المؤلفون: Matheos Giakoumi, Konstantinos Kapnisis, Andreas Anayiotos, Pavlos S. Stephanou

المصدر: Mathematical and Computational Applications, Vol 29, Iss 6, p 101 (2024)

مصطلحات موضوعية: medical implants, physiologically based toxicokinetic (PBTK) models, modeling and simulations (M&S), absorption, distribution, metabolism, and excretion (ADME), analytical solutions, matrix exponential, Applied mathematics. Quantitative methods, T57-57.97, Mathematics, QA1-939, Electronic computers. Computer science, QA75.5-76.95

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2297-8747/29/6/101; https://doaj.org/toc/1300-686X; https://doaj.org/toc/2297-8747

URL الوصول: https://doaj.org/article/84aed72bc504496391273cccd6536826

المؤلفون: Patrick Carius, Ferdinand Anton Weinelt, Chris Cantow, Markus Holstein, Aaron M. Teitelbaum, Yunhai Cui

المصدر: Pharmaceutics, Vol 16, Iss 3, p 296 (2024)

مصطلحات موضوعية: microphysiological system (MPS), gut-on-chip, polydimethylsiloxane (PDMS), absorption, distribution, metabolism, and excretion (ADME), Pharmacy and materia medica, RS1-441

Relation: https://www.mdpi.com/1999-4923/16/3/296; https://doaj.org/toc/1999-4923; https://doaj.org/article/248b0ca9c5aa433a85439c990ea5c158

الاتاحة: https://doi.org/10.3390/pharmaceutics16030296
https://doaj.org/article/248b0ca9c5aa433a85439c990ea5c158

المؤلفون: Colombo, Eleonora, Olla, Stefania, Minnelli, Cristina, Formato, Alessia, Veroni, Caterina, Corbisiero, Silvia, Pericolo, Mattia, Siguri, Chiara, Mobbili, Giovanna, Agresti, Cristina, Seneci, Pierfausto

المساهمون: E. Colombo, S. Olla, C. Minnelli, A. Formato, C. Veroni, S. Corbisiero, M. Pericolo, C. Siguri, G. Mobbili, C. Agresti, P. Seneci

مصطلحات موضوعية: absorption-distribution-metabolism-excretion (ADME), amyotrophic lateral sclerosi, antioxidant activity, chemical probe, edaravone, mechanism of action, medicinal chemistry, prodrug, remyelination, Settore CHIM/06 - Chimica Organica

Relation: info:eu-repo/semantics/altIdentifier/pmid/37836771; info:eu-repo/semantics/altIdentifier/wos/WOS:001083994200001; volume:28; issue:19; firstpage:1; lastpage:13; numberofpages:13; journal:MOLECULES; https://hdl.handle.net/2434/1012070; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85173862462

الاتاحة: https://hdl.handle.net/2434/1012070
https://doi.org/10.3390/molecules28196928

المؤلفون: Gupta, Kartikey Kumar, Sharma, Kamal Kant, Chandra, Harish, Panwar, Himalaya, Bhardwaj, Nitin, Altwaijry, Najla A., Alsfouk, Aisha A., Dlamini, Zodwa, Afzal, Obaid, Altamimi, Abdulmalik S.A., Khan, Shahanavaj, Mishra, Abhay Prakash

مصطلحات موضوعية: Breast cancer, Humulus lupulus, PI3K/AKT signaling, Xanthohumol, Anastrozole, Phosphoinositide-3-kinase (PI3K), Serine/threonine kinase (AKT), Human epidermal growth factor receptor 2 (HER2), In silico, Absorption, distribution, metabolism, and excretion (ADME), Drug-likeness properties, SDG-03: Good health and well-being

وصف الملف: application/pdf

Relation: Gupta, K.K., Sharma, K.K., Chandra, H., Panwar, H., Bhardwaj, N., Altwaijry, N.A., Alsfouk, A.A., Dlamini, Z., Afzal, O., Altamimi, A.S.A., Khan, S. & Mishra, A.P. (2022) The integrative bioinformatics approaches to predict the xanthohumol as anti-breast cancer molecule: Targeting cancer cells signaling PI3K and AKT kinase pathway. Frontiers in Oncology 12:950835. doi:10.3389/fonc.2022.950835.; 2234-943X (online); http://hdl.handle.net/2263/93958

الاتاحة: http://hdl.handle.net/2263/93958
https://doi.org/10.3389/fonc.2022.950835

المؤلفون: Xiaoqing Chang, Yu-Mei Tan, David G. Allen, Shannon Bell, Paul C. Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti J. Hakkinen, Shruti V. Kabadi, Nicole C. Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather A. Pangburn, Elijah J. Petersen, Emily N. Reinke, Alexandre J. S. Ribeiro, Nisha Sipes, Lisa M. Sweeney, John F. Wambaugh, Ronald Wange, Barbara A. Wetmore, Moiz Mumtaz

المصدر: Toxics; Volume 10; Issue 5; Pages: 232

مصطلحات موضوعية: absorption, distribution, metabolism, excretion (ADME), dosimetry, in vitro to in vivo extrapolation (IVIVE), physiologically based pharmacokinetic (PBPK) model, Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), new approach methodologies (NAMs), risk assessment, toxicity tests

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Novel Methods in Toxicology Research; https://dx.doi.org/10.3390/toxics10050232

الاتاحة: https://doi.org/10.3390/toxics10050232

المؤلفون: Evelien G. E. Hurkmans, Marije J. Klumpers, Sita H. Vermeulen, Melanie M. Hagleitner, Uta Flucke, H. W. Bart Schreuder, Hans Gelderblom, Johannes Bras, Henk-Jan Guchelaar, Marieke J. H. Coenen, D. Maroeska W. M. te Loo

المصدر: Frontiers in Pharmacology, Vol 11 (2020)

مصطلحات موضوعية: methotrexate, osteosarcoma, pharmacogenetics, absorption, distribution, metabolism, and excretion (ADME), plasma levels, toxicity, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2020.01241/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/c702ae5dc3b84a2bb86d47681b47a68d

المؤلفون: Lopalco A., Lopedota A. A., Laquintana V., Denora N., Stella V. J.

المساهمون: Lopalco, A., Lopedota, A. A., Laquintana, V., Denora, N., Stella, V. J.

مصطلحات موضوعية: Absorption, distribution, metabolism, and excretion (ADME), Boric acid, Excipient(s), Formulation, Pharmacokinetic, Physicochemical propertie, Preformulation, Toxicology

Relation: info:eu-repo/semantics/altIdentifier/pmid/32353453; info:eu-repo/semantics/altIdentifier/wos/WOS:000565467500002; volume:109; issue:8; firstpage:2375; lastpage:2386; numberofpages:12; journal:JOURNAL OF PHARMACEUTICAL SCIENCES; https://hdl.handle.net/11586/350941

الاتاحة: https://hdl.handle.net/11586/350941
https://doi.org/10.1016/j.xphs.2020.04.015

المؤلفون: Matsson, Pär, Baranczewski, Pawel, Giacomini, Kathleen M., Andersson, Tommy B., Palm, Johan, Palm, Katrin, Charman, William N., Bergström, Christel A.S., 1973

المصدر: Journal of Pharmaceutical Sciences. 110(1):2-11

مصطلحات موضوعية: Absorption, Distribution, Metabolism, and Excretion (ADME), Biopharmaceutical characterization, Caco-2 cells, Cell culture, Computational ADME, Drug delivery system(s), Gene therapy, Hepatocyte(s), In Vitro/In Vivo (IVIVC) Correlation(s), Proteomic

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431817

المؤلفون: Laroche C, Aggarwal M, Bender H, Benndorf P, Birk B, Crozier J, Dal Negro G, De Gaetano F, Desaintes C, Gardner I, Hubesch B, Irizar A, John D, Kumar V, Lostia A, Manou I, Monshouwer M, Müller BP, Paini A, Reid K, Rowan T, Sachana M, Schutte K, Stirling C, Taalman R, van Aerts L, Weissenhorn R, Sauer UG

المساهمون: Universitat Rovira i Virgili

المصدر: Regulatory Toxicology And Pharmacology ; 10.1016/j.yrtph.2018.08.006 ; Regulatory Toxicology And Pharmacology. 995-21

مصطلحات موضوعية: Medicine (Miscellaneous),Medicine, Legal,Pharmacology & Pharmacy,Toxicology, Weight-of-evidence (woe), threshold of toxicological concern (ttc), physiologically-based kinetic (pbk) modelling, metabolism, integrated approach for testing and assessment (iata), in vitro to in vivo extrapolation (ivive), hazard and risk assessment, excretion (adme), distribution, and elimination, absorption, Toxicology, Saúde coletiva, Química, Pharmacology & pharmacy, Odontología, Medicine, legal, Medicine (miscellaneous), Medicina ii, Medicina i, Interdisciplinar, Farmacia, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciência de alimentos, Biotecnología

Relation: http://hdl.handle.net/20.500.11797/imarina5132993

الاتاحة: https://hdl.handle.net/20.500.11797/imarina5132993

المؤلفون: Henk-Jan Guchelaar, Sita H. Vermeulen, Melanie M. Hagleitner, Uta Flucke, Marieke J H Coenen, Evelien G. E. Hurkmans, Johannes Bras, Marije J Klumpers, D. Maroeska W.M. te Loo, H. W. Bart Schreuder, Hans Gelderblom

المصدر: Frontiers in Pharmacology, 11
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology, 11. FRONTIERS MEDIA SA

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, CYP2B6, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Renal function, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], methotrexate, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, Pharmacokinetics, plasma levels, Internal medicine, osteosarcoma, medicine, distribution, Pharmacology (medical), absorption, distribution, metabolism, and excretion (ADME), pharmacogenetics, Pharmacology, and excretion (ADME), Creatinine, business.industry, lcsh:RM1-950, toxicity, medicine.disease, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], 030104 developmental biology, lcsh:Therapeutics. Pharmacology, chemistry, 030220 oncology & carcinogenesis, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Toxicity, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], Osteosarcoma, Methotrexate, business, absorption, metabolism, Pharmacogenetics, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0623c7750ec4bcefa909f8c81503c1b4
https://hdl.handle.net/1887/3181910

المؤلفون: Boonpawa, R., Moradi, N., Spenkelink, A., Rietjens, I.M.C.M., Punt, A.

المصدر: Biochemical Pharmacology 98 (2015) 4 ; ISSN: 0006-2952

مصطلحات موضوعية: Absorption distribution metabolism excretion (ADME), Human variation, Physiologically based kinetic (PBK) modeling, Quercetin, Species differences

وصف الملف: application/pdf

Relation: https://edepot.wur.nl/364372

الاتاحة: https://research.wur.nl/en/publications/use-of-physiologically-based-kinetic-pbk-modeling-to-study-interi
https://doi.org/10.1016/j.bcp.2015.09.022

المؤلفون: Amidon, Gregory E., Anderson, Bradley D., Balthasar, Joseph P., Bergström, Christel A.S., 1973, Huang, Shiew-Mei, Kasting, Gerald, Kesisoglou, Filippos, Khinast, Johannes G., Mager, Donald E., Roberts, Christopher J., Yu, Lian

المصدر: Journal of Pharmaceutical Sciences. 108(1):2-7

مصطلحات موضوعية: absorption, distribution, metabolism, and excretion (ADME), biophysical model(s), in silico modeling, in vitro model(s), mathematical model(s), mechanistic modeling, molecular modeling, pharmacokinetic-pharmacodynamic (PKPD) modeling, physiologically based pharmacokinetic (PBPK) modeling

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-377372

المؤلفون: Clark, Robert D

المصدر: Pest Management Science

مصطلحات موضوعية: quantitative structure–activity relationship (QSAR), Mini‐review, cytochrome P450 (CYP), modeling, bioavailability, mammalian toxicity, absorption, metabolism, absorption, distribution, metabolism and excretion (ADME)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::7c058aad4977c247ab1acbc7fb2caf75
http://europepmc.org/articles/PMC6099302

المؤلفون: 김문희

المساهمون: 김성균, Munhee Kim, 보건대학원 환경보건학과, 인체노출평가 및 독성

مصطلحات موضوعية: Polycyclic aromatic hydrocarbons (PAHs), Oral administration, Absorption-Distribution-Metabolism-Excretion (ADME), human pharmaco-kinetics, Fractional urinary excretion (Fue), pharmacokinetic model, 다환방향족탄화수소류, 흡수·분포·대사·배설, 경구투여, 인체 약물동태학, 소변 중 배설분율, 약물동태학 모델, 363.7

وصف الملف: ⅴ, 51

Relation: 000000167386; https://hdl.handle.net/10371/178212; https://dcollection.snu.ac.kr/common/orgView/000000167386; I804:11032-000000167386; 000000000046▲000000000053▲000000167386▲

الاتاحة: https://hdl.handle.net/10371/178212
https://dcollection.snu.ac.kr/common/orgView/000000167386

المؤلفون: Hurkmans, E.G.E., Klumpers, M.J., Vermeulen, S.H., Hagleitner, M.M., Flucke, U., Schreuder, H.W.B., Gelderblom, H., Bras, J., Guchelaar, H.J., Coenen, M.J.H., Loo, D.M.W.M. te

المصدر: Frontiers in Pharmacology

مصطلحات موضوعية: methotrexate, osteosarcoma, pharmacogenetics, absorption, distribution, metabolism, and excretion (ADME), plasma levels, toxicity

وصف الملف: application/pdf

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.01241/full; lumc-id: 103891608; https://hdl.handle.net/1887/3181910

الاتاحة: https://hdl.handle.net/1887/3181910
https://www.frontiersin.org/articles/10.3389/fphar.2020.01241/full
https://doi.org/10.3389/fphar.2020.01241

المؤلفون: Leif E. Peterson

مصطلحات موضوعية: Protease, Bictegravir, biology, Chemistry, Drug discovery, medicine.medical_treatment, Active site, Toxicology, Docking (molecular), Indinavir, medicine, biology.protein, Saquinavir, DrugBank, Docking, Coronavirus, SARS-CoV-2, SARS-CoV, Covid-19, Drug discovery, Pharmaceutics, Pharmacology, Repurposing, Chemoinformatics, Toxicology, Absorption, Distribution, Metabolism, Excretion, ADME, ADME, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0401f7423949eb1f1fbff3eaa6553fd5

المؤلفون: Leif E. Peterson

مصطلحات موضوعية: 2019-20 coronavirus outbreak, Protease, Coronavirus disease 2019 (COVID-19), Drug discovery, Chemistry, viruses, medicine.medical_treatment, In silico, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), fungi, medicine.disease_cause, Virology, respiratory tract diseases, body regions, Docking, SARS-CoV-2, SARS-CoV, Covid-19, Drug discovery, Repurposing, Chemoinformatics, Toxicology, Absorption, Distribution, Metabolism, Excretion, ADME, Docking (molecular), medicine, skin and connective tissue diseases, Coronavirus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e765b82cce1b184cebc97f78746fc8d2

المؤلفون: Evelien G. E. Hurkmans, Marije J. Klumpers, Sita H. Vermeulen, Melanie M. Hagleitner, Uta Flucke, H. W. Bart Schreuder, Hans Gelderblom, Johannes Bras, Henk-Jan Guchelaar, Marieke J. H. Coenen, D. Maroeska W. M. te Loo

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, methotrexate, osteosarcoma, pharmacogenetics, absorption, distribution, metabolism, and excretion (ADME), plasma levels, toxicity

Relation: https://figshare.com/articles/dataset/DataSheet_1_Analysis_of_Drug_Metabolizing_Gene_Panel_in_Osteosarcoma_Patients_Identifies_Association_Between_Variants_in_SULT1E1_CYP2B6_and_CYP4F8_and_Methotrexate_Levels_and_Toxicities_pdf/12793352

الاتاحة: https://doi.org/10.3389/fphar.2020.01241.s001
https://figshare.com/articles/dataset/DataSheet_1_Analysis_of_Drug_Metabolizing_Gene_Panel_in_Osteosarcoma_Patients_Identifies_Association_Between_Variants_in_SULT1E1_CYP2B6_and_CYP4F8_and_Methotrexate_Levels_and_Toxicities_pdf/12793352

المؤلفون: 이수진

المساهمون: 김성균, Lee, Su Jin, 보건대학원 환경보건학과

مصطلحات موضوعية: bezophenone-3, dermal application, pharmacokinetic model, the fraction of urinary excretion, absorption · distribution · metabolism · excretion (ADME), 363.7

وصف الملف: application/pdf; 847262 bytes

Relation: 000000149406; http://hdl.handle.net/10371/141945

الاتاحة: http://hdl.handle.net/10371/141945

المؤلفون: Pai, Aravinda, B.S., Jayashree, Basu-Mallik, Sanchari, Lobo, Richard

المصدر: The Thai Journal of Pharmaceutical Sciences

مصطلحات موضوعية: Luteolin, Tankyrase II, molecular docking, Absorption distribution metabolism excretion (ADME), cancer, Pharmacology

وصف الملف: application/pdf

Relation: https://digital.car.chula.ac.th/tjps/vol41/iss4/2; https://digital.car.chula.ac.th/context/tjps/article/2396/viewcontent/openpdf.php

الاتاحة: https://digital.car.chula.ac.th/tjps/vol41/iss4/2
https://doi.org/10.56808/3027-7922.2396
https://digital.car.chula.ac.th/context/tjps/article/2396/viewcontent/openpdf.php