المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/journal_contribution/Cignal_Reporter_Assay_used_to_measure_pathway_activity_and_their_associated_hallmark_pathways_/14902712

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s010

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/journal_contribution/Reporter_assay_results_compared_with_eVIP_Pathways_and_GSEA_/14902715

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s011

المؤلفون: Tudor CĂLINICI

المصدر: Applied Medical Informatics, Vol 27, Iss 4, Pp 15-20 (2010)

مصطلحات موضوعية: Virtual patients, Medical education, Labyrinths, eVip., Computer applications to medicine. Medical informatics, R858-859.7

وصف الملف: electronic resource

Relation: http://ami.info.umfcluj.ro/Full-text/AMI_27_2010/AMI27%284%29_015_020.pdf; https://doaj.org/toc/1224-5593

URL الوصول: https://doaj.org/article/6fb1993248d04be09eb16382a77c1361

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/figure/Gene_content_overlap_in_i_RNF43_G659fs_i_mutation-specific_pathways_/14902703

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s007

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/DESeq2_GFP_vs_i_RNF43_G659fs_i_/14902739

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s018

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/figure/Sparkler_plot_representation_of_functional_impact_of_ARAF_variants_/14902688

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s002

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/Overall_eVIP2_outputs_for_i_RNF43_i_variants_/14902724

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s014

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/figure/Comparing_eVIP_correlation_metrics_/14902685

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s001

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/figure/Tumor_suppressor_genes_with_a_frameshift_mutation_at_frequency_of_5_or_higher_/14902694

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s004

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/figure/Validation_of_expression_of_RNF43_frameshift_variants_/14902691

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s003

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/DESeq2_GFP_vs_i_RNF43_R117fs_i_/14902736

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s017

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/Overall_eVIP2_outputs_for_i_ARAF_i_variants_/14902718

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s012

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/eVIP_Pathways_WT-specific_genes_for_i_RNF43_G659fs_i_/14902748

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s020

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/FGSEA_results_/14902760

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s024

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/GSEA_results_/14902754

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s022

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/eVIP_Pathways_mutation-specific_genes_for_i_RNF43_G659fs_i_/14902751

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s021

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/ssGSEA_results_/14902757

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s023

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/dataset/GSEA_Investigate_Gene_Sets_with_i_RNF43_G659fs_i_mutation-specific_genes_/14902763

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.s025

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/figure/The_eVIP_algorithm_uses_RNA-seq_data_to_predict_the_function_of_somatic_mutations_/14902769

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.g001

المؤلفون: Alexis M. Thornton (11068403), Lishan Fang (10101825), April Lo (11068406), Maria McSharry (11068409), David Haan (11068412), Casey O’Brien (4671856), Alice H. Berger (11068415), Marios Giannakis (3564314), Angela N. Brooks (11068418)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Physiology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, RAS, RNF 43 R 117fs RNF 43 G 659fs, KRAS, eVIP 2 software, Additional eVIP Pathways analysis, expression-based variant impact phe., Western blot analysis, change-of-function mutation, G 659fs variants, RNF 43 WT, GOF, eVIP 2 method, GFP control cDNA, gene variants, RNF 43 WT function, gene variant function, decision tree-based algorithm, eVIP 2, RNF 43 G 659fs, HEK 293T cells

Relation: https://figshare.com/articles/figure/Validation_of_RNF43_G659fs_pathway_impact_/14902781

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009132.g004