المؤلفون: Zeng, S., Dou, W., Li, M., Zhou, Yang, 1989, Guo, J., Zhao, N., Huang, H., Zhou, Q., Hu, W., Ma, Y., Zhao, X., Xie, H.

المصدر: ChemMedChem. 15(16):1608-1617

مصطلحات موضوعية: biostability, DPP-IV, in silico testing, inhibitors, metabolism, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 6 (1h pyrazol 4 yl)thieno[3, 2 d]pyrimidin 3(4h) yl]methyl] 4 fluorobenzonitrile, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 6 (pyridin 3 yl)thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 6 (pyridin 4 yl)thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 6 [3 (trifluoromethyl)phenyl]thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 7 (pyridin 3 yl)thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (2 methoxypyridin 4 yl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (2 methylpyridin 4 yl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (3 fluorophenyl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (3, 5 dimethylisoxazol 4 yl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (4 fluorophenyl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 bromo 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 [3 (methylsulfonyl)phenyl] 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 7 bromo 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 7 fluoro 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 7 methyl 4 oxo 6 (pyridin 3 yl)thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 7 methyl 4 oxothieno[3, antidiabetic agent, cytochrome P450, dipeptidyl peptidase IV inhibitor, long acting drug, pyrimidine derivative, trelagliptin, unclassified drug, xanthine derivative, animal experiment, area under the curve, Article, computer model, controlled study, drug bioavailability, drug design, drug efficacy, drug half life, drug potency, drug transformation, glycemic control, IC50, in vitro study, in vivo study, infant, male, maximum plasma concentration, mean residence time, metabolic stability, nonhuman, priority journal, rat, time to maximum plasma concentration

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-286487
https://doi.org/10.1002/cmdc.202000175

المؤلفون: Lu Yao, Wang Hainan

المصدر: 生物医学转化, Vol 3, Iss 3, Pp 12-14-30 (2022)

مصطلحات موضوعية: "three combined" evaluation evidence system, tcm new drugs, new drug transformation, Medicine, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://swyxzh.ijournals.cn/swyxzh/article/html/20220303?st=article_issue; https://doaj.org/toc/2096-8965

URL الوصول: https://doaj.org/article/42d04645c71549bf8557a544021a034d

المؤلفون: Martinez, Marilyn N., Jelliffe, Roger W., Proost, Johannes H.

المصدر: Martinez , M N , Jelliffe , R W & Proost , J H 2020 , ' Expert Discussion of the Role of Rate Constant Versus Clearance Approaches to Define Drug Pharmacokinetics: Theoretical and Clinical Considerations ' , Aaps journal , vol. 22 , no. 2 , 25 . https://doi.org/10.1208/s12248-019-0407-x

مصطلحات موضوعية: Clearance, Discussion, Parameterization, Rate Constant, creatinine, digoxin, plasma protein, article, atrial fibrillation, conceptual framework, creatinine clearance, data analysis, drug absorption, drug clearance, drug elimination, drug information, drug monitoring, drug protein binding, drug screening, drug transformation, elimination rate constant, human, mathematical analysis, medical expert, metabolic clearance, pharmacodynamics, pharmacokinetic parameters, renal clearance, treatment response, volume of distribution

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/bd754ef5-7617-45bb-a7bb-4cccf266aaa0

الاتاحة: https://hdl.handle.net/11370/bd754ef5-7617-45bb-a7bb-4cccf266aaa0
https://research.rug.nl/en/publications/bd754ef5-7617-45bb-a7bb-4cccf266aaa0
https://doi.org/10.1208/s12248-019-0407-x
https://pure.rug.nl/ws/files/119122696/Expert_Discussion_of_the_Role_of_Rate_Constant_Versus_Clearance_Approaches_to_Define_Drug_Pharmacokinetics_Theoretical_and_Clinical_Considerations.pdf

المؤلفون: Kouznetsov V., Salas S., Vargas L.Y., Zubkov F., Varlamov A., Martfnez J.R., Alirio Palma R.

المصدر: Journal of Heterocyclic Chemistry

مصطلحات موضوعية: benzazepine derivative, cycloalkane derivative, acetylation, antiviral activity, article, central nervous system disease, depression, drug synthesis, drug transformation, nonhuman, psychosis

Relation: https://doi.org/10.1002/jhet.5570340534; https://openrepository.ru/article?id=258577

الاتاحة: https://openrepository.ru/article?id=258577

المؤلفون: Parshina N.A., Pleteneva T.V., Baikova V.N., Narimanov M.N., Tyulyandin S.A.

المصدر: Pharmaceutical Chemistry Journal

مصطلحات موضوعية: deoxycytidine, gemcitabine, analytic method, antineoplastic activity, article, controlled study, drug determination, drug structure, drug transformation, high performance liquid chromatography, human, human tissue, plasma, reproducibility

Relation: https://doi.org/10.1007/s11094-008-0110-1; https://openrepository.ru/article?id=253545

الاتاحة: https://openrepository.ru/article?id=253545

المؤلفون: Roger W. Jelliffe, Johannes H. Proost, Marilyn N. Martinez

المساهمون: Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Center for Liver, Digestive and Metabolic Diseases (CLDM), Nanomedicine & Drug Targeting

المصدر: Aaps journal, 22(2):25. SPRINGER

مصطلحات موضوعية: Computer science, data analysis, Pharmaceutical Science, drug protein binding, volume of distribution, 030226 pharmacology & pharmacy, Drug pharmacokinetics, 0302 clinical medicine, drug information, creatinine clearance, atrial fibrillation, drug monitoring, Drug elimination, creatinine, article, drug transformation, digoxin, metabolic clearance, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Clearance, Treatment response, pharmacokinetic parameters, Metabolic Clearance Rate, Pharmacology toxicology, Parameterization, Rate Constant, medical expert, Models, Biological, mathematical analysis, drug clearance, 03 medical and health sciences, pharmacodynamics, Humans, Pharmacokinetics, drug screening, human, Discussion, drug absorption, Interpretation (philosophy), drug elimination, Reproducibility of Results, renal clearance, treatment response, Epistemology, Conceptual framework, plasma protein, elimination rate constant, conceptual framework

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e5d51996b47cb5161a2f1a21201805
https://research.rug.nl/en/publications/bd754ef5-7617-45bb-a7bb-4cccf266aaa0

المؤلفون: Kalogirou, Andreas S., Michaelidou, Sophia S., White, A. J. P., Koutentis, Panayiotis Andreas

المساهمون: Koutentis, Panayiotis Andreas 0000-0002-4652-7567, Kalogirou, Andreas S. 0000-0002-5476-5805

المصدر: Tetrahedron ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923542363&doi=10.1016%2fj.tet.2015.02.006&partnerID=40&md5=3c45320a5e628ea53618d5a27c3dfda0

مصطلحات موضوعية: priority journal, unclassified drug, Article, Pyrimidines, drug synthesis, stereospecificity, Pyridines, drug structure, guanidine derivative, Guanidines, nucleophilicity, hydrolysis, ring opening, reaction time, Ring transformations, Sulfur-nitrogen heterocycles, 1,3 di n butyl 2 (3,5 dicyano 6 ethoxy 4 phenylpyridin 2 yl)guanidine, 1,3 dibenzyl 2 (3,5 dicyano 6 ethoxy 4 phenylpyridin 2 yl)guanidine, 2 [4 (diethylamino) 5h 1,2,3 dithiazol 5 ylideneamino] 6 ethoxy 4 phenylpyridine 3,5 dicarbonitrile, 4 (di n propylamino) 7 ethoxy 5 phenylpyrido[2,3 d]pyrimidine 2,6 dicarbonitrile, 4 (dibenzylamino) 7 ethoxy 5 phenylpyrido[2,3 d]pyrimidine 2,6 dicarbonitrile, 4 (diethylamino) 7 ethoxy 5 phenylpyrido[2,3 d]pyrimidine 2,6 dicarbonitrile, 6,6' [[4,4' bis(diethylamino) 5h,5'h (2,20 bithiazolylidene) 5,5' diylidene]bis(azanylylidene)] bis (2 ethoxy 4 phenylpyridine 3,5 dicarbonitrile), 7 ethoxy 5 phenyl 4 (morpholin 4 yl)pyrido[2,3 d]pyrimidine 2,6 dicarbonitrile, 7 ethoxy 5 phenyl 4 (piperidin 1 yl)pyrido[2,3 d]pyrimidine 2,6 dicarbonitrile, 7 ethoxy 5 phenyl 4 (pyrrolidin 1 yl)pyrido[2,3 d]pyrimidine 2,6 dicarbonitrile, drug transformation, KFused heterocycles, pyrido[2,3 d]pyrimidine derivative

Relation: http://gnosis.library.ucy.ac.cy/handle/7/55635

الاتاحة: http://gnosis.library.ucy.ac.cy/handle/7/55635
https://doi.org/10.1016/j.tet.2015.02.006

المؤلفون: Kautiainen, Susanna, Luurila, S., Ylitalo, P., Ylitalo, R.

المصدر: Methods and Findings in Experimental and Clinical Pharmacology. 20(4):289-295

مصطلحات موضوعية: Bisphosphonates, Drug transformation, Protein binding, bisphosphonic acid derivative, clodronic acid, etidronic acid, pamidronic acid, plasma protein, tiludronic acid, article, blood, blood sampling, drug binding, drug blood level, female, human, male, normal human, radioactivity, serum, Analgesics, Non-Narcotic, Antineoplastic Agents, Biotransformation, Carbon Radioisotopes, Diphosphonates, Humans

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-55607

المؤلفون: Andrew N. J. Moore, Keith U. Ingold

المصدر: Free Radical Biology and Medicine. 22:931-934

مصطلحات موضوعية: Male, Oral dose, Stereochemistry, medicine.medical_treatment, heart infarction, alpha tocopherylquinone, Administration, Oral, Alpha (ethology), alpha tocopherol, Biochemistry, Gas Chromatography-Mass Spectrometry, Intestinal absorption, Physiology (medical), medicine, Humans, Vitamin E, Tocopherol, Biotransformation, Aged, free radical, Chromatography, anticoagulant therapy, Single ion, Chemistry, drug effect, drug transformation, stroke, Quinone, Intestinal Absorption, drug blood level, Yield (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d642712ba0971e31fc512dd012df15b5
https://doi.org/10.1016/s0891-5849(96)00276-6

المؤلفون: Мельник, Леонід Григорович, Мельник, Леонид Григорьевич, Melnyk, Leonid Hryhorovych

مصطلحات موضوعية: индустриальный метаболизм, квазинаркотическая трансформация, свободная энергия, экономические системы, індустріальний метаболізм, квазінаркотична трансформація, вільна енергія, економічні системи, industrial metabolism, quasi-drug transformation, free energy, economic system

وصف الملف: application/pdf

Relation: Мельник, Л.Г. Индустриальный метаболизм как основа управления развитием предприятий и макроэкономических систем [Текст] / Л.Г. Мельник // Механізм регулювання економіки. — 2012. — № 1. — С. 95-109.; http://essuir.sumdu.edu.ua/handle/123456789/34147

الاتاحة: http://essuir.sumdu.edu.ua/handle/123456789/34147

المؤلفون: Onen-Bayram F.E., Durmaz I., Scherman, D., Herscovici J., Cetin-Atalay, R.

المصدر: Bioorganic and Medicinal Chemistry

مصطلحات موضوعية: Apoptosis, Cancer, Caspase-9, Cytotoxic, Terminal alkyne, Thiazolidine, 2 phenyl 3 propionyl thiazolidine 4 carboxylic acid ethyl ester, 2 phenyl 4 thiazolidinecarboxylic acid, 2 phenylthiazolidine 4 carboxylic acid ethyl ester, alc 67, antineoplastic agent, camptothecin, caspase 9, death receptor, fluorouracil, thiazolidine derivative, unclassified drug, antineoplastic activity, article, breast cancer, cancer cell culture, cell cycle, concentration response, controlled study, drug cytotoxicity, drug screening, drug structure, drug synthesis, drug transformation, endometrium cancer

وصف الملف: application/pdf

Relation: http://dx.doi.org/10.1016/j.bmc.2012.07.016; 9680896; http://hdl.handle.net/11693/21334

الاتاحة: http://hdl.handle.net/11693/21334
https://doi.org/10.1016/j.bmc.2012.07.016

المؤلفون: Melnyk, Leonid Hryhorovych

مصطلحات موضوعية: economic system, індустріальний метаболізм, економічні системи, quasi-drug transformation, квазинаркотическая трансформация, вільна енергія, индустриальный метаболизм, квазінаркотична трансформація, industrial metabolism, free energy, свободная энергия, экономические системы

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2001::40d683685d7a966dd8cc04fc166b2285
http://essuir.sumdu.edu.ua/handle/123456789/34147

المؤلفون: Murat Durmaz, Veli Yilgor Cirak, Cengiz Gokbulut, Bayram Şenlik, Quintin McKellar, Dilek Aksit

المساهمون: Uludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Öncesi Bilimler Bölümü., Çırak, Veli Yılgör, Şenlik, Bayram, Durmaz, Murat

المصدر: Veterinary parasitology. 170(1-2)

مصطلحات موضوعية: Veterinary sciences, Blood sampling, Drug bioavailability, Administration, Topical, Administration, Oral, Pharmacology, Horse, Haircoat, Drug blood level, Feces, Ivermectin, Time to maximum plasma concentration, Blood plasma, Anthelmintic, Profiles, Strongyloidea, Area under the curve, Antiparasitic Agents, Goats, Plasma concentration-time curve, General Medicine, Drug hair level, Per os, Pour-on, Area Under Curve, Biodegradation, Female, Doramectin, Drug transformation, Drug retention, medicine.drug, Half-Life, Efficacy, Paste, Drug binding, Biology, Injections, Intramuscular, Bovinae, Article, Moxidectin, Fluorescence analysis, Pharmacokinetics, Eprinomectin, Milbemycins, Abamectin, medicine, Animalia, Animals, Animal experiment, Horses, Parasite Egg Count, Strongylida Infections, Pig, Feces analysis, Maximum plasma concentration, General Veterinary, Formulations, Equidae, Nonhuman, Antiparasitic agent, Diet, Bioavailability, Sebum, Drug efficacy, Strongylus, Cattle, Drug disposition, Parasitology, Horse Diseases, Controlled study, High performance liquid chromatography

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b347e69ab95d385831dcd9f12e8f4da7
https://pubmed.ncbi.nlm.nih.gov/20181429

المصدر: Acta Neuropsychiatrica. 11(1):15-17

مصطلحات موضوعية: drug monitoring, psychopharmacology, cytochrome P450, phenotype, genotype, review, drug, drug transformation, biotransformation, human

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dris___01423::b0a4bbcf04e90ee3343edbee0531d358
https://research.rug.nl/en/publications/f805a593-b798-4fec-9fcf-e01b52058ea3

المؤلفون: Wolken, W.A.M., Tramper, J., Werf, M.J. van der

المصدر: Trends in Biotechnology, 8, 21, 338-345

مصطلحات موضوعية: Biology, Biotechnology, Cells, Radiation, Thermal effects, Toxic materials, Vegetative cells, Antibiotic agent, Antiinflammatory agent, Antineoplastic agent, Carbohydrate, Ester, Estrogen, Probiotic agent, Progesterone, Steroid, Spore, Biocatalyst, Biological pest control, Biological warfare, Biosensor, Biotransformation, Cancer control, Cell function, Desiccation, Drug transformation, Genetic procedures, Life cycle, Longevity, Microbial pest control

Relation: uuid:d4f66bf3-72e3-494f-852c-61c8d5cdfb14; 237218; http://resolver.tudelft.nl/uuid:d4f66bf3-72e3-494f-852c-61c8d5cdfb14

الاتاحة: http://resolver.tudelft.nl/uuid:d4f66bf3-72e3-494f-852c-61c8d5cdfb14

مصطلحات موضوعية: Spores, Carbohydrate, Genetic procedures, Cells, Life cycle, Longevity, Vegetative cells, Review, Biosensing Techniques, Probiotic agent, Thermal effects, Radiosensitivity, Antiinflammatory agent, Neoplasms, Biological Warfare, Animals, Humans, Ester, Desiccation, Spore germination, Biology, Steroid, Progesterone, Biotransformation, Priority journal, Radiation, Toxic materials, Biological pest control, Microbial pest control, Sporogenesis, Antibiotic agent, Probiotics, fungi, Temperature, Spore, Nonhuman, Estrogen, Weed control, Insects, Antineoplastic agent, Microspore, Biocatalyst, Drug transformation, Biosensor, Cell function, Biotechnology, Cancer control

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dris___00893::0672a3239a8b561730475a58b3038147
http://resolver.tudelft.nl/uuid:d4f66bf3-72e3-494f-852c-61c8d5cdfb14

المؤلفون: Noten, J.B.G.M., Verhoeven, W.M.A., Tuinier, S., Touw, D.

المصدر: Noten , J B G M , Verhoeven , W M A , Tuinier , S & Touw , D 1999 , ' Therapeutische drug monitoring ' , Acta Neuropsychiatrica , vol. 11 , no. 1 , pp. 15-17 . ; ISSN:0924-2708

مصطلحات موضوعية: cytochrome P450, drug, biotransformation, drug monitoring, drug transformation, genotype, human, phenotype, psychopharmacology, review

الاتاحة: http://hdl.handle.net/11370/f805a593-b798-4fec-9fcf-e01b52058ea3
https://research.rug.nl/en/publications/therapeutische-drug-monitoring(f805a593-b798-4fec-9fcf-e01b52058ea3).html

المؤلفون: Moore, A.N.J., Ingold, K. U.

مصطلحات موضوعية: alpha tocopherol, alpha tocopherylquinone, free radical, anticoagulant therapy, drug blood level, drug effect, drug transformation, heart infarction, stroke, Administration, Oral, Aged, Biotransformation, Gas Chromatography-Mass Spectrometry, Intestinal Absorption, Male, Vitamin E

وصف الملف: text

Relation: Free Radical Biology and Medicine, Volume: 22, Issue: 5, Publication date: 1997, Pages: 931–934

الاتاحة: https://doi.org/10.1016/S0891-5849(96)00276-6
https://nrc-publications.canada.ca/eng/view/object/?id=12bc1697-913c-47d8-998b-62a1513a6c78
https://nrc-publications.canada.ca/fra/voir/objet/?id=12bc1697-913c-47d8-998b-62a1513a6c78

المؤلفون: Gao, Z.-G., Jeong, L.S., Moon, H.R., Kim, H.O., Choi, W.J., Shin, D.H., Elhalem, E., Comin, M.J., Melman, N., Mamedova, L., Gross, A.S., Rodriguez, J.B., Jacobson, K.A.

مصطلحات موضوعية: A3 adenosine receptor agonist, A3 adenosine receptor antagonist, Adenylyl cyclase, Nucleosides, Partial agonist, Phospholipase C, adenosine A3 receptor agonist, adenosine A3 receptor antagonist, ribose, animal cell, article, CHO cell, controlled study, drug efficacy, drug inhibition, drug potency, drug selectivity, drug transformation, nonhuman, priority journal, receptor affinity, receptor intrinsic activity, species difference, substitution reaction

Relation: http://hdl.handle.net/20.500.12110/paper_00062952_v67_n5_p893_Gao

الاتاحة: https://hdl.handle.net/20.500.12110/paper_00062952_v67_n5_p893_Gao

المؤلفون: Careaga, V.P., Muniain, C., Maier, M.S.

مصطلحات موضوعية: (3beta,12alpha,17alpha) 12,17 dihydroxy 18 ox -18,20 epoxylanosta 7,25 dien 3 yl 3 o methyl beta dextro glucopyranosyl(1-3) beta dextro xylopyranosyl(1-4) 6 deoxy beta dextro glucopyranosyl(1-2) beta dextro xylopyranoside, (3beta,12alpha,17alpha) 12,17 dihydroxy 18 oxo 18,20 epoxylanosta 7 en 3 yl 3 o methyl beta dextro glucopyranosyl(1-3) beta dextro glucopyranosyl(1-4) 6 deoxy beta dextro glucopyranosyl(1-2) beta dextro xylopyranoside, alcohol, antifungal agent, glycoside, patagonicoside a, patagonicoside b, patagonicoside c, triterpene derivative, unclassified drug, antifungal activity, article, carbon nuclear magnetic resonance, Cladosporium, Cladosporium cladosporoides, controlled study, drug isolation, drug structure, drug transformation, electrospray mass spectrometry, fractionation, heteronuclear multiple bond correlation, heteronuclear single quantum coherence, nonhuman, nuclear magnetic resonance spectroscopy, nuclear Overhauser effect, proton nuclear magnetic resonance, Psolus patagonicus, sea cucumber, solvolysis

Relation: http://hdl.handle.net/20.500.12110/paper_16121872_v8_n3_p467_Careaga

الاتاحة: https://hdl.handle.net/20.500.12110/paper_16121872_v8_n3_p467_Careaga