المؤلفون: Xiaoyu Shi, Tong Zhao, Shuo Wang, Shujing Xu, Hui Liao, Shenghua Gao, Zhen Gao, Jian Zhang, Danhui Qi, Zhijiao Zhang, Fengxin Zheng, Youzhao Wang, Zhenqian Wang, Mingyu Yang, Qian Yang, Fan Yi, Jianxin Pang, Xinyong Liu, Peng Zhan

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, xanthine oxidase inhibitors, urate transporter 1, substituent modification strategies, metabolic diseases characterized, lower effective dosage, inhibiting urate reabsorption, glucose transporter 9, fused cyclic structures, favorable pharmacokinetic profiles, favorable druggability gout, extensive structural modifications, clinical practice due, apparent acute toxicity, improved pharmacokinetic properties, 21 μm ), novel thienopyrimidine compound, glut9 dual inhibitor, 50 , 29 , thienopyrimidine compound, vivo <, improved efficacy, 01 μm

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_a_Novel_Thienopyrimidine_Compound_as_a_Urate_Transporter_1_and_Glucose_Transporter_9_Dual_Inhibitor_with_Improved_Efficacy_and_Favorable_Druggability/25406817

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c00136.s001

المؤلفون: Xiaoyu Shi, Tong Zhao, Shuo Wang, Shujing Xu, Hui Liao, Shenghua Gao, Zhen Gao, Jian Zhang, Danhui Qi, Zhijiao Zhang, Fengxin Zheng, Youzhao Wang, Zhenqian Wang, Mingyu Yang, Qian Yang, Fan Yi, Jianxin Pang, Xinyong Liu, Peng Zhan

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, xanthine oxidase inhibitors, urate transporter 1, substituent modification strategies, metabolic diseases characterized, lower effective dosage, inhibiting urate reabsorption, glucose transporter 9, fused cyclic structures, favorable pharmacokinetic profiles, favorable druggability gout, extensive structural modifications, clinical practice due, apparent acute toxicity, improved pharmacokinetic properties, 21 μm ), novel thienopyrimidine compound, glut9 dual inhibitor, 50 , 29 , thienopyrimidine compound, vivo <, improved efficacy, 01 μm

Relation: https://figshare.com/articles/dataset/Discovery_of_a_Novel_Thienopyrimidine_Compound_as_a_Urate_Transporter_1_and_Glucose_Transporter_9_Dual_Inhibitor_with_Improved_Efficacy_and_Favorable_Druggability/25406820

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c00136.s002