المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/journal_contribution/S1_File_-/25430932

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.s001

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Heatmaps_of_the_most_frequent_residue_trios_bottleneck_radius_distribution_for_each_channel_/25430941

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g003

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Fig_1_-/25430935

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g001

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Fig_5_-/25430947

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g005

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/dataset/Exit_channels_in_CYP3A4_and_respective_gating_residues_50_/25430968

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.t002

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/dataset/Parameters_for_identified_channels_using_CAVER_/25430971

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.t003

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Transition_probabilities_for_each_gateway_residue_pair_as_a_function_of_the_distance_chosen_to_differentiate_openness_from_closedness_/25430959

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g009

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Fig_4_-/25430944

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g004

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Fig_6_-/25430950

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g006

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Distance_distributions_of_each_channel_s_gating_residues_from_all_simulations_for_the_membrane-embedded_CYP_3A4_/25430953

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g007

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/dataset/Exit_residues_used_to_calculate_the_location_of_the_channels_exits_with_respect_to_the_membrane_/25430965

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.t001

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Dual_distance_distributions_for_each_gating_residue_pair_are_plotted_against_each_other_gating_residue_pair_/25430956

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g008

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/figure/Ten-state_Hidden_Markov_Model_HMM_of_the_apo_CYP_3A4_with_circles_representing_the_state_equilibrium_population_/25430962

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.g010

المؤلفون: Edward Michael Ackad, Laurence Biggers, Mary Meister, Maria Kontoyianni

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, may potentially lead, hidden markov models, findings shed light, display coordinated motion, discuss channel properties, channel location relative, respective channel ingress, gating residues regarding, gating residues, bottleneck residues, %22">xlink ">, reduced efficacy, randomly transition, random fashion, often manifested, equilibrium landscape, enzymes metabolize, different conformations, cytochrome p450, closed states

Relation: https://figshare.com/articles/dataset/Equilibrium_populations_of_each_state_as_a_function_of_boundary_distance_/25430974

الاتاحة: https://doi.org/10.1371/journal.pone.0298424.t004

المؤلفون: Eva-Maria Krammer, Andrew Gibbons, Goedele Roos, Martine Prévost

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

مصطلحات موضوعية: Gating Residues, Divalent Compounds, Agmatine, Divalent Ligand, Solvation Free Energy, Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/f35d040aaaeb4c38b8190e9b448e6738

المؤلفون: Sacquin-Mora, Sophie

المساهمون: Laboratoire de biochimie théorique Paris (LBT (UPR_9080)), Institut de biologie physico-chimique (IBPC (FR_550)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), ANR-11-LABX-0011,DYNAMO,Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire.(2011)

المصدر: ISSN: 1742-5689.

مصطلحات موضوعية: NMR conformational ensembles, Proteins mechanics, Coarse-grain simulations, Elastic network model, Protein gating residues, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry

Relation: hal-02307948; https://hal.science/hal-02307948; https://hal.science/hal-02307948/document; https://hal.science/hal-02307948/file/532507.full.pdf; PUBMEDCENTRAL: PMC6685036

الاتاحة: https://hal.science/hal-02307948
https://hal.science/hal-02307948/document
https://hal.science/hal-02307948/file/532507.full.pdf
https://doi.org/10.1098/rsif.2019.0075

المؤلفون: Guellec, Julie, Elbahnsi, Ahmad, Le Tertre, Marlène, Uguen, Kévin, Gourlaouen, Isabelle, Férec, Claude, Ka, Chandran, Callebaut, Isabelle, Le Gac, Gérald

المساهمون: Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Institut Brestois Santé Agro Matière (IBSAM), Etablissement Français du Sang Bretagne, EFS, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement IRD : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018)

المصدر: ISSN: 0892-6638.

مصطلحات موضوعية: MFS transporters, alternating access mechanism, gating residues, iron metabolism, molecular dynamics simulations, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/31690120; PUBMED: 31690120

الاتاحة: https://hal.sorbonne-universite.fr/hal-03031336
https://hal.sorbonne-universite.fr/hal-03031336v1/document
https://hal.sorbonne-universite.fr/hal-03031336v1/file/FPN1_FASEB_20190903R.pdf
https://doi.org/10.1096/fj.201901857R

المؤلفون: Goedele Roos, Andrew Gibbons, Eva-Maria Krammer, Martine Prévost

المصدر: Scientific Reports
Scientific reports, 8 (1
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

مصطلحات موضوعية: 0301 basic medicine, Arginine, Agmatine, Amino Acid Transport Systems, Stereochemistry, Antiporter, Science, Gating, Molecular Dynamics Simulation, Divalent Ligand, Ligands, Antiporters, Article, Divalent, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Deprotonation, Escherichia coli, Binding site, chemistry.chemical_classification, Multidisciplinary, Solvation Free Energy, Binding Sites, 030102 biochemistry & molecular biology, Ligand, Escherichia coli Proteins, Biological Transport, Gating Residues, Divalent Compounds, 030104 developmental biology, chemistry, Medicine, Protons, Sciences exactes et naturelles

وصف الملف: 1 full-text file(s): application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285cd7ca3c26b872bd5e84e7f211b6ca
https://pubmed.ncbi.nlm.nih.gov/30353119