acetonitrile, bRPLC, basic reversed-phase LC, FC, fold change, IPA, ingenuity pathway analysis, STRING, Search Tool for the Retrieval of Interacting Genes/Proteins, eye diseases, Coculture Techniques, sense organs, qPCR, quantitative PCR, hESC, human-embryonic stem cell, EMT, epithelial-to-mesenchymal transition
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المؤلفون: V.T. Trossmann, Felix B. Engel, S. Lentz, Tilman U. Esser, Thomas Scheibel
المصدر: Materials Today Bio
Materials Today Bio, Vol 11, Iss, Pp 100114-(2021)مصطلحات موضوعية: Medicine (General), genetic structures, QH301-705.5, Biomedical Engineering, New materials, Fibroin, Bioengineering, FT-IR, Fourier-transform infrared (spectroscopy), EthHD1, ethidium homodimer 1, complex mixtures, Pharmacological treatment, APTES, (3-aminopropyl) triethoxysilane, Biomaterials, R5-920, Tissue engineering, MALDI-TOF, matrix-assisted laser desorption/ionization time-of-flight, Full Length Article, Spider silk, Biology (General), ATR, attenuated total reflection, DPBS, Dulbecco's phosphate-buffered saline, Induced pluripotent stem cell, Molecular Biology, Afm atomic force microscopy, biology, Chemistry, SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, fungi, Araneus diadematus, Cell Biology, eADF4, Engineered Araneus diadematus fibroin 4, biology.organism_classification, IPTG, isopropyl-β-D-thiogalactoside, Cell biology, AFM, atomic force microscopy, hiPSC, human-induced pluripotent stem cell, Biotechnology
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المؤلفون: Aleksandra Shcherbakova, Karsten Cirksena, Joachim Wittbrodt, Falk F. R. Buettner, Roman Sakson, Lars R. Jensen, Thomas Ruppert, Daniel Todt, Andreas W. Kuss, Alina Friedrich, Stefan Weiss, Hermann J. Hütte, Hans Bakker, Thomas Thumberger
المصدر: Molecular & Cellular Proteomics : MCP
مصطلحات موضوعية: RT, retention time, TSR, thrombospondin type 1 repeat, Oryzias, LTQ, Linear Trap Quadrupole, CBiPSC2, human cord blood–derived induced pluripotent stem cell clone 2, Eye, Biochemistry, Mannosyltransferases, Analytical Chemistry, ADAMTS Proteins, hiPSC, human induced pluripotent stem cell, Zebrafish, secretomics, FA, formic acid, Gene Editing, 0303 health sciences, Metalloproteinase, ESI, electrospray ionization, 030302 biochemistry & molecular biology, ADAMTS16, RI, ROCK inhibitor, Cell biology, Mannosylation, Gene Knockdown Techniques, coloboma, THBS1, thrombospondin 1, sgRNA, single-guide RNA, Induced Pluripotent Stem Cells, Biology, CHO, Chinese hamster ovary, Cell Line, TFA, trifluoroacetic acid, 03 medical and health sciences, HEK, human embryonic kidney, Cricetulus, C-mannosylation, Thrombospondin 1, Animals, Humans, Secretion, eGFP, enhanced GFP, Molecular Biology, 030304 developmental biology, Thrombospondin, Research, HEK 293 cells, LFQ, label-free quantification, ACN, acetonitrile, biology.organism_classification, EIC, extracted ion chromatogram, carbohydrates (lipids), human induced pluripotent stem cells, Eye development, FCS, fetal calf serum, Mannose, MRM, multiple reaction monitoring
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المؤلفون: Victoria Karakis, Adriana San Miguel, Jessica Mahinthakumar, Celeste Carberry, Balaji M. Rao, Adam Mischler, Julia E. Rager, Rebecca C. Fry
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, induced pluripotent stem cell, syncytiotrophoblast, Cell Culture Techniques, hESC, human embryonic stem cell, KSR, knockout serum replacement, Biochemistry, S1P, sphingosine-1 phosphate, Transcriptome, S1PR, S1P receptor, 0302 clinical medicine, EVT, extravillous trophoblast, Pregnancy, hiPSC, human induced pluripotent stem cell, CDX2 Transcription Factor, CDX2, Induced pluripotent stem cell, reproductive and urinary physiology, 0303 health sciences, DMEM, Dulbecco's modified Eagle's medium, TGFβ, transforming growth factor-beta, ROCK, RhoA associated kinase, Embryo, Cell Differentiation, differentiation, TSCM, trophoblast stem cell medium, Cell biology, Trophoblasts, medicine.anatomical_structure, embryonic structures, dhS1P, dihydrospingosine-1-phosphate, Female, Cytotrophoblasts, trophoblast stem cells, Stem cell, Research Article, Pluripotent Stem Cells, Cell type, placenta, CTB, cytotrophoblast, Biology, 03 medical and health sciences, medicine, Humans, Cell Lineage, TS, trophoblast stem, STB, syncytiotrophoblast, Molecular Biology, Embryonic Stem Cells, 030304 developmental biology, GO, gene ontology, EGF, epidermal growth factor, PCA, Principal component analysis, Cytotrophoblast, 030102 biochemistry & molecular biology, Trophoblast, Cell Biology, Embryonic stem cell, trophoblast, embryonic stem cell, FGF, fibroblast growth factor, Culture Media, 030104 developmental biology, hPSC, human pluripotent stem cell, Cell culture, BSA, bovine serum albumin, 030217 neurology & neurosurgery, extravillous trophoblast
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المؤلفون: Kevin, Sung, Nisha R, Patel, Nureddin, Ashammakhi, Kim-Lien, Nguyen
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: 3-dimensional, regenerative medicine, bioink, hCPC, human cardiac-derived progenitor cell(s), HUVEC, human umbilical vein endothelial cell(s), UV, ultraviolet, ECM, extracellular matrix, hiPSC, human induced-pluripotent stem cell(s), MSC, mesenchymal stem cell(s), cardiovascular disease, State-of-the-Art Review, tissue engineering, 3D, 3-dimensional, bioprinting
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المؤلفون: Miller, Duncan C., Harmer, Stephen C., Poliandri, Ariel, Nobles, Muriel, Edwards, Elizabeth C., Ware, James S., Sharp, Tyson V., McKay, Tristan R., Dunkel, Leo, Lambiase, Pier D., Tinker, Andrew
المساهمون: Wellcome Trust
المصدر: Stem Cell Research
Stem Cell Research, Vol 25, Iss C, Pp 233-244 (2017)
Miller, D C, Harmer, S C, Poliandri, A, Nobles, M, Edwards, E C, Ware, J S, Sharp, T V, McKay, T R, Dunkel, L, Lambiase, P D & Tinker, A 2017, ' Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters ', Stem Cell Research, vol. 25, pp. 233-244 . https://doi.org/10.1016/j.scr.2017.11.003مصطلحات موضوعية: Adult, Male, Pluripotent Stem Cells, hiPSC-cardiomyocytes, Patch-Clamp Techniques, IKr, APD, Action Potential Duration, cFPD, Corrected Field Potential Duration (Bazett's formula), Article, NAV1.5 Voltage-Gated Sodium Channel, hPSC, Human Pluripotent Stem Cell, INa, Humans, Brugada syndrome, Myocytes, Cardiac, CM, Cardiomyocyte, Br1, Brugada Type 1 ECG, lcsh:QH301-705.5, BrS, Brugada Syndrome, VF, Ventricular Fibrillation, FP, Field Potential, I Na, Ajmaline, MEA, Multi Electrode Array, ECG, Electrocardiogram, HDFs, Human Dermal Fibroblasts, hiPSC, Human Induced Pluripotent Stem Cell, fungi, I(Na), Cell Differentiation, Heart, 11 Medical And Health Sciences, 06 Biological Sciences, RMP, Resting Membrane Potential, Middle Aged, FPD, Field Potential Duration, AP, Action Potential, Activation-recovery interval, lcsh:Biology (General), I Kr, I(Kr), Anti-Arrhythmia Agents, NGS, Next Generation Sequencing, Developmental Biology
وصف الملف: text; application/pdf
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المؤلفون: Miriam Cnop, Sanna Toivonen, Paraskevi Salpea, Mariana Igoillo-Esteve
المصدر: Molecular metabolism, 6 (9
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 9, Pp 1024-1039 (2017)مصطلحات موضوعية: 0301 basic medicine, Obstétrique, IAPP, islet amyloid polypeptide, uORF, upstream open reading frame, PERK, PKR-like ER kinase, Cell, Eukaryotic Initiation Factor-2, Apoptosis, PBA, 4-phenyl butyric acid, Review, hESC, human embryonic stem cell, Endoplasmic Reticulum, ATF, activating transcription factor, ERAD, ER-associated degradation, eIF-2 Kinase, UPR, unfolded protein response, Gynécologie, Insulin-Secreting Cells, GCN2, general control non-derepressible-2, hiPSC, human induced pluripotent stem cell, Insulin, Pancreatic β cell, Phosphorylation, IER3IP1, immediate early response-3 interacting protein-1, Cell Death, Chemistry, MEHMO, mental retardation, epilepsy, hypogonadism and -genitalism, microcephaly and obesity, Diabetes, GIP, glucose-dependent insulinotropic polypeptide, TUDCA, taurine-conjugated ursodeoxycholic acid derivative, CReP, constitutive repressor of eIF2α phosphorylation, NRF2, nuclear factor, erythroid 2 like 2, Endoplasmic Reticulum Stress, SERCA, sarcoendoplasmic reticulum Ca2+ ATPase, 3. Good health, PP1, protein phosphatase 1, WFS, Wolfram syndrome, medicine.anatomical_structure, XBP1, X-box binding protein 1, CRISPR, clustered regularly interspaced short palindromic repeats, Endoplasmic reticulum stress, PDX1, Signal transduction, Signal Transduction, IRE1, inositol-requiring protein-1, Islet, lcsh:Internal medicine, medicine.medical_specialty, Programmed cell death, SERCA, XBP1, eIF2α, CHOP, C/EBP homologous protein, eIF2, eukaryotic translation initiation factor 2, ER, endoplasmic reticulum, 03 medical and health sciences, Internal medicine, medicine, Diabetes Mellitus, Animals, Humans, HRI, heme-regulated inhibitor kinase, GLP-1, glucagon-like peptide 1, PPA, phenylpropenoic acid glucoside, lcsh:RC31-1245, GWAS, genome-wide association study, Molecular Biology, PKR, protein kinase RNA, ISR, integrated stress response, RyR2, type 2 ryanodine receptor/Ca2+ release channel, Endoplasmic reticulum, Cell Biology, Pdx1, pancreatic duodenal homeobox 1, 030104 developmental biology, Endocrinology, hPSC, human pluripotent stem cell, Cancer research, Unfolded protein response, Unfolded Protein Response, RIDD, regulated IRE1-dependent decay, Biologie cellulaire, MODY, maturity-onset diabetes of the young, HNF1A, hepatocyte nuclear factor 1-α
وصف الملف: 1 full-text file(s): application/pdf