يعرض 1 - 20 نتائج من 40 نتيجة بحث عن '"electroneutral"', وقت الاستعلام: 0.49s تنقيح النتائج
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    Academic Journal

    المصدر: TA'LIM VA RIVOJLANISH TAHLILI ONLAYN ILMIY JURNALI; Vol. 3 No. 4 (2023): ТАЪЛИМ ВА РИВОЖЛАНИШ ТАҲЛИЛИ ОНЛАЙН ИЛМИЙ ЖУРНАЛИ; 270-274 ; 2181-2624

    وصف الملف: application/pdf

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    Academic Journal
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    Academic Journal
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    Academic Journal
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    Academic Journal
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    Academic Journal
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    Academic Journal

    المؤلفون: Rubinstein, I.

    المصدر: SIAM Journal on Applied Mathematics, 1987 Oct 01. 47(5), 1076-1093.

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    Academic Journal
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    Academic Journal
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    المصدر: Journal of Theoretical Biology. 217(3):287-309

    مصطلحات موضوعية: Experiments were performed to define quantitatively the substrate (K(+) and Cl(-)) dependence of the transport function (production of equally large and oppositely directed K(+)and Cl(-) flows/currents) of an earlier (Theander et al., 1999) identified electroneutral K-Cl cotransporter in the slowly adapting stretch receptor neurone of the European lobster. The experiments were based on microelectrode techniques. This allowed us to perform steady-state measurements of the so-called instantaneous current-voltage relationships (around a holding voltage of -65 mV after a blockage of the cell's action potential and hyperpolarization-activated currents) and intracellular ion concentrations at various settings of the extracellular K(+) and Cl(-) concentrations. From the results, we could then define steady-state values of all of the cell's non-KCl cotransporter K(+) and Cl(-) currents. Finally, the negative sums of the inferred non-KCl cotransporter K(+) and Cl(-) currents could be taken as equivalents of the K-Cl cotransporter's K(+) and Cl(-) currents for the reason that, in steady state, all membrane currents add up to zero. For the cotransporter currents, thus inferred for a range from 2.5/410.5 to 40.0/448.0 mM external K(+)/Cl(-), we found that their absolute values increased in a nonlinear fashion from about 5 nA cell(-1) at the lowest, to about 20 nA cell(-1) at the highest external K(+)/Cl(-) concentrations. Formally, this relationship could be reproduced by a Hill function-based enzyme kinetic expression simulating inward and outward transmembrane electroneutral ion transports. Following insertion of this expression into a comprehensive model of electrical membrane functions and intracellular solute and solvent control in the lobster stretch receptor neurone, the model predictions suggested that the K-Cl cotransporter does play an important role in (a) keeping intracellular Cl(-) low for a proper function of the cell's inhibitory system, and (b) enabling rapid transmembrane K(+) shifts that provide for a stabilization of the cell's membrane voltage and membrane excitability in cases of varying extracellular K(+) concentrations. The model predictions gave, however, no clear evidence that the K-Cl cotransporter is critically involved in the cell's volume regulation in conditions of varying extracellular osmolalities., Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Neurovetenskaper, Medical and Health Sciences, Basic Medicine, Neurosciences

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    Dissertation/ Thesis
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    Dissertation/ Thesis

    المؤلفون: Wang, Jinping

    المساهمون: Laboratoire de Chimie - UMR5182 (LC), École normale supérieure de Lyon (ENS de Lyon), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Ecole normale supérieure de lyon - ENS LYON, East China normal university (Shanghai), Jens Hasserodt, Fan Yang

    المصدر: https://theses.hal.science/tel-01162983 ; Organic chemistry. Ecole normale supérieure de lyon - ENS LYON; East China normal university (Shanghai), 2015. English. ⟨NNT : 2015ENSL0989⟩.

    Relation: NNT: 2015ENSL0989

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