المؤلفون: Jinfeng Huang, Rashik Ahmed, Madoka Akimoto, Karla Martinez Pomier, Giuseppe Melacini

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Neuroscience, Environmental Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, allosterically drive transitions, e46k promotes head, e46k mutation exhibit, multipronged mechanism provides, αs monomers harboring, promotes αs aggregation, enabling αs aggregation, e46k mutation, αs monomers, parkinson ’, open conformations, new framework, main component, longstanding question, lewy bodies, lb dementias, fibrils compared, fibril interactions, extensive interactions, currently unclear, association events

Relation: https://figshare.com/articles/journal_contribution/Early-Onset_Parkinson_Mutation_Remodels_Monomer_Fibril_Interactions_to_Allosterically_Amplify_Synuclein_s_Amyloid_Cascade/24802961

الاتاحة: https://doi.org/10.1021/jacsau.3c00655.s001
https://figshare.com/articles/journal_contribution/Early-Onset_Parkinson_Mutation_Remodels_Monomer_Fibril_Interactions_to_Allosterically_Amplify_Synuclein_s_Amyloid_Cascade/24802961

المؤلفون: Calina Glynn, Joshua E. Chun, Cameron C. Donahue, Monica J. S. Nadler, Zhanyun Fan, Bradley T. Hyman

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, like fibrils compared, identical experimental conditions, favoring cofactor concentration, different laboratory settings, core structure found, conditions previously shown, additional identical c, specific fibrillar structures, protein tau misfolds, paired helical filaments, specific mechanisms, vitro <, thfs ), shaking time, robustly yield, recombinant tau, presently uncertain, polymorph abundance, negative stain, highly variable, give rise, filament formation

Relation: https://figshare.com/articles/journal_contribution/Reconstitution_of_the_Alzheimer_s_Disease_Tau_Core_Structure_from_Recombinant_Tau_sup_297_391_sup_Yields_Variable_Quaternary_Structures_as_Seen_by_Negative_Stain_and_Cryo-EM/24915804

الاتاحة: https://doi.org/10.1021/acs.biochem.3c00425.s001
https://figshare.com/articles/journal_contribution/Reconstitution_of_the_Alzheimer_s_Disease_Tau_Core_Structure_from_Recombinant_Tau_sup_297_391_sup_Yields_Variable_Quaternary_Structures_as_Seen_by_Negative_Stain_and_Cryo-EM/24915804