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1Academic Journal
المؤلفون: Syed Masood, Hye-Young H. Kim, Edward R. Pennington, Keri A. Tallman, Ned A. Porter, Philip A. Bromberg, Rebecca L. Rice, Avram Gold, Zhenfa Zhang, James M. Samet
المصدر: Redox Biology, Vol 73, Iss , Pp 103199- (2024)
مصطلحات موضوعية: Air pollution, Cellular bioenergetics, GAPDH (glyceraldehyde-3-phosphate dehydrogenase), Oxidative stress, Protein thiol oxidation, Secondary organic aerosols, Medicine (General), R5-920, Biology (General), QH301-705.5
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: In-Young Choi, Lamiya Abasova, Joon-Ho Choi, Young-Joon Choi, Hyeon-Dong Shin
المصدر: 한국균학회지, Vol 51, Iss 3, Pp 239-243 (2023)
مصطلحات موضوعية: erysiphaceae, golovinomyces biocellatus, gapdh (glyceraldehyde-3-phosphate dehydrogenase), its (internal transcribed spacer), lsu (large subunit), multigene analysis, Biology (General), QH301-705.5
وصف الملف: electronic resource
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3Academic Journal
المؤلفون: Sara Gómez, Javier Querol-García, Gara Sánchez-Barrón, Marta Subias, Àlex González-Alsina, Virginia Franco-Hidalgo, Sebastián Albertí, Santiago Rodríguez de Córdoba, Francisco J. Fernández, M. Cristina Vega
المصدر: Frontiers in Microbiology, Vol 10 (2019)
مصطلحات موضوعية: GAPDH – glyceraldehyde-3-phosphate dehydrogenase, Streptococcus pyogenes, Clostridium perfringens, anacardic acid, curcumin, complement – immunological term, Microbiology, QR1-502
وصف الملف: electronic resource
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4Academic Journal
المؤلفون: Mele Antonietta, Mantuano Paola, De Bellis Michela, Rana Francesco, Sanarica Francesca, Conte Elena, Morgese Maria Grazia, Bove Maria, Rolland JeanFrancois, Capogrosso Roberta Francesca, Pierno Sabata, Camerino Giulia Maria, Trabace Luigia, De Luca Annamaria.
المساهمون: Mele, Antonietta, Mantuano, Paola, DE BELLIS, Michela, Rana, Francesco, Sanarica, Francesca, Conte, Elena, Morgese Maria, Grazia, Bove, Maria, Rolland, Jeanfrancoi, Capogrosso, Roberta Francesca, Pierno, Sabata, Camerino, GIULIA MARIA, Trabace, Luigia, De Luca, Annamaria.
مصطلحات موضوعية: CK = creatine kinase, CO, cardiac output, Cox4i1 = cytochrome c oxidase subunit IV isoform 1, Cs = citrate synthase, DGC = dystrophin-glycoprotein complex, DIA = diaphragm, DMD = Duchenne muscular dystrophy, EDL = extensor digitorum longu, EF = ejection fraction, Eef2 = eukaryotic translation elongation factor 2, GAPDH = glyceraldehyde-3-phosphate dehydrogenase, GC = gastrocnemius muscle, IL-6 = interleukin 6, LDH = lactate dehydrogenase, NF-kB = nuclear factor kappa-light-chain-enhancer of activated B cell, PV = percentage of vascularization, ROS = reactive oxygen specie, Rplp0 = ribosomal protein, large, P0, SF = shortening fraction, SV = stroke volume, Slc6a6 = solute carrier family 6 (neurotransmitter transporter, TauT = taurine transporter, taurine) member 6
Relation: info:eu-repo/semantics/altIdentifier/pmid/30347179; info:eu-repo/semantics/altIdentifier/wos/WOS:000456888400007; volume:204; firstpage:82; lastpage:99; numberofpages:18; journal:TRANSLATIONAL RESEARCH; http://hdl.handle.net/11586/239005; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85055646582
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5Academic Journal
المؤلفون: Dirk Roosterman, Wolfgang Meyerhof, Graeme S. Cottrell
المصدر: Frontiers in Neuroscience, Vol 12 (2018)
مصطلحات موضوعية: glycolysis/gluconeogenesis, lactate dehydrogenases, GAPDH (glyceraldehyde-3-phosphate dehydrogenase), proton transport chain, pyruvate dehydrogenase complex, monocarboxylic acid transporters, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
وصف الملف: electronic resource
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6
المؤلفون: Mai Tu Dang, Carly I. Misztal, Iakov Efimenko, Matthew Villanueva, Lin Zhang, Kelly M. Dexter, Shiv Krishnaswamy, Malinda Gerard, Fumiaki Yokoi, Patrick Lynch, Yuqing Li
المصدر: IBRO Neuroscience Reports, Vol 11, Iss, Pp 1-7 (2021)
IBRO Neuroscience Reportsمصطلحات موضوعية: medicine.medical_specialty, LTD, long-term depression, ChAT, choline acetyltransferase, Trihexyphenidyl, Dyt1 KI mice, Dyt1 ΔGAG heterozygous knock-in mice, Motor learning, PB, phosphate buffer, PBS, phosphate-buffered saline, ChI, cholinergic interneuron, Neurosciences. Biological psychiatry. Neuropsychiatry, TOR1A, Article, n.s., not significant, PET, positron emission tomography, TrkA, tropomyosin receptor kinase A, THP, trihexyphenidyl, AChE, acetylcholinesterase, Gene knockin, Internal medicine, GAPDH, Glyceraldehyde-3-phosphate dehydrogenase, Medicine, Rotarod, Dystonia, KO, knockout, DAB, 3,3′-diaminobenzidine, ACh, acetylcholine, business.industry, General Neuroscience, Antagonist, DF, degrees of freedom, Muscarinic acetylcholine receptor M1, medicine.disease, WT, wild-type, CI, confidence interval, Endocrinology, TorsinA, Excitatory postsynaptic potential, Cholinergic, BSA, bovine serum albumin, VAChT, vesicular acetylcholine transporter, business, ChT, choline transporter, Cholinergic interneuron, medicine.drug, RC321-571
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المؤلفون: David A. Frank, Isidora Tošić
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)مصطلحات موضوعية: Cancer Research, p53, tumor protein 53, MEF2D, Myocyte Enhancer Factor 2D, FASN, fatty acid synthase, OXPHOS, oxidative phosphorylation, ERH, enhancer of rudimentary homolog, PDGF, platelet-derived growth factor, PFK, phosphofructokinase, CREB, cyclic AMP response element-binding protein, HDL-C, high-density lipoprotein cholesterol, chemistry.chemical_compound, PC, phosphatidylcholine, GRIM-19, gene associated with retinoid-IFN-induced mortality, Neoplasms, Transcriptional regulation, TGFβ, transforming growth factor beta, AML, acute myeloid leukemia, RC254-282, CDK, cyclin-dependent kinase, FABP6, fatty acid binding protein 6, BCL, B-cell lymphoma, CLL, chronic lymphocytic leukemia, Chemistry, LIF, leukemia inhibitory factor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, VEGF, vascular endothelial growth factor, FBP1, fructose-bisphosphatase 1, GPI, glucose-6-phosphate isomerase, Cell biology, MMP, matrix metalloproteinase, STAT, signal transducer and activator of transcription, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, GP130, glycoprotein 130, Phosphorylation, NHL, non-Hodgkin's lymphoma, JAK, Janus kinase, Adenosine triphosphate, CNTF, ciliary neurotrophic factor, STAT3 Transcription Factor, ATP, adenosine triphosphate, TAG, triacylglycerol, Protein processing, Post-translational, PPARγ, peroxisome proliferator-activated receptor gamma, ETC, electron transport chain, TNFα, tumor necrosis factor alpha, RIME, rapid immunoprecipitation mass spectrometry of endogenous proteins, GLUT1, glucose transporter 1, PGK1, phosphoglycerate kinase, MPTP, mitochondrial permeability transition pore, Mediator, Review article, CML, chronic myeloid leukemia, HIF1α, hypoxia inducible factor 1α, PIAS, protein inhibitors of activated STATs, SOCS, suppressors of cytokine signaling, Animals, Humans, IFN, interferon, LDHA, lactate dehydrogenase A, Transcription factor, PKCδ, protein kinase C δ, TF, transcription factors, EGF, epidermal growth factor, SM, sphingomyelin, SREBP1, sterol regulatory element-binding protein 1, IAP, inhibitor of apoptosis, PTP, protein tyrosine phosphatases, Tyrosine phosphorylation, Lipid metabolism, BCSC, breast cancer stem cells, IL, interleukin, Metabolism, OSM, oncostatin M, Anaerobic glycolysis, NFκB, nuclear factor kappa B, TBK1, TANK-binding kinase 1, MCL, myeloid cell leukemia, LDL-C, low-density lipoprotein cholesterol, PBP, PPARγ binding protein, CPT1B, carnitine palmitoyltransferase 1B, FAO, fatty acid oxidation
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8
المؤلفون: Bo Tang, Cunjie Chang, Guo Chen, Xiufeng Liu, Zi-Chun Hua, Xiawei Cheng, Jianxiang Chen, Heng Dong, Yiting Qiao
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3165-3177 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PEI, polyethylenimine, NF-κB, PCR, polymerase chain reaction, 0302 clinical medicine, Salmonella, Cancer immune therapy, IFN-γ, interferon-γ, General Pharmacology, Toxicology and Pharmaceutics, TLR5, IL, interleukins, IκB, inhibitor of NF-κB, GFP, green fluorescent protein, 0303 health sciences, PD-1, programmed cell death protein-1, TIR, Toll/Interleukin-1 receptor, TME, tumor microenvironment, DN, dominant-negative, Acquired immune system, AKT, Akt serine/threonine kinase, LRR, leucine-rich repeat, PD-L1, programmed cell death-ligand 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, LPS, lipopolysaccharide, Original Article, TLR, Toll-like receptor, TRAF6, TNF receptor associated factor 6, CTLA-4, cytotoxic T-lymphocyte-associated protein 4, PBS, phosphate-buffered saline, ERKl, extracellular regulated protein kinase 1, RM1-950, Biology, CFU, colony-forming units, 03 medical and health sciences, Immune system, MyD88, myeloid differentiation factor 88, i.t., intratumorally, 030304 developmental biology, Tumor microenvironment, Flagellum, Innate immune system, Pathogen-associated molecular pattern, i.p., intraperitoneally, Immune checkpoint, NF-κB, nuclear factor kappa-B, Granzyme, ERBB2, Erb-B2 receptor tyrosine kinase 2, Cancer research, biology.protein, bacteria, Bacteria-mediated cancer therapy, Therapeutics. Pharmacology, VNP20009, Flagellin
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9Academic Journal
المؤلفون: Le May, Nicolas, Calmels, N, Abiayad, Y, Boukli, L, Semer, M, Serradj, A, Egly, Jean-Marc, Laugel, Laugel
المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Université de Strasbourg (UNISTRA), Établissement Hospitalo-Universitaire d’Oran (EHU)
المصدر: Journal of Case Reports and Studies ; https://inserm.hal.science/inserm-02462594 ; Journal of Case Reports and Studies, 2018, 6 (4), ⟨10.15744/2348-9820.6.401⟩
مصطلحات موضوعية: CPD: Cyclobutane Pyrimidine Dimers, 6-4PP: 6-4 Photoproducts, GGR: Global Genome Repair, TCR: Transcription-Coupled Repair, NR: Nuclear Receptor, RARß2: Retinoic Acid Receptor Isoform ß2, CYP26: Cytochrome P450 Family 26, DAPK1: Death Associated Protein Kinase 1 (DAPK1), GAPDH: Glyceraldehyde-3-Phosphate Dehydrogenase, RAR: Retinoic-acid Receptor, RRS: Recovery of RNA Synthesis after DNA Damage, UDS: Unscheduled DNA Synthesis, NER: Nucleotide-Excision Repair, Transcription List of abbreviations: XP: Xeroderma pigmentosum, Nucleotide-Excision Repair, DNA Repair, Algerian Patients, Xeroderma pigmentosum, [SDV]Life Sciences [q-bio], [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Relation: inserm-02462594; https://inserm.hal.science/inserm-02462594; https://inserm.hal.science/inserm-02462594/document; https://inserm.hal.science/inserm-02462594/file/6401-Xeroderma-Pigmentosum-Groups-C-and-A-in-Algerian-Patients-with-Deregulation-of-both-Transcription-and-DNA-Repair.pdf
الاتاحة: https://inserm.hal.science/inserm-02462594
https://inserm.hal.science/inserm-02462594/document
https://inserm.hal.science/inserm-02462594/file/6401-Xeroderma-Pigmentosum-Groups-C-and-A-in-Algerian-Patients-with-Deregulation-of-both-Transcription-and-DNA-Repair.pdf
https://doi.org/10.15744/2348-9820.6.401 -
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المؤلفون: Kenneth K.W. To, Jiang Ma, Stella Chai, Chunyuan Zhang, Chun Yin, Sheng Yao, Xu Wu, Thomas Efferth, Yang Ye, Onat Kadioglu, Ge Lin
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)مصطلحات موضوعية: ABCC1, ATP binding cassette subfamily C member 1, IC50, half maximal inhibitory concentration, Multidrug resistance, Pharmacology, NADPH, reduced nicotinamide adenine dinucleotide phosphate, F, bioavailability, chemistry.chemical_compound, PCR, polymerase chain reaction, 0302 clinical medicine, MDR, multidrug resistance, ECL, electrochemiluminescence, t1/2, elimination half-life, LC–MS, liquid chromatography coupled with mass spectrometry, N.D., not detected, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, media_common, ATF3, activating transcription factor 3, 0303 health sciences, Chemistry, ABC, ATP-binding cassette, NMPA, National Medical Products Administration, PXR, pregnane X receptor, SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, HBSS, Hankʹs balanced salt solution, ABCB1, Combination chemotherapy, Prodrug, Marsdenia tenacissima, Cmax, peak concentration, Paclitaxel, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, BHI, brain heart infusion, Original Article, AUC0–∞, area under plasma concentration vs. time curve, MRT, mean residence time, Drug, media_common.quotation_subject, RM1-950, Vd, volume of distribution, ABCB1, ATP binding cassette subfamily B member 1, UIC-2, mouse monoclonal ABCB1 antibody, ABCG2, ATP binding cassette subfamily G member 2, CYP, cytochrome P450 isozyme, PI, propidium iodide, TEER, transepithelial electrical resistance, 03 medical and health sciences, PBS, phosphate buffer saline, FBS, fetal bovine serum, Dox, doxorubicin, In vivo, POP, polyoxypregnane, medicine, 030304 developmental biology, EVOM, epithelial tissue voltohmmeter, Tmax, time for peak concentration, Cancer, LBE, lowest binding energy, PE, phycoerythrin, medicine.disease, Multiple drug resistance, Polyoxypregnane, Papp, apparent permeability, N.A., not applicable, Cancer cell, H&E, hematoxylin and eosin, MDR1a, multidrug resistance protein 1a, Therapeutics. Pharmacology, qPCR, quantitative PCR, M. tenacissima, Marsdenia tenacissima, CL, clearance, SD, standard derivation
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11Academic Journal
المؤلفون: Querol García, Javier, Fernández, Francisco J., Marín Marín, Ana Victoria, Gómez, Sara, Fullà, Daniel, Melchor Tafur, Cecilia, Franco Hidalgo, Virginia, Albertí, Sebastián, Juanhuix, Jordi, Rodríguez de Córdoba, Santiago, Regueiro González-Barros, José Ramón, Vega, María Cristina
مصطلحات موضوعية: 579.61, Anaphylatoxin, Complement system, C5a, GAPDH (glyceraldehyde-3-phosphate dehydrogenase), Gram-positive pathogen, Immunoevasion, X-ray crystallography, Chemoattraction, Inmunología, Microbiología médica, 2412 Inmunología, 3201.03 Microbiología Clínica
وصف الملف: application/pdf
Relation: info:eu-repo/grantAgreement/ISCII/PI12/01667; info:eu-repo/grantAgreement/MINECO//CTQ2015-66206-C2-2-R/ES/DESARROLLO DE NUEVAS GLICOESTRUCTURAS CON ACTIVIDAD ANTI-INFECCIOSA: BACTERIAS GRAM-POSITIVAS Y VIRUS DEL DENGUE/; info:eu-repo/grantAgreement/MINECO//SAF2015-72961-EXP/ES/CURACION PARA LAS ENFERMEDADES DEL COMPLEMENTO ASOCIADAS CON C3/; info:eu-repo/grantAgreement/MINECO//SAF2015-66287-R/ES/DESCIFRANDO LAS BASES MOLECULARES DE LAS ENFERMEDADES RELACIONADAS CON DESREGULACION DEL COMPLEMENTO Y APRENDIENDO COMO TRATARLAS/; info:eu-repo/grantAgreement/MINECO//SAF2014-54708-R/ES/FISIOPATOLOGIA DE LA ACTIVACION EXTRA E INTRACELULAR DEL LINFOCITO T/; info:eu-repo/grantAgreement/CAM/S2010/BD-2316; info:eu-repo/grantAgreement/UCM/CT46/15; info:eu-repo/grantAgreement/CSIC/201620E064; Querol-García J, Fernández FJ, Marin AV, Gómez S, Fullà D, Melchor-Tafur C, Franco-Hidalgo V, Albertí S, Juanhuix J, Rodríguez de Córdoba S, Regueiro JR, Vega MC. Crystal Structure of Glyceraldehyde-3-Phosphate Dehydrogenase from the Gram-Positive Bacterial Pathogen A. vaginae, an Immunoevasive Factor that Interacts with the Human C5a Anaphylatoxin. Front Microbiol. 2017 Apr 10;8:541. doi:10.3389/fmicb.2017.00541. PMID: 28443070; PMCID: PMC5385343.; https://hdl.handle.net/20.500.14352/107450; XXXX-XXXX
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المؤلفون: Li Zhaojun, Sen Zhang, Yuanyuan Chen, Xiaoguang Chen
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 340-354 (2021)مصطلحات موضوعية: SNHG1, small nucleolar RNA host gene 1, BDNF-AS, brain-derived neurotrophic factor antisense, MHRT, myosin heavy chain associated RNA transcripts, Coding (therapy), Review, SncmtRNA, sense noncoding mitochondrial RNA, Disease, siRNAs, small interfering RNAs, TncRNA, trophoblast-derived noncoding RNA, PD, Parkinson's disease, pHLIP, pH-low insertion peptide, Delivery methods, Preclinical research, Clinical trials, MALAT1, metastasis associated lung adenocarcinoma transcript 1, 0302 clinical medicine, RISC, RNA-induced silencing complex, TTTY15, testis-specific transcript, Y-linked 15, UCA1, urothelial carcinoma-associated 1, Medicine, BCAR4, breast cancer anti-estrogen resistance 4, General Pharmacology, Toxicology and Pharmaceutics, LncRNAs, CASC9, cancer susceptibility candidate 9, THRIL, TNF and HNRNPL related immunoregulatory, media_common, ANRIL, antisense noncoding RNA gene at the INK4 locus, 0303 health sciences, NEAT1, nuclear enriched abundant transcript 1, NKILA, NF-kappaB interacting lncRNA, Small molecules, MM, multiple myeloma, HULC, highly upregulated in liver cancer, CHRF, cardiac hypertrophy related factor, MEG3, maternally expressed gene 3, TWIST1, twist family BHLH transcription factor 1, LIPCAR, long intergenic noncoding RNA predicting cardiac remodeling, CRISPR, clustered regularly interspaced short palindromic repeats, TUG1, taurine-upregulated gene 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, HOTAIR, HOX transcript antisense intergenic RNA, Translational medicine, AD, Alzheimer's disease, mtlncRNA, mitochondrial long noncoding RNA, SALRNA1, senescence associated long non-coding RNA 1, Delivery, lincRNA-p21, long intergenic noncoding RNA p21, Drug, LNAs, locked nucleic acids, OIP5-AS1, opa-interacting protein 5 antisense transcript 1, DPF, diphenyl furan, media_common.quotation_subject, DACH1, dachshund homolog 1, Norad, non-coding RNA activated by DNA damage, ASO, antisense oligonucleotide, CDK, cyclin dependent kinase 1, Computational biology, 03 medical and health sciences, Genetic engineering, Gene therapy, DANCR, differentiation antagonizing non-protein coding RNA, PVT1, plasmacytoma variant translocation 1, ASncmtRNA, antisense noncoding mitochondrial RNA, GAS5, growth arrest specific 5, ENE, element for nuclear expression, NPs, nanoparticles, RGD, arginine-glycine-aspartic acid peptide, PEG, polyethylene glycol, 030304 developmental biology, PNAs, peptide nucleic acids, Targeted drug, business.industry, Erbb4-IR, Erb-B2 receptor tyrosine kinase 4-immunoreactivity, lcsh:RM1-950, ASncmtRNA, lncRNAs, long non-coding RNAs, HISLA, HIF-1α-stabilizing long noncoding RNA, sgRNA, single guide RNA, EBF3-AS, early B cell factor 3-antisense, UTF1, undifferentiated transcription factor 1, Clinical trial, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, PTO, phosphorothioate, DKD, diabetic kidney disease, XIST, X-inactive specific transcript, business
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المؤلفون: Grace L. Guo, Xiaoyun Chen, Zheng Dong, Bilon Khambu, Xiao Ming Yin, Shengmin Yan
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 973-997 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Gut Dysbiosis, OST-β, organic solute transporter subunit-β, SQSTM1, sequestosome-1, FGF15, CK19, cytokeratin 19, Gut flora, FEX, fexaramine, SHP, small heterodimer partner, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, AST, aspartate transaminase, MCA, muricholic acid, CYP8B1, cytochrome p450 family 8b1, BLU, Blu-9931, TCDCA, taurochenodeoxycholic acid, Original Research, FGFR4, fibroblast growth factor receptor 4, TBA, total bile acid, Liver injury, CA, cholic acid, biology, Bile acid, Gastroenterology, qRT-PCR, quantitative real-time polymerase chain reaction, Liver, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, NRF2, nuclear factor erythroid 2-related factor 2, BA, bile acid, 030211 gastroenterology & hepatology, TDCA, taurodeoxycholic acid, medicine.drug, medicine.medical_specialty, GM, gut microbiota, ALT, alanine transaminase, medicine.drug_class, TCA, taurocholic acid, PBS, phosphate-buffered saline, IBABP, ileal bile acid-binding protein, OST-α, organic solute transporter subunit-α, Liver Injury, ASBT (SLC10A2), apical sodium–bile acid transporter, CDCA, chenodeoxycholic acid, Bile Acids and Salts, CYP7A1, cytochrome p450 7a1, 03 medical and health sciences, FXR, farnesoid X receptor, ATG, autophagy-related gene, TUDCA, tauroursodeoxycholic acid, Internal medicine, medicine, Autophagy, BAS, bile acid sequestrants, lcsh:RC799-869, Cholestyramine, ALP, alkaline phosphatase, FGF15, fibroblast growth factor 15, SE, standard error, Hepatology, Fibroblast growth factor receptor 4, biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, 030104 developmental biology, Endocrinology, DCA, deoxycholic acid, PCoA, principal coordinates analysis, BSH, bile salt hydrolase, ABX, antibiotics, TLCA, taurolithocholic acid, TMCA, tauromuricholic acid, Farnesoid X receptor, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease
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المؤلفون: Huihuang Yan, Khashayarsha Khazaie, Gianrico Farrugia, Sabriya A. Syed, Michelle Wehling-Henricks, Makoto Kuro-o, Simon J. Gibbons, Sergiy M. Kvasha, David T. Asuzu, Rea A. Nagy, Eduardo N. Chini, Mahendra Pal Singh, Yujiro Hayashi, David R. Linden, James G. Tidball, Gabriella B. Gajdos, Michael R. Bardsley, Jair Machado Espindola Netto, Siva Arumugam Saravanaperumal, Todd A. Kellogg, Tamas Ordog, Yoshitaka Toyomasu
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 117-145 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: PE, R-phycoerythrin, Male, 0301 basic medicine, CL.CASP3, cleaved caspase 3, Aging, Cell cycle checkpoint, BrdU, 5-bromo-2′-deoxyuridine, DMSO, dimethyl sulfoxide, Mice, 0302 clinical medicine, APC, allophycocyanin, ERK, extracellular signal-regulated kinase, GSEA, gene set enrichment analysis, GEO, Gene Expression Omnibus, NES, normalized enrichment score, TRP53, transformation related protein 53, Wnt Signaling Pathway, Klotho, ANOVA, analysis of variance, Cellular Senescence, Original Research, SA-β-gal, senescence-associated beta-galactosidase, KIT, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Stomach, EdU, 5-ethynyl-2′-deoxyuridine, Gastroenterology, Wnt signaling pathway, MTS, methyltetrazolium salt, ICC, interstitial cells of Cajal, Middle Aged, CDKN1A, cyclin-dependent kinase inhibitor 1a, Up-Regulation, Cell biology, CTNNB1, catenin beta 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Models, Animal, symbols, Female, 030211 gastroenterology & hepatology, ANO1, anoctamin-1, RPKM, reads per kilobase of transcript per million mapped reads, Stem cell, Compliance, Senescence, SESN, sestrin, tsTAg, tsA58-mutant SV40 large T antigen, Adenomatous Polyposis Coli Protein, FDR Q, false discovery rate Q value, Mice, Transgenic, KLF4, Kruppel-like factor 4, Biology, DDR, DNA damage response, PI, propidium iodide, Young Adult, 03 medical and health sciences, symbols.namesake, Cyclin D1, RT-qPCR, real-time quantitative reverse-transcription polymerase chain reaction, Stem Cell, MEK, mitogen-activated protein kinase kinase, Animals, Humans, Kinase activity, lcsh:RC799-869, Klotho Proteins, CCND1, cyclin D1, Hepatology, WB, Western immunoblotting, RNA-seq, RNA sequencing, Cell Cycle Checkpoints, Interstitial Cells of Cajal, CDKN1B, cyclin-dependent kinase inhibitor 2B, WT, wild-type, Interstitial cell of Cajal, 030104 developmental biology, siRNA, small interfering RNA, ETV1, ets variant 1, ICC-SC, interstitial cells of Cajal stem cells, lcsh:Diseases of the digestive system. Gastroenterology, Tumor Suppressor Protein p53, MYC, myelocytomatosis oncogene, DAPI, 4′,6-diamidino-2-phenylindole
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المؤلفون: Di Zhao, Xuemeng Liu, Junhui Xing, Jie-Lei Zhang, Pengcheng Li, Jianwu Jiang, Yanzhou Zhang
المصدر: Journal of Advanced Research, Vol 26, Iss, Pp 123-135 (2020)
Journal of Advanced Researchمصطلحات موضوعية: 0301 basic medicine, CAD, coronary artery disease, RIP, RNA binding protein immunoprecipitation, lncRNAs, long noncoding RNAs, ICAM-1, intercellular adhesion molecule-1, HCAECs, human coronary artery endothelial cells, USF1, upstream stimulatory factor 1, TNF-α, tumor necrosis factor-α, DMEM, Dulbecco’s modified Eagle’s medium, VCAM-1, vascular cell adhesion molecule 1, 0302 clinical medicine, HFD, high fat diet, ChIP, Chromatin immunoprecipitation, LDL, low-density lipoprotein, GAPDH, Glyceraldehyde-3-phosphate dehydrogenase, SMCs, smooth muscle cells, RT-qPCR, reverse transcription quantitative polymerase chain reaction, IL-6, interleukin-6, Gene knockdown, lcsh:R5-920, Multidisciplinary, ND, normal diet, Cell adhesion molecule, Chemistry, sh, short hairpin RNA, MCP-1, monocyte chemoattractant protein-1, 030220 oncology & carcinogenesis, HE, Hematoxylin-eosin, Tumor necrosis factor alpha, medicine.symptom, Hypoxia-inducible factor 1 alpha-antisense RNA 2, lcsh:Medicine (General), ECs, endothelial cells, ATF2, activating transcription factor 2, IL-1β, interleukin-1β, Intercellular Adhesion Molecule-1, IgG, immunoglobulin G, Inflammation, Article, 03 medical and health sciences, CCK-8, cell counting kit-8, Activating transcription factor, PBS, phosphate buffered saline, Downregulation and upregulation, ox-LDL, oxidized-low-density lipoprotein, ELISA, enzyme linked immunosorbent assay, medicine, Gene silencing, Upstream transcription factor 1, lcsh:Science (General), Transcription factor, HIF1A-AS2, hypoxia-inducible factor 1 alpha-antisense RNA 2, ATCC, American Type Culture Collection, Atherosclerosis, si-NC, small interfering RNA-negative control, 030104 developmental biology, Cancer research, Long noncoding RNA, lcsh:Q1-390
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المؤلفون: Kuan Jiang, Gang Wei, Xishan Chen, Weisan Pan, Lingyu Tai, Junyi Chen, Chang Liu, Weiyue Lu
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1754-1768 (2020)مصطلحات موضوعية: PEI, polyethylenimine, medicine.medical_treatment, PLGA, poly(lactic-co-glycolic acid), EE, encapsulation efficiency, Pharmacology, L929, murine fibroblast cells, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, Hyaluronic acid, Trabeculectomy, Gene delivery, General Pharmacology, Toxicology and Pharmaceutics, HA, hyaluronic acid, DLS, dynamic light scattering, 0303 health sciences, Chemistry, HRP, horseradish peroxidase, TEM, transmission electron microscope, MWCO, molecular weight cut-off, medicine.anatomical_structure, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Fluorouracil, 030220 oncology & carcinogenesis, Original Article, medicine.drug, Penetratin, SDS, sodium dodecyl sulfate, ASO, antisense oligonucleotide, 03 medical and health sciences, FBS, fetal bovine serum, In vivo, TGF-β, transforming growth factor-β, medicine, Fibrosis prevention, Fibroblast, IBAGS, the Indiana Bleb Appearance Grading Scale, PAGE, polyacrylamide gel electrophoresis, Fu, fluorouracil, 030304 developmental biology, EGF, epidermal growth factor, PAMAM, poly(amidoamine), lcsh:RM1-950, PG5, PAMAM G5–NH2, medicine.disease, IOP, intraocular pressure, lcsh:Therapeutics. Pharmacology, SDHCEC, human corneal epithelial cells, Pene, penetratin, Wound healing, FAM, 6-carboxyfluorescein, DAPI, 4′,6-diamidino-2-phenylindole, FITC, fluorescein 5-isothiocyanate
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المؤلفون: Xiao-Jing Shi, Kai Sun, Zhong-Hua Li, Yun-Dong Fu, Bin Yu, Tao-Qian Zhao, Hong-Min Liu, Jimin Guo, Zhen-Zhen Liu, Ting Cheng
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1476-1491 (2020)مصطلحات موضوعية: Pyrimidine, BLI, biolayer interferometry technology, IC50, half maximal inhibitory concentration, USP7, ubiquitin specific peptidase 7, Deubiquitinating enzyme, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, CHX, cycloheximide, Ubiquitin, NSCLC, non-small cell lung cancer, Potency, General Pharmacology, Toxicology and Pharmaceutics, Ub, ubiquitin, MTT, 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazoliumbromide, 030304 developmental biology, LSD1, lysine specific demethylase 1, 0303 health sciences, biology, lcsh:RM1-950, EdU, 5-ethynyl-2′-deoxyuridine, Ub-AMC, ubiquitin-7-amido-4-methylcoumarin, Cell cycle, Tris, 2-amino-2-(hydroxymethyl)-1,3-propanediol, Dissociation constant, MG132, proteasome inhibitor, lcsh:Therapeutics. Pharmacology, USP28 inhibitors, chemistry, Biochemistry, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Docking (molecular), 030220 oncology & carcinogenesis, Cancer cell, biology.protein, USP28, ubiquitin specific peptidase 28, Original Article, Deubiquitination, Gastric cancer, DUBs, deubiquitinating enzymes, EMT, epithelial-mesenchymal transition, [1,2,3]Triazolo[4,5-d]pyrimidine derivatives, Kd, dissociation constant
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المؤلفون: Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)مصطلحات موضوعية: LDH, lactic dehydrogenase, MMP, mitochondrial membrane potential, Hepatocellular carcinoma, 7-AAD, 7-aminoactinomycin D, NS, no significance, TBST, Tris-buffered saline with Tween solution, DMSO, dimethyl sulfoxide, ECL, enhanced chemiluminescence, NC, negative control, 0302 clinical medicine, GSDME, gasdermin E, General Pharmacology, Toxicology and Pharmaceutics, N-GSDME, N-terminal GSDME, PARP, poly ADP-ribose polymerase, Caspase, ANOVA, analysis of variance, p-MEK, phosphorylated-MEK, DCFH-DA, dye 2,7-dichlorofluoresce diacetate, MEK, mitogen-activated and extracellular signal-regulated kinase, 0303 health sciences, DMEM, Dulbecco's modified Eagle's medium, biology, Kinase, Chemistry, Pyroptosis, HRP, horseradish peroxidase, PI3K, phosphatidylinositol 3-kinase, gRNA, guide RNA, i.p., intraperitoneal, VEGF, vascular endothelial growth factor, PBS, phosphate-based buffer, SDS-PAGE, sodium dodecyl sulphate-polyacrylamide gel electrophoresis, CRISPR, clustered regularly interspaced short palindromic repeats, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, Original Article, FITC, fluorescein isothiocyanate, RIPA, radioimmunoprecipitation assay, p-AKT, phosphorylated-AKT, IgG (H + L), immunoglobulin G (heavy chain + light chain), Intracellular, Cell death, Programmed cell death, HepG2, Miltirone, TCGA, the Cancer Genome Atlas, p-ERK1/2, phosphorylated-ERK1/2, Caspase 3, IC50, the half maximal inhibitory concentration, mTOR, mammalian target of rapamycin, MEM, minimum essential medium, PI, propidium iodide, 03 medical and health sciences, CCK-8, cell counting kit-8, ROS, reactive oxygen species, FBS, fetal bovine serum, i.v., intravenous, Viability assay, GSDMD, gasdermin D, AKT, AKT serine/threonine kinase, also known as protein kinase B, NMR, nuclear magnetic resonance, Cas9, caspase 9, 030304 developmental biology, Hepa1-6, KO, knockout, lcsh:RM1-950, lcsh:Therapeutics. Pharmacology, BAX, BCL2-associated X, Apoptosis, NAC, N-acetyl cysteine, ERK1/2, extracellular regulated protein kinases 1/2, Cancer research, biology.protein, H&E, hematoxylin and eosin, GSDME, HCC, hepatocellular carcinoma, SD, standard deviation, MS, mass spectrum
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المؤلفون: In Ho Kim, Yujun Wu, Ying Yang, Wenyu Wang
المصدر: Poultry Science
Poultry Science, Vol 101, Iss 2, Pp 101615-(2022)مصطلحات موضوعية: HWG, hydrolyzed wheat gluten, IL-1β, interleukin-1β, Glutens, inflammatory cytokines, tight junction, NRC, National Research Council, Wheat gluten, Spleen, Occludin, medicine.disease_cause, SF1-1100, digestive system, TNF-α, tumor necrosis factor-α, ZO-1, zonula occluden-1, TLR4, Toll like receptor-4, Hydrolysis, DAO, diamine oxidase, IMMUNOLOGY, HEALTH AND DISEASE, medicine, Escherichia coli, Animals, IFN-γ, interferon-γ, Food science, Intestinal Mucosa, IL-6, interleukin-6, Escherichia coli Infections, Triticum, IL-8, interleukin-8, Glu, glutamate, Tight junction, Chemistry, intestinal permeability, Gly, glycine, General Medicine, Animal Feed, Animal culture, Diet, medicine.anatomical_structure, Mrna level, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Dietary Supplements, Gln, glutamine, Animal Science and Zoology, Diamine oxidase, Chickens, hydrolyzed wheat gluten
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المؤلفون: Kazunori Nakayama, Masafumi Nakamura, Masayuki Kojima, Katsuya Nakamura, Kei Miyoshi, Shu Ichimiya, Hideya Onishi, Kenichi Nishiyama, Shogo Masuda, Akira Imaizumi, Satoko Koga, Akiko Fujimura, Masayo Umebayashi, Takashi Morisaki
المصدر: Translational Oncology, Vol 14, Iss 9, Pp 101152-(2021)
Translational Oncologyمصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_treatment, T cell, PTPN3, protein tyrosine phosphatase non-receptor type3, 03 medical and health sciences, 0302 clinical medicine, Cancer immunotherapy, ERK, extracellular signal-regulated kinase, EMT, Epithelial-mesenchymal transition, medicine, EGFR, Epidermal growth factor receptor, ZAP70, zeta-chain-associated protein kinase 70, VEGFA, Vascular endothelial growth factor A, Autocrine signalling, Lung net, Cancer immunotherapy strategy, Lymphocyte activation, RC254-282, Original Research, CACNA1G, Calcium Voltage-Gated Channel Subunit Alpha1 G, Large-cell neuroendocrine cancer, Chemistry, Cancer, FOXP3, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, CDDP, Cis-diamminedichloro-platinum, medicine.disease, AKT, protein kinase b, LCK, lymphocyte-specific protein tyrosine kinase, 030104 developmental biology, medicine.anatomical_structure, Oncology, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, PTPN3, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Cancer suppression, Tyrosine kinase, PTP, protein tyrosine phosphatase