المؤلفون: Simon J. Shaw, Dane A. Goff, Luke A. Boralsky, Rajinder Singh, David J. Sweeny, Gary Park, Tian-Qiang Sun, Yonchu Jenkins, Vadim Markovtsov, Sarkiz D. Issakani, Donald G. Payan, Yasumichi Hitoshi

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Pharmacology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, type ii diabetes, secondary amide bond, lowering fasted glucose, inhibiting amide hydrolysis, vitro safety profile, liver blood flow, reduced rat clearance, db mouse model, 32 , rat clearance, mouse liver, trans <, herg profile, target potency, strategic placement, steric environment, position 3, piperidine ring, piperidine moiety, oral dosing, insulin levels, generated around

Relation: https://figshare.com/articles/journal_contribution/Optimization_of_Pharmacokinetic_and_In_Vitro_Safety_Profile_of_a_Series_of_Pyridine_Diamide_Indirect_AMPK_Activators/24790501

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01983.s001
https://figshare.com/articles/journal_contribution/Optimization_of_Pharmacokinetic_and_In_Vitro_Safety_Profile_of_a_Series_of_Pyridine_Diamide_Indirect_AMPK_Activators/24790501

المؤلفون: Simon J. Shaw, Dane A. Goff, Luke A. Boralsky, Rajinder Singh, David J. Sweeny, Gary Park, Tian-Qiang Sun, Yonchu Jenkins, Vadim Markovtsov, Sarkiz D. Issakani, Donald G. Payan, Yasumichi Hitoshi

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Pharmacology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, type ii diabetes, secondary amide bond, lowering fasted glucose, inhibiting amide hydrolysis, vitro safety profile, liver blood flow, reduced rat clearance, db mouse model, 32 , rat clearance, mouse liver, trans <, herg profile, target potency, strategic placement, steric environment, position 3, piperidine ring, piperidine moiety, oral dosing, insulin levels, generated around

Relation: https://figshare.com/articles/dataset/Optimization_of_Pharmacokinetic_and_In_Vitro_Safety_Profile_of_a_Series_of_Pyridine_Diamide_Indirect_AMPK_Activators/24790504

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01983.s002
https://figshare.com/articles/dataset/Optimization_of_Pharmacokinetic_and_In_Vitro_Safety_Profile_of_a_Series_of_Pyridine_Diamide_Indirect_AMPK_Activators/24790504