المؤلفون: João B. Calixto, Adara Aurea dos Santos, Juliano Ferreira, Alessandra Hubner Souza, Célio José de Castro Junior, Marcus Vinicius Gomez

المصدر: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 31 (2025)

مصطلحات موضوعية: Phα1β, analgesic, Dofetilide, Kv11.1 potassium channel, hERG channel interaction, HEK293-hERG, cell viability, Arctic medicine. Tropical medicine, RC955-962, Toxicology. Poisons, RA1190-1270, Zoology, QL1-991

وصف الملف: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992025000100501&lng=en&tlng=en; http://www.scielo.br/pdf/jvatitd/v31/1678-9199-jvatitd-31-e20240039.pdf; https://doaj.org/toc/1678-9199

URL الوصول: https://doaj.org/article/be556967940d4203b212c6ebdadfd0cd

المؤلفون: Emigh Cortez, Aiyana, DeMarco, Kevin, Furutani, Kazuharu, Bekker, Slava, Sack, Jon, Wulff, Heike, Clancy, Colleen, Vorobyov, Igor, Yarov-Yarovoy, Vladimir

مصطلحات موضوعية: Rosetta, drug block, hERG channel, potassium channel, state-dependent

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2vk5v4zs
https://escholarship.org/content/qt2vk5v4zs/qt2vk5v4zs.pdf

المؤلفون: Maly, Jan, Emigh, Aiyana M, DeMarco, Kevin R, Furutani, Kazuharu, Sack, Jon T, Clancy, Colleen E, Vorobyov, Igor, Yarov-Yarovoy, Vladimir

مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, Cardiovascular, Heart Disease, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, hERG channel, potassium channel, inactivation, drug block, Rosetta, Pharmacology and Pharmaceutical Sciences, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1wx8q1xs
https://escholarship.org/content/qt1wx8q1xs/qt1wx8q1xs.pdf

المؤلفون: G. V. Mokrov

المصدر: Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 3-19 (2023)

مصطلحات موضوعية: antiarrhythmics, cardioprotectors, herg channel blockers, herg channel activators/modulators, biaromatic compounds, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.pharmacokinetica.ru/jour/article/view/338; https://doaj.org/toc/2587-7836; https://doaj.org/toc/2686-8830

URL الوصول: https://doaj.org/article/43a1aac1c6584e51b74bcc85df18821e

المؤلفون: Ylipää, Erik, Chavan, Swapnil, Bånkestad, Maria, Broberg, Johan, Glinghammar, Björn, Norinder, Ulf, 1956, Cotgreave, Ian

المصدر: Current Research in Toxicology. 5

مصطلحات موضوعية: Deep Learning, Graph -neural Network, hERG Channel, Random Forest, Recurrent -neural Network, Support -vector Machines

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-223947
https://doi.org/10.1016/j.crtox.2023.100121

المؤلفون: Aiyana M. Emigh Cortez, Kevin R. DeMarco, Kazuharu Furutani, Slava Bekker, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Igor Vorobyov, Vladimir Yarov-Yarovoy

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: hERG channel, potassium channel, state-dependent, drug block, Rosetta, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1244166/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/fd59e24e40c74bc3bfc831b84aa37187

المؤلفون: Himanshu Goel, Wenbo Yu, Alexander D. MacKerell

المصدر: Chemistry, Vol 4, Iss 3, Pp 630-646 (2022)

مصطلحات موضوعية: SILCS, hERG channel, physicochemical properties, multiple linear regression, FragMaps, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2624-8549/4/3/45; https://doaj.org/toc/2624-8549

URL الوصول: https://doaj.org/article/b4da44b444bb4915870fd72b30c63809

المؤلفون: Hui Jia Farm, Michael Clerx, Fergus Cooper, Liudmila Polonchuk, Ken Wang, David J. Gavaghan, Chon Lok Lei

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: drug binding, drug trapping, IC50 (50% inhibition concentration), mathematical modelling, hERG channel, action potential predictions, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1110555/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/dffab7b5dfe14ccc99d7e8b7c58bb678

المؤلفون: Milani, Gualtiero, Budriesi, Roberta, Tavazzani, Elisa, Cavalluzzi, Maria Maddalena, Mattioli, Laura Beatrice, Miniero, Daniela Valeria, Delre, Pietro, Belviso, Benny Danilo, Denegri, Marco, Cuocci, Corrado, Rotondo, Natalie Paola, De Palma, Annalisa, Gualdani, Roberta, Caliandro, Rocco, Mangiatordi, Giuseppe Felice, Kumawat, Amit, Camilloni, Carlo, Priori, Silvia, Lentini, Giovanni

المساهمون: G. Milani, R. Budriesi, E. Tavazzani, M.M. Cavalluzzi, L.B. Mattioli, D.V. Miniero, P. Delre, B.D. Belviso, M. Denegri, C. Cuocci, N.P. Rotondo, A. De Palma, R. Gualdani, R. Caliandro, G.F. Mangiatordi, A. Kumawat, C. Camilloni, S. Priori, G. Lentini

مصطلحات موضوعية: hERG channel, long QT syndrome, mexiletine, molecular docking, ureas, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Settore BIO/10 - Biochimica, Settore CHIM/08 - Chimica Farmaceutica

Relation: info:eu-repo/semantics/altIdentifier/pmid/37460390; info:eu-repo/semantics/altIdentifier/wos/WOS:001026761000001; firstpage:1; lastpage:17; numberofpages:17; journal:ARCHIV DER PHARMAZIE; https://hdl.handle.net/2434/989248; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85165243452

الاتاحة: https://hdl.handle.net/2434/989248
https://doi.org/10.1002/ardp.202300116

المؤلفون: Costa, Flavio, Ocello, Riccardo, Guardiani, Carlo, Giacomello, Alberto, Masetti, Matteo

المساهمون: Costa, Flavio, Ocello, Riccardo, Guardiani, Carlo, Giacomello, Alberto, Masetti, Matteo

مصطلحات موضوعية: hERG channel, Molecular docking, Molecular dynamics, Allosteric modulation, hERG activators, Network analysis

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/37504578; info:eu-repo/semantics/altIdentifier/wos/WOS:001039604000001; volume:63; issue:15; firstpage:4888; lastpage:4899; numberofpages:12; journal:JOURNAL OF CHEMICAL INFORMATION AND MODELING; https://hdl.handle.net/11585/942453; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85167833625

الاتاحة: https://hdl.handle.net/11585/942453
https://doi.org/10.1021/acs.jcim.3c00596
https://pubs.acs.org/doi/10.1021/acs.jcim.3c00596

المؤلفون: Taeho Kim, Kee-Choo Chung, Hwangseo Park

المصدر: Pharmaceuticals, Vol 16, Iss 11, p 1509 (2023)

مصطلحات موضوعية: hERG channel blockers, 3D-QSAR, structural alignment, molecular ESP descriptor, artificial neural network, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/11/1509; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/aa96ba85aeb346c1846009cfd54f653b

المؤلفون: Chiamvimonvat, Nipavan, Chen‐Izu, Ye, Clancy, Colleen E, Deschenes, Isabelle, Dobrev, Dobromir, Heijman, Jordi, Izu, Leighton, Qu, Zhilin, Ripplinger, Crystal M, Vandenberg, Jamie I, Weiss, James N, Koren, Gideon, Banyasz, Tamas, Grandi, Eleonora, Sanguinetti, Michael C, Bers, Donald M, Nerbonne, Jeanne M

المصدر: The Journal of Physiology. 595(7)

مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, Cardiovascular, Heart Disease, Good Health and Well Being, Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Heart, Humans, Models, Biological, Potassium Channels, K channel blockers, atrial fibrillation, cardiac K channels, cardiac arrhythmia, cardiac repolarization, computational modeling, hERG channel, long QT syndrome, Biological Sciences, Medical and Health Sciences, Physiology, Biological sciences, Biomedical and clinical sciences, Health sciences

URL الوصول: https://escholarship.org/uc/item/6s1697c7

المؤلفون: Jan Maly, Aiyana M. Emigh, Kevin R. DeMarco, Kazuharu Furutani, Jon T. Sack, Colleen E. Clancy, Igor Vorobyov, Vladimir Yarov-Yarovoy

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: hERG channel, potassium channel, inactivation, drug block, Rosetta, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.966463/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/2d6edb3ac4d74f63a3ae45538a385935

المؤلفون: Eiichi Watanabe, Jong-Kook Lee, Junji Toyama, Takahiko Suzuki, Yoriyasu Suzuki, Yukiomi Tsuji, 外山 淳治, 李 鍾國, 渡邉 英一, 辻 幸臣, 鈴木 孝彦, 鈴木 頼快

المصدر: 心電図 / Japanese Journal of Electrocardiology. 2022, 42(4):203

المؤلفون: Zequn Zheng, Yongfei Song, Jiangfang Lian

المصدر: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

مصطلحات موضوعية: hERG channel protein, Lumacaftor, gene mutation, retrafficking, therapeutic potential, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2022.801927/full; https://doaj.org/toc/2297-055X

URL الوصول: https://doaj.org/article/e1f95785870847bb9549c69bfbdc33db

المؤلفون: Grychowska, Katarzyna, Olejarz-Maciej, Agnieszka, Blicharz, Klaudia, Pietruś, Wojciech, Karcz, Tadeusz, Kurczab, Rafał, Koczurkiewicz, Paulina, Doroz-Płonka, Agata, Latacz, Gniewomir, Keeri, Abdul Raheem, Piska, Kamil, Satała, Grzegorz, Pęgiel, Joanna, Trybała, Wojciech, Jastrzębska-Więsek, Magdalena, Bojarski, Andrzej, Lamaty, Frédéric, Partyka, Anna, Walczak, Maria, Krawczyk, Martyna, Malikowska-Racia, Natalia, Popik, Piotr, Zajdel, Paweł

المساهمون: Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences (PAN), Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM)

المصدر: ISSN: 0223-5234.

مصطلحات موضوعية: Alzheimer's disease, MAO-B inhibitors, Glia, Cognition, Fluorinated compounds, hERG channel, [CHIM.THER]Chemical Sciences/Medicinal Chemistry

الاتاحة: https://hal.science/hal-03648220
https://hal.science/hal-03648220v1/document
https://hal.science/hal-03648220v1/file/161-2022-EJMC.pdf
https://doi.org/10.1016/j.ejmech.2022.114329

المؤلفون: Champéroux, Pascal, Fares, Raafat, Bastogne, Thierry, Richard, Serge, Le Guennec, Jean-Yves, Thireau, Jérôme

المساهمون: European Research Biology Center (ERBC), Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

المصدر: ISSN: 0007-1188.

مصطلحات موضوعية: hemodynamic, hERG channel, HF oscillations, QTc prolongation, Torsades de pointes, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology

Relation: info:eu-repo/semantics/altIdentifier/pmid/35751378; PUBMED: 35751378

الاتاحة: https://hal.science/hal-03704878
https://hal.science/hal-03704878v1/document
https://hal.science/hal-03704878v1/file/bjp2022erbcoriginalmanuscript.pdf
https://doi.org/10.1111/bph.15905

المؤلفون: Krause, Tobias

مصطلحات موضوعية: Engineered Heart Tissue, Action potential duration, hERG-channel, sharp microelectrode, arrhythmogenesis, 610: Medizin, 44.85: Kardiologie, Angiologie, Induzierte pluripotente Stammzelle, Repolarisation, Arrhythmie, Elektrophysiologie, Q-T-Verlängerung, Arzneimittelsicherheit, ddc:610:

URL الوصول: http://nbn-resolving.de/urn:nbn:de:gbv:18-ediss-97515
https://ediss.sub.uni-hamburg.de/handle/ediss/9382

المؤلفون: Mengying Huang, Zhenxing Liao, Xin Li, Zhen Yang, Xuehui Fan, Yingrui Li, Zhihan Zhao, Siegfried Lang, Lukas Cyganek, Xiaobo Zhou, Ibrahim Akin, Martin Borggrefe, Ibrahim El-Battrawy

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: short QT syndrome, arrhythmias, antiarrhythmic drugs, human-induced pluripotent stem cell-derived cardiomyocytes, hERG channel, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.675003/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/2f5fe5842def4a55bdbdf25d5c1e9677

المؤلفون: Renier van der Westhuyzen (1463818), Amanda Mabhula (9915321), Paul M. Njaria (10988180), Rudolf Müller (10988183), Denis Ngumbu Muhunga (10988186), Dale Taylor (1463830), Nina Lawrence (1463851), Mathew Njoroge (1463821), Christel Brunschwig (1463836), Atica Moosa (848176), Vinayak Singh (848177), Srinivasa P.S. Rao (1463809), Ujjini H. Manjunatha (9505), Paul W. Smith (1463833), Digby F. Warner (848178), Leslie J. Street (1463824), Kelly Chibale (503778)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Sociology, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Mycobacterium tuberculosis, oxime frontrunner compounds, hERG channel inhibition liability, series, biology triage assays, Biology Triaging Screening, benzoheterocyclic oxime carbamate, Benzoheterocyclic Oxime Carbamates, Mtb

Relation: https://figshare.com/articles/journal_contribution/Benzoheterocyclic_Oxime_Carbamates_Active_against_Mycobacterium_tuberculosis_Synthesis_Structure_Activity_Relationship_Metabolism_and_Biology_Triaging/14802752

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00707.s001